{"id":34599,"date":"2022-10-09T08:00:22","date_gmt":"2022-10-09T00:00:22","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=34599"},"modified":"2025-11-15T15:28:31","modified_gmt":"2025-11-15T07:28:31","slug":"%e8%a1%a3%e9%bb%b4%e7%b4%a0-tunicamycin-cas11089-65-9-apexbio%e8%b2%a8%e8%99%9fb7417","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=34599","title":{"rendered":"\u8863\u9ef4\u7d20 (Tunicamycin) | CAS#11089-65-9 APExBIO\u8ca8\u865fB7417"},"content":{"rendered":"<p><strong><span style=\"font-size: 12pt; color: #ff6600;\"><span style=\"font-size: 14pt;\"><span style=\"color: #800080;\">\u6297\u751f\u7d20\u7cfb\u5217\u5546\u54c1-&gt;&gt;<span style=\"color: #ff6600;\">\u8863\u9ef4\u7d20 (Tunicamycin)<\/span><\/span><\/span><\/span><\/strong><\/p>\n<p>APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<a href=\"https:\/\/biopioneer.com.tw\/?news=apexbio%e5%8f%b0%e7%81%a3%e4%bb%a3%e7%90%86%e5%95%86-brandagency%e4%bb%a3%e7%90%86%e5%93%81%e7%89%8c-apexbio-2\"><span style=\"color: #ff0000;\"><em><strong><span style=\"text-decoration: underline;\">&gt;&gt;\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/06\/%E5%A4%AA%E9%BC%8E-APExBIO-Technology-LLC-%E5%93%81%E7%89%8C.png\" width=\"1099\" height=\"274\" \/><\/p>\n<p><span style=\"color: #00ccff;\"><a style=\"color: #00ccff;\" href=\"http:\/\/biopioneer.com.tw\/?p=34599\"><span style=\"font-size: 12pt;\"><strong><span style=\"color: #33cccc;\">\u8863\u9ef4\u7d20 (Tunicamycin) | CAS#11089-65-9 APExBIO\u8ca8\u865fB7417<\/span><\/strong><\/span><\/a><\/span><\/p>\n<p>antibiotic,inhibits GlcNAc phosphotransferase (GPT)<\/p>\n<p>\u8863\u9ef4\u7d20(Tunicamycin)TCM \u6216 TM\uff09[1] [2] \u662f\u4e00\u7a2e\u6297\u751f\u7d20\u3002\u5728\u7cd6\u86cb\u767d\u5408\u6210\u7684\u7b2c\u4e00\u6b65\uff0c\u5b83\u53ef\u4ee5\u963b\u65b7UDP-N-\u4e59\u91af\u6c28\u57fa\u8461\u8404\u7cd6(UDP-N-acetylglucosamine)\u8207\u78f7\u9178\u591a\u7518\u9187(dolichol phosphate\u4e4b)\u9593\u7684\u53cd\u61c9\uff0c\u5f9e\u800c\u6291\u5236\u6240\u6709N-\u9023\u63a5\u7cd6\u86cb\u767d(N-linked glycoproteins)\u7684\u5408\u6210\uff0c\u6700\u7d42\u5f15\u8d77\u5167\u8cea\u7db2(endoplasmic reticulum, ER)\u61c9\u6fc0[3]\u3002\u5728\u67af\u8349\u82bd\u5b62\u687f\u83cc\u7d30\u80de(Bacillus subtilis cells)\u4e2d\uff0c\u4e2d\u85e5\u6291\u5236\u591a\u91cc\u5947\u57fa\u7126\u78f7\u9178 N-\u4e59\u91af\u6c28\u57fa\u8461\u8404\u7cd6 (Dol-p-p-GlcNAc) \u5f62\u6210\u7684 IC50 \u70ba 0.03 \u03bcg\/ml [2]\u3002ER \u61c9\u6fc0\u53cd\u61c9(ER stress response)\u662f\u5c0d\u7d30\u80de\u4ee3\u8b1d\u61c9\u6fc0(cellular metabolic stress)\u548c\u932f\u8aa4\u6298\u758a\u86cb\u767d(misfolded proteins)\u7684\u4e00\u7a2e\u6709\u6548\u7684\u3001\u9032\u5316\u4e0a\u4fdd\u5b88\u7684\u53cd\u61c9\u3002\u5167\u8cea\u7db2\u61c9\u6fc0\u662f\u7531\u5167\u8cea\u7db2\u529f\u80fd\u7684\u7834\u58de\u5f15\u8d77\u7684\uff0c\u4f8b\u5982\u8f49\u904b\u5230\u9ad8\u723e\u57fa\u8907\u5408\u9ad4(Golgi