{"id":27920,"date":"2021-06-25T14:28:58","date_gmt":"2021-06-25T06:28:58","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=27920"},"modified":"2022-07-19T14:12:04","modified_gmt":"2022-07-19T06:12:04","slug":"%e6%8a%97anti-anpep%e6%8a%97%e9%ab%94-anti-anpep-antibody%e8%b2%a8%e8%99%9fa2100-100","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=27920","title":{"rendered":"\u6297Anti-ANPEP\u6297\u9ad4 | Anti-ANPEP Antibody\u8ca8\u865fA2100-100"},"content":{"rendered":"

\u6297Anti-ANPEP\u6297\u9ad4 | Anti-ANPEP Antibody\u8ca8\u865f<\/strong>A2100-100<\/a><\/span><\/p>\n

2019 \u65b0\u578b\u51a0\u72c0\u75c5\u6bd2 (SARS-CoV-2)\u767c\u5c55<\/p>\n

\u51a0\u72c0\u75c5\u6bd2 (Coronaviruses, \u00a0CoV) \u662f\u6709\u5305\u819c(enveloped)\u7684\u6b63\u93c8 RNA \u75c5\u6bd2(positive-sense RNA viruses)\uff0c\u5176\u7279\u5fb5\u662f\u5f9e\u5176\u8868\u9762\u4f38\u200b\u200b\u51fa\u7684\u51a0\u72c0\u5c16\u523a(crown-like spikes)\uff0c\u9019\u662f\u4e00\u7a2e\u7570\u5e38\u5927\u7684 RNA \u57fa\u56e0\u7d44(RNA genome)\u3002\u5b83\u5011\u5728\u4e0d\u540c\u7a2e\u985e\u7684\u52d5\u7269\u4e2d\u5f15\u8d77\u5404\u7a2e\u75be\u75c5\uff0c\u5305\u62ec\u99f1\u99dd(camels)\u3001\u725b(cattle)\u3001\u8c93(cats)\u548c\u8759\u8760(bats)\uff0c\u4e26\u5728\u4eba\u985e\u4e2d\u5f15\u8d77\u6f5b\u5728\u7684\u81f4\u547d\u547c\u5438\u9053\u611f\u67d3(lethal respiratory infections)\u3002\u4e2d\u6771\u547c\u5438\u7d9c\u5408\u5fb5\u51a0\u72c0\u75c5\u6bd2 (MERS-CoV) \u548c\u56b4\u91cd\u6025\u6027\u547c\u5438\u7d9c\u5408\u5fb5\u51a0\u72c0\u75c5\u6bd2 (SARS-CoV) \u662f\u5c0e\u81f4\u4eba\u985e\u56b4\u91cd\u547c\u5438\u7cfb\u7d71\u75be\u75c5\u7684\u516d\u7a2e\u5df2\u77e5\u4eba\u985e\u51a0\u72c0\u75c5\u6bd2\u4e4b\u4e00\u3002 SARS-CoV-2 \u662f\u5728\u4e2d\u570b\u6e56\u5317\u7701\u6b66\u6f22\u5e02\u767c\u73fe\u7684\u6700\u65b0\u51a0\u72c0\u75c5\u6bd2\u682a\u3002\u6700\u8fd1\uff0c\u7814\u7a76\u4eba\u54e1\u78ba\u5b9a\u4e86\u5728\u4e2d\u570b\u51fa\u73fe\u7684\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2 (SARS-CoV-2) \u7684\u6574\u500b\u57fa\u56e0\u7d44\u5e8f\u5217\u3002 SARS-CoV-2 \u7684\u57fa\u56e0\u7d44\u5e8f\u5217\u8207 SARS-CoV \u7684\u76f8\u4f3c\u5ea6\u70ba 79%\uff0c\u8207 MERS-CoV \u7684\u76f8\u4f3c\u5ea6\u7d04\u70ba 51.8%\uff0c\u8207\u4f86\u81ea\u4e2d\u570b\u8759\u8760\u7684\u5176\u4ed6 SARS \u6a23\u51a0\u72c0\u75c5\u6bd2\u7684\u76f8\u4f3c\u5ea6\u7d04\u70ba 87%\u3002<\/p>\n

