{"id":21813,"date":"2019-08-28T15:18:13","date_gmt":"2019-08-28T07:18:13","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=21813"},"modified":"2023-09-04T10:03:21","modified_gmt":"2023-09-04T02:03:21","slug":"azide-free-fc-receptor-blocker-30-ml","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=21813","title":{"rendered":"Innovex Fc\u53d7\u9ad4\u963b\u65b7\u5291 | AZIDE-FREE Fc Receptor Blocker \u8ca8\u865fNB335"},"content":{"rendered":"

\"HOT\"<\/a><\/span>Innovex Fc\u53d7\u9ad4\u963b\u65b7\u5291 (AZIDE-FREE Fc Receptor Blocker\u00a0) | \u8ca8\u865fNB335<\/a><\/span><\/strong><\/p>\n

Fc \u53d7\u9ad4\u662f\u5206\u5b50\u91cf\u7d04\u70ba 50-70 kD \u7684\u7cd6\u86cb\u767d(glycoproteins)\u3002\u5b83\u5011\u4e3b\u8981\u5b58\u5728\u65bc\u767d\u8840\u7403 (white blood cells)\u4e0a\uff0c\u4f8b\u5982\u55ae\u6838\u7d30\u80de(monocytes)\u3001\u7d44\u7e54\u5de8\u566c\u7d30\u80de(tissue macrophages)\u3001B \u7d30\u80de(B cells)\u3001T \u7d30\u80de(T cells)\u3001\u9846\u7c92\u7d30\u80de(granulocytes)\u4ee5\u53ca\u5927\u591a\u6578\u816b\u7624\u7d30\u80de(tumor cells)\u548c\u7d30\u80de\u682a (cell lines)\u3002 Fc\u53d7\u9ad4(Fc receptors)\u5c0d\u55ae\u9ad4IgG\uff08\u6297\u9ad4\uff09(Immunoglobulins\/antibody)\u7684Fc\u5340\u6709\u5f88\u5927\u7684\u89aa\u548c\u529b\uff0c\u975e\u7279\u7570\u6027\u67d3\u8272\u548c\u80cc\u666f\u67d3\u8272\u53ef\u80fd\u662f\u514d\u75ab\u7403\u86cb\u767d\/\u6297\u9ad4\u7684 Fc \u5340\u8207\u7d30\u80de\u4e0a\u5b58\u5728\u7684 Fc \u53d7\u9ad4\u7d50\u5408\u6240\u81f4\u3002\u9019\u6a23\u7684\u5bcc\u542b Fc \u53d7\u9ad4\u7684\u6a23\u672c\u6709\u6dcb\u5df4\u7d44\u7e54(lymphoid tissues)\u3001\u6241\u6843\u9ad4\u5207\u7247(tonsil sections)\u3001\u9aa8\u9ad3\u6a19\u672c(bone marrow)\u3001\u816b\u7624\u7d30\u80de(tumor cells)\u3001\u816b\u7624\u7d30\u80de\u682a\u9ed1\u8272\u7d20\u7624(tumorcell lines)\u548c\u8840\u5857\u7247(blood smears)\u3002\u6709\u5e7e\u7a2e\u985e\u578b\u7684 Fc \u53d7\u9ad4 (Fc receptors , FcR)\uff0c\u5b83\u5011\u6839\u64da\u5b83\u5011\u8b58\u5225\u7684\u6297\u9ad4\u9032\u884c\u5206\u985e\u3002\u6709\u90a3\u4e9b\u5c0d\u55ae\u9ad4 IgG \u6297\u9ad4\u7684 Fc \u5340\u6709\u5f88\u5f37\u7684\u89aa\u548c\u529b\uff0c\u88ab\u7a31\u70baFc \u53d7\u9ad4 (Fc receptors , FcR)\uff0c\u90a3\u4e9b\u8207 IgA \u7d50\u5408\u7684\u6297\u9ad4\u7a31\u70ba Fc-\u03b1 \u53d7\u9ad4Fc \u53d7\u9ad4 (Fc receptors , FcR)\uff0c\u8207 IgE \u6297\u9ad4\u7d50\u5408\u7684\u7a31\u70ba Fc-epsilon \u53d7\u9ad4\u3002<\/p>\n

