{"id":35443,"date":"2022-10-26T16:27:21","date_gmt":"2022-10-26T08:27:21","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=35443"},"modified":"2025-06-30T16:07:14","modified_gmt":"2025-06-30T08:07:14","slug":"tubastatin-a-cas1252003-15-8-apexbio-%e8%b2%a8%e8%99%9fa4101","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=35443","title":{"rendered":"Tubastatin A | CAS#1252003-15-8 APExBIO \u8ca8\u865fA4101"},"content":{"rendered":"

Apoptosis \u7cfb\u5217\u5546\u54c1->>Tubastatin A<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<\/p>\n

<\/p>\n

Tubastatin A | CAS#1252003-15-8 APExBIO\u00a0 \u8ca8\u865fA4101<\/a><\/span><\/p>\n

HDAC6 inhibitor,potent and selective<\/p>\n

\u7d44\u86cb\u767d\u53bb\u4e59\u91af\u5316\u9176 (Histone deacetylases , HDACs) \u548c\u7d44\u86cb\u767d\u4e59\u91af\u8f49\u79fb\u9176 (histone acetyltransferases , HATs) \u4ecb\u5c0e\u7d44\u86cb\u767d\u53bb\u4e59\u91af\u5316(histone deacetylation)\u548c\u4e59\u91af\u5316(acetylation)\u4e4b\u9593\u7684\u5e73\u8861\u3002 HDAC \u9084\u8abf\u7bc0\u4fe1\u865f\u5206\u5b50(signaling molecules)\u3001\u4f34\u4fb6\u86cb\u767d(chaperones)\u548c\u975e\u7d44\u86cb\u767d(non-histone proteins)\u8f49\u9304\u56e0\u6578\u7684\u4e59\u91af\u5316\u72c0\u614b [2]\u3002 HDAC6 \u8207\u5206\u5b50\u4f34\u4fb6 HSP90 \u76f8\u4e92\u4f5c\u7528\u3002 HDAC6 \u5c0d HSP90 \u7684\u53bb\u4e59\u91af\u5316\u5c0d\u7a69\u5b9a\u6027\u548c\u8a31\u591a\u5ba2\u6236\u86cb\u767d\uff08\u5305\u62ec Bcr-Abl\u3001c-Raf \u548c A\u200b\u200bKT\uff09\u7684\u7a69\u5b9a\u6027\u5f88\u91cd\u8981\u3002\u56e0\u6b64\uff0cHDAC\u6291\u5236\u5291\u5177\u6709\u6297\u764c\u4f5c\u7528(anti-cancer function )[2]\u3002\u8207\u5176\u4ed6 HDAC \u76f8\u6bd4\uff0cTubastatin A \u662f HDAC6 \u7684\u9078\u64c7\u6027\u6291\u5236\u5291(selective inhibitor)\u3002 Tubastatin A \u7684\u9078\u64c7\u6027\u6bd4 I \u985e HDAC \u5e73\u5747\u9ad8 200 \u500d\u3002 Tubastatin A \u5c0d\u9664 HDAC8 \u4ee5\u5916\u7684\u6240\u6709\u540c\u7a2e\u578b\u5747\u8868\u73fe\u51fa\u9078\u64c7\u6027\u8d85\u904e1000\u500d\u3002 Tubastatin A \u4ee5\u5291\u91cf\u4f9d\u8cf4\u6027\u65b9\u5f0f(dose-dependent manner)\u4fdd\u8b77\u514d\u53d7 HCA \u8a98\u5c0e\u7684\u795e\u7d93\u5143\u7d30\u80de\u6b7b\u4ea1(neuronal cell death)\u3002 Tubastatin A \u5728 2.5 \u03bcM [1] \u6642\u8a98\u5c0e \uf061-tubulin \u7684\u9ad8\u4e59\u91af\u5316\u3002\u5728 LPS \u523a\u6fc0\u7684\u4eba\u985e THP-1 \u5de8\u566c\u7d30\u80de\u4e2d\uff0cTubastatin A \u986f\u793a\u51fa\u5c0d IL-6 \u548c TNF \u7684\u986f\u8457\u6291\u5236\u4f5c\u7528\uff0cIC50 \u70ba 712 nM \u548c 212 nM [3]\u3002 Tubastatin A \u5728\u5c0f\u9f20 Raw 264.7 \u5de8\u566c\u7d30\u80de\u4e2d\u986f\u793a\u51fa\u6291\u5236\u4e00\u6c27\u5316\u6c2e (NO) \u5206\u6ccc\u7684\u4f5c\u7528\uff0cIC50 \u70ba 4.2\u03bcM [3]\u3002 Tubastatin-A \u9084\u5728 KMCH \u7d30\u80de\u4e2d\u986f\u8457\u6291\u5236 10\u03bcM \u7684\u7d30\u80de\u589e\u6b96 [4]\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n335.4<\/td>\n<\/tr>\n
Cas No.<\/td>\n1252003-15-8<\/td>\n<\/tr>\n
Formula<\/td>\nC20<\/sub>H21<\/sub>N3<\/sub>O2<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in EtOH; insoluble in H2O; \u226510.75 mg\/mL in DMSO<\/td>\n<\/tr>\n
Chemical Name<\/td>\nN-hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nO=C(C1=CC=C(CN2C3=C(C4=C2C=CC=C4)CN(CC3)C)C=C1)NO<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

