{"id":26336,"date":"2020-11-23T16:43:33","date_gmt":"2020-11-23T08:43:33","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=26336"},"modified":"2022-07-19T16:06:25","modified_gmt":"2022-07-19T08:06:25","slug":"hypericin-a-potent-anticancer-and-antidepressant-agent%e8%b2%a8%e8%99%9f2526","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=26336","title":{"rendered":"Hypericin | A potent anticancer and antidepressant agent\u8ca8\u865f2526"},"content":{"rendered":"

Hypericin | \u8ca8\u865f<\/strong>2526<\/strong><\/a><\/span><\/p>\n

A potent anticancer and antidepressant agent<\/em><\/strong><\/p>\n

\u7522\u54c1\u4ecb\u7d39: Hypericin\u7531 Hypericum perforatum, St. John\u2019s Wort\u5206\u96e2\u3002Hypericin\u5df2\u986f\u793a\u51fa\u6297\u75c5\u6bd2\u548c\u6297\u9006\u8f49\u9304\u75c5\u6bd2\u6d3b\u6027\u3002\u4e00\u7a2e\u6709\u6548\u4e14\u9078\u64c7\u6027\u7684\u86cb\u767d\u6fc0\u9176C\u6291\u88fd\u5291\uff08IC 50 = 3.4 \u00b5M\uff09\u3002\u9084\u5df2\u77e5\u53ef\u4ee5\u6291\u5236\u916a\u86cb\u767d\u6fc0\u9176II\uff08inhibit Casein Kinase II , CKII\uff09\uff0cMAP\u6fc0\u9176(MAP Kinase)\uff0c\u80f0\u5cf6\u7d20R(Insulin R)\uff0cEGFR\uff0cPI-3\u6fc0\u9176\u3002\u986f\u793a\u6297\u816b\u7624(antineoplastic)\u548c\u6297\u816b\u7624\u6d3b\u6027(antitumor actitities)\u3002\u5927\u591a\u6578\u6d3b\u52d5\u9700\u8981\u5149\u6fc0\u6d3b(light activation)\u3002\u4ee51 \u00b5M\u6216\u66f4\u9ad8\u7684\u6fc3\u5ea6\u8a98\u5c0e\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u7d30\u80de\u51cb\u4ea1\uff08\u572829 mW \/ cm2\uff08tungsten light\uff09\u4e0b\uff0cIC 50 = 0.1 \u00b5M\uff09\u3002Hypericin\u88ab\u5149\u6d3b\u5316\u5f8c\u7528\u65bc\u5149\u52d5\u529b\u6cbb\u7642\u816b\u7624\uff0c\u64da\u5831\u5c0e\u5c0d\u67d0\u4e9b\u816b\u7624\u7d30\u80de\u682a\u5177\u6709\u7d30\u80de\u6bd2\u6027\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/th>\n1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione<\/td>\n<\/tr>\n
Appearance<\/th>\nBlack solid<\/td>\n<\/tr>\n
CAS #<\/th>\n548-04-9<\/td>\n<\/tr>\n
Molecular Formula<\/th>\nC\u2083\u2080H\u2081\u2086O\u2088<\/td>\n<\/tr>\n
Molecular Weight<\/th>\n504.45<\/td>\n<\/tr>\n
Purity<\/th>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/th>\nDMSO (~25 mg\/ml) or EtOH (~10 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/th>\nCC1=CC(=C2C3=C1C4=C5C(=C(C=C4C)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O<\/td>\n<\/tr>\n
InChi<\/th>\nInChI=1S\/C30H16O8\/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28\/h3-6,31-36H,1-2H3<\/td>\n<\/tr>\n
InChi Key<\/th>\nBTXNYTINYBABQR-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/th>\n5281051<\/a><\/td>\n<\/tr>\n
MDL Number<\/th>\nMFCD00016683<\/td>\n<\/tr>\n
Handling<\/th>\nProtect from air and light<\/td>\n<\/tr>\n
Storage Conditions<\/th>\n-20\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/th>\nGel Pack<\/td>\n<\/tr>\n
USAGE<\/th>\nFor Research Use Only! Not For Use in Humans.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u7a40\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176\u6d3b\u6027\u6e2c\u5b9a<\/a> | \u00a0FRAP\u6aa2\u6e2c<\/a> | \u7e3d\u81a0\u539f\u86cb\u767d\u5206\u6790<\/u><\/strong><\/a> | Dopamine\u591a\u5df4\u80fa\u6aa2\u6e2c<\/a> | \u4e09\u9178\u7518\u6cb9\u916f\u5206\u6790<\/a> | Cholesterol Efflux\u81bd\u56fa\u9187\u6392\u51fa\u87a2\u5149\u5206\u6790<\/a> | \u8102\u8cea\u904e\u6c27\u5316\uff08<\/strong>MDA<\/strong>\uff09\u6e2c\u5b9a<\/strong><\/a> | <\/strong>\u652f\u93c8\u6c28\u57fa\u9178<\/strong><\/a> BCAA<\/u><\/strong>\u6aa2\u6e2c<\/u><\/strong><\/p>\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u8ca8\u865f9210<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g, 50 g<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9211-5<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9247<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (NGS\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g<\/td>\n\n

\u91cd\u7d44\u9176\u5728Pichia pastoris\u4e2d\u8868\u9054\uff0c<\/p>\n

\u4e26\u9032\u884c\u5ee3\u6cdb\u7684\u7d14\u5316\u4ee5\u7372\u5f97\u6700\u9ad8\u7684<\/p>\n

\u512a\u8cea\u7684\u7522\u54c1\u3002\u984d\u5916\u7684\u7d14\u5316\u6b65\u9a5f\u5c0e\u81f4<\/p>\n

\u6eb6\u89e3\u5ea6\u986f\u8457\u589e\u52a0\uff082.5\u500d\uff09\uff0c\u589e\u52a0<\/p>\n

\u6bd4\u6d3b\u6027\u548c\u6e1b\u5c11\u7684DNA\u542b\u91cf<\/p>\n

 <\/td>\n<\/tr>\n

\u8ca8\u865f9250<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n
\u8ca8\u865f9251<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg ,1 g ,10 g<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Hypericin | \u8ca8\u865f2526 A potent anticancer and antidepressa […]<\/p>\n","protected":false},"author":3,"featured_media":26337,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1318],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26336"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26336"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26336\/revisions"}],"predecessor-version":[{"id":26341,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26336\/revisions\/26341"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/26337"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26336"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26336"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26336"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}