{"id":16172,"date":"2018-03-26T12:06:43","date_gmt":"2018-03-26T04:06:43","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=16172"},"modified":"2022-07-20T16:58:09","modified_gmt":"2022-07-20T08:58:09","slug":"senescence%e8%a1%b0%e8%80%81%e6%aa%a2%e6%b8%ac%e8%a9%a6%e5%8a%91%e7%9b%92-senescence-detection-kit%e8%b2%a8%e8%99%9fk320-250","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=16172","title":{"rendered":"Senescence\u8870\u8001\u6aa2\u6e2c\u8a66\u5291\u76d2 | Senescence Detection Kit\u8ca8\u865fK320-250"},"content":{"rendered":"

Senescence\u8870\u8001\u6aa2\u6e2c\u8a66\u5291\u76d2 | <\/strong>\u8ca8\u865f<\/strong>K320-250<\/a><\/span><\/p>\n

Senescence Detection Kit<\/em><\/strong><\/p>\n

\u7522\u54c1<\/strong>\u63cf\u8ff0\uff1aSenescence<\/strong>\u8870\u8001\u88ab\u8a8d\u70ba\u662fTumor suppressive mechanism\u00a0\u816b\u7624\u6291\u5236\u6a5f\u5236 (\u00a0tumor suppressive mechanism) \u548c\u8870\u8001 (aging) \u7684\u6839\u672c\u539f\u56e0\u3002 \u8870\u8001 (Senescence) \u4ee3\u8868\u4e86\u4e00\u7a2e\u88abarrested\u62d8\u7559\u7684\u72c0\u614b\uff0c\u5176\u4e2d\u7d30\u80de\u4fdd\u6301\u00a0viable\u6d3b\u529b\uff0c\u4f46\u6c92\u6709\u88abserum\u8840\u6e05\u6216\u57f9\u990a\u7269\u4e2d\u7684\u901a\u9053\u523a\u6fc0divide\u5206\u88c2\u3002 Senescent cells\u8870\u8001\u7d30\u80de\u8868\u73fe\u51fa\u7d30\u80de\u5927\u5c0f(cell size)\u7684\u589e\u52a0\uff0c\u8870\u8001\u76f8\u95dc\u03b2-\u534a\u4e73\u7cd6\u82f7\u9176\uff08\u00a0\u03b2-galactosidase, SA-\u03b2-Gal\uff09\u6d3b\u6027\u7684\u8868\u73fe\uff0c\u4ee5\u53ca\u57fa\u56e0\u8868\u9054\u6a21\u5f0f\u7684\u6539\u8b8a (gene expression) \u3002 \u00a0Senescence detection kit\u00a0\u8870\u8001\u6aa2\u6e2c\u8a66\u5291\u76d2, K320, \u8a2d\u8a08\u7528\u65bchistochemically\u7d44\u7e54\u5316\u5b78\u6aa2\u6e2c\u57f9\u990a\u7d30\u80de\u548c\u7d44\u7e54\u5207\u7247\u4e2d\u7684SA-\u03b2-Gal\u6d3b\u6027\uff0c\u9019\u662f\u8870\u8001\u7d30\u80de\u7684\u5df2\u77e5\u7279\u5fb5\u3002 SA-\u03b2-Gal\u50c5\u5b58\u5728\u65bc\u8870\u8001\u7d30\u80de\u4e2d\uff0c\u4e26\u4e14\u5728presenescent\uff0c\u975c\u6b62 (quiescent) \u6216\u6c38\u751f\u7d30\u80de(immortal cells) \u4e2d\u4e0d\u5b58\u5728\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n
Cat # +Size<\/strong><\/td>\nK320-250<\/td>\n<\/tr>\n
Size<\/strong><\/td>\n250 Stainings<\/td>\n<\/tr>\n
Species Reactivity<\/strong><\/td>\nMammalian<\/td>\n<\/tr>\n
Applications<\/strong><\/td>\nThe Senescence Detection Kit is designed to histochemically detect specific senescence marker in distinct pH in cultured cells and tissue sections.<\/td>\n<\/tr>\n
Features & Benefits<\/strong><\/td>\n\u2022 Simple procedure; takes around than 30 minutes
\n\u2022 Fast and convenient
\n\u2022 The specific histochemical marker is only present in senescent cells and is not found in presenescent, quiescent or immortal cells.<\/td>\n<\/tr>\n
Kit Components<\/strong><\/td>\n\u2022 Fixative Solution (1X)
\n\u2022 X-Gal (150 mg, lyophilized)
\n\u2022 Staining Solution (1X)
\n\u2022 Staining Supplement (100X)<\/td>\n<\/tr>\n
Storage Conditions<\/strong><\/td>\n-20\u00b0C<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5f15\u7528\u6587\u737b<\/p>\n

\n
Yi, Zhang et al. (2017) Effects of Nonsteroidal Anti-inflammatory Drugs on the Self-renewal Capacity of Blast Progenitors in Hematological Malignancies,\u00a0J Environ Pathol Toxicol Oncol. 2017;36(1):15-27.<\/a><\/div>\n<\/div>\n
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Lukasova, Emilie et al. (2017) Loss of lamin B receptor is necessary to induce cellular senescence,\u00a0Biochem J. 2017 Jan 15;474(2):281-300.<\/a><\/div>\n<\/div>\n
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Sasaki, Sheng-Hsuan et al. (2017) Sialylation regulates myofibroblast differentiation of human skin fibroblasts,\u00a0Stem Cell Res Ther. 2017 Apr 18;8(1):81.<\/a><\/div>\n<\/div>\n
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Chem et al., Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells.\u00a0J. Biol. Chem.,\u00a0Oct 2015; 290: 25475 – 25486.<\/a><\/div>\n<\/div>\n
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Li et al., p53 enables metabolic fitness and self-renewal of nephron progenitor cells.\u00a0Development,\u00a0Apr 2015; 142: 1228 – 1241.<\/a><\/div>\n<\/div>\n

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