{"id":34295,"date":"2022-09-20T16:03:59","date_gmt":"2022-09-20T08:03:59","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=34295"},"modified":"2025-11-15T16:17:26","modified_gmt":"2025-11-15T08:17:26","slug":"talabostat-mesylate-cas-150080-09-4-apexbio-%e8%b2%a8%e8%99%9fb3941","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=34295","title":{"rendered":"Talabostat mesylate | CAS# 150080-09-4 APExBIO \u8ca8\u865fB3941"},"content":{"rendered":"

\u4e8c\u80bd\u57fa\u80bd\u9176\u7cfb\u5217\u5546\u54c1->>Talabostat mesylate<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

\u86cb\u767d\u9176(Proteases)\u4e5f\u7a31\u70ba\u80bd\u9176(peptidases)\u6216\u86cb\u767d\u6c34\u89e3\u9176(proteolytic enzymes)\uff0c\u7531\u5927\u91cf\u50ac\u5316\u80bd\u9375\u6c34\u89e3(hydrolysis)\u4e26\u96a8\u5f8c\u5c0e\u81f4\u86cb\u767d\u8cea\u5e95\u7269(protein substrates)\u964d\u89e3\u70ba\u6c28\u57fa\u9178(amino acids)\u7684\u9176\u7d44\u6210\u3002\u86cb\u767d\u9176(Proteases)\u8207\u591a\u7a2e\u4eba\u985e\u75be\u75c5\u6709\u95dc\uff0c\u5305\u62ec\u764c\u75c7(cancer)\u3001\u795e\u7d93\u9000\u884c\u6027\u75be\u200b\u200b\u75c5(neurodegenerative disorders)\u3001\u708e\u75c7\u6027\u75be\u75c5(inflammatory diseases)\u548c\u5fc3\u8840\u7ba1\u75be\u75c5(cardiovascular diseases)\u3002\u56e0\u6b64\uff0c\u8a31\u591a\u86cb\u767d\u9176\u6291\u5236\u5291\u3010\u5c0f\u5206\u5b50(small molecules)\u548c\u86cb\u767d\u8cea\u3011\u5df2\u88ab\u9451\u5b9a\u70ba\u963b\u65b7\u86cb\u767d\u9176\u7684\u6d3b\u6027(proteases)\u3002\u86cb\u767d\u9176\u6291\u5236\u5291\u53ef\u4ee5\u6839\u64da\u5b83\u5011\u901a\u904e\u5169\u7a2e\u4e00\u822c\u6a5f\u5236\u6291\u5236\u7684\u86cb\u767d\u9176\u985e\u5225\u5206\u70ba\u4e0d\u540c\u7684\u985e\u578b\uff0c\u5373\u4e0d\u53ef\u9006\u7684\u201c\u6355\u7372(trapping)\u201d\u53cd\u61c9\u548c\u53ef\u9006(reversible)\u7684\u7dca\u5bc6\u7d50\u5408\u53cd\u61c9\u3002\u86cb\u767d\u9176\u6291\u5236\u5291\u5df2\u88ab\u7528\u4f5c\u6cbb\u7642\u86cb\u767d\u9176\u76f8\u95dc\u75be\u75c5\u7684\u8a3a\u65b7\u5291(diagnostic)\u6216\u6cbb\u7642\u5291(therapeutic agents)\u3002<\/p>\n

Talabostat mesylate | CAS# 150080-09-4 APExBIO\u00a0 \u8ca8\u865fB3941<\/span><\/strong><\/span><\/a><\/p>\n

