{"id":23900,"date":"2020-03-05T14:06:58","date_gmt":"2020-03-05T06:06:58","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=23900"},"modified":"2022-07-19T17:29:51","modified_gmt":"2022-07-19T09:29:51","slug":"anti-sars-cov-s-glycoprotein-%e6%8a%97%e9%ab%94-absoluteantibody%e8%b2%a8%e8%99%9fab00263-10-0","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=23900","title":{"rendered":"Anti-SARS-CoV S glycoprotein \u6297\u9ad4 | Absoluteantibody\u8ca8\u865fAb00263-10.0"},"content":{"rendered":"<p>\u514d\u75ab\u7642\u6cd5\u7814\u7a76(Immunotherapy Research) \u6d3b\u9ad4\u7528\u91cd\u7d44\u6297\u9ad4-\u7814\u7a76\u7b49\u7d1a<\/p>\n<p>\u91dd\u5c0d\u6cbb\u7642\u7814\u7a76\uff0c\u6297\u86cb\u767d\u8cea\u7684\u6297\u9ad4\u53c3\u8207co-stimulation\u548c\u514d\u75ab\u7cfb\u7d71\u8abf\u7bc0(immune cell regulation)\u3002 \u6709\u4e9b\u9032\u5165\u81e8\u5e8a\u968e\u6bb5(clinic)\uff1b\u66f4\u591a\u90e8\u4efd\u4ecd\u8655\u65bc\u7814\u7a76\u968e\u6bb5\u3002\u514d\u75ab\u7d30\u80de\u4fe1\u865f\u50b3\u5c0e(immune cell signaling)\u7684\u8a31\u591a\u65b9\u9762\u4ecd\u7136\u672a\u77e5\uff0cAbsolute Antibody\u958b\u767c\u4e86\u91dd\u5c0d\u81e8\u5e8a\u76f8\u95dc\u86cb\u767d\u7684\u91cd\u7d44\u5de5\u7a0b\u6297\u9ad4\uff0c\u63d0\u4f9b\u4e00\u7cfb\u5217\u514d\u75ab\u7642\u6cd5\u7814\u7a76(Immunotherapy Research) \u6d3b\u9ad4\u7528\u91cd\u7d44\u6297\u9ad4\u3002<\/p>\n<ul>\n<li>Your favourite research tools, now updated through antibody engineering for improved performance\u00a0<em>in vivo<\/em><\/li>\n<li>Reduce immunogenicity by matching antibody species to your host organism<\/li>\n<li>Tailor effector function by choosing from our range of antibody isotypes and subtypes<\/li>\n<li>Explore new possibilities by combining two of these antibodies into a custom bispecific reagent<\/li>\n<\/ul>\n<p><span style=\"color: #00ccff;\"><a style=\"color: #00ccff;\" href=\"http:\/\/biopioneer.com.tw\/?p=23898\">Anti-SARS-CoV S glycoprotein [S227], Human IgG1, Kappa\u8ca8\u865fAb00263-10.0<\/a><\/span><\/p>\n<p>Alternative Name(s) of Target: Severe Acute Respiratory Syndrome Coronavirus GP<\/p>\n<p>SARS-CoV\u4e2d\u548c\u578b\u6297\u9ad4hmAb(SARS-CoV-neutralizing hmAbs) \u53ef\u8207SARS-CoV S\u7cd6\u86cb\u767d\u7d50\u5408(SARS-CoV S glycoprotein)\uff0c\u4e26\u6291\u5236\u8a72\u7cd6\u86cb\u767d\u8207\u4ebaACE2\u7684\u7d50\u5408\u3002S227\u9032\u884c\u4e86\u9810\u9632\u6027\u6e2c\u8a66\uff0c\u5728\u611f\u67d3\u4e86\u81f4\u547d\u5291\u91cf\u7684SARS-CoV\uff08106 PFU\uff09<u>Urbani<\/u><u>\uff0c<\/u><u>GZ02<\/u><u>\u548c<\/u><u>HC \/ SZ \/ 61\/03\u00a0<\/u>\u768412\u500b\u6708\u5c0f\u9f20(olb BALB \/ c)\u4e2d\uff0c\u5206\u5225\u4ee510\u548c1 mg \/ kg\u7684\u5291\u91cf\u5c0dS227\u9032\u884c\u4e86\u9810\u9632\u6027\u6e2c\u8a66\u3002\u6240\u6709\u7d93S227\u8655\u7406\u7684\u52d5\u7269\u5747\u5728\u7b2c5\u5929\u6062\u5fa9\u3002SARS-CoV-neutralizing hmAbs, binds to SARS-CoV S glycoprotein, inhibiting the binding of the glycoprotein to human ACE2. S227 was tested prophylactically at 10 and 1 mg\/kg in 12-month-olb BALB\/c mice infected with a letal dose of SARS-CoV (106 PFU) Urbani, GZ02 and HC\/SZ\/61\/03. All animals treated with S227 recovered on day 5.<\/p>\n<p><strong>\u6297\u9ad4\u4ecb\u7d39:\u00a0<\/strong>SARS-CoV\u4e2d\u548c\u578b\u6297\u9ad4hmAb(SARS-CoV-neutralizing hmAbs)\u5c0dSARS-CoV S glycoprotein\u5177\u7279\u7570\u6027 (Specificity)\u3002 \u514d\u75ab\u539f(Immunogen): \u7531SARS\u5eb7\u5fa9\u4e4b\u75c5\u4eba\u6c38\u751f\u8868\u9054IgG\u7684B\u7d30\u80de\u88fd\u6210\u3002\u6297\u9ad4\u7d93\u7531Protein A\u7d14\u5316\uff0c\u6eb6\u65bcPBS \u542b\u6709 0.02% Proclin 300\u3002\u6fc3\u5ea6\u70ba1 mg\/ml.