{"id":34285,"date":"2022-09-20T13:18:28","date_gmt":"2022-09-20T05:18:28","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=34285"},"modified":"2025-11-15T16:18:36","modified_gmt":"2025-11-15T08:18:36","slug":"tapi-1-cas171235-71-5-apexbio-%e8%b2%a8%e8%99%9f-b4686","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=34285","title":{"rendered":"TAPI-1 | CAS#171235-71-5 APExBIO  \u8ca8\u865f B4686"},"content":{"rendered":"<p><strong><span style=\"font-size: 12pt; color: #ff6600;\"><span style=\"font-size: 14pt;\"><span style=\"color: #800080;\">\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1-&gt;&gt;<span style=\"color: #ff6600;\">TAPI-1<\/span><\/span><\/span><\/span><\/strong><\/p>\n<p>APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002<a href=\"https:\/\/biopioneer.com.tw\/?news=apexbio%e5%8f%b0%e7%81%a3%e4%bb%a3%e7%90%86%e5%95%86-brandagency%e4%bb%a3%e7%90%86%e5%93%81%e7%89%8c-apexbio-2\"><span style=\"color: #ff0000;\"><em><strong><span style=\"text-decoration: underline;\">&gt;&gt;\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"https:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2025\/06\/%E5%A4%AA%E9%BC%8E-APExBIO-Technology-LLC-%E5%93%81%E7%89%8C.png\" width=\"1099\" height=\"274\" \/><\/p>\n<p>\u86cb\u767d\u9176(Proteases)\u4e5f\u7a31\u70ba\u80bd\u9176(peptidases)\u6216\u86cb\u767d\u6c34\u89e3\u9176(proteolytic enzymes)\uff0c\u7531\u5927\u91cf\u50ac\u5316\u80bd\u9375\u6c34\u89e3(hydrolysis)\u4e26\u96a8\u5f8c\u5c0e\u81f4\u86cb\u767d\u8cea\u5e95\u7269(protein substrates)\u964d\u89e3\u70ba\u6c28\u57fa\u9178(amino acids)\u7684\u9176\u7d44\u6210\u3002\u86cb\u767d\u9176(Proteases)\u8207\u591a\u7a2e\u4eba\u985e\u75be\u75c5\u6709\u95dc\uff0c\u5305\u62ec\u764c\u75c7(cancer)\u3001\u795e\u7d93\u9000\u884c\u6027\u75be\u200b\u200b\u75c5(neurodegenerative disorders)\u3001\u708e\u75c7\u6027\u75be\u75c5(inflammatory diseases)\u548c\u5fc3\u8840\u7ba1\u75be\u75c5(cardiovascular diseases)\u3002\u56e0\u6b64\uff0c\u8a31\u591a\u86cb\u767d\u9176\u6291\u5236\u5291\u3010\u5c0f\u5206\u5b50(small molecules)\u548c\u86cb\u767d\u8cea\u3011\u5df2\u88ab\u9451\u5b9a\u70ba\u963b\u65b7\u86cb\u767d\u9176\u7684\u6d3b\u6027(proteases)\u3002\u86cb\u767d\u9176\u6291\u5236\u5291\u53ef\u4ee5\u6839\u64da\u5b83\u5011\u901a\u904e\u5169\u7a2e\u4e00\u822c\u6a5f\u5236\u6291\u5236\u7684\u86cb\u767d\u9176\u985e\u5225\u5206\u70ba\u4e0d\u540c\u7684\u985e\u578b\uff0c\u5373\u4e0d\u53ef\u9006\u7684\u201c\u6355\u7372(trapping)\u201d\u53cd\u61c9\u548c\u53ef\u9006(reversible)\u7684\u7dca\u5bc6\u7d50\u5408\u53cd\u61c9\u3002\u86cb\u767d\u9176\u6291\u5236\u5291\u5df2\u88ab\u7528\u4f5c\u6cbb\u7642\u86cb\u767d\u9176\u76f8\u95dc\u75be\u75c5\u7684\u8a3a\u65b7\u5291(diagnostic)\u6216\u6cbb\u7642\u5291(therapeutic agents)\u3002<\/p>\n<p><span style=\"color: #00ccff;\"><a style=\"color: #00ccff;\" href=\"http:\/\/biopioneer.com.tw\/?p=34285\"><span style=\"font-size: 12pt;\"><strong><span style=\"color: #33cccc;\"><span style=\"font-size: 12pt;\">TAPI-1 | CAS#171235-71-5 APExBIO\u00a0 \u8ca8\u865f\u00a0B4686<\/span><\/span><\/strong><\/span><\/a><\/span><\/p>\n<p>TACE\/ADAM17 inhibitor Product Citation+3<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2022\/09\/B4686.png\" alt=\"\" width=\"296\" height=\"218\" \/><\/p>\n<p>TAPI-1 \u662f\u4e00\u7a2e\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u6291\u5236\u5291(Tumour necrosis factor)\uff0cIC50 \u503c\u70ba 8.09 \u03bcM [1]\u3002TAPI-1 \u662f TACE\/ADAM17 \u7684\u6291\u5236\u5291\uff0c\u53ef\u50ac\u5316\u5168\u9577 APP \u88c2\u89e3\u70ba\u53ef\u6eb6\u6027 N \u7aef\u7247\u6bb5 (sAPP\u03b1)\u3002\u64da\u5831\u5c0e\uff0csAPP\u03b1 \u7684\u91cb\u653e\u662f\u901a\u904e\u523a\u6fc0\u6bd2\u8548\u9e7c\u53d7\u9ad4(muscarinic receptors)\u800c\u589e\u52a0\u7684\u53d7\u9ad4\u5076\u806f\u904e\u7a0b(receptor-coupled process)\u3002\u5728 HEK293 \u7d30\u80de\u4e2d\uff0cTAPI-1 \u7684\u8655\u7406\u5c0e\u81f4\u6291\u5236\u7531 M3 \u4e9e\u578b\u8868\u9054\u8a98\u5c0e\u7684\u589e\u52a0\u7684 sAPP\u03b1\u3002 TAPI-1\u6291\u5236M3\u589e\u52a0\u7684sAPP\u03b1\u548csAPP\u03b1\u7d44\u6210\u578b\u91cb\u653e\u7684IC50\u503c\u5206\u5225\u70ba3.61 \u03bcM\u548c8.09 \u03bcM\u3002\u9664 APP \u5916\uff0c\u9084\u767c\u73fe TAPI-1 \u5c0d TNF-\u03b1\u3001IL6R\u3001TNFRI \u548c TNFRII \u7684\u91cb\u653e\u5177\u6709\u6291\u5236\u4f5c\u7528\uff0cIC50 \u503c\u5206\u5225\u70ba 50-100\u30015-10\u30015-10 \u548c 25-50 mM [1 , 2]\u3002<\/p>\n<ol>\n<li>Zhang Y, Wang Y, et al. &#8220;Angiotensin \u2161 deteriorates advanced atherosclerosis by promoting MerTK cleavage and impairing efferocytosis through AT1R\/ROS\/p38MAPK\/ADAM17 pathway.&#8221; Am J Physiol Cell Physiol. 2019 Aug 7.<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31390228\">PMID:31390228<\/a><\/li>\n<li>Zhou J, Sun J, et al. &#8220;MicroRNA-145 overexpression attenuates apoptosis and increases matrix synthesis in nucleus pulposus cells.&#8221; Life Sci. 2019 Mar 15;221:274-283.