complex)\u6216\u86cb\u767d\u8cea\u7cd6\u57fa\u5316(protein glycosylation)\uff0c\u6216\u5167\u8cea\u7db2\u8154\u74b0\u5883\u7684\u7d0a\u4e82\uff0c\u4f8b\u5982\u6c27\u5316\u9084\u539f\u72c0\u614b\u6216\u9223\u7a69\u614b(calcium homeostasis)\u7684\u6539\u8b8a [3]\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2022\/10\/B7417.png\" alt=\"\" width=\"385\" height=\"356\" \/><\/p>\n<p>\u5728 RAW264.7 \u7d30\u80de\u4e2d\uff0c\u8863\u9ef4\u7d20(Tunicamycin)\u986f\u8457\u964d\u4f4e LPS \u8a98\u5c0e\u7684\u4e9e\u785d\u9178\u9e7d\u91cb\u653e\/\u7522\u751f\uff0c\u4e26\u6e1b\u5f31 mRNA \u7684\u8868\u9054\uff0c\u5f9e\u800c\u6e1b\u5f31 COX-2 \u548c iNOS \u7684\u86cb\u767d\u8cea\u3002\u6b64\u5916\uff0c\u6fc3\u5ea6\u70ba 0.5 \u03bcg\/ml \u7684\u8863\u9ef4\u7d20(Tunicamycin)\u5c0d\u7d30\u80de\u5b58\u6d3b\/\u589e\u6b96\u6c92\u6709\u4efb\u4f55\u5f71\u97ff\uff0c\u4f46\u5728 48 \u5c0f\u6642\u8863\u9ef4\u7d20(Tunicamycin)\u63d0\u4f9b\u4e86\u91dd\u5c0d\u6d3b\u5316\u8a98\u5c0e\u7684\u5de8\u566c\u7d30\u80de\u6b7b\u4ea1\u7684\u4fdd\u8b77\u4f5c\u7528\u3002\u8863\u9ef4\u7d20(Tunicamycin)\u4ee5\u6fc3\u5ea6\u4f9d\u8cf4\u6027\u65b9\u5f0f\u964d\u4f4e\u4e86\u97ff\u61c9 LPS \u7684 COX-2 \u548c iNOS \u86cb\u767d\u8868\u9054\uff0c\u4e26\u8a98\u5c0e 78-kDa \u8461\u8404\u7cd6\u8abf\u7bc0\u86cb\u767d (GRP78) \u7684\u540c\u6642\u589e\u52a0\uff0c\u9019\u662f\u4e00\u7a2e ER \u4f34\u4fb6 [3]\u3002\u5728\u91ce\u751f\u578b\u5c0f\u9f20\u7684\u5c0f\u8178\u4e2d\uff0c\u8863\u9ef4\u7d20(Tunicamycin)\u5c07\u6291\u5236\u7684 1370 \u63a2\u91dd\u548c 1291 \u63a2\u91dd\u7684\u8868\u9054\u6c34\u5e73\u63d0\u9ad8\u4e86 2 \u500d\u4ee5\u4e0a\u3002\u5728 Nrf 2 (-\/-) \u5c0f\u9f20\u7684\u5c0f\u8178\u4e2d\uff0c\u8863\u9ef4\u7d20\u6291\u5236 2024 \u500b\u63a2\u91dd\u4e26\u8a98\u5c0e 3471 \u500b\u63a2\u91dd\u8d85\u904e 2 \u500d\u3002\u8207\u5c0f\u8178\u6a23\u672c\u7684\u7d50\u679c\u76f8\u6bd4\uff0c\u5728\u91ce\u751f\u578b\u5c0f\u9f20\u809d\u81df\u4e2d\uff0c\u4e0d\u592a\u660e\u78ba\u7684\u57fa\u56e0\u88ab\u8863\u9ef4\u7d20(Tunicamycin)\u6291\u5236 (943) \u6216\u5347\u9ad8 (750) &gt;2 \u500d\uff1b\u800c\u5728 Nrf2 (-\/-) \u5c0f\u9f20\u809d\u81df\u4e2d\uff0c3170 \u500b\u57fa\u56e0\u88ab\u6291\u5236\u6216 39 \u500b\u660e\u78ba\u5b9a\u7fa9\u7684\u57fa\u56e0\u88ab\u8a98\u5c0e [1]\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2022\/10\/%E8%A1%A3%E9%BB%B4%E7%B4%A0-Tunicamycin-CAS11089-65-9-APExBIO%E8%B2%A8%E8%99%9FB7417-2.jpg\" alt=\"\" width=\"595\" height=\"473\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2022\/10\/%E8%A1%A3%E9%BB%B4%E7%B4%A0-Tunicamycin-CAS11089-65-9-APExBIO%E8%B2%A8%E8%99%9FB7417-3.jpg\" alt=\"\" width=\"579\" height=\"417\" \/><\/p>\n<table width=\"1410\">\n<tbody>\n<tr>\n<td>Physical Appearance<\/td>\n<td>A crystalline solid<\/td>\n<\/tr>\n<tr>\n<td>Storage<\/td>\n<td>Store at -20\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>M.Wt<\/td>\n<td>844.95<\/td>\n<\/tr>\n<tr>\n<td>Cas No.