{"id":34875,"date":"2022-10-17T15:29:52","date_gmt":"2022-10-17T07:29:52","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=34875"},"modified":"2024-04-04T17:59:58","modified_gmt":"2024-04-04T09:59:58","slug":"innovex-fc%e5%8f%97%e9%ab%94%e9%98%bb%e6%96%b7%e5%8a%91-innovex-fc-receptor-block-%e8%b2%a8%e8%99%9fnb309","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=34875","title":{"rendered":"Innovex Fc\u53d7\u9ad4\u963b\u65b7\u5291 (Innovex Fc Receptor Block) | \u8ca8\u865fNB309"},"content":{"rendered":"<p><span style=\"color: #33cccc; font-size: 12pt;\"><a style=\"color: #33cccc;\" href=\"http:\/\/biopioneer.com.tw\/?p=25416\">Innovex Fc\u53d7\u9ad4\u963b\u65b7\u5291 (Innovex Fc Receptor Block) | \u8ca8\u865fNB309<\/a>\u00a0 60ML\u00a0700-1000 slides\u00a0<\/span><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/innovexbio.com\/wp-content\/uploads\/2021\/04\/Fc-Cartoon-Final-Complete_Updated.gif\" alt=\"\" width=\"315\" height=\"360\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>Fc\u53d7\u9ad4\uff08Fc receptors , FcR\uff09\u662f\u5206\u5b50\u91cf\u7d04\u70ba50-70 kD\u7684\u7cd6\u86cb\u767d(glycoproteins)\u3002\u4ed6\u5011\u5ee3\u6cdb\u5728\u6574\u500b\u514d\u75ab\u7d30\u80de(immune cells)\u4e2d\u8868\u9054\u3002\u5b83\u5011\u5b58\u5728\u65bc\u767d\u8840\u7403(leukocytes)\u5982\u55ae\u6838\u7d30\u80de(monocytes)\uff0c\u7d44\u7e54\u5de8\u566c\u7d30\u80de(tissue macrophages)\uff0cB\u7d30\u80de(B cells)\uff0c\u7c92\u7d30\u80de(granulocytes)\u55dc\u9178\u6027\u7c92\u7d30\u80de(eosinophils)\uff0c\u55dc\u9e7c\u6027\u7c92\u7d30\u80de(basophils)\uff0c\u55dc\u4e2d\u6027\u7c92\u7d30\u80de(neutrophils)\uff0cNK\u7d30\u80de\u548c\u4e00\u4e9bT\u7d30\u80de\u3002Fc receptors\u80a5\u5927\u7d30\u80de\uff0c\u6ffe\u6ce1\u6a39\u7a81\u7d30\u80de(follicular dendritic cells)\uff0c\u4e0a\u76ae\u7d30\u80de(epithelial cells)\uff0c\u5167\u76ae\u7d30\u80de(endothelial cells)\uff0c\u809d\u7d30\u80de\u4e0a\u4e5f\u5b58\u5728\u53d7\u9ad4\u548clangerhans cells\u7b49\u7b49\u3002 Fc\u53d7\u9ad4\uff08FcR\uff09\u6709\u5e7e\u7a2e\u985e\u578b\uff0c\u5b83\u5011\u57fa\u65bc\u4ed6\u5011\u6240\u8b58\u5225\u7684\u6297\u9ad4\u4e0a\u3002\u6709\u4e00\u4e9b\u5c0d\u55ae\u9ad4IgG\u7684Fc\u5340\u5177\u6709\u5f88\u9ad8\u7684\u89aa\u548c\u529b\u6297\u9ad4\uff0c\u7a31\u70baFc-Gamma\u53d7\u9ad4\uff0c\u8207IgA\u6297\u9ad4\u7d50\u5408\u7684\u6297\u9ad4\u7a31\u70baFc-\u03b1\u53d7\u9ad4\uff0c\u90a3\u4e9b\u7d50\u5408IgE\u6297\u9ad4\u7684\u6297\u9ad4\u7a31\u70baFc-\u03b5\u53d7\u9ad4\u3002\u975e\u7279\u7570\u6027Fc\u53d7\u9ad4\u5728IHC\uff0c\u514d\u75ab\u87a2\u5149\uff08IF\uff09\u548c\u6d41\u5f0f\u7d30