{"id":22945,"date":"2020-01-13T15:02:35","date_gmt":"2020-01-13T07:02:35","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=22945"},"modified":"2022-07-19T17:41:44","modified_gmt":"2022-07-19T09:41:44","slug":"bmn-673-talazoparib-cas-1207456-01-6%e8%b2%a8%e8%99%9fb1861","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=22945","title":{"rendered":"BMN-673 (Talazoparib) | CAS # 1207456-01-6\u8ca8\u865fB1861"},"content":{"rendered":"

BMN-673 (Talazoparib) (PARP\u6291\u5236\u5291) | CAS #<\/strong> 1207456-01-6<\/a><\/span>\u8ca8\u865f<\/strong>B1861<\/p>\n

A potent and selective PARP1\/2 inhibitor<\/em><\/strong><\/p>\n

\u7522\u54c1\u4ecb\u7d39: BMN-673 (Talazoparib)\u662f\u4e00\u7a2e\u6709\u6548\u7684\u9078\u64c7\u6027PARP1 \/ 2\u6291\u5236\u5291(PARP1\/2 inhibitor)\uff0cKi\u503c\u5206\u5225\u70ba1.2\u548c0.9 nM\u3002\u5b83\u5c0d72\u7a2e\u53d7\u9ad4 (72 receptors)\uff0c\u96e2\u5b50\u901a\u9053(ion channels)\u548c\u9176(enzymes)\u7684\u7d44\u6210\u6c92\u6709\u5f71\u97ff\u3002 BMN-673\u986f\u793a\u51fa\u9078\u64c7\u6027\u7684\u6297\u816b\u7624\u7d30\u80de\u6bd2\u6027(antitumor cytotoxicity)\uff0c\u4e26\u4ee5\u6bd4\u65e9\u5148\u7684PARP1 \/ 2\u6291\u5236\u5291(PARP1\/2 inhibitors)\u4f4e\u5f97\u591a\u7684\u6fc3\u5ea6\u5f15\u767cDNA\u4fee\u5fa9\u751f\u7269\u6a19\u8a8c\u7269(DNA repair biomarkers)\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n(8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-1H-pyrido[4,3,2-de]phthalazin-3(2H)-one; Talazoparib<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nCrystalline solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n1207456-01-6<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2081\u2089H\u2081\u2084F\u2082N\u2086O<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n380.35<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO (>15 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nCN1C(=NC=N1)C2C(N=C3C=C(C=C4C3=C2NNC4=O)F)C5=CC=C(C=C5)F<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C19H14F2N6O\/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28\/h2-8,15-16,25H,1H3,(H,26,28)<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nIUEWAGVJRJORLA-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n53345055<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nProtect from air and light<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n
USAGE<\/strong><\/td>\nFor Research Use Only! Not For Use in Humans.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Olaparib (PARP\u6291\u5236\u5291)<\/a>\u00a0|\u00a0Rucapar (PARP\u6291\u5236\u5291)\u00a0<\/a>|\u00a0Tosylate<\/a>\u00a0|\u00a0Talazoparib<\/a>\u00a0|\u00a0PARP1 (Human) ELISA Kit<\/a>\u00a0|BRCA1 \u6297\u9ad4\u00a0<\/a>\u00a0|BRCA2 \u6297\u9ad4<\/a><\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

BMN-673 (Talazoparib) (PARP\u6291\u5236\u5291) | CAS # 1207456-01-6\u8ca8\u865fB […]<\/p>\n","protected":false},"author":3,"featured_media":22946,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486],"tags":[1736],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22945"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22945"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22945\/revisions"}],"predecessor-version":[{"id":22967,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22945\/revisions\/22967"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/22946"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22945"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22945"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22945"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}