{"id":20569,"date":"2019-06-03T15:22:31","date_gmt":"2019-06-03T07:22:31","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=20569"},"modified":"2022-07-20T11:44:34","modified_gmt":"2022-07-20T03:44:34","slug":"mln8237%e6%8a%91%e5%88%b6%e5%8a%91-cas-1028486-01-2%e8%b2%a8%e8%99%9f2718-25","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=20569","title":{"rendered":"MLN8237\u6291\u5236\u5291 | CAS #1028486-01-2\u8ca8\u865f2718-25"},"content":{"rendered":"

MLN8237<\/strong>\u6291<\/strong>\u5236<\/strong>\u5291 | <\/strong>\u8ca8\u865f<\/strong>2718-25 \u00a0<\/strong><\/a><\/span><\/p>\n

\u7522\u54c1\u4ecb\u7d39: MLN8237\u662fAurora kinase A\u7684\u6709\u6548\u9078\u64c7\u6027\u6291\u5236\u5291\uff08IC 50 = 1.2 nM\uff09\u3002 \u5b83\u986f\u793aAurora\u6fc0\u9176A\u7684\u9078\u64c7\u6027\u6bd4Aurora\u6fc0\u9176B\u9ad8200\u500d\u4ee5\u4e0a\u3002\u986f\u793a\u6297\u816b\u7624\u6d3b\u6027(antineoplastic activity)\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-benzoic acid; Alisertib<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nCrystalline solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n1028486-01-2<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2082\u2087H\u2082\u2080ClFN\u2084O\u2084<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n518.9<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO (>40 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nCOC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C27H20ClFN4O4\/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2\/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nZLHFILGSQDJULK-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n24771867<\/a><\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nProtect from air and light<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u00a0<\/strong><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

MLN8237\u6291\u5236\u5291 | \u8ca8\u865f2718-25 \u00a0 \u7522\u54c1\u4ecb\u7d39: MLN8237\u662fAurora kinase A\u7684 […]<\/p>\n","protected":false},"author":3,"featured_media":6676,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486],"tags":[2155],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/20569"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20569"}],"version-history":[{"count":1,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/20569\/revisions"}],"predecessor-version":[{"id":20570,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/20569\/revisions\/20570"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/6676"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20569"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20569"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}