{"id":35420,"date":"2022-10-26T14:13:21","date_gmt":"2022-10-26T06:13:21","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=35420"},"modified":"2025-11-15T15:58:14","modified_gmt":"2025-11-15T07:58:14","slug":"ory-1001-cas1431326-61-2-apexbio-%e8%b2%a8%e8%99%9fb5882","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=35420","title":{"rendered":"ORY-1001| CAS#1431326-61-2 APExBIO \u8ca8\u865fB5882"},"content":{"rendered":"

\u7d44\u86cb\u767d\u53bb\u7532\u57fa\u5316\u9176-\u7d30\u80de\u51cb\u4ea1\u7cfb\u5217\u5546\u54c1->>ORY-1001<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

ORY-1001| CAS#1431326-61-2 APExBIO\u00a0 \u8ca8\u865fB5882<\/a><\/span><\/p>\n

\u8cf4\u6c28\u9178 (K) \u7279\u7570\u6027\u53bb\u7532\u57fa\u5316\u9176 1A (Lysine (K)-specific demethylase 1A , KDM1A\uff0c\u53c8\u540d LSD1) \u662f\u767d\u8840\u75c5\u5e79\u7d30\u80de (leukemia stem cell , LSC) \u6f5b\u529b\u7684\u95dc\u9375\u8abf\u7bc0\u56e0\u5b50\uff0c\u662f MLL-AF9 \u81f4\u764c\u8f49\u5316(oncogenic transformation)\u6240\u5fc5\u9700\u7684\u3002 KDM1A \u8868\u9054\u6216\u6d3b\u6027\u7684\u6291\u5236\u514b\u670d\u4e86 AML \u4e2d\u7684\u5206\u5316\u963b\u6eef\u3002 ORY-1001 \u662f KDM1A \u7684\u9078\u64c7\u6027\u6291\u5236\u5291(selective inhibitor)\u3002\u9ad4\u5916(In vitro)\uff1aORY-1001 \u662f\u4e00\u7a2e\u5c0d\u6620\u9ad4\u7d14\u7684 KDM1A \u6291\u5236\u5291\uff0c\u5c0d\u76f8\u95dc\u7684 FAD \u4f9d\u8cf4\u6027\u6c28\u57fa\u6c27\u5316\u9176\u5177\u6709\u9ad8\u9078\u64c7\u6027\u3002 ORY-1001 \u4e0d\u6703\u6291\u5236\u975e\u76f8\u95dc\u7d44\u86cb\u767d\u4fee\u98fe\u7269(non-related histone modifiers)\uff0c\u4e26\u4e14\u5728 CEREP \u591a\u6a23\u6027\u9762\u677f\u4e2d\u662f\u4e7e\u6de8\u7684\u3002\u7528 ORY-1001 \u8655\u7406 THP-1 \u7d30\u80de\u6703\u5c0e\u81f4 KDM1A \u9776\u57fa\u56e0\u8655\u7684\u6642\u9593\/\u5291\u91cf\u4f9d\u8cf4\u6027 me2H3K4 \u7a4d\u7d2f\uff0c\u4e26\u4f34\u96a8\u8a98\u5c0e\u5206\u5316\u6a19\u8a8c\u7269 [1]\u3002\u9ad4\u5167(In vivo)\uff1a\u6bcf\u65e5\u53e3\u670d\u5291\u91cf < 0.020 mg\/kg \u53ef\u986f\u8457\u964d\u4f4e\u56d3\u9f52\u52d5\u7269\u7570\u7a2e\u79fb\u690d\u7269(rodent xenografts)\u4e2d\u7684\u816b\u7624\u751f\u9577\u3002\u9ad4\u5167\u7814\u7a76\u8868\u660e\uff0cORY-1001 \u5177\u6709\u512a\u7570\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u3001\u9776\u5411\u66b4\u9732\u548c\u9ad4\u5167\u6d3b\u6027 [1]\u3002\u81e8\u5e8a\u8a66\u9a57\uff1a Oryzon Genomics \u5ba3\u5e03\u5176 ORY-1001 I \u671f\u81e8\u5e8a\u8a66\u9a57\u64f4\u5c55\u968a\u5217\uff08\u7b2c 2 \u90e8\u5206\uff09\u4e2d\u7b2c\u4e00\u4f4d\u60a3\u8005\u7684\u7d66\u85e5\u3002\u8a72\u8a66\u9a57\u5c07\u5728\u897f\u73ed\u7259\u3001\u82f1\u570b\u548c\u6cd5\u570b\u7684 10 \u500b\u4e2d\u5fc3\u9032\u884c\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n303.27<\/td>\n<\/tr>\n
Cas No.<\/td>\n1431326-61-2<\/td>\n<\/tr>\n
Formula<\/td>\nC15<\/sub>H24<\/sub>Cl2<\/sub>N2<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in EtOH; \u226523.15 mg\/mL in H2O; \u22656.9 mg\/mL in DMSO with gentle warming<\/td>\n<\/tr>\n
Chemical Name<\/td>\nN1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nNC(CC1)CCC1N[C@H]2[C@H](C3=CC=CC=C3)C2<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\"<\/p>\n

