{"id":26286,"date":"2020-11-19T10:03:26","date_gmt":"2020-11-19T02:03:26","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=26286"},"modified":"2022-07-19T16:08:20","modified_gmt":"2022-07-19T08:08:20","slug":"apy29-cas1216665-49-4%e8%b2%a8%e8%99%9f2591","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=26286","title":{"rendered":"APY29 | CAS#1216665-49-4\u8ca8\u865f2591"},"content":{"rendered":"

APY29 | \u00a0CAS#1216665-49-4\u8ca8\u865f2591<\/strong><\/a><\/span><\/p>\n

A highly potent and selective allosteric modulator of IRE1\u03b1<\/em><\/strong><\/p>\n

\"\"<\/p>\n

\u7522\u54c1\u4ecb\u7d39: APY29 \u662fIRE1+\u7684\u4e00\u7a2e\u6975\u5f37\u4e14\u9078\u64c7\u6027\u7684\u7b49\u4f4d\u88fd\u8abf\u5668\u3002\u5728\u5167\u8cea\u6027\u96b1\u819c \uff08endoplasmic reticulum , ER\uff09 \u61c9\u529b\u4e0b\uff0c\u5c55\u958b\u7684\u86cb\u767d\u8cea\u5728 ER \u4e2d\u7a4d\u7d2f\uff0c\u4ee5\u555f\u52d5 ER \u8f49\u819c\u6fc0\u9176\/\u5167\u819c\u86cb\u767d\u9176 \uff08RNase\uff09[IRE1]\u3002IRE1=\u5be1\u805a\u7269\u5316\u3001\u81ea\u78f7\u9178\u916f\uff0c\u4e26\u555f\u52d5XBP1 mRNA splicing\uff0c\u5f9e\u800c\u89f8\u767c\u5c55\u958b\u7684\u86cb\u767d\u8cea\u53cd\u61c9\uff08UPR\uff09\u3002APY29 \u6291\u5236 IRE1+ \u81ea\u52d5\u78f7\u5316 \uff08IC\u2085\u2080 = 280 nM\uff09\u4e26\u555f\u52d5 IRE1+RNase \u6d3b\u6027\u3002\u7531\u65bc\u5c0d\u5b9a\u671f\u8a55\u4f30\u7684\u5931\u8abf\u56e0\u7d20\u8207\u5404\u7a2e\u7d30\u80de\u9000\u884c\u6027\u75be\u75c5\u548c\u816b\u7624\u969c\u7919\u6709\u95dc\uff0cIRE1\u00ae\u7684\u5c0f\u5206\u5b50\u8abf\u7bc0\u5668\u61c9\u8a72\u975e\u5e38\u6709\u7528\uff0c\u6709\u52a9\u65bc\u7406\u89e3 UPR \u5728\u75c5\u7406\u751f\u7406\u5b78\u4e2d\u7684\u4f5c\u7528\uff0c\u4e26\u958b\u767c\u6cbb\u7642\u6027\u61c9\u6fc0\u76f8\u95dc\u75be\u75c5\u7684\u85e5\u7269\u3002<\/p>\n

\u7a40\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176\u6d3b\u6027\u6e2c\u5b9a<\/a> | \u00a0FRAP\u6aa2\u6e2c<\/a> | \u7e3d\u81a0\u539f\u86cb\u767d\u5206\u6790<\/u><\/strong><\/a> | Dopamine\u591a\u5df4\u80fa\u6aa2\u6e2c<\/a> | \u4e09\u9178\u7518\u6cb9\u916f\u5206\u6790<\/a> | Cholesterol Efflux\u81bd\u56fa\u9187\u6392\u51fa\u87a2\u5149\u5206\u6790<\/a> | \u8102\u8cea\u904e\u6c27\u5316\uff08<\/strong>MDA<\/strong>\uff09\u6e2c\u5b9a<\/strong><\/a> | <\/strong>\u652f\u93c8\u6c28\u57fa\u9178<\/strong><\/a> BCAA<\/u><\/strong>\u6aa2\u6e2c<\/u><\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\nN2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nWhite solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n1216665-49-4<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2081\u2087H\u2081\u2086N\u2088<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n332.36<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO (>30 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nC1(NC2=CC(NC=N3)=C3C=C2)=NC=CC(NC4=NNC(C5CC5)=C4)=N1<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C17H16N8\/c1-2-10(1)13-8-16(25-24-13)22-15-5-6-18-17(23-15)21-11-3-4-12-14(7-11)20-9-19-12\/h3-10H,1-2H2,(H,19,20)(H3,18,21,22,23,24,25)<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nWJNBSTLIALIIEW-UHFFFAOYSA-N<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nProtect from light and air<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n
USAGE<\/strong><\/td>\nFor Research Use Only! Not For Use in Humans.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n\n\n\n\n\n\n\n\n
 <\/td>\n <\/td>\n <\/td>\n <\/td>\n<\/tr>\n
\u8ca8\u865f9210<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g, 50 g<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9211-5<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9247<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (NGS\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g<\/td>\n\n

\u91cd\u7d44\u9176\u5728Pichia pastoris\u4e2d\u8868\u9054\uff0c<\/p>\n

\u4e26\u9032\u884c\u5ee3\u6cdb\u7684\u7d14\u5316\u4ee5\u7372\u5f97\u6700\u9ad8\u7684<\/p>\n

\u512a\u8cea\u7684\u7522\u54c1\u3002\u984d\u5916\u7684\u7d14\u5316\u6b65\u9a5f\u5c0e\u81f4<\/p>\n

\u6eb6\u89e3\u5ea6\u986f\u8457\u589e\u52a0\uff082.5\u500d\uff09\uff0c\u589e\u52a0<\/p>\n

\u6bd4\u6d3b\u6027\u548c\u6e1b\u5c11\u7684DNA\u542b\u91cf<\/p>\n

 <\/td>\n<\/tr>\n

\u8ca8\u865f9250<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n
\u8ca8\u865f9251<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg ,1 g ,10 g<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

APY29 | \u00a0CAS#1216665-49-4\u8ca8\u865f2591 A highly potent and sel […]<\/p>\n","protected":false},"author":3,"featured_media":26287,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1330],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26286"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26286"}],"version-history":[{"count":1,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26286\/revisions"}],"predecessor-version":[{"id":26288,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26286\/revisions\/26288"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/26287"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26286"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}