{"id":34128,"date":"2022-09-13T17:09:37","date_gmt":"2022-09-13T09:09:37","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=34128"},"modified":"2025-11-15T16:19:54","modified_gmt":"2025-11-15T08:19:54","slug":"romidepsin-fk228-depsipeptide%ef%bc%89-cas128517-07-7-apexbio%e8%b2%a8%e8%99%9fa8173","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=34128","title":{"rendered":"Romidepsin (FK228, depsipeptide)\uff09| CAS#128517-07-7 APExBIO\u8ca8\u865fA8173"},"content":{"rendered":"

\u4e59\u91af\u5316\u9176 (histone deacetylases ,HDAC)\u7cfb\u5217\u5546\u54c1->>Romidepsin (FK228, depsipeptide)<\/span><\/span><\/span><\/span><\/strong><\/p>\n

APExBIO Technology LLC \u662f\u4e00\u5bb6\u9818\u5148\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291 (Small Molecule Inhibitors)\/\u6d3b\u5316\u5291(Activators)\u3001\u5316\u5408\u7269\u5eab( Compound Libraries)\u3001\u80dc\u80bd(Peptides)\u3001\u6aa2\u6e2c\u8a66\u5291\u76d2(Assay Kits)\u3001\u87a2\u5149\u6a19\u8a18(Fluorescent Label)\u3001\u9176(Enzymes)\u3001\u4fee\u98fe\u6838\u82f7\u9178(Modified Nucleotides)\u3001mRNA \u5408\u6210\u4ee5\u53ca\u5404\u7a2e\u5206\u5b50\u751f\u7269\u5b78\u5de5\u5177\u7684\u4f9b\u61c9\u5546\u3002APExBIO\u63d0\u4f9b\u5ee3\u6cdb\u7684\u7522\u54c1\u7dda\uff0c\u6db5\u84cb 20 \u591a\u500b\u4e0d\u540c\u7684\u7814\u7a76\u9818\u57df\uff0c\u4f8b\u5982\u764c\u75c7(cancer)\u3001\u514d\u75ab\u5b78(immunology)\u3001\u795e\u7d93\u79d1\u5b78(neurosciences)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u8868\u89c0\u907a\u50b3\u5b78(epigenetics)\u7b49\u3002\u516c\u53f8\u7e3d\u90e8\u4f4d\u65bc\u7f8e\u570b\u5fb7\u5dde\u4f11\u58eb\u9813USA (Houston, Texas)\uff0c\u81f4\u529b\u65bc\u670d\u52d9\u5168\u7403\u5ba2\u6236\u3002\u9ad8\u5ea6\u91cd\u8996\u7522\u54c1\u54c1\u8cea\u3002\u6240\u6709\u7522\u54c1\u5747\u9075\u5faa\u56b4\u683c\u7684\u751f\u7522\u6307\u5357\uff0c\u4e26\u9644\u6709\u5206\u6790\u8b49\u66f8\u3001HPLC\u3001\u8cea\u8b5c(Mass Spectrum)\u548cHMNR\u4ee5\u53ca\u9ad4\u5916\u9a57\u8b49(in vitro validation)\u3002 APExBIO\u7522\u54c1\u5df2\u88ab\u300aNature\u300b\u3001\u300aCell\u300b\u548c\u300aScience\u300b\u7b49\u773e\u591a\u9802\u7d1a\u540c\u884c\u8a55\u5be9\u671f\u520a\u5f15\u7528\u3002>>\u66f4\u591aAPExBio\u5546\u54c1<\/span><\/strong><\/em><\/span><\/a><\/p>\n

<\/p>\n

Romidepsin (FK228, depsipeptide)\uff09 | CAS#128517-07-7 APExBIO\u8ca8\u865fA8173<\/span><\/strong><\/a><\/span><\/p>\n

