{"id":37206,"date":"2022-12-28T14:10:16","date_gmt":"2022-12-28T06:10:16","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=37206"},"modified":"2023-10-13T18:07:03","modified_gmt":"2023-10-13T10:07:03","slug":"%e9%b9%bd%e9%85%b8%e4%ba%8c%e7%94%b2%e9%9b%99%e8%83%8dmetformin-hcl-cas1115-70-4-apexbio-%e8%b2%a8%e8%99%9fb1970","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=37206","title":{"rendered":"\u9e7d\u9178\u4e8c\u7532\u96d9\u80cd(Metformin HCl) | CAS#1115-70-4 APExBIO \u8ca8\u865fB1970"},"content":{"rendered":"

\u96f7\u5e15\u9ef4\u83cc\uff08Rapamycin\uff09<\/a>|\u00a0Romidepsin (FK228, depsipeptide)<\/a>\u00a0|\u00a0Daptomycin\u00a0<\/a>|\u00a0G-418 (80 S \u6838\u91a3\u9ad4\u5ef6\u4f38\u6291\u5236\u5291)<\/a>\u00a0<\/span><\/p>\n

\u9e7d\u9178\u4e8c\u7532\u96d9\u80cd(Metformin HCl) \u00a0| CAS#1115-70-4 APExBIO\u00a0 \u8ca8\u865fB1970<\/a>\u00a0(10mM\/10g\/50g)\u00a0<\/span><\/p>\n

