{"id":23133,"date":"2020-01-16T17:05:00","date_gmt":"2020-01-16T09:05:00","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=23133"},"modified":"2022-07-19T17:39:03","modified_gmt":"2022-07-19T09:39:03","slug":"brd2-bromodomain%e9%87%8d%e7%b5%84%e8%9b%8b%e7%99%bd-%e8%b2%a8%e8%99%9f7406-100","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=23133","title":{"rendered":"BRD2 bromodomain\u91cd\u7d44\u86cb\u767d | \u8ca8\u865f7406-100"},"content":{"rendered":"

BRD2 bromodomain\u91cd\u7d44\u86cb\u767d | <\/strong>\u8ca8\u865f<\/strong>7406-100<\/a><\/span><\/p>\n

BRD2 bromodomain (1-455 aa) (His-Tag), human recombinant<\/p>\n

\u7522\u54c1\u4ecb\u7d39: \u7d44\u86cb\u767d\u8cf4\u6c28\u9178\u6b98\u57fa(histone lysine residues)\u7684\u4e59\u9170\u5316(acetylation)\u5728\u57fa\u56e0\u8f49\u9304\u7684\u8868\u89c0\u907a\u50b3\u8abf\u63a7\u4e2d\u8d77\u95dc\u9375\u4f5c\u7528\u3002\u6eb4\u7d50\u69cb\u57df(bromodomain)\u662f\u8b58\u5225\u4e59\u9170\u5316\u8cf4\u6c28\u9178\u6b98\u57fa(acetylated lysine residues) \uff08\u4f8b\u5982\u7d44\u86cb\u767dN\u672b\u7aef\u5c3e\u5df4\u4e0a\u7684\u6b98\u57fa\uff09\u7684\u86cb\u767d\u8cea\u7d50\u69cb\u57df\u3002\u9019\u7a2e\u8b58\u5225\u901a\u5e38\u662f\u86cb\u767d\u8cea-\u7d44\u86cb\u767d\u7de0\u5408(protein-histone association)\u548c\u67d3\u8272\u8cea\u91cd\u5851(chromatin remodeling)\u7684\u5148\u6c7a\u689d\u4ef6\u3002\u9019\u4e9b\u57df\u5728\u86cb\u767d\u8cea\u8907\u5408\u7269(protein complexes )\u8207\u4e59\u9170\u5316\u6838\u5c0f\u9ad4\u7684\u9023\u63a5\u4e2d\u8d77\u4f5c\u7528\uff0c\u5f9e\u800c\u63a7\u5236\u67d3\u8272\u8cea\u7d50\u69cb(chromatin structure)\u548c\u57fa\u56e0\u8868\u9054(gene expression)\u3002\u56e0\u6b64\uff0c\u6eb4\u7d50\u69cb\u57df(bromodomains)\u5145\u7576\u7d44\u86cb\u767d\u4e59\u9170\u5316\u6a19\u8a18\u7684\u201creaders\u201d\uff0c\u5176\u8abf\u7bc0\u9776\u6a19\u555f\u52d5\u5b50\u7684\u8f49\u9304\u3002\u7531\u4e32\u806f(Bromodomains)\u548c(Extra Terminal)\u57df\u5b9a\u7fa9\u7684BET\u86cb\u767d\u5bb6\u65cf\u5305\u62ecBRD2\uff0cBRD3\uff0cBRD4\u548cBRDT\u3002 BET\u86cb\u767d\u5728\u8a31\u591a\u7d30\u80de\u904e\u7a0b\u4e2d\u8d77\u95dc\u9375\u4f5c\u7528\uff0c\u5305\u62ec\u708e\u6027\u57fa\u56e0\u8868\u9054(inflammatory gene expression)\uff0c\u6709\u7d72\u5206\u88c2(mitosis)\u548c\u75c5\u6bd2\/\u5bbf\u4e3b\u76f8\u4e92\u4f5c\u7528(viral\/host interactions)\u3002 BRD2\u548cBRD4\u7684\u5206\u96e2\u7684\u55ae\u500b\u6216\u4e32\u806f\u6eb4\u7d50\u69cb\u57df\u5df2\u986f\u793a\u8207\u4e59\u9170\u5316\u7684\u7d44\u86cb\u767d\u5c3e\u5df4\u7d50\u5408\uff0c\u53ef\u5c07\u7d44\u86cb\u767d\u7684\u4e59\u9170\u5316\u6a19\u8a18\u8207\u9776\u6a19\u555f\u52d5\u5b50\u7684\u8f49\u9304\u8abf\u63a7\u76f8\u7d50\u5408\u3002\u9019\u4e9b\u76f8\u4e92\u4f5c\u7528\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5291\u6709\u671b\u4f5c\u70ba\u4eba\u985e\u75be\u75c5\u7684\u6709\u7528\u7642\u6cd5\u3002\u8a72\u86cb\u767d\u53ef\u7528\u65bc\u7814\u7a76\u6eb4\u7d50\u69cb\u57df\u7d50\u5408\u6e2c\u5b9a\uff0c\u7be9\u9078\u6291\u5236\u5291\u548c\u9078\u64c7\u6027\u5206\u6790\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Cat # +Size<\/strong><\/td>\n7406-100<\/td>\n<\/tr>\n
Size<\/strong><\/td>\n100 \u03bcg<\/td>\n<\/tr>\n
Alternate Name<\/strong><\/td>\nRING3, RNF3, Bromodomain containing 4, D6S113E, FSH, FSRG1, NAT, RING3, RNF3<\/td>\n<\/tr>\n
Gene Symbol<\/strong><\/td>\nBRD2<\/td>\n<\/tr>\n
Gene ID<\/strong><\/td>\n6046<\/td>\n<\/tr>\n
Accession #<\/strong><\/td>\nP25440<\/td>\n<\/tr>\n
Source<\/strong><\/td>\nE. coli<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nLiquid<\/td>\n<\/tr>\n
Physical Form Description<\/strong><\/td>\n1 mg\/ml in Phosphate buffer saline (pH 7.4) containing 10% glycerol and 1 mM DTT.<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n52.8 kDa (478 aa, 1-455 aa + His Tag), confirmed by MALDI-TOF.<\/td>\n<\/tr>\n
Purity by SDS-PAGE<\/strong><\/td>\n\u226590%<\/td>\n<\/tr>\n
Amino Acid Sequence<\/strong><\/td>\nMGSSHHHHHH SSGLVPRGSH MGSMLQNVTP HNKLPGEGNA GLLGLGPEAA APGKRIRKPS LLYEGFESPT MASVPALQLT PANPPPPEVS NPKKPGRVTN QLQYLHKVVM KALWKHQFAW PFRQPVDAVK LGLPDYHKII KQPMDMGTIK RRLENNYYWA ASECMQDFNT MFTNCYIYNK PTDDIVLMAQ TLEKIFLQKV ASMPQEEQEL VVTIPKNSHK KGAKLAALQG SV<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nCentrifuge the vial prior to opening.<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-80\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nDry Ice<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

BRD2 bromodomain\u91cd\u7d44\u86cb\u767d | \u8ca8\u865f7406-100 BRD2 bromodomain (1-4 […]<\/p>\n","protected":false},"author":3,"featured_media":459,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1725],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23133"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23133"}],"version-history":[{"count":1,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23133\/revisions"}],"predecessor-version":[{"id":23134,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/23133\/revisions\/23134"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/459"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23133"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23133"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}