{"id":35425,"date":"2022-10-26T15:25:21","date_gmt":"2022-10-26T07:25:21","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=35425"},"modified":"2026-02-02T15:12:37","modified_gmt":"2026-02-02T07:12:37","slug":"oxaliplatin-cas61825-94-3-apexbio-%e8%b2%a8%e8%99%9fa8648","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=35425","title":{"rendered":"Oxaliplatin | CAS#61825-94-3 APExBIO \u8ca8\u865fA8648"},"content":{"rendered":"

DNA\/RNA\u5408\u6210-\u7d30\u80de\u51cb\u4ea1\u7cfb\u5217\u5546\u54c1->>Oxaliplatin<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

Oxaliplatin | CAS#61825-94-3 APExBIO\u00a0 \u8ca8\u865fA8648<\/a><\/span><\/p>\n

Antitumor agent. Purity = 99.92%<\/p>\n

\"\"<\/p>\n

Oxaliplatin\u4e3b\u8981\u901a\u904e\u7b26\u5408 DNA \u52a0\u5408\u7269\u4f86\u6291\u5236 DNA \u5408\u6210\u3002Oxaliplatin\u662f\u4e00\u7a2e\u9251\u5316\u5408\u7269(platinum compounds)\uff0c\u5177\u6709\u5ee3\u8b5c\u7684\u6297\u816b\u7624\u6d3b\u6027(anti-tumor activity)\uff0c\u4e26\u4e14\u5df2\u8b49\u660e\u8207\u5176\u4ed6\u9251\u5316\u5408\u7269(platinum compounds)\u7f3a\u4e4f\u4ea4\u53c9\u8010\u85e5\u6027\u3002Oxaliplatin\u8a98\u5c0e\u5c0e\u81f4\u7d30\u80de\u51cb\u4ea1(cell apoptosis)\u7684\u539f\u767c\u6027\u548c\u7e7c\u767c\u6027 DNA \u640d\u50b7\u3002<\/p>\n

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\u9ad4\u5916\uff1aOxaliplatin\u5c0d\u4eba\u9ed1\u8272\u7d20\u7624\u7d30\u80de\u7cfb(melanoma cell lines) C32 \u548c G361 \u5177\u6709\u6d3b\u6027\uff0cIC50 \u503c\u5206\u5225\u70ba 0.98 mM \u548c 0.14 mM\u3002Oxaliplatin\u6709\u6548\u6291\u5236\u8180\u80f1\u764c\u7d30\u80de\u7cfb(bladder carcinoma cell lines) RT4 \u548c TCCSUP\u3001\u5375\u5de2\u764c\u7d30\u80de\u7cfb (ovarian carcinoma cell line )A2780\u3001\u7d50\u8178\u764c\u7d30\u80de\u7cfb HT-29(colon carcinoma cell line)\u3001\u81a0\u8cea\u6bcd\u7d30\u80de\u7624\u7d30\u80de\u7cfb(glioblastoma cell lines) U-87MG \u548c U-373MG\uff0c\u4ee5\u53ca\u9ed1\u8272\u7d20\u7624\u7d30\u80de\u7cfb(melanoma cell lines) SK-MEL-2 \u548c HT-144 IC50 \u503c\u5206\u5225\u70ba 11 \u03bcM\u300115 \u03bcM\u30010.17 \u03bcM\u30010.97 \u03bcM\u300117.6 \u03bcM\u30012.95 \u03bcM\u300130.9 \u03bcM \u548c 7.85 \u03bcM\u3002<\/p>\n

\"\"<\/p>\n

\u81e8\u5e8a\u8a66\u9a57\uff1a\u5728\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\uff0c\u8207\u6c1f\u5c3f\u5627\u5576\/\u4e9e\u8449\u9178\u806f\u7528\uff0cOxaliplatin\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u548c\u5c0d\u5148\u524d\u5316\u7642\u7121\u6548\u7684\u60a3\u8005\u5747\u986f\u793a\u51fa\u5c0d\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u7684\u6d3b\u6027\u3002\u6b64\u5916\uff0cOxaliplatin\u5728\u9251\u985e\u9810\u8655\u7406\u7684\u5375\u5de2\u764c\u3001\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001\u4e73\u817a\u764c\u3001\u9593\u76ae\u7624\u548c\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u4e5f\u986f\u793a\u51fa\u7642\u6548\u3002<\/p>\n

