{"id":27059,"date":"2021-03-17T11:50:04","date_gmt":"2021-03-17T03:50:04","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=27059"},"modified":"2022-07-19T14:37:27","modified_gmt":"2022-07-19T06:37:27","slug":"%e4%ba%ba%e7%ba%96%e7%b6%ad%e8%9b%8b%e7%99%bd%e5%8e%9f%ef%bc%88pad2%e7%93%9c%e6%b0%a8%e9%85%b8%e5%8c%96%ef%bc%89-human-fibrinogen-pad2-citrullinated-%e8%b2%a8%e8%99%9fp1718","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=27059","title":{"rendered":"\u4eba\u7e96\u7dad\u86cb\u767d\u539f\uff08PAD2\u74dc\u6c28\u9178\u5316\uff09 | Human Fibrinogen (PAD2 Citrullinated) \u8ca8\u865fp1718"},"content":{"rendered":"

\u4eba\u7e96\u7dad\u86cb\u767d\u539f\uff08PAD2\u74dc\u6c28\u9178\u5316\uff09 | Human Fibrinogen (PAD2 Citrullinated) \u8ca8\u865f<\/strong>p1718<\/a><\/span><\/p>\n

Human Fibrinogen (PAD2 Citrullinated)<\/em><\/strong><\/p>\n

\u74dc\u6c28\u9178\u5316(Citrullination)\u662f\u80bd\u7cbe\u6c28\u9178\u7cbe\u6c28\u9178\u53bb\u4e9e\u6c28\u9176\uff08peptidylarginine deiminases , PAD\uff09\u5c07\u6c28\u57fa\u9178\u7cbe\u6c28\u9178(amino acid arginine)\u8f49\u5316\u70ba\u9776\u86cb\u767d\u4e2d\u7684\u74dc\u6c28\u9178(Citrulline)\u3002\u74dc\u6c28\u9178(Citrulline)\u4e0d\u662f20\u7a2e\u6a19\u6e96\u6c28\u57fa\u9178\u4e4b\u4e00\uff0c\u800c\u662f\u7ffb\u8b6f\u5f8c\u4fee\u98fe(post-translational modification)\u7684\u7d50\u679c\u3002 \u86cb\u767d\u8cea\u7684\u74dc\u6c28\u9178\u5316\u5c0d\u65bc\u7dad\u6301\u6b63\u5e38\u7684\u751f\u7406\u529f\u80fd\u975e\u5e38\u91cd\u8981\uff0c\u5305\u62ec\u901a\u904e\u7d44\u86cb\u767d\u4fee\u98fe(histone modification)\uff0c\u514d\u75ab\u53cd\u61c9(immune responses)\u7b49\u8abf\u7bc0\u57fa\u56e0\u3002\u7136\u800c\uff0c\u74dc\u6c28\u9178\u5316(Citrullination)\u5ea6\u589e\u52a0\u8207\u514d\u75ab\u75c5\u7406\u72c0\u6cc1\u548c\u795e\u7d93\u7cfb\u7d71\u75be\u75c5, \u5982\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e(rheumatoid arthritis)\uff0c\u591a\u767c\u6027\u786c\u5316\u75c7(multiple sclerosis)\u548c\u963f\u723e\u8328\u6d77\u9ed8\u6c0f\u75c5(Alzheimer\u2019s disease\uff09\u6709\u95dc\u3002 BioVision\u81ea\u8c6a\u5730\u63d0\u4f9b\u5168\u9762\u7684\u6aa2\u6e2c\u8a66\u5291\u76d2\uff0c\u86cb\u767d\u8cea\u548c\u9176\uff0c\u6297\u9ad4\u548c\u751f\u5316\u8a66\u5291\u7d44\u5408\uff0c\u4ee5\u4fc3\u9032\u74dc\u6c28\u9178\u5316\u7814\u7a76(citrullination research)\u3002<\/p>\n

