{"id":14850,"date":"2017-10-20T13:15:18","date_gmt":"2017-10-20T05:15:18","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=14850"},"modified":"2022-07-21T10:15:12","modified_gmt":"2022-07-21T02:15:12","slug":"apremilast-cas-608141-41-9%e8%b2%a8%e8%99%9f2352","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=14850","title":{"rendered":"Apremilast | CAS# 608141-41-9\u8ca8\u865f2352"},"content":{"rendered":"

\u78f7\u9178\u4e8c\u916f\u9176\uff08PDE\uff09\u4e4b\u7814\u7a76\u8207\u8a66\u5291-Phosphodiesterases (PDE) inhibitors<\/em><\/span><\/strong><\/p>\n

\u81ea\u4e8c\u5341\u5e74\u4f86\uff0c\u91dd\u5c0d\u764c\u75c7\u7684\u7814\u7a76\u4e00\u76f4\u662f\u8a31\u591a\u884c\u696d\u548c\u5b78\u8853\u5718\u9ad4\u7684\u7126\u9ede\u3002\u7531\u65bc\u5176\u7368\u7279\u7684\u7d44\u7e54\u5206\u4f48\uff0c\u7d50\u69cb\u7279\u6027\u548c\u529f\u80fd\u7279\u6027\uff0c\u78f7\u9178\u4e8c\u916f\u9176\uff08PDE\uff09\u901a\u5e38\u662f\u6d89\u53ca\u85e5\u7406\u5b78\u6291\u5236\u7684\u7814\u7a76\u7684\u76ee\u6a19\u3002\u78f7\u9178\u4e8c\u916f\u9176\u4e3b\u8981\u5305\u542b\u5728\u7b2c\u4e8c\u4fe1\u4f7f\u5206\u5b50cAMP\u548ccGMP\u4e2d\u964d\u89e3\u78f7\u9178\u4e8c\u916f\u9375\u7684\u4e00\u7d44\u9176\u3002\u56e0\u6b64\uff0cPDE\u662f\u7531\u9019\u4e9b\u7b2c\u4e8c\u4fe1\u4f7f\u5206\u5b50\u4ecb\u5c0e\u7684\u4fe1\u865f\u8f49\u5c0e\u7684\u91cd\u8981\u8abf\u7bc0\u5291\u3002 PDE\u6291\u5236\u5291\u53ef\u4ee5\u901a\u904e\u6291\u5236\u5176\u7531PDE\u964d\u89e3\u800c\u5ef6\u9577\u6216\u589e\u5f37\u7531cAMP\u6216cGMP\u4ecb\u5c0e\u7684\u751f\u7406\u904e\u7a0b\u7684\u4f5c\u7528\u3002\u56e0\u6b64\uff0cPDE\u6291\u5236\u5291\u88ab\u8a8d\u70ba\u5728\u764c\u75c7\u7684\u8f14\u52a9\u6cbb\u7642\u4e2d\u5177\u6709\u5f88\u5927\u7684\u6cbb\u7642\u50f9\u503c\u3002 PDE\u6291\u5236\u5291\u4e5f\u88ab\u7528\u65bc\u6cbb\u7642\u975e\u60e1\u6027\u75be\u75c5\u5982\u54ee\u5598\uff0c\u80ba\u52d5\u8108\u9ad8\u58d3\u548c\u52c3\u8d77\u529f\u80fd\u969c\u7919\u7b49\u3002\u6b64\u5916\uff0c\u5b83\u5011\u5df2\u88ab\u78ba\u5b9a\u70ba\u51a0\u5fc3\u75c5\uff0c\u7661\u5446\uff0c\u6291\u9b31\u75c7\u548c\u7cbe\u795e\u5206\u88c2\u75c7\u7b49\u9818\u57df\u7684\u65b0\u6f5b\u5728\u6cbb\u7642\u5291\u3002 BioVision\u7684PDE\u6291\u5236\u5291\u7d44\u5408\u5305\u62ec\u8a31\u591a\u53ef\u7528\u65bc\u4e0a\u8ff0\u7814\u7a76\u7684\u6291\u5236\u5291\u3002<\/p>\n

Apremilast <\/strong>\u00a0| \u00a0CAS#<\/strong> 608141-41-9\u8ca8\u865f<\/strong>2352<\/a><\/span><\/p>\n

A potent PDE4 (phosphodiesterase 4) inhibitor<\/em><\/strong><\/p>\n

\u7522\u54c1<\/strong>\u63cf\u8ff0\uff1a<\/strong>Apremilast\u662f\u6709\u6548\u7684PDE4\uff08\u78f7\u9178\u4e8c\u916f\u91764\uff09\u6291\u88fd\u5291\uff08IC 50 = 74nM\uff09\u3002 \u5b83\u964d\u4f4e\u4eba\u6ed1\u819c\u7d30\u80de\u4e2d\u7684TNF-\u03b1\u7522\u751f\u4e26\u986f\u8457\u6291\u5236\u5be6\u9a57\u6027\u95dc\u7bc0\u708e\u3002Apremilast\u662f\u6709\u6548\u7684PDE4\uff08\u78f7\u9178\u4e8c\u916f\u91764\uff09\u6291\u5236\u5291\uff08IC 50 = 74nM\uff09\u3002 \u5b83\u964d\u4f4e\u4eba\u6ed1\u819c\u7d30\u80de\u4e2d\u7684TNF-\u03b1\u7522\u751f\u4e26\u986f\u8457\u6291\u5236\u5be6\u9a57\u6027\u95dc\u7bc0\u708e\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\nN-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nWhite solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n608141-41-9<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2082\u2082H\u2082\u2084N\u2082O\u2087S<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n460.5<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226598% by HPLC<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nDMSO (80 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nCCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u76f8\u95dc\u8a66\u5291\"<\/span><\/a>\u00a0<\/a>PDE\u7e3d\u78f7\u9178\u4e8c\u916f\u9176\u6d3b\u6027\u6e2c\u5b9a<\/a>|\u00a0\u00a0<\/strong>Apremilast<\/a>\u00a0 |\u00a0Roflumilast<\/a>\u00a0|\u00a0Zaprinast<\/a>\u00a0|\u00a0IBMX<\/a>\u00a0|\u00a0Cilostazol\u00a0<\/a>\u00a0|\u00a0Milrinone<\/a>\u00a0|\u00a0<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n

 <\/p>\n

\u00a0<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n

\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u78f7\u9178\u4e8c\u916f\u9176\uff08PDE\uff09\u4e4b\u7814\u7a76\u8207\u8a66\u5291-Phosphodiesterases (PDE) inhibitors \u81ea\u4e8c […]<\/p>\n","protected":false},"author":3,"featured_media":14851,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486],"tags":[3083],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/14850"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=14850"}],"version-history":[{"count":4,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/14850\/revisions"}],"predecessor-version":[{"id":14868,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/14850\/revisions\/14868"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/14851"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=14850"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=14850"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=14850"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}