Product Citation+6<\/p>\n

Talabostat mesilate (PT-100; Val-boroPro) \u662f\u4e00\u7a2e\u5177\u6709\u53e3\u670d\u6d3b\u6027\u7684 DPP4 \u4e8c\u80bd\u57fa\u80bd\u9176\u7279\u7570\u6027\u6291\u5236\u5291\uff0c\u5305\u62ec\u816b\u7624\u76f8\u95dc\u6210\u7e96\u7dad\u7d30\u80de\u6d3b\u5316\u86cb\u767d (Fibroblast activation protein , FAP)\u3002\u6210\u7e96\u7dad\u7d30\u80de\u6d3b\u5316\u86cb\u767d- (Fibroblast activation protein , FAP)\uff0c\u4f5c\u70ba\u4e00\u7a2e\u5b8c\u6574\u7684\u819c\u7d72\u6c28\u9178\u86cb\u767d\u9176(integral membrane serine protease)\u548c\u5f8c\u812f\u6c28\u9170\u80bd\u9176\u5bb6\u65cf(post-prolyl peptidase family)\u7684\u6210\u54e1\uff0c\u8207\u4e8c\u80bd\u57fa\u80bd\u9176 IV (dipeptidyl peptidase IV ,DPPIV) \u5bc6\u5207\u76f8\u95dc\uff0c\u4e26\u986f\u793a\u5177\u6709\u7279\u5fb5\u6027 I-\u6c34\u89e3\u9176(characteristic)\u548c\u516b\u8449\u87ba\u65cb\u69f3\u7684 DPPIV \u6a23\u6298\u758a\u57df(DPPIV-like fold )\u3002\u9ad4\u5916(In vitro) \u901a\u904e\u5207\u5272 N \u7aef Xaa-Pro \u6216 Xaa-Ala \u6b98\u57fa\uff0ctalabostat \u963b\u65b7\u4e8c\u80bd\u57fa\u80bd\u9176(dipeptidyl peptidases)\uff0c\u4f8b\u5982\u6210\u7e96\u7dad\u7d30\u80de\u6d3b\u5316\u86cb\u767d (fibroblast activation protein , FAP)\uff0c\u5f9e\u800c\u8a98\u5c0e\u7d30\u80de\u56e0\u5b50(cytokine)\u548c\u8da8\u5316\u56e0\u5b50\u7684\u7522\u751f\uff08\u9664\u4e86\u7279\u7570\u6027 T \u7d30\u80de\u514d\u75ab\u548cT \u7d30\u80de\u4f9d\u8cf4\u6027\u6d3b\u6027\uff09\u3002\u8a72\u85e5\u5291\u9084\u53ef\u4ee5\u8a98\u5c0e\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\u7684\u7522\u751f\uff0c\u4f8b\u5982\u7c92\u7d30\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff08G-CSF\uff09\uff0c\u5f9e\u800c\u8a98\u5c0e\u9020\u8840\u3002\u4e8c\u80bd\u57fa\u80bd\u9176\u662f\u6307\u591a\u80bd\u6fc0\u7d20\u548c\u8da8\u5316\u56e0\u5b50\u7684\u6d3b\u5316\u3002Talabostat \u7565\u5fae\u964d\u4f4e\u4e86\u8868\u9054 FAP \u7684\u816b\u7624\u7684\u751f\u9577\u901f\u7387\uff0c\u4f46\u7531\u65bc PT-630 \u548c LAF-237 \u6c92\u6709\uff0c\u56e0\u6b64\u751f\u9577\u963b\u65b7\u53ef\u80fd\u8207\u6291\u5236 FAP \u6216\u76f8\u95dc\u7684\u812f\u6c28\u9170\u80bd\u9176\u5f8c\u4e8c\u80bd\u57fa\u80bd\u9176 IV \u7121\u95dc\u3002 \u9ad4\u5167\uff1a\u5230\u76ee\u524d\u70ba\u6b62\uff0c\u9084\u6c92\u6709\u9032\u884c\u9ad4\u5167\u7814\u7a76\u3002\u81e8\u5e8a\u8a66\u9a57\uff1a\u5df2\u9032\u884c\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n