<\/td>\n<td>11089-65-9<\/td>\n<\/tr>\n<tr>\n<td>Formula<\/td>\n<td>C<sub>39<\/sub>H<sub>64<\/sub>N<sub>4<\/sub>O<sub>16<\/sub>\u00a0(tunicamycin C, n=10)<\/td>\n<\/tr>\n<tr>\n<td>Solubility<\/td>\n<td>\u226525 mg\/mL in DMSO<\/td>\n<\/tr>\n<tr>\n<td>SDF<\/td>\n<td><a href=\"https:\/\/www.apexbt.com\/downloader\/sdf\/B7417.sdf\">Download SDF<\/a><\/td>\n<\/tr>\n<tr>\n<td>Shipping Condition<\/td>\n<td>Ship with blue ice, or upon other requests.<\/td>\n<\/tr>\n<tr>\n<td>General tips<\/td>\n<td>For obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2022\/10\/%E8%A1%A3%E9%BB%B4%E7%B4%A0-Tunicamycin-CAS11089-65-9-APExBIO%E8%B2%A8%E8%99%9FB7417-4.jpg\" alt=\"\" width=\"684\" height=\"512\" \/><\/p>\n<ul id=\"artul\">\n<li><a>1. Yiyang Zhao, Linkang He, et al. &#8220;2-Hydroxypropyl-\u03b2-cyclodextrin Regulates the Epithelial to Mesenchymal Transition in Breast Cancer Cells by Modulating Cholesterol Homeostasis and Endoplasmic Reticulum Stress.&#8221; Metabolites. 2021 Aug 23;11(8):562.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34436503\" target=\"_blank\" rel=\"noopener\">PMID:34436503<\/a><\/li>\n<li><a>2. KE PENG, AIQIN SUN, et al. &#8220;Restoration of the ATG5\u2011dependent autophagy sensitizes DU145 prostate cancer cells to chemotherapeutic drugs.&#8221; Oncol Lett. 2021 Sep;22(3):638.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34386060\" target=\"_blank\" rel=\"noopener\">PMID:34386060<\/a><\/li>\n<li><a>3. Yanan Li, Chaorong Wang, et al. &#8220;Discovery of a small molecule inhibitor of cullin neddylation that triggers ER stress to induce autophagy.&#8221; Acta Pharmaceutica Sinica B.<\/a><\/li>\n<li><a>4. Peng Wang, Li-Na Jiang, et al. &#8220;Estradiol-induced inhibition of endoplasmic reticulum stress normalizes splenic CD4 + T lymphocytes following hemorrhagic shock.&#8221; Sci Rep. 2021 Apr 5;11(1):7508.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33820957\" target=\"_blank\" rel=\"noopener\">PMID:33820957<\/a><\/li>\n<li><a>5. Xu H, Liu P, et al. &#8220;FKBP9 promotes the malignant behavior of glioblastoma cells and confers resistance to endoplasmic reticulum stress inducers.&#8221; J Exp Clin Cancer Res. 2020;39(1):44. Published 2020 Feb 28.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32111229\" target=\"_blank\" rel=\"noopener\">PMID:32111229<\/a><\/li>\n<li><a>6. Qin W, Wu X, et al. &#8220;Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.&#8221; Biomed Pharmacother. 2019 Jul 14;118:109188.