\u80de\u5100\u7b49\u6aa2\u6e2c\u4e2d\u53ef\u4ee5\u67d3\u8272\u3002\u9019\u662f\u7531\u65bc\u4e00\u6297\u548c\u4e8c\u6297\u7684Fc\u5340\u8207\u7d30\u80de\u4e0aFc\u53d7\u9ad4\u7684\u7d50\u5408\u6240\u81f4\u3002\u5728IHC\uff0cIF\u548c\u6d41\u5f0f\u7d30\u80de\u5100\u4e2d\uff0c\u6d88\u9664Fc\u53d7\u9ad4\u67d3\u8272\u662f\u7406\u60f3\u7684\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/biopioneer.com.tw\/wp-admin\/admin-ajax.php?action=imgedit-preview&amp;_ajax_nonce=a8742ced27&amp;postid=28623&amp;rand=96983\" alt=\"\" \/><\/p>\n<p>Innovex Fc\u53d7\u9ad4\u963b\u6eef\u5291 (Innovex Fc Receptor Blocker, NB309) \u662f\u4e00\u7a2e\u901a\u7528\u7684Fc\u963b\u6eef\u5291\uff0c\u9069\u7528\u65bc\u963b\u65b7\u6240\u6709\u985e\u578b\u7684Fc Receptor\u53d7\u9ad4\uff0c\u4f8b\u5982 I receptors\u00a0\uff0cII receptors\u00a0 \u548cIII\u578bFc-\u03b3\u53d7\u9ad4\uff1b Fc-\u03b5\u53d7\u9ad4I\u548cII\u578b\uff1b Fc \u2013\u03b1\u53d7\u9ad4\uff0cFc\u03b1\/ \u00b5R\u548cFcRn\u3002 Innovex Fc\u963b\u65b7\u5291\u4e0d\u5305\u542b\u6297\u9ad4\uff0c\u514d\u75ab\u7403\u86cb\u767d\u6216\u514d\u75ab\u7403\u86cb\u767d\u7247\u6bb5\u3002 INNOVEX Fc\u963b\u65b7\u5291\u53ef\u7528\u65bc\u963b\u65b7\u4eba\u985e\uff0c\u5c0f\u9f20\u548c\u6240\u6709\u52d5\u7269\u7b49\u6240\u6709\u7269\u7a2e\u4e2d\u7684\u6240\u6709\u985e\u578b\u7684Fc\u53d7\u9ad4\uff0c \u901a\u904e\u591a\u7a2e\u514d\u75ab\u6e2c\u5b9a\uff08\u4f8b\u5982IHC\uff0c\u514d\u75ab\u87a2\u5149\uff08Immunofluorescence, IF\uff09\u548c\u6d41\u5f0f\u7d30\u80de\u5100(Flow cytometry) \uff09\u6aa2\u6e2c\u7d30\u80de\u548c\u7d44\u7e54\u3002INNOVEX Fc Blocker is also commonly used in eliminating background staining in Brain cells\/ tissues. Fc Receptor blocker is also used for obtaining specific staining for tissues stained for kappa, lambda antibodies and Immunoglobulins (lgs) by IHC, IF and Flow cytometry assays. INNOVEX Fc\u963b\u65b7\u5291\u4e5f\u5e38\u7528\u65bc\u6d88\u9664\u8166\u7d30\u80de(\u00a0Brain cells)\/\u7d44\u7e54\u4e2d(tissues)\u7684\u80cc\u666f\u67d3\u8272\u3002 Fc\u53d7\u9ad4\u963b\u6eef\u5291\u4e5f\u53ef\u7528kappa\u00a0\uff0clambda antibodies \u53ca\u514d\u75ab\u7403\u86cb\u767d( Immunoglobulins , lgs)\u65bc IHC\uff0cIF\u548c\u6d41\u5f0f\u7d30\u80de\u9032\u884c\u7279\u7570\u6027\u67d3\u8272\u3002\u00a0\u5982CD\u8868\u578b(CD phenotyping)\uff0c\u767d\u8840\u75c5\u5206\u578b(leukemia typing )\u548c\u6d3b\u7d30\u80de\u529f\u80fd\u6e2c\u5b9a(\u00a0live cell functional assays)\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/biopioneer.com.tw\/wp-admin\/admin-ajax.php?action=imgedit-preview&amp;_ajax_nonce=78bee6a899&amp;postid=28621&amp;rand=31820\" alt=\"\" \/><img