{"id":26894,"date":"2021-02-05T16:47:29","date_gmt":"2021-02-05T08:47:29","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=26894"},"modified":"2022-07-19T15:01:11","modified_gmt":"2022-07-19T07:01:11","slug":"%e8%83%b0%e5%b3%b6%e7%b4%a0%e6%a8%a3%e7%94%9f%e9%95%b7%e5%9b%a0%e5%ad%90-1%e9%87%8d%e7%b5%84%e8%9b%8b%e7%99%bd-igf-i-human-recombinant%e8%b2%a8%e8%99%9f4119","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=26894","title":{"rendered":"\u80f0\u5cf6\u7d20\u6a23\u751f\u9577\u56e0\u5b50-1\u91cd\u7d44\u86cb\u767d | IGF-I, human recombinant\u8ca8\u865f4119"},"content":{"rendered":"

\u80f0\u5cf6\u7d20\u6a23\u751f\u9577\u56e0\u5b50-1\u91cd\u7d44\u86cb\u767d | \u00a0IGF-I, human recombinant\u8ca8\u865f<\/strong>4119<\/a><\/span><\/p>\n

IGF-I, human recombinant<\/em><\/strong><\/p>\n

\u7522\u54c1\u4ecb\u7d39:\u4ebaIGF-1\uff08(insulin-like Growth Factor-1,\u80f0\u5cf6\u7d20\u6a23\u751f\u9577\u56e0\u5b50-1\uff0cIGF1\uff0cMGF\uff0c\u751f\u9577\u6fc0\u7d20\uff09\u662f\u4e00\u7a2e\u5206\u5b50\u7d50\u69cb\u985e\u4f3c\u65bc\u80f0\u5cf6\u7d20\u7684\u6fc0\u7d20\u3002\u5b83\u662f\u4e00\u7a2e\u591a\u80bd\u751f\u9577\u56e0\u5b50(polypeptide growth factor)\uff0c\u53ef\u523a\u6fc0\u5305\u62ec\u808c\u8089(muscle)\uff0c\u9aa8\u9abc(bone)\u548c\u8edf\u9aa8\u7d44\u7e54(cartilage tissue)\u5728\u5167\u7684\u591a\u7a2e\u7d30\u80de\u985e\u578b\u7684\u589e\u6b96\u3002\u80f0\u5cf6\u7d20\u6a23\u751f\u9577\u56e0\u5b501\u5df2\u986f\u793a\u8207\u6240\u6709IGF-1\u7d50\u5408\u86cb\u767d\uff08IGFBPs\uff09\u7d50\u5408\u4f75\u76f8\u4e92\u4f5c\u7528\uff0c\u5176\u4e2d\u6709\u516d\u500b\uff08IGFBP1-6\uff09\u3002 IGFBP-3\u662f\u6700\u8c50\u5bcc\u7684\u86cb\u767d\u8cea\uff0c\u4f54\u6240\u6709IGF\u7d50\u5408\u768480\uff05\u3002 IGF-1\u4ee51\uff1a1\u7684\u6469\u723e\u6bd4\u7d50\u5408\u5230IGFBP-3\u3002 IGF-1\u8207\u81f3\u5c11\u5169\u500b\u7d30\u80de\u8868\u9762\u53d7\u9ad4\u7d50\u5408\uff1aIGF-1\u53d7\u9ad4\uff08IGF1R\uff09\u548c\u80f0\u5cf6\u7d20\u53d7\u9ad4(insulin receptor)\u3002 IGF-1\u53d7\u9ad4\u4f3c\u4e4e\u662f\u201c\u751f\u7406\u201d\u53d7\u9ad4-\u5b83\u4ee5\u6bd4\u7d50\u5408\u80f0\u5cf6\u7d20\u53d7\u9ad4\u7684IGF-1\u9ad8\u5f97\u591a\u7684\u89aa\u548c\u529b\u7d50\u5408IGF-1\u3002\u6210\u719f\u7684\u4ebaIGF I\u8207\u5c0f\u9f20IGF1\u548c\u5927\u9f20IGF1\u5206\u5225\u5177\u670994\uff05\u548c96\uff05\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u540c\u4e00\u6027\uff0c\u4e26\u8868\u73fe\u51fa\u8de8\u7269\u7a2e\u6d3b\u6027\u3002\u5b83\u8207\u6210\u719f\u7684\u4ebaIGFII\u5177\u670964\uff05\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u540c\u4e00\u6027\u3002\u4ebaIGF-1\u662f\u4e00\u7a2e7.6 kDa\u86cb\u767d\uff0c\u542b\u670970\u500b\u6c28\u57fa\u9178\u6b98\u57fa\u3002\u91cd\u7d44\u4ebaIGF-1\u662f\u4f7f\u7528\u7121\u52d5\u7269\u6e90\u6280\u8853\u751f\u7522\u7684\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\nInsulin-Like Growth Factor 1, Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF<\/td>\n<\/tr>\n
Gene Symbol<\/strong><\/td>\nIGF1A<\/td>\n<\/tr>\n
Gene ID<\/strong><\/td>\n3479<\/td>\n<\/tr>\n
Accession #<\/strong><\/td>\nP01343<\/td>\n<\/tr>\n
Source<\/strong><\/td>\nE. coli<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nRecombinant IGF-1 is available as a lyophilized powder<\/td>\n<\/tr>\n
Physical Form Description<\/strong><\/td>\nIGF-1 protein is lyophilized with no additives<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n7.6 kDa<\/td>\n<\/tr>\n
Purity by SDS-PAGE<\/strong><\/td>\n\u226598%<\/td>\n<\/tr>\n
Purity by<\/strong><\/td>\n\u226598%<\/td>\n<\/tr>\n
Endotoxin Level<\/strong><\/td>\n<0.1 ng\/\u03bcg<\/td>\n<\/tr>\n
Biological Activity<\/strong><\/td>\nEC50 is typically < 100 ng\/ml. The activity was determined using dose dependent stimulation of Balbc 3T3 cell line.<\/td>\n<\/tr>\n
Reconstitution Instructions<\/strong><\/td>\nReconstitute in H\u2082O to a concentration of 0.1-1.0 mg\/ml. This solution can be diluted into other buffered solutions or stored at 4\u00b0C for 1 week or \u201320\u00b0C for future use.<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nCentrifuge the vial prior to opening.<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5f15\u7528\u6587\u737b<\/p>\n