<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30797016\">PMID:30797016<\/a><\/li>\n<li>Ellis-Connell AL, Balgeman AJ, et al. &#8220;ALT-803 transiently reduces SIV replication in the absence of antiretroviral treatment.&#8221; J Virol. 2017 Nov 8. pii: JVI.01748-17.<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29118125\">PMID:29118125<\/a><\/li>\n<\/ol>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2022\/09\/B4686_2.jpg\" alt=\"\" width=\"666\" height=\"439\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2022\/09\/B4686_1.jpg\" alt=\"\" width=\"632\" height=\"487\" \/><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/downloads\/2022\/09\/B4686_3.jpg\" alt=\"\" width=\"605\" height=\"468\" \/><\/p>\n<table width=\"1128\">\n<tbody>\n<tr>\n<td>Physical Appearance<\/td>\n<td>A solid<\/td>\n<\/tr>\n<tr>\n<td>Storage<\/td>\n<td>Store at -20\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>M.Wt<\/td>\n<td>499.6<\/td>\n<\/tr>\n<tr>\n<td>Cas No.<\/td>\n<td>171235-71-5<\/td>\n<\/tr>\n<tr>\n<td>Formula<\/td>\n<td>C<sub>26<\/sub>H<sub>37<\/sub>N<sub>5<\/sub>O<sub>5<\/sub><\/td>\n<\/tr>\n<tr>\n<td>Solubility<\/td>\n<td>\u226524.98 mg\/mL in DMSO; \u226515.77 mg\/mL in EtOH with ultrasonic; \u226518.1 mg\/mL in H2O<\/td>\n<\/tr>\n<tr>\n<td>Chemical Name<\/td>\n<td>N1-((R)-1-(((R)-1-((2-aminoethyl)amino)-1-oxopropan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide<\/td>\n<\/tr>\n<tr>\n<td>SDF<\/td>\n<td><a href=\"https:\/\/www.apexbt.com\/downloader\/sdf\/B4686.sdf\">Download SDF<\/a><\/td>\n<\/tr>\n<tr>\n<td>Canonical SMILES<\/td>\n<td>NCCNC([C@@H](C)NC([C@H](NC(C(CC(C)C)CC(NO)=O)=O)CC1=CC2=CC=CC=C2C=C1)=O)=O<\/td>\n<\/tr>\n<tr>\n<td>Shipping Condition<\/td>\n<td>Ship with blue ice, or upon other requests.<\/td>\n<\/tr>\n<tr>\n<td>General tips<\/td>\n<td>For obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2022\/12\/%E5%93%81%E7%89%8C%E7%B9%AA%E5%9C%96-Apexbio_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1-300x300.jpg\" width=\"203\" height=\"225\" \/><\/p>\n<p><a href=\"http:\/\/www.apexbt.com\/\"><span style=\"font-size: 14pt; color: #ff6600;\"><strong><span style=\"color: #800080;\"><span style=\"font-size: 14pt;\">APExBIO\u53f0\u7063\u4ee3\u7406\u5546:\u00a0 <\/span><\/span><\/strong><\/span><\/a><span style=\"font-size: 14pt;\"><a href=\"https:\/\/www.apexbt.com\/\"><span style=\"color: #ff99cc;\"><span style=\"color: #ff6600;\">https:\/\/www.apexbt.com\/<\/span><\/span><\/a><\/span><\/p>\n<p>APExBIO\u63d0\u4f9b\u512a\u8cea\u7684\u80dc\u80bd\u548c\u751f\u7269\u5206\u6790\u8a66\u5291\uff0c\u5ee3\u6cdb\u7522\u54c1\u7dda\u5982Protease\u3001Chromatin\/Epigenetics\u8868\u89c0\u907a\u50b3\u5b78\u3001MAPK Signal\u3001DNA Damege\/DNA repair\u3001\u7d30\u80de\u51cb\u4ea1\u3001\u816b\u7624\u751f\u7269\u5b78\u3001Stem cell\u7b49\u7814\u7a76\u9818\u57df\uff0c \u9084\u63d0\u4f9b\u5b9a\u5236\u7684\u670d\u52d9\uff0c\u5305\u62ec\u591a\u80bd\u5408\u6210\uff0c\u6297\u9ad4\u7684\u751f\u7522\u548c\u6aa2\u6e2c\u7684\u767c\u5c55\u3002\u7522\u54c1\u7ddaDNA\/RNA prep kit\u3001Drug Screening panel\u3001Bioactive peptides\u3001Growth factors\u3001Biotinylation Reagents\u3001tag peptides\u3001amino Acids\u3001Growth factors\u7b49\u3002APExBIO\u7522\u54c1\u8cea\u91cf\u90fd\u4f34\u96a8\u8457\u8b49\u66f8\u7684\u5206\u6790\uff0c\u9ad8\u6548\u6db2\u76f8\u8272\u8b5c\uff0c\u8cea\u8b5c\uff0c\u548cHMNR\u6578\u64da\u3002<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"\" src=\"http:\/\/biopioneer.com.tw\/wp-content\/uploads\/2024\/09\/line-2_%E5%B7%A5%E4%BD%9C%E5%8D%80%E5%9F%9F-1.jpg\" width=\"302\" height=\"230\" \/><\/p>\n<table style=\"height: 613px;\" width=\"965\">\n<tbody>\n<tr>\n<td width=\"139\">\u54c1\u9805<\/td>\n<td width=\"139\">CAS#<\/td>\n<td width=\"138\">#\u8ca8\u865f<\/td>\n<td width=\"138\">\u61c9\u7528<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34272\">Z-VAD-FMK \u00a0<\/a><\/td>\n<td width=\"139\">CAS# 187389-52-2<\/td>\n<td width=\"138\">\u8ca8\u865f\u00a0A1902<\/td>\n<td width=\"138\">\n<p>Proteases<\/p>\n<p>ICE-like proteases<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34285\">TAPI-1 \u00a0<\/a><\/td>\n<td width=\"139\">CAS#171235-71-5<\/td>\n<td width=\"138\">\u8ca8\u865f\u00a0B4686<\/td>\n<td width=\"138\">\n<p>Proteases<\/p>\n<p>TACE\/ADAM17 inhibitor Product Citation+3<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34295\">Talabostat mesylate<\/a><\/td>\n<td width=\"139\">CAS# 150080-09-4<\/td>\n<td width=\"138\">\u8ca8\u865fB3941<\/td>\n<td width=\"138\">\n<p>Proteases<\/p>\n<p>DPP4 \u4e8c\u80bd\u57fa\u80bd\u9176\u7279\u7570\u6027\u6291\u5236\u5291<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34301\">Z-IETD-FMK<\/a><\/td>\n<td width=\"139\">CAS# 210344-98-2<\/td>\n<td width=\"138\">\u8ca8\u865fB3232<\/td>\n<td width=\"138\">inhibitor of caspase 8<\/td>\n<\/tr>\n<tr>\n<td width=\"139\">Cisplatin<\/td>\n<td width=\"139\">CAS# 15663-27-1<\/td>\n<td width=\"138\">\u8ca8\u865fA8321<\/td>\n<td