{"id":35251,"date":"2022-10-24T12:30:44","date_gmt":"2022-10-24T04:30:44","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=35251"},"modified":"2025-06-30T17:08:11","modified_gmt":"2025-06-30T09:08:11","slug":"chidamide-cas743420-02-2apexbio-%e8%b2%a8%e8%99%9fb5916","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=35251","title":{"rendered":"Chidamide | CAS#743420-02-2APExBIO \u8ca8\u865fB5916 apexbt"},"content":{"rendered":"

\u8868\u89c0\u907a\u50b3\u5b78(Epigenetics)\u7cfb\u5217\u5546\u54c1->>Chidamide<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<\/p>\n

<\/p>\n

Chromatin\/Epigenetics\u7cfb\u5217\u7522\u54c1+<\/span><\/strong><\/span><\/p>\n

\"\"<\/p>\n

\u8868\u89c0\u907a\u50b3\u5b78(Epigenetics)\u662f\u57fa\u56e0\u8868\u9054\u7684\u53ef\u907a\u50b3\u4fee\u98fe (heritable modifications)\uff0c\u8207 DNA \u5e8f\u5217(DNA sequence)\u7684\u8b8a\u5316\u7121\u95dc\u3002\u8868\u89c0\u907a\u50b3\u4fee\u98fe(Epigenetic modifications)\u4e3b\u8981\u767c\u751f\u5728 DNA \u6216\u7d44\u86cb\u767d\u516b\u805a\u9ad4(histone octamer)\u4e0a\u3002\u6709\u5e7e\u7a2e\u985e\u578b\u7684\u8868\u89c0\u907a\u50b3\u5b78\u4fee\u98fe(epigenetics modifications)\uff0cDNA-\u7532\u57fa\u8f49\u79fb\u9176 (DNMT) \u7684 DNA \u7532\u57fa\u5316\u548c\u7d44\u86cb\u767d\u7684\u5171\u50f9\u4fee\u98fe\uff0c\u4f8b\u5982\u4e59\u91af\u5316(acetylation)\u3001\u7532\u57fa\u5316(methylation)\u3001\u78f7\u9178\u5316(phosphorylation)\u548c\u6cdb\u7d20\u5316(ubiquitination)\u3002\u7d44\u86cb\u767d\u4e59\u91af\u8f49\u79fb\u9176 (HAT) \u7684\u7d44\u86cb\u767d\u4e59\u91af\u5316\u53c3\u8207\u8f49\u9304\u6fc0\u6d3b\uff0c\u800c\u7d44\u86cb\u767d\u53bb\u4e59\u91af\u5316\u9176 (HDAC) \u7684\u7d44\u86cb\u767d\u53bb\u4e59\u91af\u5316\u8207\u8f49\u9304\u6291\u5236(transcriptional repression)\u6709\u95dc\u3002\u7d44\u86cb\u767d\u53bb\u7532\u57fa\u5316(Histone demethylation)\u8207\u8cf4\u6c28\u9178\u7279\u7570\u6027\u53bb\u7532\u57fa\u5316\u9176 (lysine-specific demethylase , LSD) \u548c\u542b\u6709\u7d44\u86cb\u767d\u53bb\u7532\u57fa\u5316\u9176 (JHDM) \u7684 JmjC \u7d50\u69cb\u57df(JmjC domain)\u6709\u95dc\u3002<\/p>\n

\u6838\u5c0f\u9ad4(nucleosome)\u7531\u56db\u7a2e\u7d44\u86cb\u767d\uff08H2A\u3001H2B\u3001H3 \u548c H4\uff09\u7d44\u6210\uff0c\u5b83\u5011\u662f\u67d3\u8272\u8cea(chromatin)\u7684\u4e3b\u8981\u7d44\u6210\u90e8\u5206\u3002\u7279\u5b9a\u5316\u5b78\u57fa\u5718\u7684\u6dfb\u52a0\u548c\u53bb\u9664\u7a31\u70ba\u8868\u89c0\u907a\u50b3\u6a19\u8a18(epigenetic marks)\uff0c\u5b83\u8abf\u7bc0\u67d3\u8272\u8cea\u7d50\u69cb\u4e26\u5f71\u97ff\u57fa\u56e0\u8868\u9054\u3002\u6b64\u5916\uff0cRNA \u8207\u6291\u5236\u6027\u67d3\u8272\u8cea\u72c0\u614b(repressive chromatin state)\u7684\u5f62\u6210\u5bc6\u5207\u76f8\u95dc\u3002<\/p>\n