\"Romidepsin<\/p>\n

HDAC1\/HDAC2\uff0c\u5f37\u6548\u548c\u9078\u64c7\u6027\u6291\u5236\u5291<\/p>\n

\u7f85\u7c73\u5730\u8f9b(Romidepsin)\uff0c\u4e5f\u7a31\u70ba FK228 \u6216\u7e2e\u80bd(depsipeptide)\uff0c\u662f\u7d44\u86cb\u767d\u53bb\u4e59\u91af\u5316\u9176 (histone deacetylases ,HDAC) \u7684\u5f37\u6548\u9078\u64c7\u6027\u6291\u5236\u5291\uff0c\u5b83\u8207\u6c88\u9ed8\u7684\u816b\u7624\u6291\u5236\u57fa\u56e0(tumor suppressor genes)\u7684\u91cd\u65b0\u8868\u9054\u7684\u8abf\u7bc0\u6709\u95dc\u3002\u5b83\u662f\u7b2c\u4e00\u500b\u8868\u73fe\u51fa\u6297\u816b\u7624\u6d3b\u6027(anti-tumor activity)\u7684 HDAC \u6291\u5236\u5291(HDAC inhibitor)\uff0c\u6700\u521d\u662f\u5f9e\u65e5\u672c\u571f\u58e4\u6a23\u672c\u4e2d\u767c\u73fe\u7684\u4e00\u7a2e\u687f\u72c0\u9769\u862d\u6c0f\u9670\u6027\u7d30\u83cc\u7d2b\u8272\u8272\u687f\u83cc(rod-shaped Gram-negative bacterium)\u4e2d\u5206\u96e2\u51fa\u4f86\u7684\u3002\u8207 HDAC4 \u548c HDAC6 \u9176\uff08II \u985e\uff09\u76f8\u6bd4\uff0cRomidepsin \u5c0d HDAC1 \u548c HDAC2 \u9176\uff08I \u985e\uff09\u8868\u73fe\u51fa\u66f4\u5f37\u7684\u6291\u5236\u4f5c\u7528\uff0c\u5f9e N \u672b\u7aef\u7d44\u86cb\u767d\u5c3e(N-terminal histone tails)\u7684\u8cf4\u6c28\u9178\u6b98\u57fa(lysine residues)\u4e2d\u53bb\u9664\u4e59\u91af\u57fa\uff0c\u4e26\u4fdd\u6301\u66f4\u958b\u653e\u548c\u8f49\u9304\u6d3b\u6027\u66f4\u9ad8\u7684\u67d3\u8272\u8cea(chromatin) \u72c0\u614b\u3002\u9664\u4e86\u6291\u5236 HDAC\uff0cromidepsin \u9084\u80fd\u5920\u5728\u6210\u4eba\u60e1\u6027\u816b\u7624\u4e2d\u8a98\u5c0e\u7d30\u80de\u9031\u671f\u505c\u6eef(cell cycle arrest)\u3001\u7d30\u80de\u5206\u5316(cellular differentiation)\u3001\u7d30\u80de\u51cb\u4ea1(apoptosis)\u548c\u57fa\u56e0\u8868\u9054(gene expression)\u7684\u6539\u8b8a\u3002<\/p>\n

\"Romidepsin\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Physical Appearance<\/td>\nA solid<\/td>\n<\/tr>\n
Storage<\/td>\nStore at -20\u00b0C<\/td>\n<\/tr>\n
M.Wt<\/td>\n540.7<\/td>\n<\/tr>\n
Cas No.<\/td>\n128517-07-7<\/td>\n<\/tr>\n
Formula<\/td>\nC24<\/sub>H36<\/sub>N4<\/sub>O6<\/sub>S2<\/sub><\/td>\n<\/tr>\n
Synonyms<\/td>\nIstodax, Antibiotic FR 901228, FK228, FR 901228, FK-228, Romidepsin<\/td>\n<\/tr>\n
Solubility<\/td>\n\u226527.04 mg\/mL in DMSO; insoluble in H2O; \u226535.27 mg\/mL in EtOH with ultrasonic<\/td>\n<\/tr>\n
Chemical Name<\/td>\n(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone<\/td>\n<\/tr>\n
SDF<\/td>\nDownload SDF<\/a><\/td>\n<\/tr>\n
Canonical SMILES<\/td>\nCC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C<\/td>\n<\/tr>\n
Shipping Condition<\/td>\nShip with blue ice, or upon other requests.<\/td>\n<\/tr>\n
General tips<\/td>\nFor obtaining a higher solubility, please warm the tube at 37\u00b0C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"Romidepsin\"<\/p>\n