{"id":26282,"date":"2020-11-19T09:44:01","date_gmt":"2020-11-19T01:44:01","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=26282"},"modified":"2022-07-19T16:08:40","modified_gmt":"2022-07-19T08:08:40","slug":"mkc-8866-cas1338934-59-0%e8%b2%a8%e8%99%9fb2785","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=26282","title":{"rendered":"MKC-8866 | CAS#1338934-59-0\u8ca8\u865fB2785"},"content":{"rendered":"

MKC-8866 \u00a0| \u00a0CAS#1338934-59-0\u8ca8\u865f<\/strong>B2785<\/strong><\/a><\/span><\/p>\n

A selective IRE1 RNase inhibitor<\/em><\/strong><\/p>\n

\"\"<\/p>\n

\u7522\u54c1\u4ecb\u7d39: MKC-8866 \u662f\u4e00\u7a2e\u6709\u6548\u7684\u9078\u64c7\u6027 IRE1 RNase \u6291\u5236\u5291(selective IRE1 RNase inhibitor) \uff0c\u5728\u4eba\u985e\u9ad4\u5916IC50\u7684IC50\u70ba0.29 \u03bcM\u3002MKC-8866\u5f37\u70c8\u6291\u5236Dithiothreitol\u8a98\u5c0e\u7684XBP1s\uff08X-box-binding protein 1-spliced , XBP1s\uff09\u8868\u9054\uff0cEC50\u70ba0.52\u03bcM\uff0cunstresses RPMI 8226\u7d30\u80de\uff0cIC50\u70ba0.14\u03bcM\u3002MKC-8866\u9084\u5f37\u70c8\u6291\u5236\u524d\u5217\u817a\u764c\uff08PCa\uff09\u816b\u7624\u751f\u9577\u4f5c\u70ba\u5c0f\u9f20\u591a\u500b\u81e8\u5e8a\u524d\u6a21\u578b\u7684\u55ae\u4e00\u7642\u6cd5\uff0c\u4e26\u986f\u793a\u51fa\u8207\u7576\u524dPCa\u85e5\u7269\u7684\u5354\u540c\u6297\u816b\u7624\u4f5c\u7528\u3002<\/p>\n

\u7a40\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176\u6d3b\u6027\u6e2c\u5b9a<\/a> | \u00a0FRAP\u6aa2\u6e2c<\/a> | \u7e3d\u81a0\u539f\u86cb\u767d\u5206\u6790<\/u><\/strong><\/a> | Dopamine\u591a\u5df4\u80fa\u6aa2\u6e2c<\/a> | \u4e09\u9178\u7518\u6cb9\u916f\u5206\u6790<\/a> | Cholesterol Efflux\u81bd\u56fa\u9187\u6392\u51fa\u87a2\u5149\u5206\u6790<\/a> | \u8102\u8cea\u904e\u6c27\u5316\uff08<\/strong>MDA<\/strong>\uff09\u6e2c\u5b9a<\/strong><\/a> | <\/strong>\u652f\u93c8\u6c28\u57fa\u9178<\/strong><\/a> BCAA<\/u><\/strong>\u6aa2\u6e2c<\/u><\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n7-Hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde; MKC8866; IRE1-IN-8866<\/td>\n<\/tr>\n
Peptide Sequence<\/strong><\/td>\nN\/A<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nCrystalline solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n1338934-59-0<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2081\u2088H\u2081\u2089NO\u2087<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n361.35<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598%<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\n~ 3 mg\/ml DMSO<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nO=CC1=C(O)C(OC)=CC2=C1OC(C(CC(N3CCOCC3)=O)=C2C)=O<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C18H19NO7\/c1-10-11-7-14(24-2)16(22)13(9-20)17(11)26-18(23)12(10)8-15(21)19-3-5-25-6-4-19\/h7,9,22H,3-6,8H2,1-2H3<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nIFDGMRMUJYGWQQ-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n89542346<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nDo not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00baC<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n
USAGE<\/strong><\/td>\nFor Research Use Only! Not For Use in Humans.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n\n\n
 <\/td>\n <\/td>\n <\/td>\n <\/td>\n<\/tr>\n
\u8ca8\u865f9210<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g, 50 g<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9211-5<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9247<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (NGS\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g<\/td>\n\n

\u91cd\u7d44\u9176\u5728Pichia pastoris\u4e2d\u8868\u9054\uff0c<\/p>\n

\u4e26\u9032\u884c\u5ee3\u6cdb\u7684\u7d14\u5316\u4ee5\u7372\u5f97\u6700\u9ad8\u7684<\/p>\n

\u512a\u8cea\u7684\u7522\u54c1\u3002\u984d\u5916\u7684\u7d14\u5316\u6b65\u9a5f\u5c0e\u81f4<\/p>\n

\u6eb6\u89e3\u5ea6\u986f\u8457\u589e\u52a0\uff082.5\u500d\uff09\uff0c\u589e\u52a0<\/p>\n

\u6bd4\u6d3b\u6027\u548c\u6e1b\u5c11\u7684DNA\u542b\u91cf<\/p>\n

 <\/td>\n<\/tr>\n

\u8ca8\u865f9250<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n
\u8ca8\u865f9251<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg ,1 g ,10 g<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

MKC-8866 \u00a0| \u00a0CAS#1338934-59-0\u8ca8\u865fB2785 A selective IRE1 R […]<\/p>\n","protected":false},"author":3,"featured_media":26283,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1331],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26282"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26282"}],"version-history":[{"count":1,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26282\/revisions"}],"predecessor-version":[{"id":26284,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26282\/revisions\/26284"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/26283"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26282"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}