\"\"<\/p>\n

\u00a0<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n397.29<\/td>\n<\/tr>\n
Cas No.<\/td>\n61825-94-3<\/td>\n<\/tr>\n
Formula<\/td>\nC8<\/sub>H14<\/sub>N2<\/sub>O4<\/sub>Pt<\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in EtOH; \u226537.25 mg\/mL in DMSO; \u22653.94 mg\/mL in H2O with gentle warming<\/td>\n<\/tr>\n
Chemical Name<\/td>\n(1R,2R)-cyclohexane-1,2-diamine;oxalate;platinum(2+)<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nC1CCC(C(C1)N)N.C(=O)(C(=O)[O-])[O-].[Pt+2]<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

    \n
  1. Qing Zhang, Yue Zhou, et al. “Low-dose orlistat promotes the therapeutic effect of oxaliplatin in colorectal cancer.” Biomed Pharmacother. 2022 Sep;153:113426. PMID: 36017794<\/a><\/li>\n
  2. Xia Liao, Yaoyao Zhang, et al. “Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-\u03b2-catenin-ABCG1 signaling pathway.” J Cancer. 2021 Aug 24;12(20):6071-6080.PMID: 34539880<\/a><\/li>\n
  3. Liao X, Song G, et al. “Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.” BMC Cancer. 2020;20(1):31.PMID: 31931755<\/a><\/li>\n
  4. Feng M, Jin JQ, et al. “Pharmacological inhibition of \u03b2-catenin\/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating T(reg) cells.” Sci Adv. 2019 May 8;5(5):eaau5240.PMID: 31086813<\/a><\/li>\n
  5. Cho SY, Chae J, et al. “Unstable Genome and Transcriptome Dynamics during Tumor Metastasis Contribute to Therapeutic Heterogeneity in Colorectal Cancers.” Clin Cancer Res. 2019 Jan 22.PMID: 30670495<\/a><\/li>\n
  6. Goodspeed A, Jean A, et al. “A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer.” Eur Urol. 2019 Feb;75(2):242-250.PMID: 30414698<\/a><\/li>\n<\/ol>\n

    <\/p>\n

    APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/p>\n

    APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n


    \n\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
    DNA Damage\/DNA Repair<\/strong><\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
    SCR7<\/a><\/span><\/td>\nCAS#1533426-72-0<\/span><\/td>\n\u8ca8\u865fA8705<\/span><\/td>\nDNA ligase IV inhibitor<\/span><\/td>\n<\/tr>\n
    RHPS4n\u00a0<\/a>\u00a0<\/span><\/td>\nCAS#390362-78-4<\/span><\/td>\n\u8ca8\u865fB6186<\/span><\/td>\nTelomerase inhibitor<\/span><\/td>\n<\/tr>\n
    AZD6738<\/a><\/span><\/td>\nCAS#1352226-88-0<\/span><\/td>\n\u8ca8\u865fB6007<\/span><\/td>\nATR inhibitor<\/span><\/td>\n<\/tr>\n
    \n

    ORY-1001<\/a><\/span><\/p>\n

     <\/td>\n

    		CAS#1431326-61-2<\/span><\/td>\n\u8ca8\u865fB5882<\/span><\/td>\nSelective inhibitor of KDM1A.<\/span><\/td>\n<\/tr>\n
    RGFP966<\/a><\/span><\/td>\nCAS#1357389-11-7;1396841-57-8<\/span><\/td>\n\u8ca8\u865fA8803<\/span><\/td>\nSpecific HDAC3 inhibitor<\/span><\/td>\n<\/tr>\n
    Oxaliplatin<\/a><\/span><\/td>\nCAS#61825-94-3<\/span><\/td>\n\u8ca8\u865fA8648<\/span><\/td>\nAntitumor agent<\/span><\/td>\n<\/tr>\n
    (S)-Crizotinib<\/a><\/span><\/td>\nCAS#877399-52-5;1374356-45-2<\/span><\/td>\n\n

    \u8ca8\u865fA8802<\/span><\/p>\n

     <\/td>\n

    		Potent MTH1 inhibitor<\/span><\/td>\n<\/tr>\n
    Tubastatin A<\/a><\/span><\/td>\nCAS#1252003-15-8<\/span><\/td>\n\u8ca8\u865fA4101<\/span><\/td>\nHDAC6 inhibitor,potent and selective<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    DNA\/RNA\u5408\u6210-\u7d30\u80de\u51cb\u4ea1\u7cfb\u5217\u5546\u54c1->>Oxaliplatin APExBIO Technolo […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368,3],"tags":[5025],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35425"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35425"}],"version-history":[{"count":7,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35425\/revisions"}],"predecessor-version":[{"id":54404,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35425\/revisions\/54404"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35425"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35425"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}