Anti-diabetic drug<\/p>\n

\u9e7d\u9178\u4e8c\u7532\u96d9\u80cd(Metformin HCl) \u662f\u6cbb\u7642 2 \u578b\u7cd6\u5c3f\u75c5(type 2 diabetes)\u6700\u6709\u6548\u548c\u5ee3\u6cdb\u4f7f\u7528\u7684\u6cbb\u7642\u85e5\u7269\u4e4b\u4e00\u3002\u5b83\u9078\u64c7\u6027\u5730\u964d\u4f4e\u809d\u81df\u7cd6\u7570\u751f(hepatic gluconeogenesis)\u800c\u4e0d\u589e\u52a0\u80f0\u5cf6\u7d20(insulin)\u7684\u7522\u751f\uff0c\u5f9e\u800c\u5c0e\u81f4\u9ad4\u91cd\u589e\u52a0(weight gain)\u6216\u4f4e\u8840\u7cd6(hypoglycemia)\u3002 [1]AMPK\uff085’AMP \u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff09\u5145\u7576\u4ee3\u8b1d\u4e3b\u958b\u95dc(metabolic master switch)\uff0c\u8abf\u7bc0\u591a\u500b\u7d30\u80de\u5167\u7cfb\u7d71\uff0c\u5305\u62ec\u7684\u7d30\u80de\u8461\u8404\u7cd6\u651d\u53d6(cellular uptake of glucose)\u3001\u8102\u80aa\u9178\u7684 \u03b2 \u6c27\u5316(-oxidation)\u4ee5\u53ca GLUT4\uff08glucose transporter 4, \u8461\u8404\u7cd6\u8f49\u904b\u86cb\u767d 4\uff09\u548c\u7c92\u7dda\u9ad4(mitochondria)\u7684\u751f\u7269\u5408\u6210\u3002\u5728\u809d\u7d30\u80de(hepatocytes)\u4e2d\uff0cAMPK \u88ab\u4e8c\u7532\u96d9\u80cd(metformin)\u6fc0\u6d3b\uff0c\u96a8\u5f8c ACC\uff08acetyl-CoA carboxylase, \u4e59\u91af\u8f14\u9176 A \u7fa7\u5316\u9176\uff09\u6d3b\u6027\u964d\u4f4e\uff0c\u8a98\u5c0e\u8102\u80aa\u9178\u6c27\u5316(fatty acid oxidization)\u4e26\u6291\u5236\u8102\u80aa\u751f\u6210\u9176(lipogenic enzyme expression)\u8868\u9054\u3002 [2] Metformin\u9084\u6291\u5236 mGPD\uff08mitochondrial lycerophosphate dehydrogenase, \u7dda\u7c92\u9ad4\u7518\u6cb9\u78f7\u9178\u812b\u6c2b\u9176\uff09\uff0c\u4e00\u7a2e\u6c27\u5316\u9084\u539f\u7a7f\u68ad\u9176(redox shuttle enzyme)\uff0c\u5c0e\u81f4\u809d\u7d30\u80de\u6c27\u5316\u9084\u539f\u72c0\u614b\u6539\u8b8a(hepatocellular redox state)\u3001\u4e73\u9178(lactate)\u8f49\u5316\u6e1b\u5c11\u548c\u809d\u91a3\u7570\u751f(hepatic gluconeogenesis)\u6e1b\u5c11\u3002 [1]\u5728\u7528metformin\u6cbb\u7642\u7684\u5927\u9f20\u4e2d\uff0cSEREP-1 mRNA\/\u86cb\u767d\u7684\u809d\u81df\u8868\u9054\u548c ACC \u6d3b\u6027\u964d\u4f4e\u3002 [2] \u5728\u4e8c\u7532\u96d9\u80cd\u6cbb\u7642\u7684\u5c0f\u9f20\u4e2d\uff0c\u809d\u81df\u4e2d\u7684 LKB1 \u5c0d\u65bcmetformin\u964d\u4f4e\u8840\u7cd6\u7684\u80fd\u529b\u81f3\u95dc\u91cd\u8981 [3]\u3002\u5728\u5927\u9f20\u809d\u81df mGOD \u7684 ASO\uff08\u53cd\u7fa9\u5be1\u6838\u82f7\u9178\uff09\u6572\u4f4e\u4e2d\uff0c\u8868\u578b\u8207\u6162\u6027\u4e8c\u7532\u96d9\u80cd\u6cbb\u7642\u76f8\u4f3c\u3002\u5b83\u6d88\u9664\u4e86 mefromin \u8a98\u5c0e\u7684\u7d30\u80de\u6eb6\u8cea\u6c27\u5316\u9084\u539f\u72c0\u614b\u3001\u8840\u6f3f\u8461\u8404\u7cd6\u6fc3\u5ea6\u7684\u964d\u4f4e\u548c EGP \u6291\u5236\u3002 [1]<\/p>\n

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\"\u64cd\u4f5c\u65b9\u6cd5\"<\/a><\/strong><\/p>\n

Sirtuin \u6d3b\u6027\u6aa2\u6e2c\u8a66\u5291\u76d2 <\/span><\/strong><\/a><\/span>\u00a0| SIRT1 \u6d3b\u6027\u6aa2\u6e2c\u8a66\u5291\u76d2<\/strong><\/a><\/span> | NMN<\/strong><\/a> | NAD+\/NADH \u6bd4\u8272\u6e2c\u5b9a\u8a66\u5291\u76d2<\/strong><\/a><\/span> | \u7d30\u80de\u8870\u8001\u6aa2\u6e2c\u8a66\u5291\u76d2<\/a><\/strong><\/span> | Metformin<\/a> | \u96f7\u5e15\u9ef4\u83cc\uff08Rapamycin\uff09<\/a><\/span><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n165.62<\/td>\n<\/tr>\n
Cas No.<\/td>\n1115-70-4<\/td>\n<\/tr>\n
Formula<\/td>\nC4H12ClN5<\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in EtOH; \u226530.7 mg\/mL in H2O; \u22658.3 mg\/mL in DMSO<\/td>\n<\/tr>\n
Chemical Name<\/td>\n3-(diaminomethylidene)-1,1-dimethylguanidine;hydrochloride<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nCN(C)C(=N)N=C(N)N.Cl<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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