Fc Receptor Blocker \u53ef\u7528\u4f5c\u963b\u65b7\u5291\u4f86\u963b\u65b7\u5b58\u5728\u65bc\u9020\u8840(hematopoietic)\uff08\u8840\u6db2\u4f86\u6e90\uff09\u4e0a\u7684 Fc \u53d7\u9ad4(Fc receptors)\uff0c\u6dcb\u5df4\u7d30\u80de(lymphoid cells )\/\u7d44\u7e54\u548c\u816b\u7624\u7d30\u80de(tumor cells)\u548c\u7d30\u80de\u682a\u3002\u4e00\u6297\u6216\u4e8c\u6297\u7684 Fc \u5340\u8207\u5b58\u5728\u65bc\u767d\u8840\u7403\uff08white blood cells\uff09\u6216\u816b\u7624\u7d30\u80de\u8868\u9762\u7684 Fc \u53d7\u9ad4\u7522\u751f\u975e\u7279\u7570\u6027\u7d50\u5408(non-specific binding)\uff0c\u4e26\u4e14\u662f\u5728 IHC\u3001ICC\u3001\u514d\u75ab\u87a2\u5149(immunofluorescence)\u548c\u6d41\u5f0f\u7d30\u80de\u8853(flow cytometry assays)\u6e2c\u5b9a\u4e2d\u4f5c\u70ba\u80cc\u666f(background)\u6216\u975e\u7279\u7570\u6027\u67d3\u8272(non-specific staining)\u89c0\u5bdf\u5230\u3002Azide-free Fc\u53d7\u9ad4\u963b\u6eef\u5291(Azide-free Fc receptor blocker)\u4e0d\u542b\u758a\u6c2e\u5316\u9209(sodium azide)\u6216\u786b\u67f3\u6c5e(thimerosol)\uff0c\u56e0\u6b64\u9069\u7528\u65bc\u6709\u6548\u7684\u963b\u65b7\u6dcb\u5df4\u548c\u9020\u8840\u4f86\u6e90\u7684\u975e\u56fa\u5b9a\u6d3b\u7d30\u80de(non-fixed live cells)\u4ee5\u53ca\u816b\u7624\u7d30\u80de\u548c\u7d30\u80de\u682a\u4e2d\u7684 Fc \u53d7\u9ad4(Fc receptors)\u8868\u9762\u651c\u5e36 Fc \u53d7\u9ad4\u3002\u5bcc\u542b Fc \u53d7\u9ad4(Fc receptors)\u7684\u6a19\u672c\u5f88\u591a\uff0c\u5305\u62ec\u6241\u6843\u9ad4(tonsil)\u3001\u9aa8\u9ad3(bone marrow)\u3001\u6dcb\u5df4\u7d50(lymph nodes)\u3001\u8840\u7d30\u80de(blood cell)\u88fd\u5291\u9ed1\u8272\u7d20\u7624\u548c\u5927\u591a\u6578\u816b\u7624\u7d30\u80de\u548c\u7d30\u80de\u682a\u3002<\/p>\n

\"\u7db2\u7ad9\u898f\u683c\u5c0f\u5716_\u5de5\u4f5c\u5340\u57df<\/a><\/p>\n

\"\"<\/p>\n

Azide-free Fc Receptor Blocker \u7279\u5225\u6709\u52a9\u65bc\u963b\u65b7\u816b\u7624\u7d30\u80de\u6216\u7d30\u80de\u7cfb\u4e2d\u7684 Fc \u53d7\u9ad4\u529f\u80fd\u6e2c\u5b9a\uff0c\u5176\u4e2d\u758a\u6c2e\u5316\u9209\u548c\u5176\u4ed6\u9632\u8150\u5291\u5f15\u8d77\u5167\u541e\u4f5c\u7528(endocytosis)\u4e26\u5c0e\u81f4\u7d30\u80de\u6bd2\u6027(cytotoxicity)\u548c\u7d30\u80de\u640d\u5bb3(cell damage)\u3002\u8a72\u8a66\u5291\u65e8\u5728\u7528\u4f5c\u963b\u65b7\u5291(blocking agent)\uff0c\u7528\u65bc\u963b\u65b7\u9020\u8840(hematopoietic)\u3001\u6dcb\u5df4\u6a19\u672c(lymphoid specimens)\u4e2d\u7684 Fc \u53d7\u9ad4\u4f5c\u70ba\u8868\u9054 Fc \u53d7\u9ad4\u7684\u816b\u7624\u7d30\u80de\u548c\u7d30\u80de\u682a\u3002<\/p>\n

