{"id":23898,"date":"2020-03-05T12:56:30","date_gmt":"2020-03-05T04:56:30","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=23898"},"modified":"2022-07-19T17:29:59","modified_gmt":"2022-07-19T09:29:59","slug":"sars-cov-neutralizing-hmabs%e4%b8%ad%e5%92%8c%e6%8a%97%e9%ab%94-anti-sars-cov-s-glycoprotein%e8%b2%a8%e8%99%9fab00263-23-0","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=23898","title":{"rendered":"Anti-SARS-CoV S glycoprotein\u8ca8\u865fAb00263-23.0"},"content":{"rendered":"<p>\u514d\u75ab\u7642\u6cd5\u7814\u7a76(Immunotherapy Research) \u6d3b\u9ad4\u7528\u91cd\u7d44\u6297\u9ad4-\u7814\u7a76\u7b49\u7d1a<\/p>\n<p>\u91dd\u5c0d\u6cbb\u7642\u7814\u7a76\uff0c\u6297\u86cb\u767d\u8cea\u7684\u6297\u9ad4\u53c3\u8207co-stimulation\u548c\u514d\u75ab\u7cfb\u7d71\u8abf\u7bc0(immune cell regulation)\u3002 \u6709\u4e9b\u9032\u5165\u81e8\u5e8a\u968e\u6bb5(clinic)\uff1b\u66f4\u591a\u90e8\u4efd\u4ecd\u8655\u65bc\u7814\u7a76\u968e\u6bb5\u3002\u514d\u75ab\u7d30\u80de\u4fe1\u865f\u50b3\u5c0e(immune cell signaling)\u7684\u8a31\u591a\u65b9\u9762\u4ecd\u7136\u672a\u77e5\uff0cAbsolute Antibody\u958b\u767c\u4e86\u91dd\u5c0d\u81e8\u5e8a\u76f8\u95dc\u86cb\u767d\u7684\u91cd\u7d44\u5de5\u7a0b\u6297\u9ad4\uff0c\u63d0\u4f9b\u4e00\u7cfb\u5217\u514d\u75ab\u7642\u6cd5\u7814\u7a76(Immunotherapy Research) \u6d3b\u9ad4\u7528\u91cd\u7d44\u6297\u9ad4\u3002<\/p>\n<ul>\n<li>Your favourite research tools, now updated through antibody engineering for improved performance\u00a0<em>in vivo<\/em><\/li>\n<li>Reduce immunogenicity by matching antibody species to your host organism<\/li>\n<li>Tailor effector function by choosing from our range of antibody isotypes and subtypes<\/li>\n<li>Explore new possibilities by combining two of these antibodies into a custom bispecific reagent<\/li>\n<\/ul>\n<p><span style=\"color: #00ccff;\"><a style=\"color: #00ccff;\" href=\"http:\/\/biopioneer.com.tw\/?p=23898\">\u00a0Anti-SARS-CoV S glycoprotein [S227], Rabbit IgG, Kappa\u8ca8\u865fAb00263-23.0<\/a><\/span><\/p>\n<p>Alternative Name(s) of Target: Severe Acute Respiratory Syndrome Coronavirus GP<\/p>\n<p>SARS-CoV\u4e2d\u548c\u578b\u6297\u9ad4hmAb(SARS-CoV-neutralizing hmAbs) \u53ef\u8207SARS-CoV S\u7cd6\u86cb\u767d\u7d50\u5408(SARS-CoV S glycoprotein)\uff0c\u4e26\u6291\u5236\u8a72\u7cd6\u86cb\u767d\u8207\u4ebaACE2\u7684\u7d50\u5408\u3002S227\u9032\u884c\u4e86\u9810\u9632\u6027\u6e2c\u8a66\uff0c\u5728\u611f\u67d3\u4e86\u81f4\u547d\u5291\u91cf\u7684SARS-CoV\uff08106 PFU\uff09<u>Urbani<\/u><u>\uff0c<\/u><u>GZ02<\/u><u>\u548c<\/u><u>HC \/ SZ \/ 61\/03 <\/u>\u768412\u500b\u6708\u5c0f\u9f20(olb BALB \/ c)\u4e2d\uff0c\u5206\u5225\u4ee510\u548c1 mg \/ kg\u7684\u5291\u91cf\u5c0dS227\u9032\u884c\u4e86\u9810\u9632\u6027\u6e2c\u8a66\u3002\u6240\u6709\u7d93S227\u8655\u7406\u7684\u52d5\u7269\u5747\u5728\u7b2c5\u5929\u6062\u5fa9\u3002SARS-CoV-neutralizing hmAbs, binds to SARS-CoV S glycoprotein, inhibiting the binding of the glycoprotein to human ACE2. S227 was tested prophylactically at 10 and 1 mg\/kg in 12-month-olb BALB\/c mice infected with a letal dose of SARS-CoV (106 PFU) Urbani, GZ02 and HC\/SZ\/61\/03. All animals treated with S227 recovered on day 5.<\/p>\n<p><strong>\u6297\u9ad4\u4ecb\u7d39:\u00a0<\/strong>\u5c0dSARS-CoV S glycoprotein\u5177\u7279\u7570\u6027 (Specificity)\u3002 \u514d\u75ab\u539f(Immunogen): \u7531SARS\u5eb7\u5fa9\u4e4b\u75c5\u4eba\u6c38\u751f\u8868\u9054IgG\u7684B\u7d30\u80de\u88fd\u6210\u3002\u6297\u9ad4\u7d93\u7531Protein A\u7d14\u5316\uff0c\u6eb6\u65bcPBS \u542b\u6709 0.02% Proclin 300\u3002\u6fc3\u5ea6\u70ba1 mg\/ml.<\/p>\n<p><strong>Antibody first published in:<\/strong>\u00a0Rockx B, Corti D, Donaldson E, Sheahan T, Stadler K, Lanzavecchia A, Baric R. Structural basis for potent cross-neutralizing human monoclonal antibody protection against lethal human and zoonotic Severe Acute Respiratory Syndrome CoronaVirus challenge. J Virol. 2008 Apr;82(7):3220-35. doi: 10.1128\/JVI.02377-07. Epub 2008 Jan 16.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18199635\">PMID:18199635<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&lt;<\/p>\n<table>\n<thead>\n<tr>\n<td width=\"96\">\u7522\u54c1\u8ca8\u865f<\/td>\n<td width=\"151\">Mouse target<\/td>\n<td width=\"105\">\u6297\u9ad4clone<\/td>\n<td width=\"204\">Original Antibody format<\/td>\n<\/tr>\n<tr>\n<td width=\"96\"><a href=\"https:\/\/absoluteantibody.com\/ab\/Anti-4-1BB-LOB12-3\/\">Ab01052<\/a><\/td>\n<td width=\"151\">4-1BB (CD137)<\/td>\n<\/tr>\n<\/thead>\n<\/table>\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u514d\u75ab\u7642\u6cd5\u7814\u7a76(Immunotherapy Research) \u6d3b\u9ad4\u7528\u91cd\u7d44\u6297\u9ad4-\u7814\u7a76\u7b49\u7d1a \u91dd\u5c0d\u6cbb\u7642\u7814\u7a76\uff0c\u6297\u86cb\u767d\u8cea [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":3519,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1664],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23898"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23898"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23898\/revisions"}],"predecessor-version":[{"id":23907,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23898\/revisions\/23907"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/3519"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23898"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23898"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23898"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}