 <\/p>\n

Selective inhibitor of KDM1A.<\/p>\n

<\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n

\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n

\u7531\u65bc\u5916\u90e8\uff08exogenous, \u5916\u6e90\u6027\uff09\u548c\u5167\u90e8\uff08endogenous, \u5167\u6e90\u6027\uff09\u58d3\u529b\uff0c\u4eba\u9ad4\u7d30\u80de\u4e2d\u7684 DNA \u6bcf\u5929\u6703\u53d7\u5230\u6578\u4ee5\u842c\u8a08\u7684\u640d\u5bb3(damages)\u3002\u5916\u6e90\u6027\u640d\u5bb3(exogenous damages)\u662f\u7531\u5316\u5b78\u6c61\u67d3(chemical contamination)\u3001\u7d2b\u5916\u7dda(UV light)\u3001\u96fb\u96e2\u8f3b\u5c04(ionizing radiation)\u548c\u70f7\u57fa\u5316\/\u7532\u57fa\u5316(alkylation\/methylation)\u7b49\u5f15\u8d77\u7684\uff0c\u800c\u5167\u6e90\u6027\u640d\u5bb3(endogenous damages)\u662f\u7531\u9e7c\u7684\u6c27\u5316(oxidation)\u3001\u70f7\u57fa\u5316(alkylation)\u548c\u6c34\u89e3(hydrolysis)\u7b49\u5f15\u8d77\u7684\u3002\u7531\u65bcDNA\u640d\u50b7(double strand breaks)\u5f8c\u6703\u767c\u751f\u55ae\u934a(single strand)\u548c\u96d9\u93c8\u65b7\u88c2(double strand breaks)\uff0c\u672a\u4fee\u5fa9\u7684DNA\u640d\u50b7\u5c0e\u81f4\u7d30\u80de\u8870\u8001(cell senescent)\u3001\u51cb\u4ea1(apoptosis)\u548c\u60e1\u6027\u816b\u7624(malignancies)\u7b49\u3002\u70ba\u4e86\u514b\u670d\u9019\u7a2e\u5a01\u8105\uff0c\u7d30\u80de\u7522\u751f\u4e86 DNA \u640d\u50b7\u53cd\u61c9(DNA damage response)\uff0c\u4ee5\u6aa2\u6e2c DNA \u640d\u50b7\u4e26\u4ecb\u5c0e\u5176\u4fee\u5fa9(repair)\u3002DNA\u4fee\u5fa9\u6d89\u53ca\u932f\u914d\u3001\u9e7c\u57fa\u5207\u9664\u3001\u6838\u82f7\u9178\u5207\u9664\u4fee\u5fa9\u7b49\u591a\u7a2e\u6a5f\u5236\u3002\u4e00\u7d44\u86cb\u767d\u8cea\u548c\u9014\u5f91\u53c3\u8207\u4e86\u9019\u4e9b\u904e\u7a0b\u3002 ATM\/ATR \u6fc0\u9176\u548c DNA-PK \u5c0d\u65bc\u6aa2\u6e2c DNA \u640d\u50b7\u81f3\u95dc\u91cd\u8981\u3002\u67d3\u8272\u8cea\u91cd\u5851\u5291\u8abf\u7bc0 DNA \u4fee\u5fa9\u56e0\u5b50\u767c\u63ee\u4f5c\u7528\u7684\u67d3\u8272\u8cea\u53ef\u53ca\u6027\u3002 RPA\u3001Rad51 \u548c\u7bc4\u53ef\u5c3c\u8ca7\u8840\u86cb\u767d\u76f4\u63a5\u4f5c\u7528\u65bc\u4fee\u5fa9 DNA \u640d\u50b7\u3002 p53 \u7db2\u7d61\u3001RAS GTPase \u8d85\u5bb6\u65cf\u548c\u6cdb\u7d20\u7cfb\u7d71\u4e5f\u5728 DNA \u640d\u50b7\u53cd\u61c9\u4e2d\u767c\u63ee\u91cd\u8981\u4f5c\u7528\u3002\u7570\u5e38\u7684 DNA \u640d\u50b7\u53cd\u61c9\u8207\u8870\u8001\u3001\u764c\u75c7\u548c\u514d\u75ab\u75be\u75c5\u6709\u95dc\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
DNA Damage\/DNA Repair<\/strong><\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
SCR7<\/a><\/span><\/td>\nCAS#1533426-72-0<\/span><\/td>\n\u8ca8\u865fA8705<\/span><\/td>\nDNA ligase IV inhibitor<\/span><\/td>\n<\/tr>\n
RHPS4n\u00a0<\/a>\u00a0<\/span><\/td>\nCAS#390362-78-4<\/span><\/td>\n\u8ca8\u865fB6186<\/span><\/td>\nTelomerase inhibitor<\/span><\/td>\n<\/tr>\n
AZD6738<\/a><\/span><\/td>\nCAS#1352226-88-0<\/span><\/td>\n\u8ca8\u865fB6007<\/span><\/td>\nATR inhibitor<\/span><\/td>\n<\/tr>\n
\n

