{"id":35932,"date":"2022-11-11T16:48:40","date_gmt":"2022-11-11T08:48:40","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=35932"},"modified":"2023-09-07T13:29:21","modified_gmt":"2023-09-07T05:29:21","slug":"bay-11-7821-bay-11-7082-ikk-%e6%8a%91%e5%88%b6%e5%8a%91-cas-19542-67-7-apexbio-%e8%b2%a8%e8%99%9fa4210","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=35932","title":{"rendered":"Bay 11-7821 (BAY 11-7082) | IKK \u6291\u5236\u5291 CAS# 19542-67-7 APExBIO \u8ca8\u865fA4210 (BV1867-10)"},"content":{"rendered":"

\u96f7\u5e15\u9ef4\u83cc\uff08Rapamycin\uff09<\/a>|\u00a0Romidepsin (FK228, depsipeptide)<\/a>\u00a0|\u00a0Daptomycin\u00a0<\/a>|\u00a0G-418 (80 S \u6838\u91a3\u9ad4\u5ef6\u4f38\u6291\u5236\u5291)<\/a>\u00a0<\/span><\/p>\n

Bay 11-7821 (BAY 11-7082) | CAS# 19542-67-7 APExBIO\u00a0 \u8ca8\u865fA4210<\/span><\/a><\/span><\/p>\n

Product Citation+7<\/p>\n

IKK \u6291\u5236\u5291<\/p>\n

\"\u7522\u54c1\u7279\u9ede2\"<\/p>\n

Bay 11-7821 (Bay 11-7082) \u662f\u4e00\u7a2e IKK \u6291\u5236\u5291\uff0cIC50 \u503c\u70ba 10\u03bcM [1]\u3002Bay 11-7821 \u6291\u5236 TNF\u03b1 \u8a98\u5c0e\u7684 I\u03baB-\u03b1 \u78f7\u9178\u5316\uff0c\u5f9e\u800c\u6291\u5236 NF-\u03baB\u3002\u9019\u96a8\u5f8c\u5c0e\u81f4\u6291\u5236 TNF\u03b1 \u8a98\u5c0e\u7684 E-\u9078\u64c7\u7d20(E-selectin)\u3001VCAM-1 \u548c ICAM-1 \u7684\u8868\u9762\u8868\u9054\u3002\u64da\u5831\u5c0e\uff0cBay 11-7821 \u4e0d\u6703\u6291\u5236\u6574\u500b TNF\u03b1 \u8a98\u5c0e\u7684\u78f7\u9178\u5316(phosphorylation)\uff0c\u800c\u662f\u9078\u64c7\u6027\u5730\u6291\u5236 I\u03baB-\u03b1 \u7684\u78f7\u9178\u5316 [1]\u3002\u5be6\u9a57\u8868\u660e\uff0cBay 11-7821 \u5728\u6709\u6548 IKK \u6291\u5236\u6fc3\u5ea6\u4e0b\u5177\u6709\u5287\u6bd2\u3002\u5b83\u53ef\u4ee5\u5728MM\u7d30\u80de\u4e2d\u8a98\u5c0e\u7d30\u80de\u58de\u6b7b\u3002\u6b64\u5916\uff0cBay 11-7821 \u901a\u904e\u8a98\u5c0e B \u7d30\u80de\u6dcb\u5df4\u7624\u548c\u767d\u8840\u75c5 T \u7d30\u80de\u6b7b\u4ea1\u88ab\u8b49\u660e\u5177\u6709\u6297\u708e\u80fd\u529b\u3002\u64da\u5831\u5c0e\uff0c\u5b83\u9084\u80fd\u6291\u5236\u5de8\u566c\u7d30\u80de\u4e2d\u7684 NALP3 \u708e\u6027\u9ad4 [2, 3]\u3002<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\u64cd\u4f5c\u624b\u518a2\"<\/a><\/p>\n