\"CoronaVirus\"<\/p>\n

\u65b0\u51a0\u75c5\u6bd2(Coronavirus<\/strong>)\u3001\u8907\u88fd(Replication<\/strong>)\u3001\u767c\u75c5\u6a5f\u5236(Pathogenesis<\/strong>)\u548c\u6f5b\u5728\u7684\u6cbb\u7642\u85e5\u7269(Potential Therapeutic Agents<\/strong>)\uff1a<\/p>\n

\u51a0\u72c0\u75c5\u6bd2(Coronavirus<\/strong>)\u5305\u542b\u4e00\u500b\u7d04 30 kb \u7684\u975e\u5206\u6bb5\u7684\u6b63\u93c8 RNA \u57fa\u56e0\u7d44(non-segmented, positive-sense RNA genome)\u3002\u51a0\u72c0\u75c5\u6bd2\u75c5\u6bd2\u9846\u7c92(. Coronavirus virus particles)\u5305\u542b\u56db\u7a2e\u4e3b\u8981\u7d50\u69cb\u86cb\u767d(structural proteins)\u3002\u5b83\u5011\u662f\u523a\u7a81 (spike , S)\u3001\u819c (membrane , M)\u3001\u5305\u819c (envelope , E) \u548c\u6838\u8863\u6bbc (nucleocapsid ,N) \u86cb\u767d\uff0c\u6240\u6709\u9019\u4e9b\u86cb\u767d\u90fd\u5728\u75c5\u6bd2\u57fa\u56e0\u7d44\u7684 3′ \u7aef\u7de8\u78bc\u3002\u523a\u7a81\u7cd6\u86cb\u767d(spike glycoprotein)\u4ecb\u5c0e\u75c5\u6bd2\u9032\u5165\uff0c\u662f\u7d30\u80de\u8da8\u5411\u6027(cell tropism)\u548c\u767c\u75c5\u6a5f\u5236(pathogenesis)\u7684\u4e3b\u8981\u6c7a\u5b9a\u56e0\u7d20\u3002\u5b83\u88ab\u6b78\u985e\u70ba I \u985e\u878d\u5408\u86cb\u767d(class I fusion protein)\uff0c\u8ca0\u8cac\u8207\u5bbf\u4e3b\u7d30\u80de\u4e0a\u7684\u53d7\u9ad4\u7d50\u5408\u3002\u6b64\u5916\uff0c\u5b83\u4ecb\u5c0e\u5bbf\u4e3b\u548c\u75c5\u6bd2\u819c(viral membranes)\u7684\u878d\u5408\uff0c\u9019\u4e00\u904e\u7a0b\u7531 S \u86cb\u767d\u7684\u4e3b\u8981\u69cb\u8c61\u8b8a\u5316\u9a45\u52d5\u3002\u7531\u65bc S \u86cb\u767d(receptor recognition)\u53c3\u8207\u53d7\u9ad4\u8b58\u5225\u4ee5\u53ca\u75c5\u6bd2\u9644\u8457\u548c\u9032\u5165\uff0c\u56e0\u6b64\u5b83\u4ee3\u8868\u4e86\u958b\u767c\u75ab\u82d7(vaccines)\u548c\u6cbb\u7642\u65b9\u6cd5(therapeutics)\u7684\u6700\u91cd\u8981\u76ee\u6a19\u4e4b\u4e00\u3002spike\u4e5f\u662f\u4e2d\u548c\u6297\u9ad4\u7684\u4e3b\u8981\u76ee\u6a19\u3002\u6700\u8fd1\u7684 SARS-CoV-2 \u7206\u767c\u523a\u6fc0\u4e86\u5c0d CoV \u75c5\u6bd2\u7684\u7814\u7a76\uff0c\u9019\u9805\u7814\u7a76\u5df2\u7d93\u78ba\u5b9a\u4e86\u5927\u91cf\u5408\u9069\u7684\u6297\u75c5\u6bd2\u9776\u9ede\uff0c\u4f8b\u5982\u75c5\u6bd2\u86cb\u767d\u9176(viral proteases)\u3001\u805a\u5408\u9176(polymerases)\u548c\u9032\u5165\u86cb\u767d(entry proteins)\u3002\u7136\u800c\uff0c\u4ecd\u7136\u9700\u8981\u5927\u91cf\u7814\u7a76\u4f86\u958b\u767c\u91dd\u5c0d\u9019\u4e9b\u904e\u7a0b\u4e26\u53ef\u4ee5\u6291\u5236\u75c5\u6bd2\u8907\u88fd(inhibit viral replication)\u7684\u85e5\u7269\u3002<\/p>\n

