{"id":34765,"date":"2022-10-14T14:57:46","date_gmt":"2022-10-14T06:57:46","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=34765"},"modified":"2026-02-27T13:26:58","modified_gmt":"2026-02-27T05:26:58","slug":"bleomycin-sulfate-cas-9041-93-4-apexbio-%e8%b2%a8%e8%99%9fa8331","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=34765","title":{"rendered":"Bleomycin Sulfate | CAS# 9041-93-4 APExBIO \u8ca8\u865fA8331"},"content":{"rendered":"

\u5316\u7642\u85e5\u7269\/\u8a98\u5c0eDNA\u93c8\u65b7\u88c2\u7cfb\u5217\u5546\u54c1->>Bleomycin Sulfate<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

Bleomycin Sulfate | CAS# 9041-93-4 APExBIO\u00a0 \u8ca8\u865fA8331<\/a><\/span><\/p>\n

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Chemotherapy agent, induces DNA strand break<\/p>\n

\u786b\u9178\u535a\u4f86\u9ef4\u7d20 (BLENOXANE\u00ae) \u662f\u7531\u8f2a\u679d\u93c8\u9ef4\u83cc\u83cc\u682a(streptomyces verticillus)\u7522\u751f\u7684\u7d30\u80de\u6bd2\u6027\u7cd6\u80bd\u6297\u751f\u7d20(cytotoxic glycopeptide antibiotics)\u7684\u6df7\u5408\u7269\u3002\u5df2\u77e5\u8a72\u6210\u5206\u901a\u904e\u63a5\u8fd1\u91d1\u5c6c(metals)\u548c\u914d\u4f4d\u5206\u5b50\u6c27(coordinate dioxygen)\u4f86\u7522\u751f\u6d3b\u6027\u7269\u8cea\uff0c\u5f9e\u800c\u5c0e\u81f4 DNA \u4e2d\u7684\u55ae\u934a\u548c\/\u6216\u96d9\u93c8\u65b7\u88c2(single and\/ or double-stranded breaks)\u3002\u786b\u9178\u535a\u4f86\u9ef4\u7d20(Hodgkin’s lymphoma) \u8655\u7406\u901a\u904e\u6291\u5236 DNA \u548c\u86cb\u767d\u8cea\u5408\u6210\u5c0e\u81f4\u5927\u8178\u687f\u83cc\u7d30\u80de\u4f38\u9577\u548c HeLa \u7d30\u80de\u589e\u5927 [1]\u3002<\/p>\n

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\u8a72\u6210\u5206\u8207\u591a\u67d4\u6bd4\u661f(doxorubicin)\u806f\u5408\u6cbb\u7642\u970d\u5947\u91d1\u6dcb\u5df4\u7624(Hodgkin’s lymphoma)\u3001\u777e\u4e38\u764c(squamous cell carcinomas)\u3001\u9c57\u72c0\u7d30\u80de\u764c(squamous cell carcinomas)\u3001\u80ba\u7e96\u7dad\u5316(pulmonary fiborosis)\u4ee5\u53ca\u8db3\u5e95\u75a3(plantar warts)\u7684\u6cbb\u7642\u5ee3\u6cdb\u4f7f\u7528\u3002\u4f8b\u5982\uff0c\u786b\u9178\u535a\u4f86\u9ef4\u7d20(Bleomycin sulfate)\u4e5f\u88ab\u8b49\u660e\u5177\u6709\u5c0d\u52de\u65af\u8089\u7624\u75c5\u6bd2\u8a98\u5c0e\u7684\u5c0f\u9f20\u8179\u6c34\u8089\u7624\u6709\u4e2d\u5ea6\u81f3\u986f\u8457\u5f71\u97ff\uff0c\u7279\u5225\u662f\u7576 F1 \u96dc\u4ea4\u5c0f\u9f20\u7528\u4f5c\u5bbf\u4e3b\u52d5\u7269\u6642 [2]\u3002\u6b64\u5916\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u652f\u6301\u4fc3\u708e\u7d30\u80de\u56e0\u5b50 IL-18(proinflammatory cytokines IL-18) \u548c IL-1beta \u5728\u786b\u9178\u535a\u4f86\u9ef4\u7d20(bleomycin sulfate)\u8a98\u5c0e\u7684\u4eba\u548c\u5c0f\u9f20\u80ba\u640d\u50b7\u6a5f\u5236\u4e2d\u7684\u4f5c\u7528 [3]\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nDesiccate at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n508.99<\/td>\n<\/tr>\n
Cas No.<\/td>\n273404-37-8<\/td>\n<\/tr>\n
Formula<\/td>\nC24<\/sub>H33<\/sub>ClN4<\/sub>O6<\/sub><\/td>\n<\/tr>\n
Solubility<\/td>\ninsoluble in H2O; \u2265313 mg\/mL in DMSO; \u226550.5 mg\/mL in EtOH with ultrasonic<\/td>\n<\/tr>\n
Chemical Name<\/td>\n(2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nCCOC1C(CC(=O)O1)NC(=O)C2CCCN2C(=O)C(C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n