{"id":18732,"date":"2019-01-21T17:33:00","date_gmt":"2019-01-21T09:33:00","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=18732"},"modified":"2022-07-20T14:53:57","modified_gmt":"2022-07-20T06:53:57","slug":"lenvatinib-%e5%8f%97%e9%ab%94%e9%85%aa%e6%b0%a8%e9%85%b8%e6%bf%80%e9%85%b6%e7%9a%84%e6%9c%89%e6%95%88%e6%8a%91%e5%88%b6%e5%8a%91-cas-417716-92-8%e8%b2%a8%e8%99%9fb1157","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=18732","title":{"rendered":"Lenvatinib | \u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u7684\u6709\u6548\u6291\u5236\u5291 CAS# 417716-92-8\u8ca8\u865fB1157"},"content":{"rendered":"

Lenvatinib<\/strong> |<\/strong> \u00a0CAS#<\/strong> 417716-92-8<\/strong>\u8ca8\u865f<\/strong>B1157\u00a0<\/a>\u00a0<\/span>\u591a\u7a2e\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u7684\u6709\u6548\u6291\u5236\u5291<\/p>\n

\u7522\u54c1\u63cf\u8ff0\uff1aLenvatinib<\/strong>\u662fmultiple receptor tyrosine kinases\u591a\u7a2e\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u7684\u6709\u6548\u6291\u5236\u5291\uff0c\u5c0dVEGFR-1\uff0cVEGFR-2\uff0cVEGFR-3\uff0cPDGFR\u03b2\u7684IC 50\u503c\u5206\u5225\u70ba22 nM\uff0c4 nM\uff0c5.2 nM\uff0c39 nM\u548c35 nM \u548cRET\u3002 \u6291\u5236SCF-\u548cVEGF\u8a98\u5c0e\u7684\u8868\u9054SCF\u53d7\u9ad4KIT\u7684\u4eba\u81cd\u975c\u8108\u5167\u76ae\u7d30\u80de\u7684\u8840\u7ba1\u751f\u6210\uff0cIC 50\u503c\u5206\u5225\u70ba5.2 nM\u548c5.1 nM\u3002 Lenvatinib\u6291\u5236\u4eba\u5c0f\u7d30\u80de\u80ba\u764cH146\u7570\u7a2e\u79fb\u690d\u6a21\u578b\u4e2d\u7684\u816b\u7624\u751f\u9577\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide; E7080<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nCrystalline solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n417716-92-8<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2082\u2081H\u2081\u2089ClN\u2084O\u2084<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n426.85<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO (>35 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nCOC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C21H19ClN4O4\/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11\/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nWOSKHXYHFSIKNG-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n9823820<\/a><\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nProtect from air and light<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

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\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Lenvatinib | \u00a0CAS# 417716-92-8\u8ca8\u865fB1157\u00a0\u00a0\u591a\u7a2e\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u7684\u6709\u6548\u6291\u5236\u5291 […]<\/p>\n","protected":false},"author":3,"featured_media":18733,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486],"tags":[2406],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/18732"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18732"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/18732\/revisions"}],"predecessor-version":[{"id":18736,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/18732\/revisions\/18736"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/18733"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18732"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=18732"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=18732"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}