{"id":22936,"date":"2020-01-13T14:43:48","date_gmt":"2020-01-13T06:43:48","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=22936"},"modified":"2022-07-19T17:42:01","modified_gmt":"2022-07-19T09:42:01","slug":"ag-014699-phosphate-rucapar-parp%e6%8a%91%e5%88%b6%e5%8a%91-cas459868-92-9%e8%b2%a8%e8%99%9f2890","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=22936","title":{"rendered":"AG-014699 phosphate\/ Rucapar (PARP\u6291\u5236\u5291) | CAS#459868-92-9\u8ca8\u865f2890"},"content":{"rendered":"

AG-014699 phosphate\/ Rucapar (PARP\u6291\u5236\u5291) |\u00a0\u8ca8\u865f<\/strong>2890<\/a><\/span><\/p>\n

A potent PARP1 inhibitor<\/em><\/strong><\/p>\n

\u7522\u54c1\u4ecb\u7d39: AG-014699\u78f7\u9178\u9e7d (AG-014699 phosphate)\u662f\u4e00\u7a2e\u6709\u6548\u7684PARP1\u7d30\u80de\u6ef2\u900f\u6291\u5236\u5291(cell-permeable inhibitor)\uff0cKi\u70ba1.4 nM\u3002\u5b83\u9078\u64c7\u6027\u5730\u8207PARP 1\u7d50\u5408\u4f75\u6291\u5236PARP1\u4ecb\u5c0e\u7684DNA\u4fee\u5fa9\uff0c\u5f9e\u800c\u589e\u5f37\u4e86\u57fa\u56e0\u7d44\u7684\u4e0d\u7a69\u5b9a\u6027\u548c\u7d30\u80de\u51cb\u4ea1\u3002\u986f\u793a\u6297\u816b\u7624\u6d3b\u6027(antineoplastic activity)\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate; Rucaparib;\u00a0PF-01367338<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nLight yellow to yellow solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n459868-92-9<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2081\u2089H\u2082\u2081FN\u2083O\u2085P<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n421.36<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO (~20 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nCNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F.OP(=O)(O)O<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C19H18FN3O.H3O4P\/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15;1-5(2,3)4\/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24);(H3,1,2,3,4)<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nFCCGJTKEKXUBFZ-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n9931953<\/a><\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nProtect from air and moisture<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Olaparib (PARP\u6291\u5236\u5291)<\/a>\u00a0|\u00a0Rucapar (PARP\u6291\u5236\u5291)\u00a0<\/a>|\u00a0Tosylate<\/a>\u00a0|\u00a0Talazoparib<\/a>\u00a0|\u00a0PARP1 (Human) ELISA Kit<\/a>\u00a0|BRCA1 \u6297\u9ad4\u00a0<\/a>\u00a0|BRCA2 \u6297\u9ad4<\/a><\/p>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

AG-014699 phosphate\/ Rucapar (PARP\u6291\u5236\u5291) |\u00a0\u8ca8\u865f2890 A poten […]<\/p>\n","protected":false},"author":3,"featured_media":22937,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486],"tags":[1738],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22936"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22936"}],"version-history":[{"count":2,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22936\/revisions"}],"predecessor-version":[{"id":22971,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22936\/revisions\/22971"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/22937"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22936"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22936"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22936"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}