{"id":35416,"date":"2022-10-26T13:56:34","date_gmt":"2022-10-26T05:56:34","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=35416"},"modified":"2025-06-30T16:42:14","modified_gmt":"2025-06-30T08:42:14","slug":"azd6738-cas1352226-88-0-apexbio-%e8%b2%a8%e8%99%9fb6007","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=35416","title":{"rendered":"AZD6738 | CAS#1352226-88-0 APExBIO \u8ca8\u865fB6007"},"content":{"rendered":"

ATR\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1->>AZD6738<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<\/p>\n

<\/p>\n

 <\/p>\n

AZD6738| APExBIO\u8ca8\u865f B6007<\/a><\/span><\/p>\n

\u7522\u54c1\u4ecb\u7d39<\/span><\/strong><\/span><\/p>\n

AZD6738 \u662f\u4e00\u7a2e\u9078\u64c7\u6027 ATR\uff0c\u6bdb\u7d30\u8840\u7ba1\u64f4\u5f35\u6027\u5171\u6fdf\u5931\u8abf\u53ca RAD3 \u76f8\u95dc\u6291\u5236\u5291 (Ataxia Telangiectasia and RAD3-related) \uff09\uff0c\u5c0d\u975c\u6b62\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5 (CLL) \u7d30\u80de\u7684 IC50 \u7d04\u70ba 30 \u03bcM [1] [2]\u3002ATR \u662f\u4e00\u7a2e PI3K \u76f8\u95dc\u7684\u6fc0\u9176\uff0c\u53c3\u8207 DNA \u640d\u50b7\u7684\u4fee\u5fa9\u3002\u5728\u7d30\u80de\u5206\u88c2\u904e\u7a0b\u4e2d\uff0c\u5b83\u5728\u55ae\u80a1 DNA \u65b7\u88c2\u8655\u88ab\u52df\u96c6\u4e26\u6fc0\u6d3b\uff0c\u5f9e\u800c\u555f\u52d5 DNA \u4fee\u5fa9 [1]\u3002\u03b3H2AX \u662f DNA \u640d\u50b7\u7684\u751f\u7269\u6a19\u8a18\u3002\u5728\u9ad4\u5916\u53ef\u7e41\u6b96\u6a21\u578b\u4e2d\uff0cAZD6738 \u6cbb\u7642\u958b\u59cb\u5f8c 70 \u5c0f\u6642\u5167\uff0c\u03b3H2AX \u8a0a\u865f\u6301\u7e8c\u5b58\u5728 [1]\u3002\u505c\u6eef\u7684\u8907\u88fd\u53c9\u53ef\u80fd\u6703\u7834\u58de DNA \u96d9\u80a1\u65b7\u88c2\u7684\u5f62\u6210\u548c\u6bdb\u7d30\u8840\u7ba1\u64f4\u5f35\u6027\u5171\u6fdf\u5931\u8abf\u7a81\u8b8a (ATM) \u6fc0\u9176\u7684\u6d3b\u5316\u3002 AZD6738 \u4f5c\u70ba\u55ae\u85e5\uff0c\u5728\u591a\u7a2e\u764c\u7d30\u80de\u7cfb\u4e2d\u5747\u5177\u6709\u6d3b\u6027\u3002\u5728\u7f3a\u4e4f ATM \u8def\u5f91\u7684\u7d30\u80de\u7cfb\u4e2d\uff0cAZD6738 \u7684\u654f\u611f\u6027\u589e\u5f37 [3]\u3002\u5728 ATM \u7f3a\u4e4f\u4f46 ATM \u529f\u80fd\u6b63\u5e38\u7684\u9ad4\u5167\u6a21\u578b\u4e2d\uff0c\u55ae\u7368\u4f7f\u7528 AZD6738 \u6cbb\u7642\u53ef\u5728\u7b49\u6548\u8010\u53d7\u5291\u91cf\u4e0b\u986f\u8457\u6291\u5236\u816b\u7624\u6d3b\u6027\u3002\u96fb\u96e2\u8f3b\u5c04 (IR) \u662f\u4e00\u7a2e DNA \u640d\u50b7\u8a98\u5c0e\u5291\u3002\u7576 AZD6738 \u8207 IR \u5408\u4f75\u4f7f\u7528\u6642\uff0c\u53ef\u89c0\u5bdf\u5230\u816b\u7624\u6d88\u9000\u6216\u6297\u816b\u7624\u751f\u9577\u6291\u5236\u6d3b\u6027\u3002\u5728\u816b\u7624\u7d44\u7e54\u4e2d\uff0cAZD6738 \u8207\u6301\u7e8c\u7684 \u03b3H2AX \u67d3\u8272\u589e\u52a0\u6709\u95dc\u3002\u5728\u6b63\u5e38\u8178\u9053\u7d44\u7e54\u6216\u9aa8\u9ad3\u4e2d\uff0cAZD6738 \u6cbb\u7642\u50c5\u66ab\u6642\u589e\u52a0 \u03b3H2AX \u67d3\u8272 [3]\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA crystalline solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n412.51<\/td>\n<\/tr>\n
Cas No.<\/td>\n1352226-88-0<\/td>\n<\/tr>\n
Formula<\/td>\nC20<\/sub>H24<\/sub>N6<\/sub>O2<\/sub>S<\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in H2O; \u226582 mg\/mL in DMSO; \u226582.4 mg\/mL in EtOH<\/td>\n<\/tr>\n
Chemical Name<\/td>\n(R)-3-methyl-4-(6-(1-((R)-S-methylsulfonimidoyl)cyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)morpholine<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nC[C@H]1N(C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(C5([S@](=O)(C)=N)CC5)=C2)CCOC1<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.<\/td>\n<\/tr>\n
General tips<\/td>\nWe do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\"<\/p>\n

