{"id":22953,"date":"2020-01-13T15:30:39","date_gmt":"2020-01-13T07:30:39","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=22953"},"modified":"2022-07-19T17:41:35","modified_gmt":"2022-07-19T09:41:35","slug":"brca1-%e6%8a%97%e9%ab%94-tumor-suppressor%e8%b2%a8%e8%99%9f3364","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=22953","title":{"rendered":"BRCA1 \u6297\u9ad4 | tumor suppressor\u8ca8\u865f3364"},"content":{"rendered":"

BRCA1 \u6297\u9ad4 | tumor suppressor<\/strong>\u8ca8\u865f<\/strong>3364<\/a><\/span><\/p>\n

\u7522\u54c1\u4ecb\u7d39: BRCA1\u662f\u4e73\u817a\u764c\u6613\u611f\u57fa\u56e0(breast cancer susceptibility gene)\uff0c\u4f4d\u65bc\u67d3\u8272\u9ad417q(chromosome 17q)\u3002\u8a72\u57fa\u56e0\u5167\u7684\u7a81\u8b8a\u7d04\u4f54\u4e73\u817a\u764c(breast cancer) \u9ad8\u767c\u5bb6\u5ead\u7684\u7d0445\uff05\uff0c\u4e26\u4e14\u81f3\u5c11\u4f54\u65e9\u767c\u4e73\u817a\u764c(early-onset breast cancer)\u548c\u5375\u5de2\u764c(ovarian cancer.)\u767c\u75c5\u7387\u7684\u5bb6\u5ead\u768480\uff05\u3002 BRCA1\u57fa\u56e0\u5728\u5305\u62ec\u4e73\u623f\u548c\u5375\u5de2\u5728\u5167\u7684\u8a31\u591a\u7d44\u7e54\u4e2d\u8868\u9054\uff0c\u4e26\u7de8\u78bc1863\u500b\u6c28\u57fa\u9178\u7684\u9810\u6e2c\u86cb\u767d\u3002\u50cf\u8a31\u591a\u5176\u4ed6\u8207\u5bb6\u65cf\u6027\u764c\u75c7\u6709\u95dc\u7684\u57fa\u56e0\u4e00\u6a23\uff0cBRCA1\u4f3c\u4e4e\u7de8\u78bc\u4e00\u7a2e\u6291\u764c\u57fa\u56e0(tumor suppressor)\uff0c\u4e00\u7a2e\u6291\u5236\u816b\u7624\u751f\u9577\u7684\u86cb\u767d\u8cea\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Antibody Target<\/strong><\/td>\nBRCA1<\/td>\n<\/tr>\n
Host<\/strong><\/td>\nRabbit<\/td>\n<\/tr>\n
Antibody Type<\/strong><\/td>\nPolyclonal<\/td>\n<\/tr>\n
Isotype<\/strong><\/td>\nRabbit IgG<\/td>\n<\/tr>\n
Immunogen<\/strong><\/td>\nSynthetic peptide surrounding amino acid 1852 of human BRCA1<\/td>\n<\/tr>\n
Accession #<\/strong><\/td>\nP38398<\/td>\n<\/tr>\n
Gene ID<\/strong><\/td>\n672<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nColorless liquid<\/td>\n<\/tr>\n
Concentration<\/strong><\/td>\n0.2 mg\/ml<\/td>\n<\/tr>\n
Formulation<\/strong><\/td>\n0.5mg\/ml in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin.<\/td>\n<\/tr>\n
Purification<\/strong><\/td>\nAffinity purified<\/td>\n<\/tr>\n
Species Reactivity<\/strong><\/td>\nHuman, mouse, rat<\/td>\n<\/tr>\n
Application<\/strong><\/td>\nWestern blot, Immunoprecipitation, Immunohistochemistry<\/td>\n<\/tr>\n
Application & Usage<\/strong><\/td>\nWestern blotting (1-4 \u00b5g\/ml), immunoprecipitation (10-20 \u00b5g\/ml), and Immunohistochemistry (10-20 \u00b5g\/ml). However, the optimal conditions should be determined individually.<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nThe antibody solution should be gently mixed before use.<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20 \u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Olaparib (PARP\u6291\u5236\u5291)<\/a>\u00a0|\u00a0Rucapar (PARP\u6291\u5236\u5291)\u00a0<\/a>|\u00a0Tosylate<\/a>\u00a0|\u00a0Talazoparib<\/a>\u00a0|\u00a0PARP1 (Human) ELISA Kit<\/a>\u00a0|BRCA1 \u6297\u9ad4\u00a0<\/a>\u00a0|BRCA2 \u6297\u9ad4<\/a><\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

BRCA1 \u6297\u9ad4 | tumor suppressor\u8ca8\u865f3364 \u7522\u54c1\u4ecb\u7d39: BRCA1\u662f\u4e73\u817a\u764c\u6613\u611f\u57fa\u56e0(b […]<\/p>\n","protected":false},"author":3,"featured_media":22954,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[136,3],"tags":[1735],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22953"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22953"}],"version-history":[{"count":2,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22953\/revisions"}],"predecessor-version":[{"id":22969,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22953\/revisions\/22969"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/22954"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22953"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22953"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22953"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}