{"id":23978,"date":"2020-03-12T17:25:10","date_gmt":"2020-03-12T09:25:10","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=23978"},"modified":"2022-07-19T17:28:22","modified_gmt":"2022-07-19T09:28:22","slug":"vinca-alkaloid-%e8%b2%a8%e8%99%9f1957","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=23978","title":{"rendered":"vinca alkaloid | \u8ca8\u865f1957"},"content":{"rendered":"

Home<\/strong><\/a> \u00a0 \u00a0<\/strong>Literature<\/strong><\/a>\u00a0 \u00a0<\/strong>Promotions<\/strong><\/a>\u00a0\u00a0<\/strong>Product Citations<\/strong><\/a><\/p>\n

vinca alkaloid | \u8ca8\u865f1957<\/a><\/span><\/p>\n

An anti-mitotic and antitumor agent<\/p>\n

\u7522\u54c1\u63cf\u8ff0\uff1a<\/strong> \u534a\u5408\u6210\u9577\u6625\u82b1\u751f\u7269\u9e7c(vinca alkaloid)\uff0c\u5177\u6709\u6709\u6548\u7684\u6297\u6709\u7d72\u5206\u88c2(anti-mitotic)\u548c\u6297\u816b\u7624(anti-tumor properties)\u7279\u6027\u3002\u5b83\u7684\u4e3b\u8981\u4f5c\u7528\u6a5f\u7406\u88ab\u8a8d\u70ba\u662f\u6291\u5236\u5fae\u7ba1\u52d5\u529b\u5b78(microtubule dynamics)\uff0c\u5f9e\u800c\u5c0e\u81f4\u6709\u7d72\u5206\u88c2\u505c(mitotic arrest)\u6eef\u4e26\u6700\u7d42\u5c0e\u81f4\u7d30\u80de\u6b7b\u4ea1(cell death)\u3002\u5145\u7576\u5fae\u7ba1\u53bb\u7a69\u5b9a\u5291(microtubule destabilizing agent.)\u3002\u5728\u9ad8\u6fc3\u5ea6\u4e0b\uff0c\u5b83\u6703\u523a\u6fc0\u5fae\u7ba1\u89e3\u805a(microtubule depolymerization)\u548c\u6709\u7d72\u5206\u88c2\u7d21\u9318\u9ad4\u7834\u58de(microtubule destabilizing)\u3002\u5728\u8f03\u4f4e\u7684\u81e8\u5e8a\u76f8\u95dc\u6fc3\u5ea6\u4e0b\uff0c\u9577\u6625\u745e\u6ff1(vinorelbine)\u80fd\u963b\u65b7\u6709\u7d72\u5206\u88c2\u9032\u7a0b\u3002\u5b83\u7684\u4e3b\u8981\u76ee\u6a19\u662f\u5fae\u7ba1\u86cb\u767d(tubulin)\u548c\u5fae\u7ba1(microtubules)\u3002\u8207\u7d2b\u6749\u70f7\u985e\u8207\u53ef\u6eb6\u6027\u5fae\u7ba1\u86cb\u767d\u7684\u7d50\u5408\u8f03\u5f31\uff0c\u9577\u6625\u745e\u6ff1(vinorelbine)\u53ef\u4ee5\u8207\u53ef\u6eb6\u6027\u548c\u5fae\u7ba1\u76f8\u95dc\u7684\u5fae\u7ba1\u86cb\u767d\u7d50\u5408\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n3\u2032,4\u2032-Didehydro-4\u2032-deoxy-C\u2032-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5\u2032-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartrate<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nOff-white solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n125317-39-7<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2084\u2085H\u2085\u2084N\u2084O\u2088.C\u2088H\u2081\u2082O\u2081\u2082<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n1079.11<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nWater (~ 10 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nCCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C45H54N4O8.2C4H6O6\/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10\/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10)\/t28?,37-,38+,39+,42+,43+,44-,45-;2*1-,2-\/m011\/s1<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nCILBMBUYJCWATM-NPJYPKOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n607791<\/a><\/td>\n<\/tr>\n
MDL Number<\/strong><\/td>\nMFCD03613607<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nProtect from light and moisture<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n
USAGE<\/strong><\/td>\nFor Research Use Only! Not For Use in Humans.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e7e\u6d74\u52a0\u71b1\u6c34\u6d74\u69fd<\/strong><\/a>\u00a0|\u00a0 <\/strong>Finnpipette F3 <\/strong>\u5fae\u91cf\u5206\u6ce8\u5668<\/strong><\/a>\u00a0| \u00a0<\/strong>\u8a66\u7ba1\u632f\u76ea\u5668 Vortex Mixer\u00a0<\/strong><\/a>\u00a0|\u00a0 <\/strong>Genereach<\/strong>\u8ff7\u4f60\u578b\u5fae\u91cf\u96e2\u5fc3\u6a5f<\/strong><\/a>\u00a0 |\u00a0\u00a0 <\/strong>ELISA<\/strong>\u5100\u5668<\/strong><\/a><\/span><\/p>\n

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\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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