{"id":18200,"date":"2018-11-14T16:16:43","date_gmt":"2018-11-14T08:16:43","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=18200"},"modified":"2022-07-20T15:17:45","modified_gmt":"2022-07-20T07:17:45","slug":"pt-2385%e6%8a%91%e5%88%b6%e5%8a%91-%e9%81%b8%e6%93%87%e6%80%a7%e7%bc%ba%e6%b0%a7%e8%aa%98%e5%b0%8e%e5%9b%a0%e5%ad%90%ef%bc%88hif-2%ce%b1%ef%bc%89%e6%8a%91%e5%88%b6%e5%8a%91-biovision%e8%b2%a8","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=18200","title":{"rendered":"PT-2385\u6291\u5236\u5291 | \u9078\u64c7\u6027\u7f3a\u6c27\u8a98\u5c0e\u56e0\u5b50\uff08HIF-2\u03b1\uff09\u6291\u5236\u5291 Biovision\u8ca8\u865fB1920"},"content":{"rendered":"

PT-2385<\/em><\/strong>\u6291\u5236\u5291 | <\/strong>\u8ca8\u865f<\/strong>B1920<\/a><\/span><\/p>\n

A potent ad selective inhibitor of hypoxia inducible factor (HIF-2\u03b1)<\/em><\/strong><\/p>\n

\u7522\u54c1\u63cf\u8ff0\uff1a<\/strong>PT-2385\u662f\u4e00\u7a2e\u6709\u6548\u6027\u9078\u64c7\u6027\u7f3a\u6c27\u8a98\u5c0e\u56e0\u5b50\uff08HIF-2\u03b1\uff09\u6291\u5236\u5291\uff0c\u5177\u6709\u6f5b\u5728\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002 PT-2385\u9078\u64c7\u6027\u5730\u7834\u58deHIF-2\u03b1\u8207HIF-1\u03b2\u7684\u7570\u4e8c\u805a\u5316\u3002 \u5728\u963b\u65b7\u900f\u660e\u7d30\u80de\u814e\u7d30\u80de\u764c\uff08ccRCC\uff09\u4e2d\u7684\u764c\u7d30\u80de\u751f\u9577\uff0c\u589e\u6b96\u548c\u816b\u7624\u8840\u7ba1\u751f\u6210\u65b9\u9762\u975e\u5e38\u6709\u6548\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n(S)-3-((2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile; PT2385<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nCrystalline solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n1672665-49-4<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2081\u2087H\u2081\u2082F\u2083NO\u2084S<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n383.34<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nCS(=O)(=O)C1=C2C(C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)(F)F)O<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C17H12F3NO4S\/c1-26(23,24)14-3-2-13(12-7-17(19,20)16(22)15(12)14)25-11-5-9(8-21)4-10(18)6-11\/h2-6,16,22H,7H2,1H3\/t16-\/m0\/s1<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nONBSHRSJOPSEGS-INIZCTEOSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n91754484<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nProtect from air and light<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

PT-2385\u6291\u5236\u5291 | \u8ca8\u865fB1920 A potent ad selective inhibitor of […]<\/p>\n","protected":false},"author":3,"featured_media":18201,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486],"tags":[2495],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/18200"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18200"}],"version-history":[{"count":1,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/18200\/revisions"}],"predecessor-version":[{"id":18202,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/18200\/revisions\/18202"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/18201"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18200"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=18200"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=18200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}