{"id":22930,"date":"2020-01-13T13:58:01","date_gmt":"2020-01-13T05:58:01","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=22930"},"modified":"2023-03-10T09:53:30","modified_gmt":"2023-03-10T01:53:30","slug":"olaparibparp%e6%8a%91%e5%88%b6%e5%8a%91cas763113-22-0-%e8%b2%a8%e8%99%9f1952","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=22930","title":{"rendered":"Olaparib\/PARP\u6291\u5236\u5291|CAS#763113-22-0 \u8ca8\u865f1952"},"content":{"rendered":"

Olaparib (PARP\u6291\u5236\u5291) | CAS#763113-22-0\u00a0\u8ca8\u865f<\/strong>1952<\/a><\/span><\/p>\n

A highly potent and selective PARP-inhibitor<\/p>\n

\u7522\u54c1\u4ecb\u7d39:<\/span> <\/strong><\/span>Olaparib\u70ba\u7d30\u80de\u53ef\u6ef2\u900f(Cell-permeable)\uff0c\u4e00\u7a2e\u9ad8\u6548\u4e14\u9078\u64c7\u6027\u7684PARP\u6291\u5236\u5291 (selective PARP-inhibitor)\uff0c\u5c0d\u65bcPARP-1\u548cPARP-2\uff0cIC\u2085\u2080\u503c\u5206\u5225\u70ba5 nM\u548c1 nM\u3002 Olaparib\u5728\u7f3a\u4e4fBRCA-1\u7684\u4e73\u817a\u764c\u7d30\u80de\u4e2d\u986f\u793a\u51fa\u7368\u7acb\u7684\u6d3b\u6027\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n4-(3-(4-(cycloprppanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazine-1(2H)-one; ADZ-2281; KU-59436<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nWhite to off-white solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n763113-22-0<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2082\u2084H\u2082\u2083FN\u2084O\u2083<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n434.46<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO (~33 mg\/ml) or EtOH (~ 1.7 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nC1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C24H23FN4O3\/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16\/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nFDLYAMZZIXQODN-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n23725625<\/a><\/td>\n<\/tr>\n
MDL Number<\/strong><\/td>\nMFCD13185161<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nProtect from light and air<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00b0C<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Olaparib (PARP\u6291\u5236\u5291)<\/a>\u00a0|\u00a0Rucapar (PARP\u6291\u5236\u5291)\u00a0<\/a>|\u00a0Tosylate<\/a>\u00a0|\u00a0Talazoparib<\/a>\u00a0|\u00a0PARP1 (Human) ELISA Kit<\/a>\u00a0|BRCA1 \u6297\u9ad4\u00a0<\/a>\u00a0|BRCA2 \u6297\u9ad4<\/a><\/span><\/p>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Olaparib (PARP\u6291\u5236\u5291) | CAS#763113-22-0\u00a0\u8ca8\u865f1952 A highly po […]<\/p>\n","protected":false},"author":3,"featured_media":22931,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486],"tags":[1739],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22930"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22930"}],"version-history":[{"count":4,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22930\/revisions"}],"predecessor-version":[{"id":39763,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22930\/revisions\/39763"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/22931"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22930"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22930"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}