<\/p>\n<p><strong>Antibody first published in:<\/strong>\u00a0Rockx B, Corti D, Donaldson E, Sheahan T, Stadler K, Lanzavecchia A, Baric R. Structural basis for potent cross-neutralizing human monoclonal antibody protection against lethal human and zoonotic Severe Acute Respiratory Syndrome CoronaVirus challenge. J Virol. 2008 Apr;82(7):3220-35. doi: 10.1128\/JVI.02377-07. Epub 2008 Jan 16.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18199635\">PMID:18199635<\/a><\/p>\n<table>\n<thead>\n<tr>\n<td width=\"96\">\u7522\u54c1\u8ca8\u865f<\/td>\n<td width=\"151\">Mouse target<\/td>\n<td width=\"105\">\u6297\u9ad4clone<\/td>\n<td width=\"204\">Original Antibody format<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-4-1BB-LOB12-3\/\">Ab01052<\/a><\/td>\n<td width=\"151\">4-1BB (CD137)<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-4-1BB-LOB12-3\/\">LOB12.3<\/a><\/td>\n<td width=\"204\">Rat IgG1<\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-4-1bbl-at113-2\/\">Ab01054<\/a><\/td>\n<td width=\"151\">4-1BBL (CD137L)<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-4-1bbl-at113-2\/\">AT113-2<\/a><\/td>\n<td width=\"204\">Rat IgG1<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-4-1BBL-TKS-1\/\">Ab00881<\/a><\/td>\n<td width=\"151\">4-1BBL (CD137L)<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-4-1BBL-TKS-1\/\">TKS-1<\/a><\/td>\n<td width=\"204\">Rat IgG2a<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-BTLA-HMBT-6B2\/\">Ab01027<\/a><\/td>\n<td width=\"151\">BTLA<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-BTLA-HMBT-6B2\/\">HMBT-6B2<br \/>\n<\/a><\/td>\n<td width=\"204\">Hamster IgG<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CD27-LG-3A10\/\">Ab00670<\/a><\/td>\n<td width=\"151\">CD27<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CD27-LG-3A10\/\">LG.3A10<\/a><\/td>\n<td width=\"204\">Hamster IgG<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CD27-RM27-3E5\/\">Ab00895<\/a><\/td>\n<td width=\"151\">CD27<\/td>\n<td width=\"105\">\n<p><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CD27-RM27-3E5\/\">RM27-3E5<\/a><\/p>\n<p>&nbsp;<\/td>\n<td width=\"204\">Rat IgG2a<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CD28-E18\/\">Ab00286<\/a><\/td>\n<td width=\"151\">CD28<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CD28-E18\/\">E18<br \/>\n<\/a><\/td>\n<td width=\"204\">Mouse IgG2b<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/Anti-CD28-D665\/\">Ab00285<\/a><\/td>\n<td width=\"151\">CD28<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/Anti-CD28-D665\/\">D665<br \/>\n<\/a><\/td>\n<td width=\"204\">Mouse IgG1<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-cd40-323\/\">Ab01109<\/a><\/td>\n<td width=\"151\">CD40<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-cd40-323\/\">3\/23<br \/>\n<\/a><\/td>\n<td width=\"204\">Rat IgG2a<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CD40L-MR1\/\">Ab01087<\/a><\/td>\n<td width=\"151\">CD40L (CD154)<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CD40L-MR1\/\">MR1<br \/>\n<\/a><\/td>\n<td width=\"204\">Hamster IgG<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CD70-TAN-1-7\/\">Ab00816<\/a><\/td>\n<td width=\"151\">CD70<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CD70-TAN-1-7\/\">TAN 1-7<br \/>\n<\/a><\/td>\n<td width=\"204\">Rat IgG2a<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-cd70-tan1-6\/\">Ab01056<\/a><\/td>\n<td width=\"151\">CD70<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-cd70-tan1-6\/\">TAN1-6<br \/>\n<\/a><\/td>\n<td width=\"204\">Rat IgG2a<\/td>\n<\/tr>\n<tr>\n<td width=\"96\">Ab01028<\/td>\n<td width=\"151\">CD80 (B7-1)<\/td>\n<td width=\"105\">RM80<\/td>\n<td width=\"204\">Rat IgG2a<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-cd86-po-3\/\">Ab01029<\/a><\/td>\n<td