    \n
  1. Andreas Linder, Stefan Bauernfried, et al. “CARD8 inflammasome activation triggers pyroptosis in human T cells.” EMBO J 2020 Aug 25;e105071.PMID:32840892<\/a><\/li>\n
  2. Chen M, Lei X, et al. “Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents.” J Clin Invest. 2017 Oct 2;127(10):3689-3701.PMID:28846068<\/a><\/li>\n
  3. Feng X, Wang Q, et al. “A synthetic urinary probe-coated nanoparticles sensitive to fibroblast activation protein \u03b1 for solid tumor diagnosis.” Int J Nanomedicine. 2017 Jul 27;12:5359-5372.PMID:28794628<\/a><\/li>\n<\/ol>\n

    \"\"<\/p>\n

    \"\"<\/p>\n

    \"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
    Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
    Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
    M.Wt<\/td>\n310.18<\/td>\n<\/tr>\n
    Cas No.<\/td>\n150080-09-4<\/td>\n<\/tr>\n
    Formula<\/td>\nC10H23BN2O6S<\/td>\n<\/tr>\n
    Solubility<\/td>\n\u226511.45 mg\/mL in DMSO; \u226531 mg\/mL in H2O; \u22658.2 mg\/mL in EtOH with ultrasonic<\/td>\n<\/tr>\n
    SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
    Canonical SMILES<\/td>\nOS(=O)(C)=O.O=C([C@H](C(C)C)N)N1[C@H](B(O)O)CCC1<\/td>\n<\/tr>\n
    Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
    General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    <\/p>\n

    APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a>https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n

    APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n

    <\/p>\n\n\n\n\n\n\n\n\n\n\n\n
    \u54c1\u9805<\/td>\nCAS#<\/td>\n#\u8ca8\u865f<\/td>\n\u61c9\u7528<\/td>\n<\/tr>\n
    Z-VAD-FMK \u00a0<\/a><\/td>\nCAS# 187389-52-2<\/td>\n\u8ca8\u865f\u00a0A1902<\/td>\n\n

    Proteases<\/p>\n

    ICE-like proteases<\/td>\n<\/tr>\n

    TAPI-1 \u00a0<\/a><\/td>\nCAS#171235-71-5<\/td>\n\u8ca8\u865f\u00a0B4686<\/td>\n\n

    Proteases<\/p>\n

    TACE\/ADAM17 inhibitor Product Citation+3<\/td>\n<\/tr>\n

    Talabostat mesylate<\/a><\/td>\nCAS# 150080-09-4<\/td>\n\u8ca8\u865fB3941<\/td>\n\n

    Proteases<\/p>\n

    DPP4 \u4e8c\u80bd\u57fa\u80bd\u9176\u7279\u7570\u6027\u6291\u5236\u5291<\/td>\n<\/tr>\n

    Z-IETD-FMK<\/a><\/td>\nCAS# 210344-98-2<\/td>\n\u8ca8\u865fB3232<\/td>\ninhibitor of caspase 8<\/td>\n<\/tr>\n
    Cisplatin<\/td>\nCAS# 15663-27-1<\/td>\n\u8ca8\u865fA8321<\/td>\n\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/td>\n<\/tr>\n
    17-DMAG (Alvespimycin) HCl<\/a><\/td>\nCAS#467214-21-7<\/td>\n\u00a0\u8ca8\u865fA2213<\/td>\nHsp90 inhibitor<\/td>\n<\/tr>\n
    CA-074 Me\u00a0<\/a><\/td>\nCAS# 147859-80-1<\/td>\n\u8ca8\u865fA8239<\/td>\nCathepsin B inhibitor<\/td>\n<\/tr>\n
    VX-765<\/a><\/td>\nCAS# 273404-37-8<\/td>\n\u8ca8\u865fA8238<\/td>\nCaspase-1 inhibitor<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    \u4e8c\u80bd\u57fa\u80bd\u9176\u7cfb\u5217\u5546\u54c1->>Talabostat mesylate APExBIO Technolog […]<\/p>\n","protected":false},"author":3,"featured_media":45049,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368,486],"tags":[4956],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34295"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34295"}],"version-history":[{"count":6,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34295\/revisions"}],"predecessor-version":[{"id":53804,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34295\/revisions\/53804"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/45049"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34295"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}