BioVision \u63d0\u4f9b\u591a\u7a2e\u7522\u54c1\u4f86\u652f\u6301\u51a0\u72c0\u75c5\u6bd2\u7814\u7a76\uff0c\u5305\u62ec\u6aa2\u6e2c\u8a66\u5291\u76d2\u3001\u6297\u9ad4\u3001\u86cb\u767d\u8cea\u3001\u751f\u7269\u5316\u5b78\u54c1\u548c\u8a31\u591a\u96dc\u9805\u7522\u54c1\uff0c\u63d0\u4f9b\u51a0\u72c0\u75c5\u6bd2\u7814\u7a76\u7684\u7522\u54c1\u3002<\/p>\n

\"\"<\/p>\n

\u6297Anti-ANPEP\u6297\u9ad4\u7522\u54c1\u4ecb\u7d39:<\/span><\/strong><\/p>\n

\u6c28\u80bd\u9176 N (Aminopeptidase N)\u4f4d\u65bc\u5c0f\u8178(small-intestinal)\u548c\u814e\u5fae\u7d68\u6bdb\u819c(renal microvillar membrane)\u4e2d\uff0c\u4e5f\u4f4d\u65bc\u5176\u4ed6plasma membranes\u4e2d\u3002\u5728\u5c0f\u8178(small intestine)\u4e2d\uff0c\u6c28\u80bd\u9176 N (aminopeptidase N)\u5728\u80c3\u86cb\u767d\u9176(gastric proteases)\u548c\u80f0\u86cb\u767d\u9176\u6c34\u89e3\u86cb\u767d\u8cea(pancreatic proteases)\u6240\u7522\u751f\u7684\u80bd\u7684\u6700\u7d42\u6d88\u5316\u4e2d\u767c\u63ee\u4f5c\u7528\u3002\u5b83\u5728\u8fd1\u7aef\u814e\u5c0f\u7ba1\u4e0a\u76ae\u7d30\u80de(proximal tubular epithelial cells)\u548c\u5176\u4ed6\u7d30\u80de\u985e\u578b\u4e2d\u7684\u529f\u80fd\u4e0d\u592a\u6e05\u695a\u3002<\/p>\n