width=\"151\">CD86 (B7-2)<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-cd86-po-3\/\">PO.3<\/a><\/td>\n<td width=\"204\">Rat IgG2b<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-cd153-rm153\/\">Ab01089<\/a><\/td>\n<td width=\"151\">CD153<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-cd153-rm153\/\">RM153<\/a><\/td>\n<td width=\"204\">Rat IgG2b<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-cd96-6a6\/\">Ab01297<\/a><\/td>\n<td width=\"151\">CD96<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-cd96-6a6\/\">6A6<\/a><\/td>\n<td width=\"204\">Rat IgG2a<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CTLA-4-9H10\/\">Ab00894<\/a><\/td>\n<td width=\"151\">CTLA-4<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CTLA-4-9H10\/\">9H10<\/a><\/td>\n<td width=\"204\">Hamster IgG2<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CTLA-4-9D9\/\">Ab01018<\/a><\/td>\n<td width=\"151\">CTLA-4<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-CTLA-4-9D9\/\">9D9<\/a><\/td>\n<td width=\"204\">Mouse IgG2b<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-galectin-9-rg9-35\/\">Ab01088<\/a><\/td>\n<td width=\"151\">GAL-9<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-galectin-9-rg9-35\/\">RG9-35<\/a><\/td>\n<td width=\"204\">Rat IgG2a<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-gitr-dta-1\/\">Ab01060<\/a><\/td>\n<td width=\"151\">GITR<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/product\/anti-gitr-dta-1\/\">DTA-1<\/a><\/td>\n<td width=\"204\">Rat IgG2a<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-GITR-YGITR-860-103-5\/\">Ab00374<\/a><\/td>\n<td width=\"151\">GITR<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-GITR-YGITR-860-103-5\/\">YGITR 860.103.5<\/a><\/td>\n<td width=\"204\">Rat IgG2b<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-GITR-YGITR765\/\">Ab00631<\/a><\/td>\n<td width=\"151\">GITR<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-GITR-YGITR765\/\">YGITR765<\/a><\/td>\n<td width=\"204\">Rat IgG2b<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-GITRL-YGL386\/\">Ab00630<\/a><\/td>\n<td width=\"151\">GITRL<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-GITRL-YGL386\/\">YGL386<\/a><\/td>\n<td width=\"204\">Rat IgG1<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-HVEM-HMHV-1B18\/\">Ab01026<\/a><\/td>\n<td width=\"151\">HVEM<\/td>\n<td width=\"105\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-HVEM-HMHV-1B18\/\">HMHV-1B18<\/a><\/td>\n<td width=\"204\">Hamster IgG<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-ICOS-7E-17G9\/\">Ab00814<\/a><\/td>\n<td width=\"151\">ICOS<\/td>\n<td width=\"105\"><a href=\"https:\/\/absolut\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u514d\u75ab\u7642\u6cd5\u7814\u7a76(Immunotherapy Research) \u6d3b\u9ad4\u7528\u91cd\u7d44\u6297\u9ad4-\u7814\u7a76\u7b49\u7d1a \u91dd\u5c0d\u6cbb\u7642\u7814\u7a76\uff0c\u6297\u86cb\u767d\u8cea [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":3519,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[1663],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23900"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23900"}],"version-history":[{"count":2,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23900\/revisions"}],"predecessor-version":[{"id":23906,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23900\/revisions\/23906"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/3519"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23900"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23900"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23900"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}