{"id":34592,"date":"2022-10-09T07:19:32","date_gmt":"2022-10-08T23:19:32","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=34592"},"modified":"2025-06-30T17:36:27","modified_gmt":"2025-06-30T09:36:27","slug":"%e5%85%a9%e6%80%a7%e9%bb%b4%e7%b4%a0-b-amphotericin-b-cas-1397-89-3-apexbio%e8%b2%a8%e8%99%9fb1885","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=34592","title":{"rendered":"\u5169\u6027\u9ef4\u7d20 B (Amphotericin B) | CAS# 1397-89-3 APExBIO\u8ca8\u865fB1885"},"content":{"rendered":"

\u6297\u751f\u7d20\u5316\u5408\u7269\u7cfb\u5217\u5546\u54c1->>\u5169\u6027\u9ef4\u7d20 B (Amphotericin B)<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<\/p>\n

<\/p>\n

\u5169\u6027\u9ef4\u7d20 B (Amphotericin B) | CAS# 1397-89-3 APExBIO\u8ca8\u865fB1885<\/span><\/strong><\/span><\/a><\/span><\/p>\n

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\u5169\u6027\u9ef4\u7d20 B(Amphotericin B) \u662f\u4e00\u7a2e\u591a\u70ef\u985e\u6297\u771f\u83cc\u6297\u751f\u7d20(polyene antifungal antibiotic)\uff0c\u7531\u7d50\u7bc0\u93c8\u9ef4\u83cc\u83cc\u682a(Streptomyces nodosus)\u751f\u7522\uff0cIC50 \u70ba 0.028\u20130.290 \u03bcg\/ml\u3002\u9ad4\u5916\u8a66\u9a57\uff1a\u5169\u6027\u9ef4\u7d20 B(Amphotericin B) \u00a0\u662f\u6cbb\u7642\u8a31\u591a\u5371\u53ca\u751f\u547d\u7684\u771f\u83cc\u611f\u67d3(fungal infections)\u6700\u6709\u6548\u7684\u85e5\u7269\u3002\u5728\u8868\u9054 TLR2 \u548c CD14 \u7684\u7d30\u80de\u4e2d\uff0c\u5169\u6027\u9ef4\u7d20 B(Amphotericin B) \u00a0\u8a98\u5c0e\u4fe1\u865f\u8f49\u5c0e(signal transduction)\u548c\u708e\u6027\u7d30\u80de\u56e0\u5b50\u91cb\u653e(inflammatory cytokine release)\u3002\u5728\u8868\u9054 TLR2\u3001CD14 \u548c\u929c\u63a5\u86cb\u767d MyD88 \u7684\u539f\u4ee3\u9f20\u5de8\u566c\u7d30\u80de(primary murine macrophages)\u548c\u4eba\u985e\u7d30\u80de\u682a\u4e2d\uff0c\u5169\u6027\u9ef4\u7d20 B(Amphotericin B)\u8a98\u5c0e NF-\u03baB \u4f9d\u8cf4\u6027\u5831\u544a\u57fa\u56e0\u6d3b\u6027\u548c\u7d30\u80de\u56e0\u5b50\u91cb\u653e\uff0c\u800c\u7f3a\u4e4f\u4efb\u4f55\u9019\u4e9b\u7684\u7d30\u80de\u90fd\u6c92\u6709\u53cd\u61c9\u3002\u8207\u8868\u9054\u6b63\u5e38 TLR4 \u7684\u7d30\u80de\u76f8\u6bd4\uff0c\u5177\u6709 TLR4 \u7a81\u8b8a\u7684\u7d30\u80de\u5c0d\u5169\u6027\u9ef4\u7d20 B(Amphotericin B)\u523a\u6fc0\u7684\u53cd\u61c9\u8f03\u5f31 [1]\u3002<\/p>\n

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\u5169\u6027\u9ef4\u7d20 B(Amphotericin B) \u00a0\u53ef\u8207\u81bd\u56fa\u9187(cholesterol)\uff08\u54fa\u4e73\u52d5\u7269\u7d30\u80de\u819c\u7684\u4e3b\u8981\u753e\u9187\uff09\u76f8\u4e92\u4f5c\u7528\uff0c\u56e0\u6b64\u7531\u65bc\u5176\u76f8\u5c0d\u8f03\u9ad8\u7684\u6bd2\u6027\u800c\u9650\u5236\u4e86\u5169\u6027\u9ef4\u7d20 B(Amphotericin B) \u00a0\u7684\u7528\u9014 [2]\u3002\u4f4e AmB \u6fc3\u5ea6 (\u2264 0.1 \u03bcM) \u5728\u61f8\u6d6e\u5728\u7b49\u6ef2\u8517\u7cd6\u6eb6\u6db2\u4e2d\u7684 KCl \u8ca0\u8f09\u8102\u8cea\u9ad4\u4e2d\u8a98\u5c0e\u6975\u5316\u96fb\u4f4d\uff0c\u8868\u660e K+ leakage\u3002 AmB (\uff1e 0.1 \u03bcM) \u5141\u8a31\u967d\u96e2\u5b50\u548c\u9670\u96e2\u5b50\u904b\u52d5\u3002\u61f8\u6d6e\u5728\u7b49\u6ef2 NaCl \u6eb6\u6db2\u4e2d\u4e26\u66b4\u9732\u65bc AmB (0.05 \u03bcM) \u7684 LP \u8868\u73fe\u51fa\u5e7e\u4e4e\u5b8c\u5168\u7684\u8ca0\u819c\u96fb\u4f4dcollapse\uff0c\u8868\u660e Na+ \u9032\u5165\u4e86\u7d30\u80de [3]\u3002<\/p>\n

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References:<\/p>\n

[1]. Sau K1,Mambula SS,Latz E,Henneke P,Golenbock DT,Levitz SM.The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism.J Biol Chem.2003 Sep 26;278(39):37561-8. Epub 2003 Jul 14.<\/p>\n

[2]. Demaimay R1,Adjou K,Lasm\u00e9zas C,Lazarini F,Cherifi K,Seman M,Deslys JP,Dormont D.Pharmacological studies of a new derivative of amphotericin B, MS-8209, in mouse and hamster scrapie.J Gen Virol.1994 Sep;75 ( Pt 9):2499-503.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n924.08<\/td>\n<\/tr>\n
Cas No.<\/td>\n1397-89-3<\/td>\n<\/tr>\n
Formula<\/td>\nC47H73NO17<\/td>\n<\/tr>\n
Solubility<\/td>\n\u226546.2 mg\/mL in DMSO; insoluble in EtOH; insoluble in H2O<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nO=C(C[C@@H](C[C@@H](CC[C@@H](O)[C@@H]1O)O)O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\/C=C\/C=C\/C=C\/C=C\/C=C\/C=C\/C=C\/[C@H](O[C@H]2[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O2)C[C@@H]([C@H](C(O)=O)[C@@H](O)C3)OC3(O)C[C@H](C1)O<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002
\n\"\u578b\u9304\u4e0b\u8f09\"<\/a><\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6297\u751f\u7d20\u5316\u5408\u7269\u7cfb\u5217\u5546\u54c1->>\u5169\u6027\u9ef4\u7d20 B (Amphotericin B) APExBIO Tech […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[478,486],"tags":[4983],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34592"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34592"}],"version-history":[{"count":7,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34592\/revisions"}],"predecessor-version":[{"id":51854,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34592\/revisions\/51854"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34592"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34592"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34592"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}