width=\"138\">\u9ad8\u6548\u3001\u5ee3\u8b5c\u7684\u5316\u7642\u85e5\u7269<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34314\">17-DMAG (Alvespimycin) HCl<\/a><\/td>\n<td width=\"139\">CAS#467214-21-7<\/td>\n<td width=\"138\">\u00a0\u8ca8\u865fA2213<\/td>\n<td width=\"138\">Hsp90 inhibitor<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34320\">CA-074 Me\u00a0<\/a><\/td>\n<td width=\"139\">CAS# 147859-80-1<\/td>\n<td width=\"138\">\u8ca8\u865fA8239<\/td>\n<td width=\"138\">Cathepsin B inhibitor<\/td>\n<\/tr>\n<tr>\n<td width=\"139\"><a href=\"http:\/\/biopioneer.com.tw\/?p=34325\">VX-765<\/a><\/td>\n<td width=\"139\">CAS# 273404-37-8<\/td>\n<td width=\"138\">\u8ca8\u865fA8238<\/td>\n<td width=\"138\">Caspase-1 inhibitor<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<table width=\"1075\">\n<tbody>\n<tr>\n<td width=\"96\">A3608<\/td>\n<td width=\"375\">MK 0893<\/td>\n<td width=\"158\">870823-12-4<\/td>\n<td width=\"79\">98.58%<\/td>\n<td width=\"367\">Glucagon receptor\/IGF-1R antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3609<\/td>\n<td>MK-0591<\/td>\n<td>136668-42-3<\/td>\n<td>98.00%<\/td>\n<td>FLAP inhibitor,potent and selective<\/td>\n<\/tr>\n<tr>\n<td>A3611<\/td>\n<td>MK-0812<\/td>\n<td>624733-88-6<\/td>\n<td>98.00%<\/td>\n<td>antagonist of chemokine receptor CCR-2<\/td>\n<\/tr>\n<tr>\n<td>A3612<\/td>\n<td>MK-0974<\/td>\n<td>781649-09-0<\/td>\n<td>98.00%<\/td>\n<td>CGRP receptor antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3613<\/td>\n<td>MK-2894<\/td>\n<td>1006036-87-8<\/td>\n<td>98.00%<\/td>\n<td>EP4 receptor inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3615<\/td>\n<td>MK-3207<\/td>\n<td>957118-49-9<\/td>\n<td>98.00%<\/td>\n<td>CGRP receptor antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3617<\/td>\n<td>MK-4827<\/td>\n<td>1038915-60-4<\/td>\n<td>98.93%<\/td>\n<td>PARP-1\/-2 inhibitor,potent and selective<\/td>\n<\/tr>\n<tr>\n<td>A3618<\/td>\n<td>MK-5172<\/td>\n<td>1350514-68-9<\/td>\n<td>99.79%<\/td>\n<td>HCV NS3\/4a protease inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3619<\/td>\n<td>MK-5172 hydrate<\/td>\n<td>1350462-55-3<\/td>\n<td>98.00%<\/td>\n<td>HCV NS3\/4a protease inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3620<\/td>\n<td>MK-5172 potassium salt<\/td>\n<td>1206524-86-8<\/td>\n<td>98.00%<\/td>\n<td>HCV NS3\/4a protease inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3621<\/td>\n<td>MK-5172 sodium salt<\/td>\n<td>1425038-27-2<\/td>\n<td>98.00%<\/td>\n<td>HCV NS3\/4a protease inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3623<\/td>\n<td>MK-6892<\/td>\n<td>917910-45-3<\/td>\n<td>99.65%<\/td>\n<td>Highly potential GPR109A agonist<\/td>\n<\/tr>\n<tr>\n<td>A3624<\/td>\n<td>MK-8033<\/td>\n<td>1001917-37-8<\/td>\n<td>98.00%<\/td>\n<td>C-MET inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3626<\/td>\n<td>ML-7 hydrochloride<\/td>\n<td>110448-33-4<\/td>\n<td>98.43%<\/td>\n<td>Myosin light chain kinase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3627<\/td>\n<td>MLN 2480<\/td>\n<td>1096708-71-2<\/td>\n<td>98.99%<\/td>\n<td>Pan-Raf kinase inhibitor,investigational<\/td>\n<\/tr>\n<tr>\n<td>A3628<\/td>\n<td>MLN120B<\/td>\n<td>783348-36-7<\/td>\n<td>99.82%<\/td>\n<td>I\u03baB Kinase \u03b2 Inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3629<\/td>\n<td>MLN4924 HCl salt<\/td>\n<td>1160295-21-5<\/td>\n<td>98.00%<\/td>\n<td>NAE inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3630<\/td>\n<td>MMAD<\/td>\n<td>203849-91-6<\/td>\n<td>98.00%<\/td>\n<td>Tubulin inhibitor,highly potent<\/td>\n<\/tr>\n<tr>\n<td>A3631<\/td>\n<td>Monomethyl auristatin E<\/td>\n<td>474645-27-7<\/td>\n<td>98.34%<\/td>\n<td>Antimitotic agent<\/td>\n<\/tr>\n<tr>\n<td>A3632<\/td>\n<td>Motesanib<\/td>\n<td>453562-69-1<\/td>\n<td>98.00%<\/td>\n<td>Inhibitor of Flk-1\/Flt-4\/PDGFR-\/c-Kit<\/td>\n<\/tr>\n<tr>\n<td>A3633<\/td>\n<td>MPEP Hydrochloride<\/td>\n<td>219911-35-0<\/td>\n<td>98.00%<\/td>\n<td>MGlu5 receptor antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3634<\/td>\n<td>MPTP hydrochloride<\/td>\n<td>23007-85-4<\/td>\n<td>99.79%<\/td>\n<td>Dopaminergic neurotoxin,induced reduction in the DOPAC HVA\/dopamine (DA) ratio<\/td>\n<\/tr>\n<tr>\n<td>A3636<\/td>\n<td>MTEP hydrochloride<\/td>\n<td>1186195-60-7<\/td>\n<td>98.00%<\/td>\n<td>MGlu5 antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3637<\/td>\n<td>GDC-mTOR inhibitor<\/td>\n<td>1207358-59-5<\/td>\n<td>98.00%<\/td>\n<td>MTOR inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3641<\/td>\n<td>Naphthoquine phosphate<\/td>\n<td>173531-58-3<\/td>\n<td>98.00%<\/td>\n<td>Antimalarial drug<\/td>\n<\/tr>\n<tr>\n<td>A3642<\/td>\n<td>Narciclasine<\/td>\n<td>29477-83-6<\/td>\n<td>98.00%<\/td>\n<td>Modulates the Rho\/ROCK\/LIM kinase\/cofilin pathway<\/td>\n<\/tr>\n<tr>\n<td>A3643<\/td>\n<td>Narlaprevir<\/td>\n<td>865466-24-6<\/td>\n<td>98.00%<\/td>\n<td>HCV NS3 protease inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3645<\/td>\n<td>NB-598<\/td>\n<td>131060-14-5<\/td>\n<td>99.35%<\/td>\n<td>SE inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3646<\/td>\n<td>NB-598 hydrochloride<\/td>\n<td>136719-25-0<\/td>\n<td>98.00%<\/td>\n<td>SE inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3647<\/td>\n<td>NB-598 Maleate<\/td>\n<td>155294-62-5<\/td>\n<td>98.97%<\/td>\n<td>Squalene epoxidase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3649<\/td>\n<td>NBD-556<\/td>\n<td>333353-44-9<\/td>\n<td>98.00%<\/td>\n<td>HIV-1 entry inhibitor,CD4 mimetic,block gp120-CD4 interaction<\/td>\n<\/tr>\n<tr>\n<td>A3652<\/td>\n<td>Necrostatin 2<\/td>\n<td>852391-19-6<\/td>\n<td>98.00%<\/td>\n<td>In vitro necroptosis inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3653<\/td>\n<td>Nelfinavir Mesylate<\/td>\n<td>159989-65-8<\/td>\n<td>98.04%<\/td>\n<td>HIV protease inhibitor,antiretroviral drug for HIV treatment<\/td>\n<\/tr>\n<tr>\n<td>A3655<\/td>\n<td>Nesbuvir<\/td>\n<td>691852-58-1<\/td>\n<td>99.79%<\/td>\n<td>NS5B polymerase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3658<\/td>\n<td>NG25<\/td>\n<td>1315355-93-1<\/td>\n<td>98.00%<\/td>\n<td>TAK1 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3659<\/td>\n<td>Nifuratel<\/td>\n<td>4936-47-4<\/td>\n<td>98.00%<\/td>\n<td>Antibacterial, antifungal, and antiprotozoal compound<\/td>\n<\/tr>\n<tr>\n<td>A3660<\/td>\n<td>Nilotinib monohydrochloride monohydrate<\/td>\n<td>923288-90-8<\/td>\n<td>99.89%<\/td>\n<td>Bcr-Abl inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3662<\/td>\n<td>NNC 55-0396<\/td>\n<td>357400-13-6<\/td>\n<td>98.00%<\/td>\n<td>T-type calcium channel blocker<\/td>\n<\/tr>\n<tr>\n<td>A3663<\/td>\n<td>Noopept<\/td>\n<td>157115-85-0<\/td>\n<td>98.00%<\/td>\n<td>Nootropic and neuroprotective agent<\/td>\n<\/tr>\n<tr>\n<td>A3664<\/td>\n<td>Nordihydroguaiaretic acid<\/td>\n<td>500-38-9<\/td>\n<td>99.83%<\/td>\n<td>Anti-tumor agent;lipoxygenase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3665<\/td>\n<td>Nortadalafil<\/td>\n<td>171596-36-4<\/td>\n<td>98.00%<\/td>\n<td>PDE5 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3666<\/td>\n<td>NP118809<\/td>\n<td>41332-24-5<\/td>\n<td>98.00%<\/td>\n<td>N-type calcium channel blocker<\/td>\n<\/tr>\n<tr>\n<td>A3667<\/td>\n<td>NPS-2143 hydrochloride<\/td>\n<td>324523-20-8<\/td>\n<td>99.89%<\/td>\n<td>Calcium ion-sensing receptor antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3668<\/td>\n<td>NS309<\/td>\n<td>18711-16-5<\/td>\n<td>98.00%<\/td>\n<td>Calcium-Activated Potassium Channel activator<\/td>\n<\/tr>\n<tr>\n<td>A3670<\/td>\n<td>Nucleozin<\/td>\n<td>341001-38-5<\/td>\n<td>99.55%<\/td>\n<td>Targets influenza A nucleoprotein (NP),cell-permeable isoxazolylpiperazine compound<\/td>\n<\/tr>\n<tr>\n<td>A3671<\/td>\n<td>Nutlin-3a chiral<\/td>\n<td>675576-98-4<\/td>\n<td>98.39%<\/td>\n<td>MDM2 inhibitor, antiproliferative and antiproapoptotic<\/td>\n<\/tr>\n<tr>\n<td>A3672<\/td>\n<td>NVP-BAG956<\/td>\n<td>853910-02-8<\/td>\n<td>98.00%<\/td>\n<td>PI3K and PDK1 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3673<\/td>\n<td>NVP-BGJ398 phosphate<\/td>\n<td>1310746-10-1<\/td>\n<td>99.78%<\/td>\n<td>FGFR inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3674<\/td>\n<td>NVP-BKM120 Hydrochloride<\/td>\n<td>1312445-63-8<\/td>\n<td>98.02%<\/td>\n<td>PI3K inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3675<\/td>\n<td>NVP-BSK805<\/td>\n<td>1092499-93-8<\/td>\n<td>98.00%<\/td>\n<td>ATP-competitive JAK2 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3676<\/td>\n<td>NVP-LCQ195<\/td>\n<td>902156-99-4<\/td>\n<td>97.50%<\/td>\n<td>CDK1\/CDK2\/CDK5 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3680<\/td>\n<td>Olcegepant<\/td>\n<td>204697-65-4<\/td>\n<td>97.46%<\/td>\n<td>Non-peptide receptor of CGRP,first potent and selective<\/td>\n<\/tr>\n<tr>\n<td>A3681<\/td>\n<td>Olmesartan<\/td>\n<td>144689-24-7<\/td>\n<td>99.20%<\/td>\n<td>Angiotensin II receptor antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3683<\/td>\n<td>Olprinone Hydrochloride<\/td>\n<td>119615-63-3<\/td>\n<td>99.74%<\/td>\n<td>Phosphodiesterase 3 (PDE3) inhibitor, selective<\/td>\n<\/tr>\n<tr>\n<td>A3684<\/td>\n<td>ONO-AE3-208<\/td>\n<td>402473-54-5<\/td>\n<td>97.73%<\/td>\n<td>EP4 receptor antagonist,high affinity and selective<\/td>\n<\/tr>\n<tr>\n<td>A3686<\/td>\n<td>Orteronel<\/td>\n<td>566939-85-3<\/td>\n<td>98.00%<\/td>\n<td>For castration-resistant prostate cancer, clinical candidate<\/td>\n<\/tr>\n<tr>\n<td>A3688<\/td>\n<td>Oseltamivir<\/td>\n<td>196618-13-0<\/td>\n<td>96.83%<\/td>\n<td>inhibitor of influenza neuraminidase<\/td>\n<\/tr>\n<tr>\n<td>A3689<\/td>\n<td>Oseltamivir acid<\/td>\n<td>187227-45-8<\/td>\n<td>99.08%<\/td>\n<td>Influenza neuraminidase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3690<\/td>\n<td>Otamixaban<\/td>\n<td>193153-04-7<\/td>\n<td>98.00%<\/td>\n<td>Direct factor Xa inhibitors,potent and selective<\/td>\n<\/tr>\n<tr>\n<td>A3691<\/td>\n<td>Otenabant<\/td>\n<td>686344-29-6<\/td>\n<td>98.00%<\/td>\n<td>CB1 receptor antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3692<\/td>\n<td>OTX-015<\/td>\n<td>202590-98-5<\/td>\n<td>99.57%<\/td>\n<td>BRD inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3695<\/td>\n<td>Pafuramidine<\/td>\n<td>186953-56-0<\/td>\n<td>98.00%<\/td>\n<td>Prodrug of furamidine<\/td>\n<\/tr>\n<tr>\n<td>A3696<\/td>\n<td>Palifosfamide<\/td>\n<td>31645-39-3<\/td>\n<td>98.00%<\/td>\n<td>Active metabolite of ifosfamide (IFOS)<\/td>\n<\/tr>\n<tr>\n<td>A3697<\/td>\n<td>Palonosetron<\/td>\n<td>135729-61-2<\/td>\n<td>98.00%<\/td>\n<td>5-HT3 antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3700<\/td>\n<td>Paradol<\/td>\n<td>27113-22-0<\/td>\n<td>98.00%<\/td>\n<td>Active flavor constituent of the seeds of Guinea pepper<\/td>\n<\/tr>\n<tr>\n<td>A3702<\/td>\n<td>Paricalcitol<\/td>\n<td>131918-61-1<\/td>\n<td>98.00%<\/td>\n<td>Analog of VD2 active form<\/td>\n<\/tr>\n<tr>\n<td>A3704<\/td>\n<td>PD 123319 ditrifluoroacetate<\/td>\n<td>136676-91-0<\/td>\n<td>99.14%<\/td>\n<td>Angiotensin AT2 receptor antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3706<\/td>\n<td>PDK1 inhibitor<\/td>\n<td>1001409-50-2<\/td>\n<td>98.00%<\/td>\n<td>PDK1 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3707<\/td>\n<td>Pemetrexed disodium hemipenta hydrate<\/td>\n<td>357166-30-4<\/td>\n<td>99.94%<\/td>\n<td>Antifolate and antimetabolite agent<\/td>\n<\/tr>\n<tr>\n<td>A3708<\/td>\n<td>Pentostatin<\/td>\n<td>53910-25-1<\/td>\n<td>99.05%<\/td>\n<td>Irreversible adenosine deaminase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3709<\/td>\n<td>Peramivir<\/td>\n<td>330600-85-6<\/td>\n<td>99.01%<\/td>\n<td>Aeuraminidase inhibitor;antiviral drug<\/td>\n<\/tr>\n<tr>\n<td>A3711<\/td>\n<td>PF-03084014<\/td>\n<td>865773-15-5<\/td>\n<td>98.52%<\/td>\n<td>\u03b3-secretase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3712<\/td>\n<td>PF-04217903 methanesulfonate<\/td>\n<td>956906-93-7<\/td>\n<td>98.00%<\/td>\n<td>C-Met inhibitor,selective and ATP-competitive<\/td>\n<\/tr>\n<tr>\n<td>A3715<\/td>\n<td>PF-04971729<\/td>\n<td>1210344-57-2<\/td>\n<td>98.00%<\/td>\n<td>SGLT inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3716<\/td>\n<td>PF-3758309<\/td>\n<td>898044-15-0<\/td>\n<td>98.39%<\/td>\n<td>PAK4 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3717<\/td>\n<td>PF-543<\/td>\n<td>1415562-82-1<\/td>\n<td>99.32%<\/td>\n<td>SphK1 inhibitor,cell-permeate,potent and selective<\/td>\n<\/tr>\n<tr>\n<td>A3718<\/td>\n<td>PF-543 Citrate<\/td>\n<td>1415562-83-2<\/td>\n<td>98.95%<\/td>\n<td>SphK1 inhibitor,potent and cell-permeate<\/td>\n<\/tr>\n<tr>\n<td>A3719<\/td>\n<td>PF-670462<\/td>\n<td>950912-80-8<\/td>\n<td>99.66%<\/td>\n<td>CK1 \u03b5\/\u03b4 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3720<\/td>\n<td>PF-8380<\/td>\n<td>1144035-53-9<\/td>\n<td>98.23%<\/td>\n<td>Autotaxin inhibitor,potent and specific<\/td>\n<\/tr>\n<tr>\n<td>A3721<\/td>\n<td>PHA-767491<\/td>\n<td>845714-00-3<\/td>\n<td>99.03%<\/td>\n<td>Cdc7\/cdk9 inhibitor, potent, ATP-competitive<\/td>\n<\/tr>\n<tr>\n<td>A3722<\/td>\n<td>Phenylpiracetam<\/td>\n<td>77472-70-9<\/td>\n<td>99.21%<\/td>\n<td>Nootropic derivative of piracetam<\/td>\n<\/tr>\n<tr>\n<td>A3723<\/td>\n<td>Phloretin<\/td>\n<td>60-82-2<\/td>\n<td>99.12%<\/td>\n<td>A dihydrochalcone found in apple<\/td>\n<\/tr>\n<tr>\n<td>A3724<\/td>\n<td>PI-103 Hydrochloride<\/td>\n<td>371935-79-4<\/td>\n<td>98.00%<\/td>\n<td>DNA-PK\/PI 3-kinase\/mTOR inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3727<\/td>\n<td>Pitolisant hydrochloride<\/td>\n<td>903576-44-3<\/td>\n<td>99.71%<\/td>\n<td>Nonimidazole inverse agonist<\/td>\n<\/tr>\n<tr>\n<td>A3729<\/td>\n<td>PJ34<\/td>\n<td>344458-19-1<\/td>\n<td>95.69%<\/td>\n<td>PARP-l inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3730<\/td>\n<td>PND-1186<\/td>\n<td>1061353-68-1<\/td>\n<td>99.75%<\/td>\n<td>Potent FAK inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3732<\/td>\n<td>Poloxin<\/td>\n<td>321688-88-4<\/td>\n<td>98.00%<\/td>\n<td>PLK1 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3733<\/td>\n<td>Pramipexole dihydrochloride<\/td>\n<td>104632-25-9<\/td>\n<td>98.94%<\/td>\n<td>Dopamine receptor agonist<\/td>\n<\/tr>\n<tr>\n<td>A3735<\/td>\n<td>Preladenant<\/td>\n<td>377727-87-2<\/td>\n<td>98.00%<\/td>\n<td>Adenosine A2A receptor antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3736<\/td>\n<td>PRT062607 Hydrochloride<\/td>\n<td>1370261-97-4<\/td>\n<td>98.63%<\/td>\n<td>SYK inhibitor,potent and selective<\/td>\n<\/tr>\n<tr>\n<td>A3738<\/td>\n<td>PSI-7977<\/td>\n<td>1190307-88-0<\/td>\n<td>99.81%<\/td>\n<td>Antiviral agents for chronic HCV infection<\/td>\n<\/tr>\n<tr>\n<td>A3740<\/td>\n<td>Puromycin aminonucleoside<\/td>\n<td>58-60-6<\/td>\n<td>98.19%<\/td>\n<td>Aminonucleoside portion of the antibiotic puromycin<\/td>\n<\/tr>\n<tr>\n<td>A3741<\/td>\n<td>Pyridone 6<\/td>\n<td>457081-03-7<\/td>\n<td>99.60%<\/td>\n<td>Pan-JAK inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3742<\/td>\n<td>Pyridostatin<\/td>\n<td>1085412-37-8<\/td>\n<td>98.02%<\/td>\n<td>Drug used for promoting growth arrest<\/td>\n<\/tr>\n<tr>\n<td>A3744<\/td>\n<td>Quetiapine<\/td>\n<td>111974-69-7<\/td>\n<td>98.00%<\/td>\n<td>Dopamine receptor antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3746<\/td>\n<td>R1530<\/td>\n<td>882531-87-5<\/td>\n<td>98.00%<\/td>\n<td>Antiangiogenesis,mitosis-angiogenesis inhibitor (MAI)<\/td>\n<\/tr>\n<tr>\n<td>A3747<\/td>\n<td>R-7128<\/td>\n<td>940908-79-2<\/td>\n<td>98.00%<\/td>\n<td>NS5B inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3749<\/td>\n<td>Radezolid<\/td>\n<td>869884-78-6<\/td>\n<td>99.32%<\/td>\n<td>Novel oxazolidinone antibiotic agent<\/td>\n<\/tr>\n<tr>\n<td>A3750<\/td>\n<td>Regorafenib hydrochloride<\/td>\n<td>835621-07-3<\/td>\n<td>98.57%<\/td>\n<td>Tyrosine kinase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3752<\/td>\n<td>Reparixin<\/td>\n<td>266359-83-5<\/td>\n<td>98.11%<\/td>\n<td>Inhibitor of CXCL8 receptor and CXCR1\/CXCR2 activation<\/td>\n<\/tr>\n<tr>\n<td>A3753<\/td>\n<td>Reparixin L-lysine salt<\/td>\n<td>266359-93-7<\/td>\n<td>97.82%<\/td>\n<td>CXCR1\/CXCR2 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3754<\/td>\n<td>RepSox<\/td>\n<td>446859-33-2<\/td>\n<td>99.83%<\/td>\n<td>ALK5 inhibitor,potent and selective<\/td>\n<\/tr>\n<tr>\n<td>A3755<\/td>\n<td>Resminostat hydrochloride<\/td>\n<td>1187075-34-8<\/td>\n<td>98.00%<\/td>\n<td>HDAC inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3756<\/td>\n<td>Retaspimycin<\/td>\n<td>857402-23-4<\/td>\n<td>98.00%<\/td>\n<td>HSP90 inhibitor,antiproliferative and antineoplastic<\/td>\n<\/tr>\n<tr>\n<td>A3758<\/td>\n<td>Retigabine dihydrochloride<\/td>\n<td>150812-13-8<\/td>\n<td>99.27%<\/td>\n<td>Antiepileptic compound<\/td>\n<\/tr>\n<tr>\n<td>A3759<\/td>\n<td>Retinyl glucoside<\/td>\n<td>136778-12-6<\/td>\n<td>98.00%<\/td>\n<td>Metabolites of vitamin A<\/td>\n<\/tr>\n<tr>\n<td>A3760<\/td>\n<td>Reversine<\/td>\n<td>656820-32-5<\/td>\n<td>99.09%<\/td>\n<td>A3 adenosine receptor antagonist,ARK-1\/-2\/-3 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3761<\/td>\n<td>RG2833<\/td>\n<td>1215493-56-3<\/td>\n<td>98.06%<\/td>\n<td>Brain-penetrant HDAC inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3762<\/td>\n<td>RG7112<\/td>\n<td>939981-39-2<\/td>\n<td>98.58%<\/td>\n<td>MDM2 inhibitor, first clinical<\/td>\n<\/tr>\n<tr>\n<td>A3763<\/td>\n<td>RG7388<\/td>\n<td>1229705-06-9<\/td>\n<td>99.82%<\/td>\n<td>MDM2 antagonist, oral, selective<\/td>\n<\/tr>\n<tr>\n<td>A3764<\/td>\n<td>RI-1<\/td>\n<td>415713-60-9<\/td>\n<td>99.54%<\/td>\n<td>RAD51 inhibitor,cell-permeable<\/td>\n<\/tr>\n<tr>\n<td>A3765<\/td>\n<td>Rilpivirine<\/td>\n<td>500287-72-9<\/td>\n<td>99.64%<\/td>\n<td>Inhibitor of next-generation nonnucleoside reverse transcriptase<\/td>\n<\/tr>\n<tr>\n<td>A3766<\/td>\n<td>Rimonabant hydrochloride<\/td>\n<td>158681-13-1<\/td>\n<td>98.01%<\/td>\n<td>CB1 receptor inverse agonist<\/td>\n<\/tr>\n<tr>\n<td>A3767<\/td>\n<td>Riociguat<\/td>\n<td>625115-55-1<\/td>\n<td>99.77%<\/td>\n<td>Soluble guanylate cyclase (sGC) stimulator<\/td>\n<\/tr>\n<tr>\n<td>A3768<\/td>\n<td>Rivastigmine<\/td>\n<td>123441-03-2<\/td>\n<td>99.68%<\/td>\n<td>Cholinesterase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3770<\/td>\n<td>RJR-2403 oxalate<\/td>\n<td>220662-95-3<\/td>\n<td>98.00%<\/td>\n<td>Nicotinic receptor agonist<\/td>\n<\/tr>\n<tr>\n<td>A3771<\/td>\n<td>RKI-1447<\/td>\n<td>1342278-01-6<\/td>\n<td>99.52%<\/td>\n<td>Potent ROCK1\/ROCK2 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3776<\/td>\n<td>Rotigotine<\/td>\n<td>99755-59-6<\/td>\n<td>98.00%<\/td>\n<td>Agonist of dopamine D2\/D3 receptor<\/td>\n<\/tr>\n<tr>\n<td>A3777<\/td>\n<td>Rotigotine hydrochloride<\/td>\n<td>125572-93-2<\/td>\n<td>98.00%<\/td>\n<td>Agonist of dopamine D2\/D3 receptor<\/td>\n<\/tr>\n<tr>\n<td>A3778<\/td>\n<td>RS 127445<\/td>\n<td>199864-87-4<\/td>\n<td>98.01%<\/td>\n<td>5-HT2B receptor antagonist,high affinity<\/td>\n<\/tr>\n<tr>\n<td>A3780<\/td>\n<td>RU 58841<\/td>\n<td>154992-24-2<\/td>\n<td>98.40%<\/td>\n<td>Androgen receptor antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3781<\/td>\n<td>Ruxolitinib phosphate<\/td>\n<td>1092939-17-7<\/td>\n<td>98.75%<\/td>\n<td>JAK1\/JAK2 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3783<\/td>\n<td>S0859<\/td>\n<td>1019331-10-2<\/td>\n<td>98.00%<\/td>\n<td>NBC inhibitor,potent and selective<\/td>\n<\/tr>\n<tr>\n<td>A3784<\/td>\n<td>Safinamide<\/td>\n<td>133865-89-1<\/td>\n<td>99.64%<\/td>\n<td>MAO-B inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3787<\/td>\n<td>Salirasib<\/td>\n<td>162520-00-5<\/td>\n<td>99.28%<\/td>\n<td>Inhibitor of active Ras protein<\/td>\n<\/tr>\n<tr>\n<td>A3789<\/td>\n<td>Salmeterol xinafoate<\/td>\n<td>94749-08-3<\/td>\n<td>98.11%<\/td>\n<td>\u03b22-adrenergic receptor agonist<\/td>\n<\/tr>\n<tr>\n<td>A3790<\/td>\n<td>Saquinavir<\/td>\n<td>127779-20-8<\/td>\n<td>98.00%<\/td>\n<td>HIV Protease Inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3791<\/td>\n<td>Saquinavir mesylate<\/td>\n<td>149845-06-7<\/td>\n<td>99.75%<\/td>\n<td>HIV Protease Inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3792<\/td>\n<td>SB 239063<\/td>\n<td>193551-21-2<\/td>\n<td>98.63%<\/td>\n<td>P38 MAP kinase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3794<\/td>\n<td>SB1317<\/td>\n<td>937270-47-8<\/td>\n<td>98.02%<\/td>\n<td>CDK,JAK and FLT inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3795<\/td>\n<td>SB-222200<\/td>\n<td>174635-69-9<\/td>\n<td>98.86%<\/td>\n<td>Human NK-3 receptor antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3798<\/td>\n<td>SB-408124 Hydrochloride<\/td>\n<td>1431697-90-3<\/td>\n<td>98.00%<\/td>\n<td>OX1 receptor antagonist,selective and non-peptide<\/td>\n<\/tr>\n<tr>\n<td>A3800<\/td>\n<td>SB-674042<\/td>\n<td>483313-22-0<\/td>\n<td>98.00%<\/td>\n<td>OX1 selective antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3802<\/td>\n<td>SCH 527123<\/td>\n<td>473727-83-2<\/td>\n<td>99.40%<\/td>\n<td>CXCR1 and CXCR2 receptors antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3804<\/td>\n<td>SCH-1473759<\/td>\n<td>1094069-99-4<\/td>\n<td>98.00%<\/td>\n<td>Aurora A\/B inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3805<\/td>\n<td>SCH772984<\/td>\n<td>942183-80-4<\/td>\n<td>98.06%<\/td>\n<td>ERK1 and ERK2 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3806<\/td>\n<td>SCH900776 S-isomer<\/td>\n<td>891494-64-7<\/td>\n<td>99.18%<\/td>\n<td>Checkpoint kinase(Chk)inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3808<\/td>\n<td>SD-208<\/td>\n<td>627536-09-8<\/td>\n<td>99.11%<\/td>\n<td>TGF-\u03b2R I kinase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3809<\/td>\n<td>SDZ 220-581<\/td>\n<td>174575-17-8<\/td>\n<td>98.00%<\/td>\n<td>NMDA glutamate receptor subtype antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3811<\/td>\n<td>SEA0400<\/td>\n<td>223104-29-8<\/td>\n<td>99.20%<\/td>\n<td>Specific inhibitor of Na+\/Ca2+ exchange<\/td>\n<\/tr>\n<tr>\n<td>A3814<\/td>\n<td>Seocalcitol<\/td>\n<td>134404-52-7<\/td>\n<td>98.00%<\/td>\n<td>Vitamin D receptor agonist<\/td>\n<\/tr>\n<tr>\n<td>A3815<\/td>\n<td>Setiptiline<\/td>\n<td>57262-94-9<\/td>\n<td>98.00%<\/td>\n<td>Serotonin receptor antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3816<\/td>\n<td>Setiptiline maleate<\/td>\n<td>85650-57-3<\/td>\n<td>98.00%<\/td>\n<td>Serotonin receptor antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3818<\/td>\n<td>Silvestrol<\/td>\n<td>697235-38-4<\/td>\n<td>98.00%<\/td>\n<td>Antineoplastic<\/td>\n<\/tr>\n<tr>\n<td>A3820<\/td>\n<td>Simeprevir<\/td>\n<td>923604-59-5<\/td>\n<td>99.42%<\/td>\n<td>Inhibitor of HCV NS3\/4A protease<\/td>\n<\/tr>\n<tr>\n<td>A3821<\/td>\n<td>SRT2104 (GSK2245840)<\/td>\n<td>1093403-33-8<\/td>\n<td>98.50%<\/td>\n<td>SIRT1 activator,selective<\/td>\n<\/tr>\n<tr>\n<td>A3823<\/td>\n<td>SJB2-043<\/td>\n<td>63388-44-3<\/td>\n<td>99.78%<\/td>\n<td>USP1 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3824<\/td>\n<td>Skepinone-L<\/td>\n<td>1221485-83-1<\/td>\n<td>99.88%<\/td>\n<td>P38-MAPK inhibitor,potent and selective<\/td>\n<\/tr>\n<tr>\n<td>A3825<\/td>\n<td>SLx-2119<\/td>\n<td>911417-87-3<\/td>\n<td>98.80%<\/td>\n<td>Selective ROCK2 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3826<\/td>\n<td>SMIP004<\/td>\n<td>143360-00-3<\/td>\n<td>98.17%<\/td>\n<td>Apoptosis inducer<\/td>\n<\/tr>\n<tr>\n<td>A3828<\/td>\n<td>Sobetirome<\/td>\n<td>211110-63-3<\/td>\n<td>99.01%<\/td>\n<td>Agonist of tyroid hormone receptor<\/td>\n<\/tr>\n<tr>\n<td>A3829<\/td>\n<td>sodium 4-pentynoate<\/td>\n<td>101917-30-0<\/td>\n<td>98.00%<\/td>\n<td>chemical reporter for the profiling of acetylated proteins<\/td>\n<\/tr>\n<tr>\n<td>A3832<\/td>\n<td>Solasodine<\/td>\n<td>126-17-0<\/td>\n<td>98.00%<\/td>\n<td>Neuroprotective antioxidant glycoalkaloid<\/td>\n<\/tr>\n<tr>\n<td>A3834<\/td>\n<td>SQ109<\/td>\n<td>502487-67-4<\/td>\n<td>98.00%<\/td>\n<td>Antibiotic for treatment of pulmonary TB<\/td>\n<\/tr>\n<tr>\n<td>A3835<\/td>\n<td>SR1078<\/td>\n<td>1246525-60-9<\/td>\n<td>98.65%<\/td>\n<td>Orphan receptor agonist<\/td>\n<\/tr>\n<tr>\n<td>A3836<\/td>\n<td>SR3335<\/td>\n<td>293753-05-6<\/td>\n<td>99.52%<\/td>\n<td>ROR\u03b1 agonist,partial inverse and selective<\/td>\n<\/tr>\n<tr>\n<td>A3837<\/td>\n<td>DL-\u03b1-Hydroxyglutaric acid disodium salt<\/td>\n<td>40951-21-1<\/td>\n<td>98.00%<\/td>\n<td>alpha hydroxy acid<\/td>\n<\/tr>\n<tr>\n<td>A3838<\/td>\n<td>SRT3109<\/td>\n<td>1204707-71-0<\/td>\n<td>98.00%<\/td>\n<td>CXCR2 ligand<\/td>\n<\/tr>\n<tr>\n<td>A3839<\/td>\n<td>SRT3190<\/td>\n<td>1204707-73-2<\/td>\n<td>99.56%<\/td>\n<td>CXCR2 ligand,SIRT1 activator<\/td>\n<\/tr>\n<tr>\n<td>A3840<\/td>\n<td>ST 2825<\/td>\n<td>894787-30-5<\/td>\n<td>98.00%<\/td>\n<td>Inhibitor of MyD88 dimerization<\/td>\n<\/tr>\n<tr>\n<td>A3843<\/td>\n<td>SU 5402<\/td>\n<td>215543-92-3<\/td>\n<td>98.48%<\/td>\n<td>VEGFR2\/FGFR\/PDGFR\/EGFR inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3844<\/td>\n<td>SU14813<\/td>\n<td>627908-92-3<\/td>\n<td>98.00%<\/td>\n<td>Tyrosine kinase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3846<\/td>\n<td>SU14813 maleate<\/td>\n<td>849643-15-8<\/td>\n<td>98.00%<\/td>\n<td>VEGFR\/PDGFR\/Kit\/FLT-3 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3847<\/td>\n<td>SU5416<\/td>\n<td>204005-46-9<\/td>\n<td>99.06%<\/td>\n<td>VEGF receptor inhibitor and AHR agonist<\/td>\n<\/tr>\n<tr>\n<td>A3848<\/td>\n<td>Tacalcitol<\/td>\n<td>57333-96-7<\/td>\n<td>98.00%<\/td>\n<td>Promotes normal bone development by regulating calcium<\/td>\n<\/tr>\n<tr>\n<td>A3850<\/td>\n<td>TAK-242<\/td>\n<td>243984-11-4<\/td>\n<td>99.53%<\/td>\n<td>TLR 4 signaling inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3853<\/td>\n<td>Talarozole<\/td>\n<td>201410-53-9<\/td>\n<td>98.00%<\/td>\n<td>Cytochrome P450 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3854<\/td>\n<td>Talnetant<\/td>\n<td>174636-32-9<\/td>\n<td>98.00%<\/td>\n<td>NK3 receptor antagonist,potent and selective<\/td>\n<\/tr>\n<tr>\n<td>A3856<\/td>\n<td>Tamibarotene<\/td>\n<td>94497-51-5<\/td>\n<td>98.41%<\/td>\n<td>RAR\u03b1 agonist<\/td>\n<\/tr>\n<tr>\n<td>A3857<\/td>\n<td>Tanaproget<\/td>\n<td>304853-42-7<\/td>\n<td>98.00%<\/td>\n<td>Progesterone receptor agonist<\/td>\n<\/tr>\n<tr>\n<td>A3858<\/td>\n<td>Taranabant<\/td>\n<td>701977-09-5<\/td>\n<td>98.00%<\/td>\n<td>Cannabinoid receptor type 1 inverse agonist<\/td>\n<\/tr>\n<tr>\n<td>A3859<\/td>\n<td>Tariquidar methanesulfonate, hydrate<\/td>\n<td>625375-83-9<\/td>\n<td>99.49%<\/td>\n<td>P-glycoprotein inhibitor, potent and selective<\/td>\n<\/tr>\n<tr>\n<td>A3860<\/td>\n<td>Tasquinimod<\/td>\n<td>254964-60-8<\/td>\n<td>99.47%<\/td>\n<td>Antiangiogenic and antineoplastic agent<\/td>\n<\/tr>\n<tr>\n<td>A3861<\/td>\n<td>TBB<\/td>\n<td>17374-26-4<\/td>\n<td>99.23%<\/td>\n<td>Casein kinase-2 (CK2) inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3862<\/td>\n<td>TC-DAPK 6<\/td>\n<td>315694-89-4<\/td>\n<td>98.00%<\/td>\n<td>DAPK inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3863<\/td>\n<td>Tedizolid<\/td>\n<td>856866-72-3<\/td>\n<td>99.63%<\/td>\n<td>Oxazolidinone for gram-positive infections<\/td>\n<\/tr>\n<tr>\n<td>A3864<\/td>\n<td>Tegobuvir<\/td>\n<td>1000787-75-6<\/td>\n<td>98.97%<\/td>\n<td>HCV RNA replication inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3865<\/td>\n<td>Teneligliptin hydrobromide<\/td>\n<td>906093-29-6<\/td>\n<td>99.90%<\/td>\n<td>Dipeptidyl peptidase-4 inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3870<\/td>\n<td>TG 100801<\/td>\n<td>867331-82-6<\/td>\n<td>98.00%<\/td>\n<td>Multi-kinase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3872<\/td>\n<td>TH-302<\/td>\n<td>918633-87-1<\/td>\n<td>98.40%<\/td>\n<td>Hypoxia-activated prodrug,inhibits H460\/HT29 cell growth<\/td>\n<\/tr>\n<tr>\n<td>A3873<\/td>\n<td>Tianeptine<\/td>\n<td>66981-73-5; 72797-41-2<\/td>\n<td>99.46%<\/td>\n<td>5-HT facilitator<\/td>\n<\/tr>\n<tr>\n<td>A3874<\/td>\n<td>Tiotropium Bromide<\/td>\n<td>136310-93-5<\/td>\n<td>99.39%<\/td>\n<td>MAChR M antagonist<\/td>\n<\/tr>\n<tr>\n<td>A3875<\/td>\n<td>Tipiracil hydrochloride<\/td>\n<td>183204-72-0<\/td>\n<td>99.74%<\/td>\n<td>Thymidine phosphorylase inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3876<\/td>\n<td>Tipranavir<\/td>\n<td>174484-41-4<\/td>\n<td>98.00%<\/td>\n<td>HIV protease inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3877<\/td>\n<td>Tirofiban hydrochloride monohydrate<\/td>\n<td>150915-40-5<\/td>\n<td>99.46%<\/td>\n<td>Glycoprotein IIb\/IIIa inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3878<\/td>\n<td>TMC353121<\/td>\n<td>857066-90-1<\/td>\n<td>98.00%<\/td>\n<td>Potent RSV fusion inhibitor<\/td>\n<\/tr>\n<tr>\n<td>A3879<\/td>\n<td>Toceranib<\/td>\n<td>356068-94-5<\/td>\n<td>98.00%<\/td>\n<td>c-Kit\/VEGFR\/PDGFR inhibtor<\/td>\n<\/tr>\n<tr>\n<td>A3881<\/td>\n<td>Toll-like receptor modulator<\/td>\n<td>926927-42-6<\/td>\n<td>98.00%<\/td>\n<td>TLR antagonist<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u816b\u7624\u58de\u6b7b\u56e0\u5b50\u6291\u5236\u5291\u7cfb\u5217\u5546\u54c1-&gt;&gt;TAPI-1 APExBIO Technology LLC \u662f\u4e00\u5bb6 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":51043,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5368,486],"tags":[4954],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34285"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34285"}],"version-history":[{"count":6,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34285\/revisions"}],"predecessor-version":[{"id":53806,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/34285\/revisions\/53806"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/51043"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34285"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34285"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34285"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}