<\/a>\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31315072\" target=\"_blank\" rel=\"noopener\">PMID:31315072<\/a><\/li>\n<\/ul>\n<table width=\"553\">\n<tbody>\n<tr>\n<td width=\"139\">\u54c1\u9805<\/td>\n<td width=\"139\">CAS#<\/td>\n<td width=\"138\">#\u8ca8\u865f<\/td>\n<td width=\"138\">\u61c9\u7528<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34128\">Romidepsin (FK228, depsipeptide)<\/a><\/td>\n<td width=\"139\">\n<p>CAS#128517-07-7<\/p>\n<p>&nbsp;<\/td>\n<td width=\"138\">\u8ca8\u865fA8173<\/td>\n<td width=\"138\">HDAC1\/HDAC2\uff0c\u5f37\u6548\u548c\u9078\u64c7\u6027\u6291\u5236\u5291<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34607\">Pirarubicin<\/a><\/td>\n<td width=\"139\">CAS#72496-41-4<\/td>\n<td width=\"138\">\u8ca8\u865fB2295<\/td>\n<td width=\"138\">\u00a0anthracycline anti-neoplastic doxorubicin<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34599\">Tunicamycin<\/a><\/td>\n<td width=\"139\">CAS# 15663-27-1<\/td>\n<td width=\"138\">\n<p>\u8ca8\u865fA8321<\/p>\n<p>&nbsp;<\/td>\n<td width=\"138\">\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34612\">Azithromycin<\/a><\/td>\n<td width=\"139\">CAS#83905-01-5<\/td>\n<td width=\"138\">\u00a0\u8ca8\u865fA2213<\/td>\n<td width=\"138\">Hsp90 inhibitor<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34765\">Bleomycin Sulfate<\/a><\/td>\n<td width=\"139\">\n<p>CAS# 9041-93-4<\/p>\n<p>&nbsp;<\/td>\n<td width=\"138\">\u8ca8\u865fB1398<\/td>\n<td width=\"138\">Antibiotic by inhibiting protein synthesis<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34625\">Nystatin (Fungicidin)<\/a><\/td>\n<td width=\"139\">CAS#1400-61-9<\/td>\n<td width=\"138\">\u8ca8\u865fB1993<\/td>\n<td width=\"138\">antifungal antibiotic<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34118\">Rapamycin<\/a><\/td>\n<td width=\"139\">CAS#53123-88-9<\/td>\n<td width=\"138\">\u8ca8\u865fA8167<\/td>\n<td width=\"138\">Original antifungal antibiotic<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34140\">Daptomycin<\/a><\/td>\n<td width=\"139\">CAS#103060-53-3<\/td>\n<td width=\"138\">\u8ca8\u865fA1206<\/td>\n<td width=\"138\">Calcium-dependent antibiotic<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6297\u751f\u7d20\u7cfb\u5217\u5546\u54c1-&gt;&gt;\u8863\u9ef4\u7d20 (Tunicamycin) APExBIO Technology LL [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[478,5368,486],"tags":[4984],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34599"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34599"}],"version-history":[{"count":8,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34599\/revisions"}],"predecessor-version":[{"id":53712,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34599\/revisions\/53712"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34599"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34599"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34599"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}