{"id":34325,"date":"2022-09-21T14:23:40","date_gmt":"2022-09-21T06:23:40","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=34325"},"modified":"2025-11-15T16:12:27","modified_gmt":"2025-11-15T08:12:27","slug":"vx-765-cas-273404-37-8-apexbio-%e8%b2%a8%e8%99%9fa8238","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=34325","title":{"rendered":"VX-765 | CAS# 273404-37-8 APExBIO \u8ca8\u865fA8238"},"content":{"rendered":"

Proteases\u7cfb\u5217\u5546\u54c1->>VX-765<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

\u86cb\u767d\u9176(Proteases)\u4e5f\u7a31\u70ba\u80bd\u9176(peptidases)\u6216\u86cb\u767d\u6c34\u89e3\u9176(proteolytic enzymes)\uff0c\u7531\u5927\u91cf\u50ac\u5316\u80bd\u9375\u6c34\u89e3(hydrolysis)\u4e26\u96a8\u5f8c\u5c0e\u81f4\u86cb\u767d\u8cea\u5e95\u7269(protein substrates)\u964d\u89e3\u70ba\u6c28\u57fa\u9178(amino acids)\u7684\u9176\u7d44\u6210\u3002\u86cb\u767d\u9176(Proteases)\u8207\u591a\u7a2e\u4eba\u985e\u75be\u75c5\u6709\u95dc\uff0c\u5305\u62ec\u764c\u75c7(cancer)\u3001\u795e\u7d93\u9000\u884c\u6027\u75be\u200b\u200b\u75c5(neurodegenerative disorders)\u3001\u708e\u75c7\u6027\u75be\u75c5(inflammatory diseases)\u548c\u5fc3\u8840\u7ba1\u75be\u75c5(cardiovascular diseases)\u3002\u56e0\u6b64\uff0c\u8a31\u591a\u86cb\u767d\u9176\u6291\u5236\u5291\u3010\u5c0f\u5206\u5b50(small molecules)\u548c\u86cb\u767d\u8cea\u3011\u5df2\u88ab\u9451\u5b9a\u70ba\u963b\u65b7\u86cb\u767d\u9176\u7684\u6d3b\u6027(proteases)\u3002\u86cb\u767d\u9176\u6291\u5236\u5291\u53ef\u4ee5\u6839\u64da\u5b83\u5011\u901a\u904e\u5169\u7a2e\u4e00\u822c\u6a5f\u5236\u6291\u5236\u7684\u86cb\u767d\u9176\u985e\u5225\u5206\u70ba\u4e0d\u540c\u7684\u985e\u578b\uff0c\u5373\u4e0d\u53ef\u9006\u7684\u201c\u6355\u7372(trapping)\u201d\u53cd\u61c9\u548c\u53ef\u9006(reversible)\u7684\u7dca\u5bc6\u7d50\u5408\u53cd\u61c9\u3002\u86cb\u767d\u9176\u6291\u5236\u5291\u5df2\u88ab\u7528\u4f5c\u6cbb\u7642\u86cb\u767d\u9176\u76f8\u95dc\u75be\u75c5\u7684\u8a3a\u65b7\u5291(diagnostic)\u6216\u6cbb\u7642\u5291(therapeutic agents)\u3002<\/p>\n

VX-765 | CAS# 273404-37-8 APExBIO\u00a0 \u8ca8\u865fA8238<\/span><\/strong><\/span><\/a><\/span><\/p>\n

\"\"<\/p>\n

Product Citation+4<\/p>\n

Caspase-1 inhibitor,potent and selective<\/p>\n

VX-765 \u662f VRT-043198 \u7684\u53e3\u670d\u5438\u6536\u524d\u85e5(orally- absorbed pro-drug)\uff0c\u662f\u4e00\u7a2e\u6709\u6548\u7684\u9078\u64c7\u6027 caspase-1 \u6291\u5236\u5291\uff0c\u5c6c\u65bc ICE\/caspase-1 \u4e9e\u5bb6\u65cf caspase\u3002Caspase-1 \u88ab\u7a31\u70ba\u767d\u7d30\u80de\u4ecb\u7d20 (interleukin , IL)-1 \u8f49\u63db\u9176\uff0c\u8ca0\u8cac\u5c07\u95dc\u9375\u708e\u75c7\u4ecb\u8cea IL-1\u03b2 (inflammatory mediator IL-1\u03b2)\u5f9e\u7121\u6d3b\u6027\u524d\u9ad4\u52a0\u5de5\u6210\u6709\u6d3b\u6027\u7684\u5206\u6ccc\u86cb\u767d\u3002\u64da\u5831\u5c0e\uff0c\u4f5c\u70ba\u5c0d\u7d30\u80de\u5167\u7d30\u83cc\u7684\u53cd\u61c9\uff0ccaspase-1 \u53c3\u8207\u4e86\u4e00\u500b\u5feb\u901f\u7684\u7d30\u80de\u6b7b\u4ea1\u7a0b\u5e8f(programme of cell death)\uff0c\u7a31\u70ba\u5de8\u566c\u7d30\u80de(macrophages)\u4e2d\u7684\u7d30\u80de\u7126\u4ea1(pyroptosis )[1]\u3002<\/p>\n

