{"id":22885,"date":"2020-01-07T16:44:47","date_gmt":"2020-01-07T08:44:47","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=22885"},"modified":"2022-07-19T17:43:44","modified_gmt":"2022-07-19T09:43:44","slug":"carbamazepine-%e8%b2%a8%e8%99%9fb2401","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=22885","title":{"rendered":"Carbamazepine | \u8ca8\u865fB2401"},"content":{"rendered":"<p><span style=\"color: #00ccff;\"><a style=\"color: #00ccff;\" href=\"http:\/\/biopioneer.com.tw\/?p=22885\">Carbamazepine<strong style=\"color: #00ccff;\"> | <\/strong><\/a><strong style=\"color: #00ccff;\"><a style=\"color: #00ccff;\" href=\"http:\/\/biopioneer.com.tw\/?p=22885\">\u8ca8\u865fB<\/a>2401<\/strong><\/span><\/p>\n<p>Inhibitor of neuronal NaV channels<\/p>\n<p>\u7522\u54c1\u4ecb\u7d39: \u5361\u99ac\u897f\u5e73(Carbamazepine)\u662f\u795e\u7d93\u5143\u96fb\u58d3\u9580\u63a7Na +\u901a\u9053(neuronal voltage-gated Na+ channels)\u7684inhibitor\u3002\u5b83\u986f\u793a\u6297\u7672\u7647\u6d3b\u6027(anticonvulsant activity)\uff0c\u4e26\u5728\u8868\u9054GABAA\u53d7\u9ad4\u03b11\u03b22\u03b32\u4e9e\u578b\u7d44\u5408\u7684HEK 293\u7d30\u80de\u4e2d\u589e\u5f37GABA\u8a98\u5c0e\u7684Cl\u96fb\u6d41\u3002\u53ef\u4ee5\u901a\u904e\u6291\u5236\u808c\u9187\u5408\u6210(inositol synthesis)\u4f86\u8a98\u5c0e\u81ea\u566c(autophagy)\u3002\u4e5f\u53ef\u4f5c\u70baCYP3A4\u7684\u9ad4\u5916\u8a98\u5c0e\u5291(in vitro inducer)\uff0cCYP3A4\u662f\u809d\u81df\u548c\u8178\u9053\u4e2d\u4e3b\u8981\u7684\u4eba\u9ad4\u4ee3\u8b1d\u9176(metabolizing enzyme)\u3002<\/p>\n<table width=\"838\">\n<tbody>\n<tr>\n<td><strong>Alternate Name<\/strong><\/td>\n<td>5H-Dibenz[b,f]azepine-5-carboxamide, CBZ<\/td>\n<\/tr>\n<tr>\n<td><strong>Appearance<\/strong><\/td>\n<td>White solid<\/td>\n<\/tr>\n<tr>\n<td><strong>CAS #<\/strong><\/td>\n<td>298-46-4<\/td>\n<\/tr>\n<tr>\n<td><strong>Molecular Formula<\/strong><\/td>\n<td>C\u2081\u2085H\u2081\u2082N\u2082O<\/td>\n<\/tr>\n<tr>\n<td><strong>Molecular Weight<\/strong><\/td>\n<td>236.27<\/td>\n<\/tr>\n<tr>\n<td><strong>Purity<\/strong><\/td>\n<td>\u226598% by HPLC<\/td>\n<\/tr>\n<tr>\n<td><strong>Solubility<\/strong><\/td>\n<td>&gt;20 mg\/ml in DMSO<\/td>\n<\/tr>\n<tr>\n<td><strong>SMILES<\/strong><\/td>\n<td>C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N<\/td>\n<\/tr>\n<tr>\n<td><strong>InChi<\/strong><\/td>\n<td>InChI=1S\/C15H12N2O\/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17\/h1-10H,(H2,16,18)<\/td>\n<\/tr>\n<tr>\n<td><strong>InChi Key<\/strong><\/td>\n<td>FFGPTBGBLSHEPO-UHFFFAOYSA-N<\/td>\n<\/tr>\n<tr>\n<td><strong>PubChem CID<\/strong><\/td>\n<td>2554<\/td>\n<\/tr>\n<tr>\n<td><strong>MDL Number<\/strong><\/td>\n<td>MFCD00005073<\/td>\n<\/tr>\n<tr>\n<td><strong>Handling<\/strong><\/td>\n<td>Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.<\/td>\n<\/tr>\n<tr>\n<td><strong>Storage Conditions<\/strong><\/td>\n<td>-20\u00baC<\/td>\n<\/tr>\n<tr>\n<td><strong>Shipping Conditions<\/strong><\/td>\n<td>Gel Pack<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Carbamazepine | \u8ca8\u865fB2401 Inhibitor of neuronal NaV chann [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":22886,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1750],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22885"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22885"}],"version-history":[{"count":1,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22885\/revisions"}],"predecessor-version":[{"id":22887,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22885\/revisions\/22887"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/22886"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22885"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}