{"id":14564,"date":"2017-10-16T13:20:07","date_gmt":"2017-10-16T05:20:07","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=14564"},"modified":"2022-07-21T10:27:41","modified_gmt":"2022-07-21T02:27:41","slug":"chenodeoxycholic-acid%e8%84%ab%e6%b0%a7%e8%86%bd%e9%85%b8-%e8%86%bd%e6%b1%81%e9%85%b8%e5%92%8cfxr%e9%85%8d%e9%ab%94cas75621-03-3%e8%b2%a8%e8%99%9f2831","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=14564","title":{"rendered":"Chenodeoxycholic acid\u812b\u6c27\u81bd\u9178 | \u81bd\u6c41\u9178\u548cFXR\u914d\u9ad4CAS#75621-03-3\u8ca8\u865f2831"},"content":{"rendered":"

\"BioVision\u00a0\u86cb\u767d\u8cea\u8403\u53d6\u7cfb\u5217<\/strong>-Detergen<\/strong>\u6d17\u6ecc\u5291<\/strong>\u5546\u54c1<\/strong><\/span><\/p>\n

Detergents\u6d17\u6ecc\u5291\u662f\u5305\u542bpolar\u6975\u6027\u548chydrophobic regions\u758f\u6c34\u5340\u57df\u7684amphipathic molecules\u5169\u89aa\u6027\u5206\u5b50\uff0c\u5176\u5141\u8a31\u5b83\u5011\u4f5c\u70basolubilizing agents\u589e\u6eb6\u5291\u3002\u6d17\u6ecc\u5291\u53ef\u4ee5\u5206\u70ba\u5e7e\u500b\u4e3b\u8981\u985e\u5225\uff1a\u96e2\u5b50\u6d17\u6ecc\u5291;\u975e\u96e2\u5b50\u6d17\u6ecc\u5291\u548c\u5169\u6027\u96e2\u5b50\u6d17\u6ecc\u5291\u3002\u96e2\u5b50\u6d17\u6ecc\u5291\u5177\u6709\u5e36\u96fb\u982d\u57fa\uff08\u9670\u96e2\u5b50\u6216\u967d\u96e2\u5b50\uff09\uff0c\u53ef\u7528\u65bcSDS-PAGE\u671f\u9593\u7d30\u80de\u7684\u5b8c\u5168\u7834\u58de\u548c\u86cb\u767d\u8cea\u8b8a\u6027\u5206\u96e2\u3002\u9019\u4e9b\u53ef\u4ee5\u5305\u62ec\u9670\u96e2\u5b50\u6d17\u6ecc\u5291\u5982SDS\uff0c\u967d\u96e2\u5b50\u6d17\u6ecc\u5291\u5982CTAP\u548c\u9670\u96e2\u5b50\u81bd\u6c41\u9e7d\u5982deoxycholate\u812b\u6c27\u81bd\u9178\u9e7d\u3002\u901a\u5e38\u7a31\u70ba\u975e\u8b8a\u6027\u6d17\u6ecc\u5291\u7684\u975e\u96e2\u5b50\u6d17\u6ecc\u5291\u53ef\u7528\u65bc\u819c\u86cb\u767d\u7684\u6eb6\u89e3\uff0c\u56e0\u70ba\u5b83\u5011\u80fd\u5920\u7834\u58de\u8102\u8cea – \u8102\u8cea\u548c\u8102\u8cea – \u86cb\u767d\u8cea\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4f46\u5177\u6709\u6709\u9650\u7684\u7834\u58de\u86cb\u767d\u8cea – \u86cb\u767d\u8cea\u76f8\u4e92\u4f5c\u7528\u7684\u80fd\u529b\u3002\u5b83\u5011\u5305\u62ec\u4f4eCMC\u6d17\u6ecc\u5291\u5982Triton