decoding=\"async\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2022\/10\/fc_receptor_block_current.jpg\" alt=\"\" \/><\/p>\n<p>Fc\u53d7\u9ad4\u963b\u6eef\u5291 (Innovex Fc Receptor Block) \uff0c\u5148\u9032\u548c\u7368\u7279\u7684\u529f\u80fd\uff1b\u963b\u65b7\u4eba\u548c\u52d5\u7269\u7d30\u80de\u4e2d\u7684Fc\u53d7\u9ad4\u3002\u662f\u6e96\u78ba\u7684\u6dcb\u5df4\u7624\uff0c\u767d\u8840\u75c5\u548c\u9ed1\u8272\u7d20\u7624\u5206\u578b\u4ee5\u53ca\u7121\u80cc\u666fKappa\u548c\u03bb\u67d3\u8272\u7684\u5fc5\u9700\u54c1\u3002Innovex Fc Receptor Block\u662f\u4e00\u7a2e\u57fa\u65bcpeptide based\u7684\u6280\u8853\uff0c\u4e0d\u542b\u6297\u9ad4\uff0c\u8840\u6e05\uff0c\u514d\u75ab\u7403\u86cb\u767d\uff0c\u514d\u75ab\u7403\u86cb\u767d\u7247\u6bb5\u6216\u93c8\u9ef4\u86cb\u767d\u9176\u3002\u76ee\u7684\u70ba\u963b\u65b7\u6240\u6709\u767d\u8840\u7403\u7d30\u80de\uff08white blood cells\uff09\uff0c\u6dcb\u5df4\u7624(lymphomas)\u548c\u9ed1\u8272\u7d20\u7624(melanomas)\u4e2d\u5b58\u5728\u7684Fc\u53d7\u9ad4(Fc Receptors)\u3002\u5728\u5ba4\u6eab\u4e0b\u5c0d\u4eba\u9ad4\u7d44\u7e54\/\u7d30\u80de\u9032\u884c30\u5206\u9418\u7684\u5b75\u80b2\u6b65\u9a5f\uff1b\u52d5\u7269\u7d44\u7e54\/\u7d30\u80de\u5b75\u80b245\u5206\u9418\u81f31\u5c0f\u6642\u3002\u6d88\u9664\u767d\u8840\u7403\u7d30\u80de\uff0c\u6dcb\u5df4\u7d44\u7e54\uff0c\u7d30\u80de\u682a\uff08\u8840\u6db2\u548c\u9aa8\u9ad3\uff09\uff0c\u9ed1\u8272\u7d20\u7624\u548c\u5176\u4ed6\u8868\u9054Fc\u7684\u816b\u7624\u7684\u5047\u967d\u6027\u67d3\u8272\uff0c\u78ba\u4fdd\u51c6\u78ba\u7684\u6dcb\u5df4\u7624\u548c\u767d\u8840\u75c5\u5206\u578b\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2022\/10\/FCReceptorBlocker.jpg\" alt=\"\" width=\"617\" height=\"234\" \/><\/p>\n<p><img decoding=\"async\" src=\"http:\/\/innovexbiosciencesinc01.businesscatalyst.com\/img\/pages\/fcReceptorBlock\/fc_receptor_block_current.jpg\" alt=\"\" \/>Fc\u53d7\u9ad4(Fc Receptors)\u4e5f\u5728\u5927\u591a\u6578\u816b\u7624(tumors)\u4e0a\u8868\u9054\u3002\u963b\u65b7Fc\u53d7\u9ad4\u5c0d\u65bc\u6dcb\u5df4(lymphoid)\u548c\u816b\u7624\u7d44\u7e54(tumor tissues)\u548c\u7d30\u80de\u7684\u6e96\u78ba\u5206\u578b\u81f3\u95dc\u91cd\u8981\u3002 Fc\u53d7\u9ad4\u67d3\u8272\u901a\u904e\u7d30\u80de\u4e0a\u5b58\u5728\u7684Fc\u53d7\u9ad4\u8207\u521d\u7d1a\u548c\/\u6216\u7b2c\u4e8c\u6297\u9ad4\u7684Fc\u5340\u7684\u7d50\u5408\u800c\u767c\u751f\u3002 Fc\u53d7\u9ad4\u963b\u65b7\u5291\u53ef\u7528\u65bcIHC\uff08\u51b7\u51cd\u548c\u77f3\u881f\uff09\uff0c\u514d\u75ab\u87a2\u5149(immunofluorescence)\uff0c\u6d41\u5f0f\u7d30\u80de\u8853(flow