{"id":22610,"date":"2019-12-13T13:16:05","date_gmt":"2019-12-13T05:16:05","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=22610"},"modified":"2022-07-19T17:51:19","modified_gmt":"2022-07-19T09:51:19","slug":"zanubrutinib-btk%e6%8a%91%e5%88%b6%e5%8a%91-%e8%b2%a8%e8%99%9fb2512-1","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=22610","title":{"rendered":"Zanubrutinib |Btk\u6291\u5236\u5291 \u8ca8\u865fB2512-1"},"content":{"rendered":"

Zanubrutinib | <\/strong>\u8ca8\u865f<\/strong>B2512-1<\/a><\/span><\/p>\n

\u7522\u54c1\u4ecb\u7d39: \u00a0Zanubrutinib\uff08BGB3111\uff09\u662f\u4e00\u7a2e\u6709\u6548\u7684\uff0c\u9078\u64c7\u6027\u7684\u548c\u53e3\u670d\u7684Btk\u6291\u5236\u5291 (Btk inhibitor) \u3002\u8207\u4f9d\u9b6f\u66ff\u5c3c(Ibrutinib)\u76f8\u6bd4\uff0c\u91dd\u5c0d\u5305\u62ecITK\u5728\u5167\u7684\u4e00\u7cfb\u5217\u6fc0\u9176\u986f\u793a\u51fa\u66f4\u591a\u53d7\u9650\u5236\u7684\u812b\u9776\u6d3b\u6027(off-target activities)\u3002 BGB-3111\u8207BTK\u9078\u64c7\u6027\u7d50\u5408\u4f75\u6291\u5236\u5176\u6d3b\u6027\uff0c\u4e26\u963b\u6b62B\u7d30\u80de\u6297\u539f\u53d7\u9ad4\uff08BCR\uff09\u4fe1\u865f\u50b3\u5c0e\u9014\u5f91\u7684\u6fc0\u6d3b\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n(7S)-4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide; BGB-3111; (S)-Zanubrutinib; BGB3111<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nWhite to off-white solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n1691249-45-2<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2082\u2087H\u2082\u2089N\u2085O\u2083<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n471.56<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\n>50 mg\/ml in DMSO<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nC=CC(=O)N1CCC(CC1)C2CCNC3=C(C(=NN23)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=O)N<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C27H29N5O3\/c1-2-23(33)31-16-13-18(14-17-31)22-12-15-29-27-24(26(28)34)25(30-32(22)27)19-8-10-21(11-9-19)35-20-6-4-3-5-7-20\/h2-11,18, 22,29H,1,12-17H2,(H2,28,34)<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nRNOAOAWBMHREKO-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n135905454<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nDo not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00baC<\/td>\n<\/tr>\n
Shipping Conditions<\/strong><\/td>\nGel Pack<\/td>\n<\/tr>\n
USAGE<\/strong><\/td>\nFor Research Use Only! Not For Use in Humans.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Zanubrutinib | \u8ca8\u865fB2512-1 \u7522\u54c1\u4ecb\u7d39: \u00a0Zanubrutinib\uff08BGB3111\uff09\u662f\u4e00 […]<\/p>\n","protected":false},"author":3,"featured_media":22611,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486],"tags":[1792],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22610"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22610"}],"version-history":[{"count":1,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22610\/revisions"}],"predecessor-version":[{"id":22612,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/22610\/revisions\/22612"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/22611"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22610"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}