{"id":34301,"date":"2022-09-20T17:57:06","date_gmt":"2022-09-20T09:57:06","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=34301"},"modified":"2025-11-15T14:58:47","modified_gmt":"2025-11-15T06:58:47","slug":"z-ietd-fmk-cas-210344-98-2-apexbio-%e8%b2%a8%e8%99%9fb3232","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=34301","title":{"rendered":"Z-IETD-FMK | CAS# 210344-98-2 APExBIO \u8ca8\u865fB3232"},"content":{"rendered":"

\u86cb\u767d\u9176(Proteases)\u7cfb\u5217\u5546\u54c1->>Z-IETD-FMK<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

\u86cb\u767d\u9176(Proteases)\u4e5f\u7a31\u70ba\u80bd\u9176(peptidases)\u6216\u86cb\u767d\u6c34\u89e3\u9176(proteolytic enzymes)\uff0c\u7531\u5927\u91cf\u50ac\u5316\u80bd\u9375\u6c34\u89e3(hydrolysis)\u4e26\u96a8\u5f8c\u5c0e\u81f4\u86cb\u767d\u8cea\u5e95\u7269(protein substrates)\u964d\u89e3\u70ba\u6c28\u57fa\u9178(amino acids)\u7684\u9176\u7d44\u6210\u3002\u86cb\u767d\u9176(Proteases)\u8207\u591a\u7a2e\u4eba\u985e\u75be\u75c5\u6709\u95dc\uff0c\u5305\u62ec\u764c\u75c7(cancer)\u3001\u795e\u7d93\u9000\u884c\u6027\u75be\u200b\u200b\u75c5(neurodegenerative disorders)\u3001\u708e\u75c7\u6027\u75be\u75c5(inflammatory diseases)\u548c\u5fc3\u8840\u7ba1\u75be\u75c5(cardiovascular diseases)\u3002\u56e0\u6b64\uff0c\u8a31\u591a\u86cb\u767d\u9176\u6291\u5236\u5291\u3010\u5c0f\u5206\u5b50(small molecules)\u548c\u86cb\u767d\u8cea\u3011\u5df2\u88ab\u9451\u5b9a\u70ba\u963b\u65b7\u86cb\u767d\u9176\u7684\u6d3b\u6027(proteases)\u3002\u86cb\u767d\u9176\u6291\u5236\u5291\u53ef\u4ee5\u6839\u64da\u5b83\u5011\u901a\u904e\u5169\u7a2e\u4e00\u822c\u6a5f\u5236\u6291\u5236\u7684\u86cb\u767d\u9176\u985e\u5225\u5206\u70ba\u4e0d\u540c\u7684\u985e\u578b\uff0c\u5373\u4e0d\u53ef\u9006\u7684\u201c\u6355\u7372(trapping)\u201d\u53cd\u61c9\u548c\u53ef\u9006(reversible)\u7684\u7dca\u5bc6\u7d50\u5408\u53cd\u61c9\u3002\u86cb\u767d\u9176\u6291\u5236\u5291\u5df2\u88ab\u7528\u4f5c\u6cbb\u7642\u86cb\u767d\u9176\u76f8\u95dc\u75be\u75c5\u7684\u8a3a\u65b7\u5291(diagnostic)\u6216\u6cbb\u7642\u5291(therapeutic agents)\u3002<\/p>\n

Z-IETD-FMK | CAS# 210344-98-2 APExBIO\u00a0 \u8ca8\u865fB3232<\/span><\/strong><\/a><\/p>\n

\"Z-IETD-FMK\"<\/p>\n

Product Citation+6<\/p>\n

Z-IETD-FMK is an inhibitor of caspase 8 [1].<\/p>\n

Z-IETD-FMK \u662f\u534a\u80f1\u5929\u51ac\u9176 8 \u7684\u6291\u5236\u5291 [1]\u3002Z-IETD-FMK \u6291\u5236 PHA \u6216\u6297 CD3 \u52a0\u6297 CD28 \u8a98\u5c0e\u7684 T \u7d30\u80de\u589e\u6b96\uff0c\u800c\u5c0dresting \u7684T cells\u6c92\u6709\u6bd2\u6027\u3002\u9019\u7a2e\u6291\u5236 Z-IETD-FMK \u7684\u6a5f\u5236\u5df2\u88ab\u8b49\u660e\u4e0d\u662f\u901a\u904e\u5c0d IL-2 \u5206\u6ccc\u6216 IFN-\u03b3 \u7522\u751f\u7684\u5f71\u97ff\uff0c\u800c\u662f\u901a\u904e\u964d\u4f4e CD25 \u8868\u9054\u3002\u5be6\u9a57\u8868\u660e\uff0c\u5728\u6c92\u6709\u6fc0\u6d3b\u4fe1\u865f\u7684\u60c5\u6cc1\u4e0b\uff0cZ-IETD-FMK\u5c0d\u6b63\u5e38\u7d30\u80de\u751f\u9577\u6c92\u6709\u5f71\u97ff\u3002\u9084\u767c\u73fe Z-IETD-FMK \u5728\u6fc3\u5ea6\u70ba 100 \u03bcM \u6642\u986f\u8457\u6291\u5236 NF-\u03baB \u6d3b\u5316 [1]\u3002\u9664\u4e86\u6291\u5236\u7d30\u80de\u589e\u6b96\u7684\u80fd\u529b\u5916\uff0c\u64da\u5831\u5c0e Z-IETD-FMK \u9084\u80fd\u6291\u5236 TRAIL \u4ecb\u5c0e\u7684\u7d30\u80de\u6bba\u50b7\u3002\u5b83\u4fdd\u8b77 procaspase 9\u30012 \u548c 3\uff0c\u4e26\u5728 HCT116 \u548c SW480 \u7d30\u80de\u4e2d\u4ee5\u76f8\u4f3c\u7684\u7a0b\u5ea6\u4fdd\u8b77 PARP [2]\u3002<\/p>\n

\"Z-IETD-FMK\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n654.68<\/td>\n<\/tr>\n
Cas No.<\/td>\n210344-98-2<\/td>\n<\/tr>\n
Formula<\/td>\nC30<\/sub>H43<\/sub>FN4<\/sub>O11<\/sub><\/td>\n<\/tr>\n
Synonyms<\/td>\nBenzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone, Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK<\/td>\n<\/tr>\n
Solubility<\/td>\n\u226532.73 mg\/mL in DMSO; insoluble in EtOH; insoluble in H2O<\/td>\n<\/tr>\n
Chemical Name<\/td>\nmethyl 5-[[1-[(5-fluoro-1-methoxy-1,4-dioxopentan-3-yl)amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[[3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoate<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nCCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

APExBIO\u53f0\u7063\u4ee3\u7406\u5546<\/a><\/span><\/h2>\n

APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

\"Z-IETD-FMK\"<\/p>\n