{"id":26277,"date":"2020-11-19T09:34:41","date_gmt":"2020-11-19T01:34:41","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=26277"},"modified":"2022-07-19T16:08:52","modified_gmt":"2022-07-19T08:08:52","slug":"kira-6-cas1589527-65-0%e8%b2%a8%e8%99%9fb2494","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=26277","title":{"rendered":"KIRA-6 | CAS#1589527-65-0\u8ca8\u865fB2594"},"content":{"rendered":"

KIRA-6 | \u00a0CAS#1589527-65-0\u8ca8\u865f<\/strong>B2594<\/strong><\/a><\/span><\/p>\n

An ATP-competitive allosteric IRE1-\u03b1 inhibitor<\/em><\/strong><\/p>\n

\"\"<\/p>\n

\u7522\u54c1\u4ecb\u7d39: KIRA-6 is an ATP-competitive IRE1\u03b1 kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1\u03b1 RNase kinase activity (IC\u2085\u2080 = 0.6 \u00b5M) and blocks oligomerization. It has been shown to inhibit IRE1\u03b1 in vivo and to promote cell survival under ER stress\u3002KIRA-6 \u662f\u4e00\u7a2e\u5177\u6709 ATP \u7af6\u722d\u529b\u7684 IRE1\u00ae \u6fc0\u9176\u6291\u5236 RNase \u8870\u6e1b\u5668 \uff08ATP-competitive IRE1\u03b1 kinase inhibiting RNase attenuator , KIRA\uff09\uff0c\u5176\u7570\u9ad4\u6291\u5236 IRE1+ RNase \u6fc0\u9176\u6d3b\u6027 \uff08IC\u2085\u2080 = 0.6 \u03bcM\uff09\u4e26\u963b\u6b62\u5be1\u805a\u5316(oligomerization\u3002)\u5b83\u5df2\u88ab\u8b49\u660e\u6291\u5236 IRE1\u00ae\u9ad4\u5167\uff0c\u4e26\u4fc3\u9032\u7d30\u80de\u5728 ER \u58d3\u529b(ER stress)\u4e0b\u7684\u751f\u5b58\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\nKIRA 6, KIRA6, 1-(4-(8-Amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea, KIRA-6<\/td>\n<\/tr>\n
Peptide Sequence<\/strong><\/td>\nN\/A<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nCrystalline solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n1589527-65-0<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2082\u2088H\u2082\u2085F\u2083N\u2086O<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n518.54<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\n~20 mg\/ml in DMSO<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nNC1=NC=CN2C1=C(C3=C(C=CC=C4)C4=C(NC(NC5=CC(C(F)(F)F)=CC=C5)=O)C=C3)N=C2C(C)(C)C<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C28H25F3N6O\/c1-27(2,3)25-36-22(23-24(32)33-13-14-37(23)25)20-11-12-21(19-10-5-4-9-18(19)20)35-26(38) 34-17-8-6-7-16(15-17)28(29,30)31\/h4-15H,1-3H3,(H2,32,33)(H2,34,35,38)<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nNOHQEAFAESMMDX-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n73425700<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nDo not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00baC<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n
USAGE<\/strong><\/td>\nFor Research Use Only! Not For Use in Humans.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7a40\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176\u6d3b\u6027\u6e2c\u5b9a<\/a> | \u00a0FRAP\u6aa2\u6e2c<\/a> | \u7e3d\u81a0\u539f\u86cb\u767d\u5206\u6790<\/u><\/strong><\/a> | Dopamine\u591a\u5df4\u80fa\u6aa2\u6e2c<\/a> | \u4e09\u9178\u7518\u6cb9\u916f\u5206\u6790<\/a> | Cholesterol Efflux\u81bd\u56fa\u9187\u6392\u51fa\u87a2\u5149\u5206\u6790<\/a> | \u8102\u8cea\u904e\u6c27\u5316\uff08<\/strong>MDA<\/strong>\uff09\u6e2c\u5b9a<\/strong><\/a> | <\/strong>\u652f\u93c8\u6c28\u57fa\u9178<\/strong><\/a> BCAA<\/u><\/strong>\u6aa2\u6e2c<\/u><\/strong><\/p>\n\n\n\n\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u8ca8\u865f9210<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g, 50 g<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9211-5<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9247<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (NGS\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g<\/td>\n\n

\u91cd\u7d44\u9176\u5728Pichia pastoris\u4e2d\u8868\u9054\uff0c<\/p>\n

\u4e26\u9032\u884c\u5ee3\u6cdb\u7684\u7d14\u5316\u4ee5\u7372\u5f97\u6700\u9ad8\u7684<\/p>\n

\u512a\u8cea\u7684\u7522\u54c1\u3002\u984d\u5916\u7684\u7d14\u5316\u6b65\u9a5f\u5c0e\u81f4<\/p>\n

\u6eb6\u89e3\u5ea6\u986f\u8457\u589e\u52a0\uff082.5\u500d\uff09\uff0c\u589e\u52a0<\/p>\n

\u6bd4\u6d3b\u6027\u548c\u6e1b\u5c11\u7684DNA\u542b\u91cf<\/p>\n

 <\/td>\n<\/tr>\n

\u8ca8\u865f9250<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n
\u8ca8\u865f9251<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg ,1 g ,10 g<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

KIRA-6 | \u00a0CAS#1589527-65-0\u8ca8\u865fB2594 An ATP-competitive al […]<\/p>\n","protected":false},"author":3,"featured_media":26278,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1332],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26277"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26277"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26277\/revisions"}],"predecessor-version":[{"id":26285,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26277\/revisions\/26285"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/26278"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26277"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26277"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}