X-100\u548c\u4e0d\u80fd\u900f\u6790\u7684NP-40\u66ff\u4ee3\u7269\uff0c\u4e0d\u5e36\u96fb\u7684\u81bd\u6c41\u9e7d\uff0c\u5982Big Chap\uff08\u53ef\u900f\u6790\uff09\u548c\u975e\u5e38\u900f\u6790\u7684\uff08CMC\u301c25mM\uff09\u70f7\u57fa\u8461\u7cd6\u82f7\u5982\u8f9b\u57fa\u5421\u5583\u8461\u8404\u7cd6\u82f7\u3002\u5169\u6027\u96e2\u5b50\u6d17\u6ecc\u5291\u4fdd\u8b77\u86cb\u767d\u8cea\u7684\u5929\u7136\u72c0\u614b\u800c\u4e0d\u6539\u8b8a\u86cb\u767d\u8cea\u5206\u5b50\u7684\u5929\u7136\u96fb\u8377\u3002\u9664\u4e86\u6eb6\u89e3\u6027\u8cea\u5916\uff0c\u5169\u6027\u96e2\u5b50\u6d17\u6ecc\u5291\u5c0d\u65bc\u7b49\u96fb\u805a\u7126\u548c2D\u96fb\u6cf3\u975e\u5e38\u6709\u7528\u3002\u8a31\u591a\u5408\u6210\u7684\u5169\u6027\u96e2\u5b50\u6d17\u6ecc\u5291\u88ab\u7a31\u70ba\u78fa\u57fa\u751c\u83dc\u9e7c\u3002\u78fa\u57fa\u751c\u83dc\u9e7c\u5728\u5ee3\u6cdb\u7684pH\u7bc4\u570d\u5167\u4fdd\u6301\u5176\u5169\u6027\u96e2\u5b50\u7279\u5fb5\uff0c\u4e26\u5ee3\u6cdb\u7528\u65bc2D\u51dd\u81a0\u96fb\u6cf3\u3002\u975e\u6d17\u6ecc\u5291\u78fa\u57fa\u751c\u83dc\u9e7c\uff08NDSB\uff09\u662f\u4e00\u985e\u5169\u6027\u96e2\u5b50\u5316\u5408\u7269\uff0c\u5177\u6709\u985e\u4f3c\u65bc\u5169\u6027\u96e2\u5b50\u6d17\u6ecc\u5291\u7684\u89aa\u6c34\u57fa\u5718\uff0c\u4f46\u5177\u6709\u66f4\u77ed\u7684\u758f\u6c34\u93c8\uff0c\u4e0d\u80fd\u805a\u96c6\u5f62\u6210\u81a0\u675f\u3002\u96d6\u7136\u4e0d\u88ab\u8a8d\u70ba\u662f\u6d17\u6ecc\u5291\uff0c\u4f46\u662f\u7576\u8207\u6d17\u6ecc\u5291\u4e00\u8d77\u4f7f\u7528\u6642\uff0cNDSB\u53ef\u4ee5\u63d0\u9ad8\u819c\uff0c\u6838\u548c\u7d30\u80de\u9aa8\u67b6\u86cb\u767d\u7684\u7522\u91cf\u3002\u7d50\u5408\u78fa\u57fa\u751c\u83dc\u9e7c\u57fa\u5718\u7684\u96fb\u8377\u4e2d\u548c\u7684\u77ed\u758f\u6c34\u57fa\u5718\u5c0e\u81f4\u7372\u5f97\u66f4\u9ad8\u7684\u819c\u86cb\u767d\u7522\u7387\u3002 NDSB\u9084\u6709\u52a9\u65bc\u6e1b\u5c11\u805a\u96c6\u4e26\u5e6b\u52a9\u91cd\u6298\u758a\u5305\u6db5\u9ad4\u548c\u7d30\u83cc\u8868\u9054\u7cfb\u7d71\u4e2d\u767c\u73fe\u7684\u86cb\u767d\u8cea\u3002 NDSB\u5728\u5becpH\u7bc4\u570d\u5167\u662f\u5169\u6027\u96e2\u5b50\u7684\uff0c\u901a\u904e\u900f\u6790\u5bb9\u6613\u53bb\u9664\uff0c\u4e26\u4e14\u5728\u8fd1\u7d2b\u5916\u7bc4\u570d\u5167\u4e0d\u6703\u986f\u8457\u5438\u6536\u3002<\/p>\n