<\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002
\n\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
DNA Damage\/DNA Repair<\/strong><\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
SCR7<\/a><\/span><\/td>\nCAS#1533426-72-0<\/span><\/td>\n\u8ca8\u865fA8705<\/span><\/td>\nDNA ligase IV inhibitor<\/span><\/td>\n<\/tr>\n
RHPS4n\u00a0<\/a>\u00a0<\/span><\/td>\nCAS#390362-78-4<\/span><\/td>\n\u8ca8\u865fB6186<\/span><\/td>\nTelomerase inhibitor<\/span><\/td>\n<\/tr>\n
AZD6738<\/a><\/span><\/td>\nCAS#1352226-88-0<\/span><\/td>\n\u8ca8\u865fB6007<\/span><\/td>\nATR inhibitor<\/span><\/td>\n<\/tr>\n
\n

ORY-1001<\/a><\/span><\/p>\n

 <\/td>\n

CAS#1431326-61-2<\/span><\/td>\n\u8ca8\u865fB5882<\/span><\/td>\nSelective inhibitor of KDM1A.<\/span><\/td>\n<\/tr>\n
RGFP966<\/a><\/span><\/td>\nCAS#1357389-11-7;1396841-57-8<\/span><\/td>\n\u8ca8\u865fA8803<\/span><\/td>\nSpecific HDAC3 inhibitor<\/span><\/td>\n<\/tr>\n
Oxaliplatin<\/a><\/span><\/td>\nCAS#61825-94-3<\/span><\/td>\n\u8ca8\u865fA8648<\/span><\/td>\nAntitumor agent<\/span><\/td>\n<\/tr>\n
(S)-Crizotinib<\/a><\/span><\/td>\nCAS#877399-52-5;1374356-45-2<\/span><\/td>\n\n

\u8ca8\u865fA8802<\/span><\/p>\n

 <\/td>\n

Potent MTH1 inhibitor<\/span><\/td>\n<\/tr>\n
Tubastatin A<\/a><\/span><\/td>\nCAS#1252003-15-8<\/span><\/td>\n\u8ca8\u865fA4101<\/span><\/td>\nHDAC6 inhibitor,potent and selective<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Apoptosis \u7cfb\u5217\u5546\u54c1->>Tubastatin A APExBIO Technology […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[5027],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35443"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35443"}],"version-history":[{"count":5,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35443\/revisions"}],"predecessor-version":[{"id":51805,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35443\/revisions\/51805"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35443"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35443"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}