{"id":26402,"date":"2020-11-27T14:16:08","date_gmt":"2020-11-27T06:16:08","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=26402"},"modified":"2022-07-19T16:03:07","modified_gmt":"2022-07-19T08:03:07","slug":"vivopurex-invivo%e6%8a%97%e9%ab%94-anti-il-10r-1b1-3a-mouse-igg2a-fc-silent-kappa%e8%b2%a8%e8%99%9fab01490-2-3","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=26402","title":{"rendered":"VivopureX\u2122 invivo\u6297\u9ad4 | Anti-IL-10R, Mouse IgG2a, Fc Silent\u2122, Kappa\u8ca8\u865fAb01490-2.3"},"content":{"rendered":"

VivopureX\u2122\u6297\u9ad4\u7528\u65bc\u9ad4\u5167\u7814\u7a76<\/p>\n

VivopureX\u2122\u6297\u9ad4\u662f\u91cd\u7d44\u5c0f\u9f20\u6297\u9ad4\uff0c\u975e\u5e38\u9069\u5408\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u9032\u884c\u9ad4\u5167\u7814\u7a76\u3002\u8a72\u96c6\u5408\u5305\u62ec\u6d41\u884c\u7684\u6297\u9ad4\u514b\u9686(antibody clones)\uff0c\u5176\u4e2d\u8a31\u591a\u6700\u521d\u662f\u5f9e\u5927\u9f20\u6216\u5009\u9f20\u7372\u5f97\u7684\uff0cAbsolute Antibody\u5df2\u5c07\u9019\u4e9b\u6297\u9ad4\u514b\u9686\u5de5\u7a0b\u5316\u70ba\u5c0f\u9f20\u6297\u5c0f\u9f20\u91cd\u7d44\u9ad4\uff0c\u4ee5\u6539\u5584\u7814\u7a76\u7d50\u679c\u3002<\/p>\n

\"\"<\/p>\n

\u8207\u539f\u59cb\u6297\u9ad4\u5f62\u5f0f\u76f8\u6bd4\uff0cVivopureX\u2122\u91cd\u7d44\u5c0f\u9f20\u6297\u9ad4\u5177\u6709\u8a31\u591a\u512a\u52e2\uff0c\u5305\u62ec\uff1a<\/p>\n

    \n
  1. \u514d\u75ab\u539f\u6027\u964d\u4f4e(Reduced immunogenicity)\uff1a\u5728\u5bbf\u4e3b\u751f\u7269\u9ad4\u4e2d\u672a\u8a98\u5c0e\u51fa\u4efb\u4f55\u4e2d\u548c\u6297\u9ad4(neutralizing antibodies)\uff0c\u9019\u610f\u5473\u8457\u8a72\u6297\u9ad4\u7684\u4f5c\u7528\u6642\u9593\u66f4\u9577\uff0c\u4e26\u4e14\u7fa4\u9ad4\u53cd\u61c9\u66f4\u52a0\u4e00\u81f4\u3002<\/li>\n
  2. Tailored effector function\uff1a\u589e\u52a0\u7684Fc\u53d7\u9ad4\u7d50\u5408\u589e\u52a0\u4e86\u8017\u76e1\u7684\u6f5b\u529b\uff0c\u800c\u6e1b\u5c11\u7684Fc\u53d7\u9ad4\u7d50\u5408\u6e1b\u5c11\u4e86\u963b\u65b7\u7684\u526f\u4f5c\u7528\u3002<\/li>\n
  3. \u589e\u5f37\u7684\u6548\u529b\uff1a\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u5be6\u73fe\u76f8\u540c\u53cd\u61c9\u6240\u9700\u7684\u6297\u9ad4\u66f4\u5c11\u3002<\/li>\n
  4. \u6279\u6b21\u9593\u7684\u53ef\u91cd\u8907\u6027\uff1a\u91cd\u7d44\u751f\u7522\u53ef\u78ba\u4fdd\u6700\u9ad8\u7684\u53ef\u91cd\u8907\u6027\uff0c\u4e26\u78ba\u4fdd\u9ad8\u7d14\u5ea6\u548c\u4f4e\u5167\u6bd2\u7d20\uff08<0.5 EU \/ mg\uff09\u3002<\/li>\n<\/ol>\n

    \"\"<\/p>\n

     <\/p>\n

    Anti-IL-10R [1B1.3a], Mouse IgG2a, Fc Silent\u2122, Kappa\u00a0 | \u8ca8\u865fAb01490-2.3\u00a0<\/a><\/span><\/p>\n

    \u8a72\u6297\u9ad4\u8b58\u5225\u5c0f\u9f20IL-10R\uff0c\u5b83\u662f\u4e00\u7a2e\u7d30\u80de\u8868\u9762\u7cd6\u86cb\u767d\uff0c\u662f\u6297\u708e\u6027IL-10\u7684\u5f8c\u4ee3\u3002\u8a72\u6297\u9ad4\u8b58\u5225\u7684\u8868\u4f4d\u5df2\u5b9a\u4f4d\u65bc\u5c0f\u9f20IL-10R\u7d30\u80de\u5916\u5340\u57df\u5167\u7684\u914d\u9ad4\u7d50\u5408\u7d50\u69cb\u57df\u3002<\/p>\n

    UniProt Accession Number of Target Protein:<\/strong>\u00a0Q61727<\/p>\n

    Alternative Name(s) of Target:<\/strong>\u00a0CD210; Interleukin-10 receptor subunit; Interleukin-10 receptor subunit alpha; Il10ra Il10r; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; IBI-3A; 1B1-3A
    \nImmunogen:<\/strong>\u00a0This antibody was raised by immunising rats with the purified recombinant extracellular region of mouse Interleukin 10 Receptor.<\/p>\n

