{"id":22960,"date":"2020-01-13T15:43:10","date_gmt":"2020-01-13T07:43:10","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=22960"},"modified":"2022-07-19T17:41:28","modified_gmt":"2022-07-19T09:41:28","slug":"brca2-%e6%8a%97%e9%ab%94-tumor-suppressor%e8%b2%a8%e8%99%9f3675","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=22960","title":{"rendered":"BRCA2 \u6297\u9ad4 | tumor suppressor\u8ca8\u865f3675"},"content":{"rendered":"

BRCA2 \u6297\u9ad4 | tumor suppressor<\/strong>\u8ca8\u865f<\/strong>3675<\/a><\/span><\/p>\n

\u7522\u54c1\u4ecb\u7d39: BRCA 1\u548c2\u662f\u4e73\u817a\u764c\u6613\u611f\u6027\u86cb\u767d(breast cancer susceptibility proteins)\uff0c\u5728DNA\u640d\u50b7(DNA damage)\uff0c\u4fee\u5fa9(repair)\uff0c\u7d30\u80de\u9031\u671f\u9032\u7a0b(cell cycle progression)\uff0c\u8f49\u9304(transcription)\u548c\u7d30\u80de\u51cb\u4ea1(apoptosis)\u7b49\u904e\u7a0b\u4e2d\u767c\u63ee\u4f5c\u7528\u3002BRCA1\u57fa\u56e0\u5728\u8a31\u591a\u7d44\u7e54\uff08\u5305\u62ec\u4e73\u623f\u548c\u5375\u5de2\uff09\u4e2d\u8868\u9054\uff0c\u7de8\u78bc\u7684\u9810\u6e2c\u86cb\u767d\u70ba1863\u6c28\u57fa\u9178\u3002\u5df2\u986f\u793aBRCA2\u662fRad51\u00a0 localization\u00a0 DSBs\uff08\u96d9\u93c8\u65b7\u88c2, double stranded breaks\uff09\u4f4d\u9ede\u6240\u5fc5\u9700\u7684\u3002\u7f3a\u5c11BRCA1\u548cBRCA2\u7684\u7d30\u80de\u7121\u6cd5\u901a\u904eRad51\u4f9d\u8cf4\u6027\u904e\u7a0b\u4fee\u5fa9DSB\uff08\u96d9\u93c8\u65b7\u88c2\u00a0 double stranded breaks\uff09\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Antibody Target<\/strong><\/td>\nBRCA2<\/td>\n<\/tr>\n
Host<\/strong><\/td>\nRabbit<\/td>\n<\/tr>\n
Antibody Type<\/strong><\/td>\nPolyclonal<\/td>\n<\/tr>\n
Isotype<\/strong><\/td>\nRabbit IgG<\/td>\n<\/tr>\n
Immunogen<\/strong><\/td>\nSynthetic peptide mapping to the N-terminus of human BRCA2<\/td>\n<\/tr>\n
Accession #<\/strong><\/td>\nP51587<\/td>\n<\/tr>\n
Gene ID<\/strong><\/td>\n675<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nColorless liquid<\/td>\n<\/tr>\n
Concentration<\/strong><\/td>\n0.5 mg\/ml<\/td>\n<\/tr>\n
Formulation<\/strong><\/td>\n0.5 mg\/ml in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin<\/td>\n<\/tr>\n
Purification<\/strong><\/td>\nAffinity purified<\/td>\n<\/tr>\n
Species Reactivity<\/strong><\/td>\nHuman, mouse<\/td>\n<\/tr>\n
Application<\/strong><\/td>\nWestern blot<\/td>\n<\/tr>\n
Application & Usage<\/strong><\/td>\nWestern blotting (0.5-4 \u00b5g\/ml). However, the optimal conditions should be determined individually. HeLa cell lysate can be used as a positive control.<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nThe antibody solution should be gently mixed before use.<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20 \u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Olaparib (PARP\u6291\u5236\u5291)<\/a>\u00a0|\u00a0Rucapar (PARP\u6291\u5236\u5291)\u00a0<\/a>|\u00a0Tosylate<\/a>\u00a0|\u00a0Talazoparib<\/a>\u00a0|\u00a0PARP1 (Human) ELISA Kit<\/a>\u00a0|BRCA1 \u6297\u9ad4\u00a0<\/a>\u00a0|BRCA2 \u6297\u9ad4<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

BRCA2 \u6297\u9ad4 | tumor suppressor\u8ca8\u865f3675 \u7522\u54c1\u4ecb\u7d39: BRCA 1\u548c2\u662f\u4e73\u817a\u764c\u6613\u611f\u6027 […]<\/p>\n","protected":false},"author":3,"featured_media":22964,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[136,3],"tags":[1734],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22960"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22960"}],"version-history":[{"count":2,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22960\/revisions"}],"predecessor-version":[{"id":22968,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22960\/revisions\/22968"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/22964"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22960"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22960"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22960"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}