{"id":13607,"date":"2017-09-01T15:46:57","date_gmt":"2017-09-01T07:46:57","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=13607"},"modified":"2022-07-21T10:45:18","modified_gmt":"2022-07-21T02:45:18","slug":"ono-4059%e9%a1%9e%e4%bc%bc%e7%89%a9-%e8%a1%80%e7%ae%a1%e7%94%9f%e6%88%90%e5%8c%96%e5%90%88%e7%89%a9-btk%e6%8a%91%e5%88%b6%e5%8a%91-%e8%b2%a8%e8%99%9fcc8033","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=13607","title":{"rendered":"ONO-4059\u985e\u4f3c\u7269-BTK\u6291\u5236\u5291 | \u8840\u7ba1\u751f\u6210\u5316\u5408\u7269-BTK\u6291\u5236\u5291 CAS#1351635-67-0\u8ca8\u865fCC8033"},"content":{"rendered":"

Angiogenesis<\/strong>\u8840\u7ba1\u751f\u6210\u6291\u5236\u5291 |\u00a0ONO-4059\u985e\u4f3c\u7269\u8ca8\u865fCC8033<\/strong><\/strong><\/a><\/span><\/p>\n

Chemcatch\u63d0\u4f9b\u4e00\u7cfb\u5217\u8840\u7ba1\u65b0\u751f\u6291\u5236\u5291\uff0c\u7522\u54c1\u5305\u62ecSrc<\/a> HIF<\/a> FLT3<\/a> Bcr-Abl<\/a> VDA<\/a> FGFR<\/a> Syk<\/a> FAK<\/a> BTK<\/a>\u7b49\u8840\u7ba1\u751f\u6210\u5316\u5408\u7269\uff0c\u5177\u6709\u4e0d\u540c\u5305\u88dd\u7d44\u5408\u3002\u00a0<\/strong>ONO-4059\u985e\u4f3c\u7269\uff0c\u5177\u9ad8\u6548\u548c\u9078\u64c7\u6027\u7684\u53e3\u670dBTK\u6291\u5236\u5291\uff0cIC50\u70ba23.9nM(\u968e\u6bb51)<\/p>\n

\"CC8033\"<\/p>\n\n\n\n\n\n\n\n\n
\u5206\u5b50\u91cfMolecular Weight (MW)<\/strong><\/td>\n456.50<\/td>\n<\/tr>\n
\u5316\u5b78\u5f0fFormula<\/strong><\/td>\nC25<\/sub>H24<\/sub>N6<\/sub>O3<\/sub><\/td>\n<\/tr>\n
CAS<\/strong>\u865fCAS No.<\/strong><\/td>\n1351635-67-0<\/td>\n<\/tr>\n
\u6eb6\u89e3\u6027Solubility (25\u00b0C)\u00a0*<\/em><\/strong><\/td>\n\u00a0<\/strong>\u4e8c\u7532\u57fa\u4e9e\u78b8DMSO<\/strong><\/td>\n20mg\/mLwarmed<\/td>\n<\/tr>\n
\u6c34Water<\/strong><\/td>\n<1mg\/mLwarmed<\/td>\n<\/tr>\n
\u4e59\u9187Alcohol<\/strong><\/td>\n<1mg\/mL<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u914d\u7f6e\u5b58\u5132\u6eb6\u6db2\uff1a<\/strong><\/p>\n\n\n\n\n\n\n\n
<\/td>\n1 mg<\/strong><\/td>\n5 mg<\/strong><\/td>\n10 mg<\/strong><\/td>\n<\/tr>\n
1 mM<\/td>\n2.1906 mL<\/td>\n10.9529 mL<\/td>\n21.9058 mL<\/td>\n<\/tr>\n
5 mM<\/td>\n0.4381 mL<\/td>\n2.1906 mL<\/td>\n4.3812 mL<\/td>\n<\/tr>\n
10 mM<\/td>\n0.2191 mL<\/td>\n1.0953 mL<\/td>\n2.1906 mL<\/td>\n<\/tr>\n
50 mM<\/td>\n0.0438 mL<\/td>\n0.2191 mL<\/td>\n0.4381 mL<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u76f8\u95dc\u8840\u7ba1\u65b0\u751f\u6291\u5236\u5546\u54c1<\/strong><\/span>\u00a0Src\u6291\u5236\u5291<\/a>\u00a0|\u00a0HIF\u6291\u5236\u5291<\/a>\u00a0|\u00a0FLT3\u6291\u5236\u5291<\/a>\u00a0|\u00a0Bcr-Abl\u6291\u5236<\/a>\u00a0|\u00a0VDA\u6291\u5236\u5291<\/a>\u00a0|\u00a0FGFR\u6291\u5236\u5291<\/a>\u00a0|\u00a0SYK\u6291\u5236\u5291<\/a>\u00a0|\u00a0FAK\u6291\u5236\u5291<\/a>\u00a0|\u00a0BTK\u6291\u5236\u5291<\/a><\/span><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Angiogenesis\u8840\u7ba1\u751f\u6210\u6291\u5236\u5291 |\u00a0ONO-4059\u985e\u4f3c\u7269\u8ca8\u865fCC8033 Chemcatch\u63d0\u4f9b\u4e00\u7cfb […]<\/p>\n","protected":false},"author":3,"featured_media":13608,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486,87],"tags":[3241],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/13607"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13607"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/13607\/revisions"}],"predecessor-version":[{"id":13714,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/13607\/revisions\/13714"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/13608"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13607"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13607"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}