\"\"<\/p>\n

\u7d30\u80de\u5916\u7fa7\u57fa\u672b\u7aef\u7d50\u69cb\u57df(extracellular carboxyterminal domain)\u5305\u542b\u92c5\u7d50\u5408\u91d1\u5c6c\u86cb\u767d\u9176\u8d85\u5bb6\u65cf\u6210\u54e1(zinc-binding metalloproteinase superfamily)\u7279\u5fb5\u7684\u4e94\u80bd\u5171\u6709\u5e8f\u5217\u3002\u8207\u6b64\u985e\u5df2\u77e5\u9176\u7684\u5e8f\u5217\u6bd4\u8f03\u8868\u660e\uff0cCD13 \u548c\u6c28\u80bd\u9176 N\u662f\u76f8\u540c\u7684\u3002\u5f8c\u4e00\u7a2e\u9176\u88ab\u8a8d\u70ba\u53c3\u8207\u591a\u7a2e\u7d30\u80de\u985e\u578b\u7684\u8abf\u7bc0\u80bd\u4ee3\u8b1d\uff0c\u5305\u62ec\u5c0f\u8178(small intestinal)\u548c\u814e\u5c0f\u7ba1\u4e0a\u76ae\u7d30\u80de(renal tubular epithelial cells)\u3001\u5de8\u566c\u7d30\u80de(macrophages)\u3001\u7c92\u7d30\u80de(granulocytes)\u548c\u4f86\u81ea\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u7684\u7a81\u89f8\u819c(synaptic membranes)\u3002\u4eba\u6c28\u80bd\u9176 N (Human aminopeptidase N)\u662f\u4e00\u7a2e\u4eba\u51a0\u72c0\u75c5\u6bd2\u682a\u7684\u53d7\u9ad4\uff0c\u662f\u4e0a\u547c\u5438\u9053\u611f\u67d3\u7684\u91cd\u8981\u539f\u56e0\u3002\u8a72\u57fa\u56e0\u7684\u7f3a\u9677\u4f3c\u4e4e\u662f\u5c0e\u81f4\u5404\u7a2e\u985e\u578b\u767d\u8840\u75c5(leukemia)\u6216\u6dcb\u5df4\u7624(lymphoma)\u7684\u539f\u56e0\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Cat # +Size<\/strong><\/td>\nA2100-100<\/td>\n<\/tr>\n
Size<\/strong><\/td>\n100 \u03bcl<\/td>\n<\/tr>\n
Antibody Target<\/strong><\/td>\nANPEP<\/td>\n<\/tr>\n
Alternate Name<\/strong><\/td>\nAlanyl (membrane) aminopeptidase; Alanyl aminopeptidase; Aminopeptidase M; Aminopeptidase N; AMPN_HUMAN; ANPEP; AP M; AP N; AP-M; AP-N; APN; CD 13; CD13; gp150; hAPN; LAP 1; LAP1; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; p150; PEPN<\/td>\n<\/tr>\n
Host<\/strong><\/td>\nRabbit<\/td>\n<\/tr>\n
Antibody Type<\/strong><\/td>\nPolyclonal<\/td>\n<\/tr>\n
Isotype<\/strong><\/td>\nIgG<\/td>\n<\/tr>\n
Immunogen<\/strong><\/td>\nRecombinant Human Aminopeptidase N protein<\/td>\n<\/tr>\n
Gene ID<\/strong><\/td>\n290<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nColorless liquid<\/td>\n<\/tr>\n
Formulation<\/strong><\/td>\nIn 0.01 M PBS, pH 7.4, 50% Glycerol, 0.03% proclin 300<\/td>\n<\/tr>\n
Purification<\/strong><\/td>\nProtein G purified<\/td>\n<\/tr>\n
Species Reactivity<\/strong><\/td>\nMouse, Human<\/td>\n<\/tr>\n
Application<\/strong><\/td>\nImmunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting<\/td>\n<\/tr>\n
Application & Usage<\/strong><\/td>\nWB 1:500-1:5000, IHC 1:20-1:200, IF 1:50-1:200<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nThe antibody solution should be gently mixed before use.<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00baC<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n
USAGE<\/strong><\/td>\nFor Research Use Only! Not For Use in Humans.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u6297ACE2\u6297\u9ad4<\/a> |<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u6297Anti-ANPEP\u6297\u9ad4 | Anti-ANPEP Antibody\u8ca8\u865fA2100-100 2019 \u65b0\u578b\u51a0 […]<\/p>\n","protected":false},"author":3,"featured_media":6997,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1119],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/27920"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27920"}],"version-history":[{"count":2,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/27920\/revisions"}],"predecessor-version":[{"id":28043,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/27920\/revisions\/28043"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/6997"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=27920"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=27920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}