{"id":26274,"date":"2020-11-19T09:24:56","date_gmt":"2020-11-19T01:24:56","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=26274"},"modified":"2022-07-19T16:09:01","modified_gmt":"2022-07-19T08:09:01","slug":"4%ce%bc8c-rnase%e6%b4%bb%e6%80%a7%e9%81%b8%e6%93%87%e6%80%a7%e6%8a%91%e5%88%b6%e5%8a%91-cas14003-96-4%e8%b2%a8%e8%99%9fb2495","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=26274","title":{"rendered":"4\u03bc8C-RNase\u6d3b\u6027\u9078\u64c7\u6027\u6291\u5236\u5291 | CAS#14003-96-4\u8ca8\u865fB2495"},"content":{"rendered":"

4\u03bc8C | \u00a0CAS#14003-96-4\u8ca8\u865f<\/strong>B2495<\/strong><\/a><\/span><\/p>\n

Proteinase K, Standard GradeAn inositol requiring enzyme 1 \u03b1 (IRE1\u03b1) inhibitor<\/em><\/strong><\/p>\n

\"\"<\/p>\n

\u7522\u54c1\u4ecb\u7d39: 4\u00b58C is a selective inhibitor of IRE1\u03b1 ribonuclease (RNase) activity (IC\u2085\u2080 = 60 nM). It blocks substrate access to the active site of IRE1\u03b1 and inactivates IRE1\u03b1-mediated mRNA degradation. Displays no effect on the IRE1\u03b1-related endoribonuclease RNase L. 4\u03bc8C \u662f IRE1+ \u6838\u7cd6\u9176 \uff08RNase\uff09 \u6d3b\u6027 \uff08IC\u2085\u2080 60 nM\uff09 \u7684\u9078\u64c7\u6027\u6291\u5236\u5291(selective inhibitor\u3002)\u5b83\u963b\u6b62IRE1+ active site\uff0c\u4e26\u6ec5\u6d3b IRE1+ \u4e2d\u4f4d mRNA \u964d\u89e3\u3002\u986f\u793a\u5c0d IRE1\u00ae \u76f8\u95dc\u5167\u7aef\u9178\u9176 RNase L \u6c92\u6709\u4efb\u4f55\u5f71\u97ff\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\nIRE1 Inhibitor III; 7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nWhite to off-white solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n14003-96-4<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2081\u2081H\u2088O\u2084<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n204.18<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\n>25 mg\/ml in DMSO<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nCC1=CC(=O)OC2=C1C=CC(=C2C=O)O<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C11H8O4\/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12\/h2-5,13H,1H3<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nRTHHSXOVIJWFQP-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n12934390<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nDo not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00baC<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n
USAGE<\/strong><\/td>\nFor Research Use Only! Not For Use in Humans.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u7a40\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176\u6d3b\u6027\u6e2c\u5b9a<\/a> | \u00a0FRAP\u6aa2\u6e2c<\/a> | \u7e3d\u81a0\u539f\u86cb\u767d\u5206\u6790<\/u><\/strong><\/a> | Dopamine\u591a\u5df4\u80fa\u6aa2\u6e2c<\/a> | \u4e09\u9178\u7518\u6cb9\u916f\u5206\u6790<\/a> | Cholesterol Efflux\u81bd\u56fa\u9187\u6392\u51fa\u87a2\u5149\u5206\u6790<\/a> | \u8102\u8cea\u904e\u6c27\u5316\uff08<\/strong>MDA<\/strong>\uff09\u6e2c\u5b9a<\/strong><\/a> | <\/strong>\u652f\u93c8\u6c28\u57fa\u9178<\/strong><\/a> BCAA<\/u><\/strong>\u6aa2\u6e2c<\/u><\/strong><\/p>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n\n\n\n\n\n\n\n\n
 <\/td>\n <\/td>\n <\/td>\n <\/td>\n<\/tr>\n
\u8ca8\u865f9210<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g, 50 g<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9211-5<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u5206\u5b50\u7b49\u7d1aRNase\/DNase free)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6 99% (Native PAGE and SDS PAGE assay)<\/td>\n<\/tr>\n
\u8ca8\u865f9247<\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (NGS\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg, 1 g, 10 g<\/td>\n\n

\u91cd\u7d44\u9176\u5728Pichia pastoris\u4e2d\u8868\u9054\uff0c<\/p>\n

\u4e26\u9032\u884c\u5ee3\u6cdb\u7684\u7d14\u5316\u4ee5\u7372\u5f97\u6700\u9ad8\u7684<\/p>\n

\u512a\u8cea\u7684\u7522\u54c1\u3002\u984d\u5916\u7684\u7d14\u5316\u6b65\u9a5f\u5c0e\u81f4<\/p>\n

\u6eb6\u89e3\u5ea6\u986f\u8457\u589e\u52a0\uff082.5\u500d\uff09\uff0c\u589e\u52a0<\/p>\n

\u6bd4\u6d3b\u6027\u548c\u6e1b\u5c11\u7684DNA\u542b\u91cf<\/p>\n

 <\/td>\n<\/tr>\n

\u8ca8\u865f9250<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n5 ml, 25 ml, 100 m (20 mg\/ml Solution)<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n
\u8ca8\u865f9251<\/a><\/td>\n\u91cd\u7d44\u86cb\u767d\u9176K (\u6a19\u6e96\u7b49\u7d1a)<\/a><\/td>\n100 mg, 500 mg ,1 g ,10 g<\/td>\n\u7d14\u5ea6>90%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

4\u03bc8C | \u00a0CAS#14003-96-4\u8ca8\u865fB2495 Proteinase K, Standard Gr […]<\/p>\n","protected":false},"author":3,"featured_media":26275,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1333],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26274"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26274"}],"version-history":[{"count":1,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26274\/revisions"}],"predecessor-version":[{"id":26276,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/26274\/revisions\/26276"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/26275"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26274"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}