\u8868\u89c0\u907a\u50b3(Epigenetic)\u6a5f\u5236\u5728\u7d30\u80de\u6c34\u5e73\u4e0a\u97ff\u61c9\u74b0\u5883\u8b8a\u5316\uff0c\u5f9e\u800c\u5f71\u97ff\u7d30\u80de\u53ef\u5851\u6027(plasticity)\u3002\u67d3\u8272\u8cea(Chromatin)\u548c\u8868\u89c0\u907a\u50b3\u8abf\u63a7(epigenetic regulation)\u5728\u767c\u80b2\u548c\u61c9\u6fc0\u53cd\u61c9\u671f\u9593\u7684\u57fa\u56e0\u7d44\u7de8\u7a0b\u4e2d\u767c\u63ee\u91cd\u8981\u4f5c\u7528\uff0c\u8868\u89c0\u907a\u50b3\u5b78\u7f3a\u9677(defects in epigenetics)\u53ef\u5c0e\u81f4\u764c\u75c7(cancer)\u3001\u708e\u75c7(inflammation)\u548c\u4ee3\u8b1d\u7d0a\u4e82(metabolic disorders)\u7b49\u3002<\/p>\n

Chidamide | CAS#743420-02-2APExBIO\u00a0 \u8ca8\u865fB5916<\/a><\/span><\/p>\n

\"\"<\/p>\n

Product Citation+1<\/p>\n

Novel HDAC inhibitor<\/p>\n

Chidamide \u662f\u4e00\u7a2e\u65b0\u578b\u82ef\u7532\u9170\u80fa\u578b\u7d44\u86cb\u767d\u812b\u4e59\u91af\u9176 (benzamide-type histone deacetylase , HDAC) \u6291\u5236\u5291\u3002\u4eba\u5011\u7814\u7a76\u4e86 CS055 \u5c0d\u4eba\u767d\u8840\u75c5\u7d30\u80de\u7cfb\u548c\u539f\u767c\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u7d30\u80de\u589e\u6b96(proliferation)\u3001\u5206\u5316(differentiation)\u548c\u51cb\u4ea1(apoptosis)\u7684\u5f71\u97ff\u3002\u7d44\u86cb\u767d\u53bb\u4e59\u91af\u5316\u9176 (Histone deacetylases , HDAC) \u662f\u4e00\u7cfb\u5217\u9176\uff0c\u5176\u4f5c\u7528\u662f\u4f7f\u7d44\u86cb\u767d\u7684\u6c28\u57fa\u672b\u7aef\u8cf4\u6c28\u9178\u6b98\u57fa(amino-terminal lysine residues)\u4e59\u91af\u5316\u548c\u53bb\u4e59\u91af\u5316\uff0c\u5f9e\u800c\u5c0e\u81f4\u67d3\u8272\u8cea\u7d50\u69cb\u7684\u91cd\u5851(remodeling)\u4e26\u5f71\u97ff\u67d3\u8272\u8cea(chromatin)\u5c0d\u8f49\u9304\u56e0\u5b50\u7684\u53ef\u53ca\u6027\uff0c\u5f9e\u800c\u555f\u52d5\u57fa\u56e0\u8f49\u9304(gene transcription)\u3002 [2 ]\u897f\u9054\u672c\u80fa(Chidamide) \u5c0d\u7d30\u80de\u9031\u671f(cell cycle)\u6709\u5f71\u97ff\uff0c\u5b83\u986f\u8457\u964d\u4f4e\u4e86\u4e0d\u540c p53 \u72c0\u614b\u7684 BEL-7402 \u548c HCC-9204 \u7d30\u80de\u7684 S \u671f\u7d30\u80de\u5206\u6578\uff0c\u540c\u6642\u8a98\u5c0e G1 \u671f\u7d30\u80de\u5206\u6578\u986f\u8457\u589e\u52a0\u3002\u96a8\u8457\u5291\u91cf\u7684\u589e\u52a0\uff0c\u897f\u9054\u672c\u80fa(Chidamide)\u986f\u8457\u6539\u8b8a\u4e86\u968e\u6bb5\u5206\u6578\u4e2d\u7684\u7d30\u80de\u6578\u91cf\u3002 [2]\u672c\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0c\u897f\u9054\u672c\u80fa(Chidamide)\u662f\u4e00\u7a2e HDACi\uff0c\u901a\u904e\u6291\u5236\u7d30\u80de\u589e\u6b96(cell proliferation)\u3001\u8a98\u5c0e\u4eba\u9ad4\u7d30\u80de\u5206\u5316(differentiation)\u548c\u51cb\u4ea1(apoptosis)\uff0c\u5728\u591a\u7a2e\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624(haematological malignancies)\u4e2d\u5177\u6709\u6f5b\u5728\u7684\u6cbb\u7642\u50f9\u503c\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n390.41<\/td>\n<\/tr>\n
Cas No.<\/td>\n743420-02-2<\/td>\n<\/tr>\n
Formula<\/td>\nC22<\/sub>H19<\/sub>FN4<\/sub>O2<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in H2O; insoluble in EtOH; \u226518.55 mg\/mL in DMSO<\/td>\n<\/tr>\n
Chemical Name<\/td>\nN-(2-amino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nFC1=CC(NC(C2=CC=C(CNC(C=CC3=CC=CN=C3)=O)C=C2)=O)=C(N)C=C1<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\"<\/p>\n

