{"id":22940,"date":"2020-01-13T14:52:58","date_gmt":"2020-01-13T06:52:58","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=22940"},"modified":"2022-07-19T17:41:53","modified_gmt":"2022-07-19T09:41:53","slug":"mk-4827-tosylate-parp%e6%8a%91%e5%88%b6%e5%8a%91-cas-1038915-73-9%e8%b2%a8%e8%99%9fb2003","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=22940","title":{"rendered":"MK-4827 (Tosylate) (PARP\u6291\u5236\u5291) | CAS #1038915-73-9\u8ca8\u865fB2003"},"content":{"rendered":"

MK-4827 (Tosylate) (PARP\u6291\u5236\u5291) | CAS #<\/strong>1038915-73-9\u8ca8\u865f<\/strong>B2003<\/a><\/span><\/p>\n

A selective PARP-1 and PARP-2 inhibitor<\/p>\n

\u7522\u54c1\u4ecb\u7d39: MK-4827\u662f\u4e00\u7a2e\u6709\u6548\u7684\u9078\u64c7\u6027PARP-1\u548cPARP-2\u6291\u5236\u5291\uff0cIC 50\u503c\u5206\u5225\u70ba3.8 nM\u548c2.1 nM\u3002\u5b83\u5728\u81e8\u5e8a\u524d\u816b\u7624\u6a21\u578b\u4e2dBRCA\u548cPTEN\u529f\u80fd\u55aa\u5931\u3002\u8a98\u5c0e\u5408\u6210\u81f4\u6b7b\u6027(synthetic lethality) \u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n(3S)-3-[4-[7-(Aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidine Tosylate; MK-4827 Tosylate; Niraparib tosylate<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nOff-white to pale yellow solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n1038915-73-9<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2081\u2089H\u2082\u2080N\u2084O \u2022C\u2087H\u2088O\u2083S<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n492.6<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO (~25 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nCC1=CC=C(C=C1)S(=O)(=O)O.C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C19H20N4O.C7H8O3S\/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14;1-6-2-4-7(5-3-6)11(8,9)10\/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);2-5H,1H3,(H,8,9,10)\/t14-;\/m1.\/s1<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nLCPFHXWLJMNKNC-PFEQFJNWSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n78357761<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nProtect from air and light<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n
USAGE<\/strong><\/td>\nFor Research Use Only! Not For Use in Humans.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Olaparib (PARP\u6291\u5236\u5291)<\/a>\u00a0|\u00a0Rucapar (PARP\u6291\u5236\u5291)\u00a0<\/a>|\u00a0Tosylate<\/a>\u00a0|\u00a0Talazoparib<\/a>\u00a0|\u00a0PARP1 (Human) ELISA Kit<\/a>\u00a0|BRCA1 \u6297\u9ad4\u00a0<\/a>\u00a0|BRCA2 \u6297\u9ad4<\/a><\/p>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

MK-4827 (Tosylate) (PARP\u6291\u5236\u5291) | CAS #1038915-73-9\u8ca8\u865fB2003 […]<\/p>\n","protected":false},"author":3,"featured_media":22941,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486],"tags":[1737],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22940"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22940"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22940\/revisions"}],"predecessor-version":[{"id":22970,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22940\/revisions\/22970"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/22941"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22940"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}