{"id":35622,"date":"2022-10-29T16:09:13","date_gmt":"2022-10-29T08:09:13","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=35622"},"modified":"2025-11-15T13:09:11","modified_gmt":"2025-11-15T05:09:11","slug":"erastin-cas571203-78-6-apexbio%e8%b2%a8%e8%99%9fb1524","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=35622","title":{"rendered":"Erastin | CAS#571203-78-6 APExBIO\u8ca8\u865fB1524"},"content":{"rendered":"

\u81ea\u566c\/Ferroptosis \u7cfb\u5217\u5546\u54c1->>Erastin<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

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Erastin | CAS#571203-78-6 APExBIO\u8ca8\u865fB1524<\/span><\/a><\/span><\/p>\n

cell-permeable ferroptosis activator and antitumor agent<\/p>\n

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Erastin \u662f\u4e00\u7a2e\u7d30\u80de\u53ef\u6ef2\u900f\u7684 ferroptosis \u6fc0\u6d3b\u5291(cell-permeable ferroptosis activatior)\u548c\u4e00\u7a2e\u6297\u816b\u7624\u5291(antitumor agent)\u3002ferroptosis\u662f\u4e00\u7a2e\u7368\u7279\u7684\u9435\u4f9d\u8cf4\u6027\u975e\u51cb\u4ea1\u6027\u7d30\u80de\u6b7b\u4ea1\u5f62\u5f0f\u3002 \u5b83\u662f\u7531\u81f4\u764c RAS \u9078\u64c7\u6027\u81f4\u6b7b\u5c0f\u5206\u5b50 erastin \u89f8\u767c\u7684\u3002 ferroptosis \u7684\u6fc0\u6d3b\u5c0e\u81f4\u764c\u7d30\u80de\u7684\u975e\u51cb\u4ea1\u7834\u58de\u3002\u5728 BJ-TERT\/LT\/ST\/RASV12 \u7d30\u80de\u4e2d\uff0cErastin \u6fc0\u6d3b\u4e86\u4e00\u500b\u5feb\u901f\u3001\u6c27\u5316\u548c\u975e\u51cb\u4ea1\u7684\u7d30\u80de\u6b7b\u4ea1\u904e\u7a0b\u3002 \u5b83\u5c0d\u5177\u6709\u6d89\u53ca RAS-RAF-MEF \u901a\u8def\u7684 HRAS\u3001KRA \u6216 BRAF \u81f4\u764c\u7a81\u8b8a\u7684\u4eba\u985e\u764c\u7d30\u80de\u767c\u63ee\u6bba\u50b7\u529b\uff0c\u4e26\u901a\u904e\u8abf\u7bc0 VDAC\uff08volatage-dependent anion channels, \u96fb\u58d3\u4f9d\u8cf4\u6027\u9670\u96e2\u5b50\u901a\u9053\uff09\u8d77\u4f5c\u7528\u3002 [1] \u5728 HT 1080 \u7d30\u80de\u4e2d\uff0cErastin \u8a98\u5c0e\u7684\u6b7b\u4ea1\u89f8\u767c\u4e86\u7d30\u80de\u6eb6\u8cea ROS \u7684\u7a4d\u7d2f\uff0c\u4e26\u4e14\u8a98\u5c0e\u7684\u6c27\u5316\u6b7b\u4ea1\u662f\u9435\u4f9d\u8cf4\u6027\u7684\u3002 Erastin \u9084\u6291\u5236\u7368\u7acb\u7684\u80f1\u6c28\u9178\/\u8c37\u6c28\u9178(cystine\/glutamate)\u9006\u5411\u8f49\u904b\u86cb\u767d\u7cfb\u7d71 xc- \u7684\u6d3b\u6027\u3002 [2]]<\/p>\n

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  1. Yang Liu, Libo He, et al. “Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway.” iScience. 2022 Jun 6;25(7):104533. PMID: 35784791<\/a><\/li>\n
  2. Zongbo Wei, Caili Hao, et al. “Aging lens epithelium is susceptible to ferroptosis.” Free Radic Biol Med. 2021 May 1;167:94-108.PMID: 33722625<\/a><\/li>\n
  3. Xinzhi Yang, Jiangang Liu, et al. “miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities.” Oncogenesis. 2021 Feb 12;10(2):15.PMID: 33579899<\/a><\/li>\n
  4. Ali Ghoochani, En-Chi Hsu, et al. “Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer.” Cancer Res. 2021 Mar 15;81(6):1583-1594.PMID: 33483372<\/a><\/li>\n
  5. Qi Wang, Yaxun Guo, et al. “RNA binding protein DAZAP1 promotes HCC progression and regulates ferroptosis by interacting with SLC7A11 mRNA.” Exp Cell Res. 2021 Feb 1;399(1):112453.PMID: 33358859<\/a><\/li>\n
  6. Hu Z, Zhang H, et al. “VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis.” Cell Death Dis. 2020;11(1):73. Published 2020 Jan 29.\u00a0PMID: 31996668<\/a><\/li>\n<\/ol>\n

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    APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/p>\n

    APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a>
    \n\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n

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     <\/p>\n","protected":false},"excerpt":{"rendered":"

    \u81ea\u566c\/Ferroptosis \u7cfb\u5217\u5546\u54c1->>Erastin APExBIO Technology […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368,486,87,3],"tags":[5031],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35622"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35622"}],"version-history":[{"count":9,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35622\/revisions"}],"predecessor-version":[{"id":53617,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35622\/revisions\/53617"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35622"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35622"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35622"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}