<\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002
\n\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
\u54c1\u9805<\/span><\/td>\nCAS#<\/span><\/td>\n#\u8ca8\u865f<\/span><\/td>\n\u61c9\u7528<\/span><\/td>\n<\/tr>\n
MG 149 \u00a0(Tip60 HAT inhibitor) \u9078\u64c7\u6027\u6291\u5236\u5291\u00a0<\/u><\/strong><\/a><\/span><\/td>\nCAS#\u00a01243583-85-8<\/span><\/td>\n\u8ca8\u865f\u00a0B3276<\/span><\/td>\nHAT inhibitor<\/span><\/td>\n<\/tr>\n
4′-bromo-Resveratrol<\/a><\/span><\/td>\nCAS# 1224713-90-9\u00a0<\/a><\/span><\/td>\n\u8ca8\u865f C3552<\/span><\/td>\nSirt1 \u548c Sirt3 \u6291\u5236\u5291<\/span><\/td>\n<\/tr>\n
MS023<\/a><\/span><\/td>\nCAS# 1831110-54-3<\/span><\/td>\n\u8ca8\u865f B6183<\/span><\/td>\ntype I PRMTs inhibitor\u6291\u5236\u5291<\/span><\/td>\n<\/tr>\n
CHZ868<\/a><\/span><\/td>\nN\/O<\/span><\/td>\n\u8ca8\u865fB5980<\/span><\/td>\nType II JAK2 inhibitor<\/span><\/td>\n<\/tr>\n
Chidamide<\/a><\/span><\/td>\nCAS#743420-02-2<\/span><\/td>\n\u8ca8\u865fB5916<\/span><\/td>\nNovel HDAC inhibitor<\/span><\/td>\n<\/tr>\n
RGFP966<\/a><\/span><\/td>\nCAS#1357389-11-7\/1396841-57-8<\/span><\/td>\n\u8ca8\u865fA8803<\/span><\/td>\nSpecific HDAC3 inhibitor<\/span><\/td>\n<\/tr>\n
EPZ-6438<\/a><\/span><\/td>\nCAS#1403254-99-8<\/span><\/td>\n\u8ca8\u865fA8221<\/span><\/td>\nEZH2 inhibitor, potent and selective<\/span><\/td>\n<\/tr>\n
Bromodomain Inhibitor, (+)-JQ1<\/a><\/span><\/td>\nCAS# 1268524-70-4<\/span><\/td>\n\u8ca8\u865fA1910<\/span><\/td>\nBET bromodomain inhibitor<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u8868\u89c0\u907a\u50b3\u5b78(Epigenetics)\u7cfb\u5217\u5546\u54c1->>Chidamide APExBIO Techno […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368,3],"tags":[5017],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35251"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=35251"}],"version-history":[{"count":6,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35251\/revisions"}],"predecessor-version":[{"id":51825,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/35251\/revisions\/51825"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=35251"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=35251"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=35251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}