{"id":15806,"date":"2018-03-06T16:16:42","date_gmt":"2018-03-06T08:16:42","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=15806"},"modified":"2022-07-20T17:19:49","modified_gmt":"2022-07-20T09:19:49","slug":"belizatinib-tsr-011-egfr%e5%b0%8f%e5%88%86%e5%ad%90%e6%8a%91%e5%88%b6%e5%8a%91%ef%bc%88%e8%a1%a8%e7%9a%ae%e7%94%9f%e9%95%b7%e5%9b%a0%e5%ad%90%e5%8f%97%e9%ab%94%ef%bc%89cas-1357920-84-3-%e8%b2%a8","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=15806","title":{"rendered":"Belizatinib (TSR-011) | EGFR\u5c0f\u5206\u5b50\u6291\u5236\u5291\uff08\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff09CAS #1357920-84-3 \u8ca8\u865fB2028"},"content":{"rendered":"

ALK\uff08\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff09\u6291\u5236\u5291\u7522\u54c1<\/span><\/strong><\/p>\n

\"ALK<\/p>\n

EGFR\u5c0f\u5206\u5b50\u6291\u5236\u5291\uff08\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff09\u5df2\u5ee3\u6cdb\u7528\u65bc\u80ba\u764c\u6cbb\u7642\u3002\u5df2\u7d93\u986f\u793a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u4e00\u5c0f\u90e8\u5206\uff083-13\uff05\uff09\u5728ALK\uff08\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff09\u57fa\u56e0\u4e2d\u5177\u6709\u91cd\u6392\u3002\u5728\u904e\u53bb\u5e7e\u5e74\u4e2d\uff0c\u8207\u5e38\u898f\u5316\u7642\u76f8\u6bd4\uff0cALK\u6291\u5236\u5291\u5728ALK\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u6cbb\u7642\u4e2d\u986f\u793a\u51fa\u986f\u8457\u7684\u76ca\u8655\u3002\u651c\u5e36ALK\u67d3\u8272\u9ad4\u91cd\u6392\u7684\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7642\u5df2\u7d93\u7531Crizotinib\uff08\u4e00\u7a2e\u916a\u6c28\u9178\u6fc0\u9176ALK\uff0cROS1\u548cMET\u7684\u5c0f\u5206\u5b50\u6291\u88fd\u5291\uff09\u7684\u767c\u5c55\u5e36\u4f86\u4e86\u9769\u547d\u6027\u7684\u8b8a\u5316\u3002\u7136\u800c\uff0c\u4f7f\u7528\u514b\u5511\u66ff\u5c3c\u6cbb\u7642NSCLC\u7684\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u6709\u9650\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u9032\u5c55\u901f\u7387\u5c0e\u81f4\u4e86\u7b2c\u4e8c\u4ee3ALK\u6291\u5236\u5291\u5982Ceritinib\uff08Zykadia\uff09\u548cAlectinib\uff08Alecensa\uff09\u7684\u767c\u5c55\u53ef\u4ee5\u6291\u5236\u9a45\u52d5\u514b\u91cc\u5511\u66ff\u5c3c\u8010\u85e5\u7684\u5927\u591a\u6578\u81e8\u5e8a\u89c0\u5bdf\u5230\u7684ALK\u7a81\u8b8a\u3002\u5e7e\u7a2e\u65b0\u7684\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKIs\uff09\u8655\u65bcALK\u967d\u6027\u764c\u75c7\u7684\u81e8\u5e8a\u767c\u5c55\u7684\u4e0d\u540c\u968e\u6bb5\u3002\u9019\u4e9b\u85e5\u7269\u4e2d\u7684\u8a31\u591a\u5728CNS\u548c\u5c0d\u514b\u5511\u66ff\u5c3c\u6709\u6297\u6027\u7684\u764c\u75c7\u4e2d\u90fd\u5177\u6709\u6d3b\u6027\u3002<\/p>\n

Belizatinib (TSR-011) | CAS #1357920-84-3\u8ca8\u865fB2028<\/a><\/span><\/p>\n

\u7522\u54c1<\/strong>\u63cf\u8ff0\uff1a<\/strong> Belizatinib\uff08TSR-011\uff09\u662f\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u548c\u539f\u808c\u7403\u86cb\u767d\u76f8\u95dc\u6fc0\u9176\uff08TRK\uff09TRKA\uff0cTRKB\u548cTRKC\u7684\u6709\u6548\u6291\u5236\u5291\uff0c\u5177\u6709\u6f5b\u5728\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002 \u6291\u5236\u5c0e\u81f4ALK-\u548cTRK-\u4ecb\u5c0e\u7684\u4fe1\u865f\u50b3\u5c0e\u7684\u7834\u58de\u4e26\u963b\u7919\u904e\u8868\u9054ALK \/ TRK\u7684\u816b\u7624\u7d30\u80de\u4e2d\u7684\u816b\u7624\u7d30\u80de\u751f\u9577\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\n4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2-yl)benzamide; TSR011<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nCrystalline solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n1357920-84-3<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2083\u2083H\u2084\u2084FN\u2085O\u2083<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n577.75<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nCC(C)NC(=O)C1CCC(CC1)N2C3=C(C=CC(=C3)CN4CCC(CC4)C(C)(C)O)N=C2NC(=O)C5=CC=C(C=C5)F<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nInChI=1S\/C33H44FN5O3\/c1-21(2)35-30(40)24-8-12-27(13-9-24)39-29-19-22(20-38-17-15-25(16-18-38)33(3,4)42)5-14-28(29)36-32(39)37-31(41)23-6-10-26(34)11-7-23\/h5-7,10-11,14,19,21,24-25,27,42H,8-9,12-13,15-18,20H2,1-4H3,(H,35,40)(H,36,37,41)<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nWSTUJEXAPHIEIM-UHFFFAOYSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n57345941<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u76f8\u95dc\u8a66\u5291\"<\/strong>\u00a0A 83-01\u6291\u5236\u5291\u00a0<\/a>\u00a0|\u00a0\u00a0TPX-0005\u6291\u5236\u5291\u00a0<\/a>\u00a0|\u00a0NVP-TAE684<\/a>\u6291\u5236\u5291\u00a0|\u00a0Belizatinib (TSR-011)<\/a>\u6291\u5236\u5291<\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

ALK\uff08\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff09\u6291\u5236\u5291\u7522\u54c1 EGFR\u5c0f\u5206\u5b50\u6291\u5236\u5291\uff08\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff09\u5df2\u5ee3\u6cdb\u7528\u65bc\u80ba\u764c\u6cbb\u7642\u3002\u5df2\u7d93\u986f\u793a\u975e\u5c0f […]<\/p>\n","protected":false},"author":3,"featured_media":5627,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[478,486],"tags":[2872],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/15806"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15806"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/15806\/revisions"}],"predecessor-version":[{"id":15840,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/15806\/revisions\/15840"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/5627"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15806"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=15806"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=15806"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}