cytometry)\u548c\u539f\u4f4d\u96dc\u4ea4(in-situ hybridization)\u3002\u5c0d\u65bc\u6d3b\u7d30\u80de\u548c\u529f\u80fd\u6e2c\u5b9a\uff0c\u5efa\u8b70\u4f7f\u7528Azide-Free Fc Block (\u8ca8\u865fNB335)\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2021\/08\/%E6%93%8D%E4%BD%9C%E6%89%8B%E5%86%8A2-300x95.jpg\" alt=\"\u64cd\u4f5c\u624b\u518a2\" width=\"140\" height=\"43\" \/><\/p>\n<p><img decoding=\"async\" src=\"http:\/\/biopioneer.com.tw\/wp-admin\/admin-ajax.php?action=imgedit-preview&amp;_ajax_nonce=a8742ced27&amp;postid=28623&amp;rand=96983\" alt=\"\" \/><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2021\/08\/%E7%94%A2%E5%93%81%E7%89%B9%E9%BB%9E2-300x101.jpg\" alt=\"\u7522\u54c1\u7279\u9ede2\" width=\"142\" height=\"46\" \/><\/p>\n<ol>\n<li>Blocks Fc Receptors in both human and animal cells<\/li>\n<li>30 minute incubation step at room temperature for human tissues\/cells<\/li>\n<li>45 minutes to 1-hour incubation for animal tissues\/cells<\/li>\n<li>Eliminates false positive staining of white blood cells, lymphoid tissues, cytosmears (blood &amp; bone marrow), melanoma tumors and other Fc expressing tumors<\/li>\n<li>Insures accurate lymphoma and leukemia typing<\/li>\n<li>liminates negative control staining of lymphomas, lymphoid tissues, and blood and bone marrow smears<\/li>\n<li>Eliminates false positive staining for Kappa and Lambda staining<\/li>\n<li>Eliminates false positive staining of Reed Sternberg cells<\/li>\n<li>A must for CD markers staining in IHC, immunofluorescence<\/li>\n<li>A must for CD phenotyping via flow cytometry<\/li>\n<li>A must for Immunoglobulins (Igs) staining via IHC, flow cytometry and immunofluorescence<\/li>\n<li>A must for kappa and lambda staining<\/li>\n<\/ol>\n<p>https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4395339\/<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Innovex Fc\u53d7\u9ad4\u963b\u65b7\u5291 (Innovex Fc Receptor Block) | \u8ca8\u865fNB309\u00a0  [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":34873,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[4998],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34875"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34875"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34875\/revisions"}],"predecessor-version":[{"id":49103,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34875\/revisions\/49103"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34873"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34875"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34875"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}