Wang et al,The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis. Mol. Cancer Ther., Apr 2015; 14: 982 – 993.<\/p>\n

Fotovati, A. et. al. YB-1 Bridges Neural Stem Cells and Brain Tumor\u2013Initiating Cells via Its Roles in Differentiation and Cell Growth. Cancer Res., Aug 2011; 71: 5569 – 5578.<\/p>\n

Wang, P. et al. Protein-Tyrosine Phosphatase alpha Acts as an Upstream Regulator of Fyn Signaling to Promote Oligodendrocyte Differentiation and Myyelination. J. Biol. Chem. 2009; 284: 33692-33702.<\/p>\n

\u7a40\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176\u6d3b\u6027\u6e2c\u5b9a<\/a> | \u00a0FRAP\u6aa2\u6e2c<\/a> | \u7e3d\u81a0\u539f\u86cb\u767d\u5206\u6790<\/u><\/strong><\/a> | Dopamine\u591a\u5df4\u80fa\u6aa2\u6e2c<\/a> | \u4e09\u9178\u7518\u6cb9\u916f\u5206\u6790<\/a> | Cholesterol Efflux\u81bd\u56fa\u9187\u6392\u51fa\u87a2\u5149\u5206\u6790<\/a> | \u8102\u8cea\u904e\u6c27\u5316\uff08MDA<\/strong>\uff09\u6e2c\u5b9a<\/strong><\/a> | <\/strong>\u652f\u93c8\u6c28\u57fa\u9178<\/strong><\/a> BCAA<\/u><\/strong>\u6aa2\u6e2c<\/u><\/strong><\/p>\n

 <\/p>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n\n\n\n\n\n\n\n\n
 <\/td>\n <\/td>\n <\/td>\n <\/td>\n<\/tr>\n
\u8ca8\u865f9210<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g, 50 g<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9211-5<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9247<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (NGS\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g<\/td>\n\n

\u91cd\u7d44\u9176\u5728Pichia pastoris\u4e2d\u8868\u9054\uff0c<\/p>\n

\u4e26\u9032\u884c\u5ee3\u6cdb\u7684\u7d14\u5316\u4ee5\u7372\u5f97\u6700\u9ad8\u7684<\/p>\n

\u512a\u8cea\u7684\u7522\u54c1\u3002\u984d\u5916\u7684\u7d14\u5316\u6b65\u9a5f\u5c0e\u81f4<\/p>\n

\u6eb6\u89e3\u5ea6\u986f\u8457\u589e\u52a0\uff082.5\u500d\uff09\uff0c\u589e\u52a0<\/p>\n

\u6bd4\u6d3b\u6027\u548c\u6e1b\u5c11\u7684DNA\u542b\u91cf<\/p>\n

 <\/td>\n<\/tr>\n

\u8ca8\u865f9250<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n
\u8ca8\u865f9251<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg ,1 g ,10 g<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u80f0\u5cf6\u7d20\u6a23\u751f\u9577\u56e0\u5b50-1\u91cd\u7d44\u86cb\u767d | \u00a0IGF-I, human recombinant\u8ca8\u865f4119 IGF-I, […]<\/p>\n","protected":false},"author":3,"featured_media":459,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1205,1204],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26894"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26894"}],"version-history":[{"count":1,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26894\/revisions"}],"predecessor-version":[{"id":26895,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26894\/revisions\/26895"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/459"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26894"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26894"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26894"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}