Chenodeoxycholic acid<\/strong>\u812b\u6c27\u81bd\u9178<\/strong> | CAS#<\/strong>75621-03-3\u8ca8\u865f<\/strong>2831<\/a><\/span><\/p>\n

\u81bd\u6c41\u9178\u548c<\/em><\/strong>FXR<\/em><\/strong>\u914d\u9ad4<\/em><\/strong><\/p>\n

\u7522\u54c1<\/strong>\u63cf\u8ff0\uff1a<\/strong>\u53bb\u6c27\u81bd\u9178\uff08CDCA\uff09\u662f\u4e00\u7a2e\u758f\u6c34\u6027\u539f\u59cb\u81bd\u6c41\u9178\uff0c\u53ef\u6fc0\u6d3b\u53c3\u8207\u81bd\u56fa\u9187\u4ee3\u8b1d\u7684\u6838\u53d7\u9ad4\u3002 \u6fc0\u6d3bFXR\uff08\u6cd5\u5462\u578bX\u53d7\u9ad4\uff09\u7684EC50\u6fc3\u5ea6\u7bc4\u570d\u70ba13-34\u03bcM\u3002 \u5728\u7d30\u80de\u4e2d\uff0cCDCA\u9084\u7d50\u5408\u81bd\u6c41\u9178\u7d50\u5408\u86cb\u767d\uff08BABP\uff09\uff0c\u5831\u5c0e\u7684\u5316\u5b78\u8a08\u91cf\u70ba1\uff1a2\u3002<\/p>\n

\"\"<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Alternate Name<\/strong><\/td>\nCDCA; Fluibil; Hekbilin; Anthropodeoxycholic Acid; Kebilis; Ulmenide<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nWhite to off-white solid<\/td>\n<\/tr>\n
CAS #<\/strong><\/td>\n474-25-9<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2082\u2084H\u2084\u2080O\u2084<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n392.57<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226595%<\/td>\n<\/tr>\n
Solubility<\/strong><\/td>\nEtOH (50 mg\/ml)<\/td>\n<\/tr>\n
SMILES<\/strong><\/td>\nCC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C<\/td>\n<\/tr>\n
InChi<\/strong><\/td>\nC[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C<\/td>\n<\/tr>\n
InChi Key<\/strong><\/td>\nRUDATBOHQWOJDD-BSWAIDMHSA-N<\/td>\n<\/tr>\n
PubChem CID<\/strong><\/td>\n10133<\/a><\/td>\n<\/tr>\n
MDL Number<\/strong><\/td>\nMFCD00064142<\/td>\n<\/tr>\n
Handling<\/strong><\/td>\nHygroscopic<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\u76f8\u95dc\u8a66\u5291\"\u00a0<\/strong>\u00a0Dodecyl-\u03b2-D-maltopyranoside<\/strong>\u00a0<\/strong><\/a>\u00a0|\u00a08<\/strong>\u7a2e\u86cb\u767d\u8cea\u6d17\u6ecc\u5291\u5957\u7d44<\/strong><\/a>\u00a0|\u00a0\u6c34\u6eb6\u6027<\/strong>Digitonin<\/strong>\u00a0<\/a>\u00a0|\u00a0Chenodeoxycholic acid<\/strong>\u812b\u6c27\u81bd\u9178<\/strong><\/a>\u00a0|\u9ad8\u7d14\u5ea6<\/strong>CHAPS<\/strong>\u00a0<\/a>\u00a0 |\u00a0BRIJ\u00ae 35 MegaPure\u2122 Detergent<\/strong>\u8a66\u5291<\/strong><\/a>\u00a0|\u00a0ASB-14<\/strong><\/a><\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u00a0\u86cb\u767d\u8cea\u8403\u53d6\u7cfb\u5217-Detergen\u6d17\u6ecc\u5291\u5546\u54c1 Detergents\u6d17\u6ecc\u5291\u662f\u5305\u542bpolar\u6975\u6027\u548chydropho […]<\/p>\n","protected":false},"author":3,"featured_media":14565,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[179],"tags":[3124],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/14564"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=14564"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/14564\/revisions"}],"predecessor-version":[{"id":14599,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/14564\/revisions\/14599"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/14565"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=14564"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=14564"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=14564"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}