{"id":21649,"date":"2019-08-15T16:06:20","date_gmt":"2019-08-15T08:06:20","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=21649"},"modified":"2022-07-20T10:52:37","modified_gmt":"2022-07-20T02:52:37","slug":"tigit-1b4-%e6%8a%97%e9%ab%94-absoluteantibody%e8%b2%a8%e8%99%9fab01258-1-1","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=21649","title":{"rendered":"TIGIT [1B4] \u6297\u9ad4 | Absoluteantibody\u8ca8\u865fAb01258-1.1"},"content":{"rendered":"<p><span style=\"color: #00ccff;\"><a style=\"color: #00ccff;\" href=\"http:\/\/biopioneer.com.tw\/?p=21649\">TIGIT [1B4] \u6297\u9ad4 | \u8ca8\u865fAb01258-1.1<\/a><\/span><\/p>\n<p><strong>\u6297\u9ad4\u4ecb\u7d39<\/strong><strong>:<\/strong> \u00a0TIGIT [1B4] \u6297\u9ad4\u5c0dTIGIT\u7684\u7d50\u5408\u7279\u7570\u6027 (Specificity)\u3002\u5df2\u901a\u904eELISA\u5206\u6790(ELISA analysis) \u548c\u4f7f\u7528TIGIT\u548c\u6d3b\u5316\u7684\u5c0f\u9f20\u813e\u7d30\u80de\u7684\u6d41\u5f0f\u7d30\u80de\u8853\u8b49\u5be6(flow cytometry)\uff08Dixon\u7b49\uff0c2018\uff09\u3002 TIGIT\u6297\u9ad4\u5177\u6709\u7279\u7570\u6027\u67d3\u8272\u6d3b\u5316\u7684\u539f\u4ee3\u91ce\u751f\u578bT\u7d30\u80de (primary wild-type T cells)\uff08Dixon\u7b49\uff0c2018\uff09\u3002 TIGIT\u6297\u9ad4\u5b8c\u5168\u963b\u65b7CD155\u8207TIGIT\u7684\u7d50\u5408\uff0c\u4e26\u5728\u9ad4\u5167\u5145\u7576TIGIT\u963b\u65b7\u6297\u9ad4(blocking antibody)\u3002Administration of this antibody increases experimental autoimmune encephalomyelitis (EAE) severity\uff0c\u4e26\u78ba\u5b9a\u5df2\u5efa\u7acb\u7684MC38\u7d50\u8178\u764c(colon carcinoma)\u548cGL261\u81a0\u8cea\u6bcd\u7d30\u80de\u7624\u751f\u9577\uff08Dixon\u7b49\uff0c2018\uff09\u3002 \u8a72\u6297\u9ad4\u8207\u6297PD-1\u963b\u65b7\u6297\u9ad4\u5354\u540c\u4f5c\u7528\uff0c\u4ee5\u5728\u7d50\u8178\u764c\u6a21\u578b\u4e2d\u5be6\u73fe\u5b8c\u5168tumour regression\uff08Dixon\u7b49\uff0c2018\uff09\u3002 \u539f\u59cb\u5c0f\u9f20IgG1\u6297\u9ad4\u5728\u9ad4\u5167\u4e0d\u8017\u76e1TIGIT\u8868\u9054\u7684CD4 +\u6216CD8 + T\u7d30\u80de\uff0c\u4e5f\u4e0d\u5f71\u97ff\u9ad4\u5916T\u7d30\u80de\u589e\u6b96\uff08Dixon\u7b49\uff0c2018\uff09\u3002\u6b64\u6297\u9ad4\u53ef\u61c9\u7528\u65bcBlocking, ELISA, FC\u7b49\u5be6\u9a57\u3002<\/p>\n<p>Alternative Name(s) of Target: Ig\u7d30\u80de\u548cITIM\u7d50\u69cb\u57df; \u5177\u6709Ig\u548cITIM\u7d50\u69cb\u57df\u7684T\u7d30\u80de\u514d\u75ab\u53d7\u9ad4; V-set\u548c\u542b\u8de8\u819c\u7d50\u69cb\u57df\u7684\u86cb\u767d3; VSTM3<\/p>\n<p>\u514d\u75ab\u539f(Immunogen: \u901a\u904e\u7528\u9f20\u91cd\u7d44TIGIT\u56db\u805a\u9ad4\u514d\u75abTIGIT\u00a0 &#8211;\u00a0 \/\u00a0 &#8211; \u5c0f\u9f20\u4f86\u7522\u751f\u8a72\u6297\u9ad4\u3002<\/p>\n<p><strong>Antibody first published in:<\/strong>\u00a0Dixon et al. Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity J Immunol. 2018 Apr 15;200(8):3000-3007\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29500245\">PMID:29500245<\/a><\/p>\n<p>UniProt Accession Number of Target Protein: P86176<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>TIGIT [1B4] \u6297\u9ad4 | \u8ca8\u865fAb01258-1.1 \u6297\u9ad4\u4ecb\u7d39: \u00a0TIGIT [1B4] \u6297\u9ad4\u5c0dTI [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":21650,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[1971],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/21649"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21649"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/21649\/revisions"}],"predecessor-version":[{"id":21653,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/21649\/revisions\/21653"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/21650"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21649"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}