\u00a0\"\"<\/em><\/strong><\/p>\n

\u7522\u54c1\u4ecb\u7d39:\u7e96\u7dad\u86cb\u767d\u539f(Fibrinogen)\u662f\u4e00\u7a2e\u7cd6\u86cb\u767d\u8907\u5408\u7269(polypeptides , glycoprotein complex)\uff0c\u7531\u4e09\u7a2e\u4e0d\u540c\u7684\u591a\u80bd\uff08\u03b1\uff0c\u03b2\uff0c\u03b3\uff09\u7d44\u6210\uff0c\u88ab\u51dd\u8840\u9176\u88c2\u89e3\u5f62\u6210\u4e0d\u6eb6\u6027\u7e96\u7dad\u86cb\u767d\u57fa\u8cea(insoluble fibrin matrix)\uff0c\u53ef\u4f5c\u70ba\u8840\u6f3f\u51dd\u8840\u56e0\u5b50\u3002 \u7e96\u7dad\u86cb\u767d\u539f\u548c\u7e96\u7dad\u86cb\u767d\u7684\u5207\u5272\u7522\u7269\u8abf\u7bc0\u7d30\u80de\u7c98\u9644(cell adhesion)\u4e26\u6fc0\u6d3b\u8da8\u5316\u6027(activate chemotaxis)\u3002\u6162\u6027\u708e\u75c7\u53ef\u8a98\u5c0e\u7cbe\u6c28\u9178\u812b\u4e9e\u6c28\u9176\uff08\u4f8b\u5982PAD2\u548cPAD4\uff09\u74dc\u6c28\u9178\u5316\u7e96\u7dad\u86cb\u767d\u539f\uff0c\u9019\u8207\u985e\u98a8\u6fd5\u95dc\u7bc0\u708e(rheumatoid arthritis)\u7684\u81ea\u8eab\u6297\u9ad4\u6709\u95dc<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\nFib2; FGA; HEL-S-78p; FGB; FGG<\/td>\n<\/tr>\n
Gene ID<\/strong><\/td>\n\u03b1 – 2243; \u03b2 – 2244; \u03b3 – 2266<\/td>\n<\/tr>\n
Accession #<\/strong><\/td>\n\u03b1 – P02671; \u03b2 – P02675; \u03b3 – P02679<\/td>\n<\/tr>\n
Source<\/strong><\/td>\nHuman plasma<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nLiquid protein<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n\u03b1 – 2 isoforms at 95 kDa and 69.8 kDa; \u03b2 – 55.9 kDa; \u03b3 – 51.5 kDa<\/td>\n<\/tr>\n
Purity by SDS-PAGE<\/strong><\/td>\n\u2265 95%<\/td>\n<\/tr>\n
Amino Acid Sequence<\/strong><\/td>\nPurified from human plasma that tested negative for HBsAg and for antibodies to HIV and HCV; citrullinated with human recombinant PAD2<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nCentrifuge the vial prior to opening.<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-80\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n
USAGE<\/strong><\/td>\nFor Research Use Only! Not For Use in Humans.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u7a40\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176\u6d3b\u6027\u6e2c\u5b9a<\/a> | \u00a0FRAP\u6aa2\u6e2c<\/a> | \u7e3d\u81a0\u539f\u86cb\u767d\u5206\u6790<\/u><\/strong><\/a> | Dopamine\u591a\u5df4\u80fa\u6aa2\u6e2c<\/a> | \u4e09\u9178\u7518\u6cb9\u916f\u5206\u6790<\/a> | Cholesterol Efflux\u81bd\u56fa\u9187\u6392\u51fa\u87a2\u5149\u5206\u6790<\/a> | \u8102\u8cea\u904e\u6c27\u5316\uff08MDA<\/strong>\uff09\u6e2c\u5b9a<\/strong><\/a> | <\/strong>\u652f\u93c8\u6c28\u57fa\u9178<\/strong><\/a> BCAA<\/u><\/strong>\u6aa2\u6e2c<\/u><\/strong><\/p>\n

 <\/p>\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u8ca8\u865f9210<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g, 50 g<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9211-5<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9247<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (NGS\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g<\/td>\n\n

\u91cd\u7d44\u9176\u5728Pichia pastoris\u4e2d\u8868\u9054\uff0c<\/p>\n

\u4e26\u9032\u884c\u5ee3\u6cdb\u7684\u7d14\u5316\u4ee5\u7372\u5f97\u6700\u9ad8\u7684<\/p>\n

\u512a\u8cea\u7684\u7522\u54c1\u3002\u984d\u5916\u7684\u7d14\u5316\u6b65\u9a5f\u5c0e\u81f4<\/p>\n

\u6eb6\u89e3\u5ea6\u986f\u8457\u589e\u52a0\uff082.5\u500d\uff09\uff0c\u589e\u52a0<\/p>\n

\u6bd4\u6d3b\u6027\u548c\u6e1b\u5c11\u7684DNA\u542b\u91cf<\/p>\n

 <\/td>\n<\/tr>\n

\u8ca8\u865f9250<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n
\u8ca8\u865f9251<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg ,1 g ,10 g<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u4eba\u7e96\u7dad\u86cb\u767d\u539f\uff08PAD2\u74dc\u6c28\u9178\u5316\uff09 | Human Fibrinogen (PAD2 Citrullinated […]<\/p>\n","protected":false},"author":3,"featured_media":459,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1176],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/27059"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27059"}],"version-history":[{"count":2,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/27059\/revisions"}],"predecessor-version":[{"id":27063,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/27059\/revisions\/27063"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/459"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27059"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=27059"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=27059"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}