    Specificity:<\/strong>\u00a0This antibody recognises mouse IL-10R which is a cell surface glycoprotein and a receprot for anti-inflammatory IL-10. The epitope recognised by this antibody has been localised to the ligand binding domain within the extracellular region of mouse IL-10R.<\/p>\n

    Application Notes:<\/strong>\u00a01B1.3a has been widely applied in flow cytometric analyses where the detection of IL-10R was needed. Furthermore, this antibody was also successfully utilised as a blocking agent; one group used it to demonstrate that IL-10 mediates suppressive activity, by targeting its receptor IL-10R with this antibody (Wang et al., 2004). Castro et al. (2000) demonstrated that 1B1.3a is able to make a soluble peptide or protein antigen immunogenic for subsequent Th1 recall responses in a situation when there is an additional signal, such as LPS, activating the immune system. Consequently, this antibody is a hugely promising agent in the potential development of vaccines for immunotherapy. Similarly, Vicari and colleagues (2002) showed that this antibody has an enormous potential as a therapeutic anti-tumour agent when combined with the administration of CpG to stimulate the immune system.<\/p>\n

    Antibody first published in:<\/strong>\u00a0O’Farrell et al. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J. 1998 Feb 16;17(4):1006-18.\u00a0PMID:9463379<\/a>
    \nNote on publication:<\/strong>\u00a0This article describes the method of generation of antibodies like 1B1.3a.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    Antibody Name [Clone]<\/td>\nEngineered Format<\/td>\nTop Application<\/td>\nAvailable Bulk Sizes<\/td>\n<\/tr>\n
    Anti-OX40\/CD134 [OX86]<\/a><\/td>\nMouse IgG2a<\/td>\nAgonism<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-PD-1 [RMP1-14]<\/a><\/td>\nMouse IgG2a Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-CTLA-4 [9D9]<\/a><\/td>\nMouse IgG2a<\/td>\nBlocking, Treg depletion<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-CTLA-4 [9D9]<\/a><\/td>\nMouse IgG2a Fc Silent\u2122<\/td>\nBlocking, peripheral Treg expansion<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-GITR [DTA-1]<\/a><\/td>\nMouse IgG2a<\/td>\nAgonism<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-CD25 [PC-61.5.3]<\/a><\/td>\nMouse IgG2a<\/td>\nDepletion<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-TIGIT [1B4]<\/a><\/td>\nMouse IgG1<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-Lag3 [C9B7W]<\/a><\/td>\nMouse IgG2a Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-CD96 [6A6]<\/a><\/td>\nMouse IgG2a Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-IL-10R [1B1.3a]<\/a><\/td>\nMouse IgG2a Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-B7-H4 [7A1-6]<\/a><\/td>\nMouse IgG2a Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-BTLA [HMBT-6B2]<\/a><\/td>\nMouse IgG2a Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-Tim-4 [3A1]<\/a><\/td>\nMouse IgG2a Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-Tim-4 [5G3]<\/a><\/td>\nMouse IgG2a Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-TIM-2 [RMT2-14]<\/a><\/td>\nMouse IgG2a Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-Tim-1 [3B3]<\/a><\/td>\nMouse IgG1<\/td>\nAgonism<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-Tim-3 [2C12]<\/a><\/td>\nMouse IgG2a Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-CD115\/M-CSFR [AFS98]<\/a><\/td>\nMouse IgG2a<\/td>\nDepletion<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-PD-L1 [10F.9G2]<\/a><\/td>\nMouse IgG2b Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-IFN-gamma receptor 1 [GR20]<\/a><\/td>\nMouse IgG2b Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-VISTA [13F3]<\/a><\/td>\nMouse IgG2b Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-CD20 [18B12]<\/a><\/td>\nMouse IgG2a<\/td>\nDepletion<\/td>\n10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-CD4 epitope A [YTS 177.9]<\/a><\/td>\nMouse IgG2a<\/td>\nDepletion<\/td>\n10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-CD4 epitope A [YTS 191.1]<\/a><\/td>\nMouse IgG2a<\/td>\nDepletion<\/td>\n10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-CD8 alpha\/Lyt-2 [YTS 169.4]<\/a><\/td>\nMouse IgG2a<\/td>\nDepletion<\/td>\n10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-Ly6G [1A8]<\/a><\/td>\nMouse IgG2a<\/td>\nDepletion<\/td>\n10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-CD200R [OX131]<\/a><\/td>\nMouse IgG1 Fc Silent\u2122<\/td>\nBlocking<\/td>\n10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n
    Anti-PD-L2 [TY25]<\/a><\/td>\nMouse IgG2a Fc Silent\u2122<\/td>\nBlocking<\/td>\n1 mg, 10 mg, 25 mg, 100 mg<\/td>\n<\/tr>\n<\/thead>\n<\/table>\n

     <\/p>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    VivopureX\u2122\u6297\u9ad4\u7528\u65bc\u9ad4\u5167\u7814\u7a76 VivopureX\u2122\u6297\u9ad4\u662f\u91cd\u7d44\u5c0f\u9f20\u6297\u9ad4\uff0c\u975e\u5e38\u9069\u5408\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u9032\u884c\u9ad4\u5167\u7814\u7a76 […]<\/p>\n","protected":false},"author":3,"featured_media":3519,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1305,1306,1304,1303],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26402"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26402"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26402\/revisions"}],"predecessor-version":[{"id":26411,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26402\/revisions\/26411"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/3519"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26402"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26402"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26402"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}