{"id":23520,"date":"2020-02-07T11:07:37","date_gmt":"2020-02-07T03:07:37","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=23520"},"modified":"2022-07-19T17:34:40","modified_gmt":"2022-07-19T09:34:40","slug":"mk-1439-doravirine-cas-1338225-97-0-%e8%b2%a8%e8%99%9fb1250-25","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=23520","title":{"rendered":"MK-1439\/ Doravirine | CAS# 1338225-97-0 \u8ca8\u865fB1250-25"},"content":{"rendered":"

MK-1439\/ Doravirine\u00a0| CAS#<\/strong> 1338225-97-0 <\/strong>\u8ca8\u865f<\/strong>B1250-25<\/a><\/span><\/p>\n

\u7522\u54c1\u4ecb\u7d39: \u00a0MK-1439\uff08\u4e5f\u7a31\u70baDoravirine\uff09\u662f\u4e00\u7a2e\u4e0d\u53ef\u9006\u7684\u9006\u8f49\u9304\u9176\u6291\u5236\u5291(non-reversible reverse transcriptase inhibitor)\uff0c\u7528\u65bc\u6cbb\u7642HIV \/ AIDS\uff0c\u91dd\u5c0d\u91ce\u751f\u578b\uff08WT\uff09\uff0cK103N\u548cY181C\u9006\u8f49\u9304\u9176\u7684IC50\u503c\u70ba12\u30019.7\u548c9.7 nM\u3002 \uff08RT\uff09\u7a81\u8b8a\u9ad4\u3002 \u572895\uff05\u6709\u6548\u6fc3\u5ea6\u70ba20 nM\u7684\u689d\u4ef6\u4e0b\uff0c\u5b83\u5177\u6709\u51fa\u8272\u7684\u6291\u5236WT\u75c5\u6bd2\u8907\u88fd\u7684\u6d3b\u6027\u3002 \u5b83\u9084\u5c0d10\u7a2e\u4e0d\u540c\u7684HIV-1\u4e9e\u578b\u75c5\u6bd2\uff08\u5305\u62ecK103N\uff0cY81C\uff09\u5177\u6709\u6297\u75c5\u6bd2\u6d3b\u6027\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n\u00a03-Chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile; Doravirine<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nPale yellow solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n1338225-97-0<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2081\u2087H\u2081\u2081ClF\u2083N\u2085O\u2083<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n425.75<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nCN1C(=NNC1=O)CN2C=CC(=C(C2=O)OC3=CC(=CC(=C3)C#N)Cl)C(F)(F)F<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C17H11ClF3N5O3\/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11\/h2-6H,8H2,1H3,(H,24,28)<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nZIAOVIPSKUPPQW-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n58460047<\/a><\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nProtect from air and light<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n
USAGE<\/strong><\/td>\nFor Research Use Only! Not For Use in Humans.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

MK-1439\/ Doravirine\u00a0| CAS# 1338225-97-0 \u8ca8\u865fB1250-25 \u7522\u54c1\u4ecb\u7d39 […]<\/p>\n","protected":false},"author":3,"featured_media":23521,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486],"tags":[1700],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23520"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23520"}],"version-history":[{"count":1,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23520\/revisions"}],"predecessor-version":[{"id":23522,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23520\/revisions\/23522"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/23521"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23520"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}