ORY-1001<\/a><\/span><\/p>\n

 <\/td>\n

CAS#1431326-61-2<\/span><\/td>\n\u8ca8\u865fB5882<\/span><\/td>\nSelective inhibitor of KDM1A.<\/span><\/td>\n<\/tr>\n
RGFP966<\/a><\/span><\/td>\nCAS#1357389-11-7;1396841-57-8<\/span><\/td>\n\u8ca8\u865fA8803<\/span><\/td>\nSpecific HDAC3 inhibitor<\/span><\/td>\n<\/tr>\n
Oxaliplatin<\/a><\/span><\/td>\nCAS#61825-94-3<\/span><\/td>\n\u8ca8\u865fA8648<\/span><\/td>\nAntitumor agent<\/span><\/td>\n<\/tr>\n
(S)-Crizotinib<\/a><\/span><\/td>\nCAS#877399-52-5;1374356-45-2<\/span><\/td>\n\n

\u8ca8\u865fA8802<\/span><\/p>\n

 <\/td>\n

Potent MTH1 inhibitor<\/span><\/td>\n<\/tr>\n
Tubastatin A<\/a><\/span><\/td>\nCAS#1252003-15-8<\/span><\/td>\n\u8ca8\u865fA4101<\/span><\/td>\nHDAC6 inhibitor,potent and selective<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u7d44\u86cb\u767d\u53bb\u7532\u57fa\u5316\u9176-\u7d30\u80de\u51cb\u4ea1\u7cfb\u5217\u5546\u54c1->>ORY-1001 APExBIO Technology L […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368,3],"tags":[5024],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35420"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35420"}],"version-history":[{"count":6,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35420\/revisions"}],"predecessor-version":[{"id":53773,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35420\/revisions\/53773"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35420"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35420"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}