    \n
  1. Can Liu, Qiu Peng, et al. ” Deficiency of Lactoferrin aggravates lipopolysaccharide-induced acute inflammation via recruitment macrophage in mice.” Biometals. 2022 Jun 1;1-14. PMID: 35650365<\/a><\/li>\n
  2. Mingze Ma, Fengxian Shi, et al. “TGF-\u03b2 promote epithelial-mesenchymal transition via NF-\u03baB\/NOX4\/ROS signal pathway in lung cancer cells.” Mol Biol Rep. 2021 Mar;48(3):2365-2375.PMID: 33792826<\/a><\/li>\n
  3. Liu Hui-heng, Wang Jun-sheng, et al. “LPS induced PCT production via TLR-4\/NF-\u043aB passway: it is the difference of G-\/G+ bacteremia rats.” Cytokine. 2020 Oct 7;137:155317.PMID: 33039977<\/a><\/li>\n
  4. Ma L, Jiang M, et al. “Cigarette and IL-17A synergistically induce bronchial epithelial-mesenchymal transition via activating IL-17R\/NF-\u03baB signaling.” BMC Pulm Med. 2020;20(1):26. Published 2020 Jan 30.\u00a0PMID: 32000730<\/a><\/li>\n
  5. Zhang X, Yan K, et al. “Cyclooxygenase 2 promotes proliferation and invasion in ovarian cancer cells via the PGE2\/NF-\u03baB pathway.” Cell Transplant. 2019 Dec 10:963689719890597.PMID: 31822119<\/a><\/li>\n
  6. Wang Z, Chen J, et al. “cGAS\/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.” J Clin Invest. 2019 Aug 13;130:4850-4862.PMID: 31408442<\/a><\/li>\n
  7. MXinwei Feng, Junfeng Lu, et al. “Mycobacterium smegmatis Induces Neurite Outgrowth and Differentiation in an Autophagy-Independent Manner in PC12 and C17.2 Cells.” Front. Cell. Infect. Microbiol. 19 June 2018.<\/li>\n<\/ol>\n\n\n\n\n\n\n\n\n\n\n\n\n
    Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
    M.Wt<\/td>\n207.25<\/td>\n<\/tr>\n
    Cas No.<\/td>\n19542-67-7<\/td>\n<\/tr>\n
    Formula<\/td>\nC10<\/sub>H9<\/sub>NO2<\/sub>S<\/td>\n<\/tr>\n
    Solubility<\/td>\ninsoluble in H2O; \u226564 mg\/mL in DMSO; \u226510.64 mg\/mL in EtOH with gentle warming and ultrasonic<\/td>\n<\/tr>\n
    Chemical Name<\/td>\n(E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile<\/td>\n<\/tr>\n
    SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
    Canonical SMILES<\/td>\nCC1=CC=C(C=C1)S(=O)(=O)C=CC#N<\/td>\n<\/tr>\n
    Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
    General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    \"\u539f\u5ee0\u578b\u9304\"<\/a><\/p>\n

     <\/p>\n

     <\/p>\n

    APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/p>\n

    https:\/\/www.apexbt.com\/<\/p>\n

    APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
    \u54c1\u9805<\/td>\nCAS#<\/td>\n#\u8ca8\u865f<\/td>\n\u61c9\u7528<\/td>\n<\/tr>\n
    Z-VAD-FMK\u00a0 <\/a><\/td>\nCAS# 187389-52-2<\/td>\n\u8ca8\u865f\u00a0A1902<\/td>\n\n

    Proteases<\/p>\n

    ICE-like proteases<\/td>\n<\/tr>\n

    TAPI-1\u00a0 <\/a><\/td>\nCAS#171235-71-5<\/td>\n\u8ca8\u865f\u00a0B4686<\/td>\n\n

    Proteases<\/p>\n

    TACE\/ADAM17 inhibitor Product Citation+3<\/td>\n<\/tr>\n

    Talabostat mesylate<\/a><\/td>\nCAS# 150080-09-4<\/td>\n\u8ca8\u865fB3941<\/td>\n\n

    Proteases<\/p>\n

    DPP4 \u4e8c\u80bd\u57fa\u80bd\u9176\u7279\u7570\u6027\u6291\u5236\u5291<\/td>\n<\/tr>\n

    Z-IETD-FMK <\/a><\/td>\nCAS# 210344-98-2<\/td>\n\u8ca8\u865fB3232<\/td>\ninhibitor of caspase 8<\/td>\n<\/tr>\n
    Cisplatin<\/td>\nCAS# 15663-27-1<\/td>\n\u8ca8\u865fA8321<\/td>\n\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/td>\n<\/tr>\n
    17-DMAG (Alvespimycin) HCl<\/a><\/td>\nCAS#467214-21-7<\/td>\n\u00a0\u8ca8\u865fA2213<\/td>\nHsp90 inhibitor<\/td>\n<\/tr>\n
    CA-074 Me\u00a0 <\/a><\/td>\nCAS# 147859-80-1<\/td>\n\u8ca8\u865fA8239<\/td>\nCathepsin B inhibitor<\/td>\n<\/tr>\n
    VX-765<\/a><\/td>\nCAS# 273404-37-8<\/td>\n\u8ca8\u865fA8238<\/td>\nCaspase-1 inhibitor<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    \u96f7\u5e15\u9ef4\u83cc\uff08Rapamycin\uff09|\u00a0Romidepsin (FK228, depsipeptide)\u00a0|\u00a0Dap […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[5045],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35932"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35932"}],"version-history":[{"count":5,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35932\/revisions"}],"predecessor-version":[{"id":45707,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35932\/revisions\/45707"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35932"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35932"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35932"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}