AZD6738 \u662f\u4e00\u7a2e\u9078\u64c7\u6027 ATR\uff08Ataxia Telangiectasia and RAD3-related, \u5171\u6fdf\u5931\u8abf\u6bdb\u7d30\u8840\u7ba1\u64f4\u5f35\u75c7\u548c RAD3 \u76f8\u95dc\uff09\u6291\u5236\u5291\uff0c\u5c0dresting CLL \u7d30\u80de\u7684 IC50 \u7d04\u70ba 30 uM [1] [2]\u3002ATR \u662f\u4e00\u7a2e PI3K \u76f8\u95dc\u6fc0\u9176\u3002\u5b83\u53c3\u8207DNA\u640d\u50b7\u7684\u4fee\u5fa9(repair)\u3002\u5728\u7d30\u80de\u5206\u88c2(cell division)\u904e\u7a0b\u4e2d\uff0c\u5b83\u5728\u55ae\u93c8 DNA \u65b7\u88c2\u4f4d(single strand DNA breaks)\u9ede\u88ab\u52df\u96c6(recruited)\u548c\u6fc0\u6d3b(activated)\uff0c\u4ee5\u5e6b\u52a9\u555f\u52d5 DNA \u4fee\u5fa9(DNA repair) [1]\u3002\u03b3H2AX \u4f5c\u70ba DNA \u640d\u50b7(DNA damage)\u7684\u751f\u7269\u6a19\u8a8c\u7269\u3002\u5728\u4e00\u500b\u80fd\u5920\u8907\u88fd\u7684\u9ad4\u5916\u6a21\u578b\u4e2d\uff0c\u5728\u958b\u59cb\u4f7f\u7528 AZD6738 \u6cbb\u7642 70 \u5c0f\u6642\u5f8c\uff0c\u03b3H2AX \u4fe1\u865f\u6301\u7e8c\u5b58\u5728 [1]\u3002\u505c\u6eef\u7684\u8907\u5236\u53c9(Stalled replication forks)\u53ef\u80fd\u6703\u7834\u58de DNA \u96d9\u93c8\u65b7\u88c2(DNA double stranded breaks)\u7684\u5f62\u6210\u548c\u5171\u6fdf\u5931\u8abf\u6bdb\u7d30\u8840\u7ba1\u64f4\u5f35\u75c7\u7a81\u8b8a (ataxia telangiectasia mutated , ATM) \u6fc0\u9176\u7684\u6fc0\u6d3b\u3002\u4f5c\u70ba\u8de8\u764c\u7d30\u80de\u7cfb\u7684\u55ae\u4e00\u85e5\u7269\uff0cAZD6738 \u5177\u6709\u6d3b\u6027\u3002\u5728\u7f3a\u4e4f ATM \u901a\u8def\u7684\u7d30\u80de\u7cfb\u4e2d\uff0cAZD6738 \u7684\u654f\u611f\u6027(sensitivity)\u589e\u5f37 [3]\u3002\u5728 ATM \u7f3a\u9677(ATM-deficient)\u4f46\u4e0d\u7cbe\u901a ATM \u7684\u9ad4\u5167\u6a21\u578b\u4e2d\uff0c\u55ae\u7368\u4f7f\u7528 AZD6738 \u6cbb\u7642\u53ef\u986f\u8457\u6291\u5236\u7b49\u6548\u8010\u53d7\u5291\u91cf\u7684\u816b\u7624\u6d3b\u6027\u3002\u96fb\u96e2\u8f3b\u5c04 (Ionizing radiation , IR) \u662f\u4e00\u7a2e DNA \u640d\u50b7\u8a98\u5c0e\u5291\u3002\u7576AZD6738\u548cIR\u4e00\u8d77\u4f7f\u7528\u6642\uff0c\u89c0\u5bdf\u5230\u6d88\u9000\u6216\u6297\u816b\u7624\u751f\u9577\u6291\u5236\u6d3b\u6027\u3002\u5728\u816b\u7624\u7d44\u7e54\u4e2d\uff0cAZD6738 \u8207\u6301\u7e8c\u7684 \u03b3H2AX \u67d3\u8272\u589e\u52a0\u6709\u95dc\u3002\u5728\u6b63\u5e38\u8178\u9053\u7d44\u7e54(gut tissue)\u6216\u9aa8\u9ad3(bone marrow)\u4e2d\uff0c\u7528 AZD6738 \u6cbb\u7642\u53ea\u6703\u66ab\u6642\u589e\u52a0 \u03b3H2AX \u67d3\u8272 [3]\u3002<\/p>\n