\"\u7522\u54c1\u539f\u7406_\u5de5\u4f5c\u5340\u57df<\/p>\n

Fc\u53d7\u9ad4\u963b\u6eef\u5291 (Innovex AZIDE-FREE Fc Receptor Blocker\u00a0) \uff0c\u5148\u9032\u548c\u7368\u7279\u7684\u529f\u80fd\uff1b\u963b\u65b7\u4eba\u548c\u52d5\u7269\u7d30\u80de\u4e2d\u7684Fc\u53d7\u9ad4\u3002\u662f\u6e96\u78ba\u7684\u6dcb\u5df4\u7624\uff0c\u767d\u8840\u75c5\u548c\u9ed1\u8272\u7d20\u7624\u5206\u578b\u4ee5\u53ca\u7121\u80cc\u666fKappa\u548c\u03bb\u67d3\u8272\u7684\u5fc5\u9700\u54c1\u3002Innovex Fc Receptor Block\u662f\u4e00\u7a2e\u57fa\u65bcpeptide based\u7684\u6280\u8853\uff0c\u4e0d\u542b\u6297\u9ad4\uff0c\u8840\u6e05\uff0c\u514d\u75ab\u7403\u86cb\u767d\uff0c\u514d\u75ab\u7403\u86cb\u767d\u7247\u6bb5\u6216\u93c8\u9ef4\u86cb\u767d\u9176\u3002\u76ee\u7684\u70ba\u963b\u65b7\u6240\u6709\u767d\u8840\u7403\u7d30\u80de\uff08white blood cells\uff09\uff0c\u6dcb\u5df4\u7624(lymphomas)\u548c\u9ed1\u8272\u7d20\u7624(melanomas)\u4e2d\u5b58\u5728\u7684Fc\u53d7\u9ad4(Fc Receptors)\u3002\u5728\u5ba4\u6eab\u4e0b\u5c0d\u4eba\u9ad4\u7d44\u7e54\/\u7d30\u80de\u9032\u884c30\u5206\u9418\u7684\u5b75\u80b2\u6b65\u9a5f\uff1b\u52d5\u7269\u7d44\u7e54\/\u7d30\u80de\u5b75\u80b245\u5206\u9418\u81f31\u5c0f\u6642\u3002\u6d88\u9664\u767d\u8840\u7403\u7d30\u80de\uff0c\u6dcb\u5df4\u7d44\u7e54\uff0c\u7d30\u80de\u682a\uff08\u8840\u6db2\u548c\u9aa8\u9ad3\uff09\uff0c\u9ed1\u8272\u7d20\u7624\u548c\u5176\u4ed6\u8868\u9054Fc\u7684\u816b\u7624\u7684\u5047\u967d\u6027\u67d3\u8272\uff0c\u78ba\u4fdd\u51c6\u78ba\u7684\u6dcb\u5df4\u7624\u548c\u767d\u8840\u75c5\u5206\u578b\u3002\"\"Fc\u53d7\u9ad4(Fc Receptors)\u4e5f\u5728\u5927\u591a\u6578\u816b\u7624(tumors)\u4e0a\u8868\u9054\u3002\u963b\u65b7Fc\u53d7\u9ad4\u5c0d\u65bc\u6dcb\u5df4(lymphoid)\u548c\u816b\u7624\u7d44\u7e54(tumor tissues)\u548c\u7d30\u80de\u7684\u6e96\u78ba\u5206\u578b\u81f3\u95dc\u91cd\u8981\u3002 Fc\u53d7\u9ad4\u67d3\u8272\u901a\u904e\u7d30\u80de\u4e0a\u5b58\u5728\u7684Fc\u53d7\u9ad4\u8207\u521d\u7d1a\u548c\/\u6216\u7b2c\u4e8c\u6297\u9ad4\u7684Fc\u5340\u7684\u7d50\u5408\u800c\u767c\u751f\u3002 Fc\u53d7\u9ad4\u963b\u65b7\u5291\u53ef\u7528\u65bcIHC\uff08\u51b7\u51cd\u548c\u77f3\u881f\uff09\uff0c\u514d\u75ab\u87a2\u5149(immunofluorescence)\uff0c\u6d41\u5f0f\u7d30\u80de\u8853(flow cytometry)\u548c\u539f\u4f4d\u96dc\u4ea4(in-situ hybridization)\u3002\u5c0d\u65bc\u6d3b\u7d30\u80de\u548c\u529f\u80fd\u6e2c\u5b9a\uff0c\u5efa\u8b70\u4f7f\u7528Azide-Free Fc Block (\u8ca8\u865fNB335)\u3002<\/p>\n

\"\u7522\u54c1\u7279\u9ede_\u5de5\u4f5c\u5340\u57df<\/p>\n

    \n
  1. Blocks Fc Receptors in both human and animal cells<\/li>\n
  2. 30 minute incubation step at room temperature for human tissues\/cells<\/li>\n
  3. 45 minutes to 1-hour incubation for animal tissues\/cells<\/li>\n
  4. Eliminates false positive staining of white blood cells, lymphoid tissues, cytosmears (blood & bone marrow), melanoma tumors and other Fc expressing tumors<\/li>\n
  5. Insures accurate lymphoma and leukemia typing<\/li>\n
  6. liminates negative control staining of lymphomas, lymphoid tissues, and blood and bone marrow smears<\/li>\n
  7. Eliminates false positive staining for Kappa and Lambda staining<\/li>\n
  8. Eliminates false positive staining of Reed Sternberg cells<\/li>\n
  9. A must for CD markers staining in IHC, immunofluorescence<\/li>\n
  10. A must for CD phenotyping via flow cytometry<\/li>\n
  11. A must for Immunoglobulins (Igs) staining via IHC, flow cytometry and immunofluorescence<\/li>\n
  12. A must for kappa and lambda staining<\/li>\n<\/ol>\n

    \"\u5f15\u7528\u6587\u737b_\u5de5\u4f5c\u5340\u57df<\/p>\n

    https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4395339\/<\/p>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    Innovex Fc\u53d7\u9ad4\u963b\u65b7\u5291 (AZIDE-FREE Fc Receptor Blocker\u00a0) | \u8ca8\u865fN […]<\/p>\n","protected":false},"author":3,"featured_media":21811,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5374],"tags":[1953],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/21813"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21813"}],"version-history":[{"count":6,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/21813\/revisions"}],"predecessor-version":[{"id":45623,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/21813\/revisions\/45623"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/21811"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21813"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21813"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21813"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}