\"\"<\/p>\n

VX-765 \u901a\u5e38\u4ee3\u8b1d\u70ba\u6d3b\u6027\u5206\u5b50 VRT-043198\u3002\u5728\u7528\u7d30\u83cc\u7522\u7269\u523a\u6fc0\u7684\u5916\u5468\u8840\u55ae\u500b\u6838\u7d30\u80de\u57f9\u990a\u7269\u4e2d\uff0cVRT-043198 \u6291\u5236\u767d\u7d30\u80de\u4ecb\u7d20 (IL)-1\u03b2 \u548c IL-18 \u7684\u91cb\u653e\uff0c\u4f46\u4e0d\u5f71\u97ff\u5176\u4ed6\u7d30\u80de\u56e0\u5b50\u5982 IL-\u03b1\u3001TNF\u03b1\u3001IL-6 \u7684\u5206\u6ccc\u548c IL-8 [2]\u3002\u8a72\u7522\u54c1\u4e5f\u7528\u65bc\u5176\u4ed6\u6a21\u578b\u4ee5\u8aaa\u660e Caspase-1 \u7684\u529f\u80fd\u3002\u53e3\u670d VX-765 \u53ef\u986f\u8457\u964d\u4f4e\u985e\u98a8\u6fd5\u95dc\u7bc0\u708e(rheumatoid arthritis)\u548c\u76ae\u819a\u708e\u75c7(skin inflammation)\u5c0f\u9f20\u6a21\u578b\u7684\u75be\u75c5\u56b4\u91cd\u7a0b\u5ea6\u4ee5\u53ca\u708e\u6027\u7d30\u80de\u56e0\u5b50(inflammatory cytokines)\u548c\u8da8\u5316\u56e0\u5b50(chemokines)\u7684\u5206\u6ccc[1]\u3002\u6b64\u5916\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0cVX-765 \u5728 HIV \u611f\u67d3\u7684\u6dcb\u5df4\u7d44\u7e54(HIV-infected lymphoid tissues)\u4e2d\u4ee5\u5291\u91cf\u4f9d\u8cf4\u6027\u65b9\u5f0f\u9810\u9632 CD4 T \u7d30\u80de\u7126\u4ea1\u6b7b\u4ea1(T-cell pyroptotic death) [3]\u3002<\/p>\n

\"\"<\/p>\n

    \n
  1. Hila Israelov, Orly Ravid, et al. “Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair.” J Neuroinflammation 2020 Sep 9;17(1):267.PMID:32907600<\/a><\/li>\n
  2. Darren C. Johnson, Marian C. Okondo, et al. “DPP8\/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes.” Cell Death Dis. 2020 Aug 14;11(8):628.PMID:32796818<\/a><\/li>\n
  3. Panina SB, Baran N, et al. “A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugs.” Cell Death Dis. 2019 Aug 13;10(8):617.PMID:31409768<\/a><\/li>\n
  4. Yang G, Wang J, et al. “White spot syndrome virus infection activates Caspase 1-mediated cell death in crustacean.” Virology. 2018 Dec 13;528:37-47.PMID:30554072<\/a><\/li>\n<\/ol>\n

    \"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
    Storage<\/td>\nDesiccate at -20\u00b0C<\/td>\n<\/tr>\n
    M.Wt<\/td>\n508.99<\/td>\n<\/tr>\n
    Cas No.<\/td>\n273404-37-8<\/td>\n<\/tr>\n
    Formula<\/td>\nC24<\/sub>H33<\/sub>ClN4<\/sub>O6<\/sub><\/td>\n<\/tr>\n
    Solubility<\/td>\ninsoluble in H2O; \u2265313 mg\/mL in DMSO; \u226550.5 mg\/mL in EtOH with ultrasonic<\/td>\n<\/tr>\n
    Chemical Name<\/td>\n(2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide<\/td>\n<\/tr>\n
    SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
    Canonical SMILES<\/td>\nCCOC1C(CC(=O)O1)NC(=O)C2CCCN2C(=O)C(C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl<\/td>\n<\/tr>\n
    Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
    General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    <\/h4>\n

    <\/p>\n

    APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n

    APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

    Proteases\u7cfb\u5217\u5546\u54c1->>VX-765 APExBIO Technology LLC \u662f\u4e00\u5bb6 […]<\/p>\n","protected":false},"author":3,"featured_media":34308,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368,486],"tags":[4961],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34325"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34325"}],"version-history":[{"count":7,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34325\/revisions"}],"predecessor-version":[{"id":53795,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34325\/revisions\/53795"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/34308"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34325"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34325"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}