 <\/p>\n

    \n
  1. Karin Broennimann, Inna Ricardo-Lax, et al. “RNR-R2 Upregulation by a Short Non-Coding Viral Transcript.” Biomolecules. 2021 Dec 3;11(12):1822.PMID:34944466<\/a><\/li>\n
  2. Inna Ricardo-Lax, Karin Broennimann,et al. “A short HBV RNA region induces RNR-R2 expression in non-cycling cells and in primary human hepatocytes.”bioRxiv. 2018 October 31.<\/li>\n<\/ol>\n

     <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    Physical Appearance<\/td>\nA crystalline solid<\/td>\n<\/tr>\n
    Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
    M.Wt<\/td>\n412.51<\/td>\n<\/tr>\n
    Cas No.<\/td>\n1352226-88-0<\/td>\n<\/tr>\n
    Formula<\/td>\nC20<\/sub>H24<\/sub>N6<\/sub>O2<\/sub>S<\/td>\n<\/tr>\n
    Solubility<\/td>\ninsoluble in H2O; \u226582 mg\/mL in DMSO; \u226582.4 mg\/mL in EtOH<\/td>\n<\/tr>\n
    Chemical Name<\/td>\n(R)-3-methyl-4-(6-(1-((R)-S-methylsulfonimidoyl)cyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)morpholine<\/td>\n<\/tr>\n
    SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
    Canonical SMILES<\/td>\nC[C@H]1N(C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(C5([S@](=O)(C)=N)CC5)=C2)CCOC1<\/td>\n<\/tr>\n
    Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
    General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    <\/p>\n

    APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n

    APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002APExBIO\u63d0\u4f9b\u4e00\u7cfb\u5217DNA Damage\/DNA Repair\u00a0\u751f\u7269\u5316\u5408\u7269\uff0c<\/strong>\u5305\u62ecSCR7<\/a>\u3001RHPS4n\u00a0<\/a>\u00a0\u3001AZD6738<\/a>\u3001ORY-1001<\/a>\u3001RGFP966<\/a>\u3001Oxaliplatin<\/a>\u3001(S)-Crizotinib<\/a>\u3001Tubastatin A<\/a>\u7b49\u7cfb\u5217\u5546\u54c1\u3002<\/p>\n


    \n\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
    DNA Damage\/DNA Repair<\/strong><\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
    SCR7<\/a><\/span><\/td>\nCAS#1533426-72-0<\/span><\/td>\n\u8ca8\u865fA8705<\/span><\/td>\nDNA ligase IV inhibitor<\/span><\/td>\n<\/tr>\n
    RHPS4n\u00a0<\/a>\u00a0<\/span><\/td>\nCAS#390362-78-4<\/span><\/td>\n\u8ca8\u865fB6186<\/span><\/td>\nTelomerase inhibitor<\/span><\/td>\n<\/tr>\n
    AZD6738<\/a><\/span><\/td>\nCAS#1352226-88-0<\/span><\/td>\n\u8ca8\u865fB6007<\/span><\/td>\nATR inhibitor<\/span><\/td>\n<\/tr>\n
    \n

    ORY-1001<\/a><\/span><\/p>\n

     <\/td>\n

    		CAS#1431326-61-2<\/span><\/td>\n\u8ca8\u865fB5882<\/span><\/td>\nSelective inhibitor of KDM1A.<\/span><\/td>\n<\/tr>\n
    RGFP966<\/a><\/span><\/td>\nCAS#1357389-11-7;1396841-57-8<\/span><\/td>\n\u8ca8\u865fA8803<\/span><\/td>\nSpecific HDAC3 inhibitor<\/span><\/td>\n<\/tr>\n
    Oxaliplatin<\/a><\/span><\/td>\nCAS#61825-94-3<\/span><\/td>\n\u8ca8\u865fA8648<\/span><\/td>\nAntitumor agent<\/span><\/td>\n<\/tr>\n
    (S)-Crizotinib<\/a><\/span><\/td>\nCAS#877399-52-5;1374356-45-2<\/span><\/td>\n\n

    \u8ca8\u865fA8802<\/span><\/p>\n

     <\/td>\n

    		Potent MTH1 inhibitor<\/span><\/td>\n<\/tr>\n
    Tubastatin A<\/a><\/span><\/td>\nCAS#1252003-15-8<\/span><\/td>\n\u8ca8\u865fA4101<\/span><\/td>\nHDAC6 inhibitor,potent and selective<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    ATR\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1->>AZD6738 APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148 […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[5023],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35416"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35416"}],"version-history":[{"count":4,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35416\/revisions"}],"predecessor-version":[{"id":51815,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35416\/revisions\/51815"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35416"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35416"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35416"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}