{"id":12782,"date":"2017-08-14T12:04:31","date_gmt":"2017-08-14T04:04:31","guid":{"rendered":"http:\/\/biopioneer.com.tw\/?p=12782"},"modified":"2022-07-21T11:24:20","modified_gmt":"2022-07-21T03:24:20","slug":"d2hgdh%e9%87%8d%e7%b5%84%e6%b4%bb%e6%80%a7%e8%9b%8b%e7%99%bd-active-d-2-hydroxyglutarate-dehydrogenase-%e8%b2%a8%e8%99%9fp1001","status":"publish","type":"post","link":"http:\/\/biopioneer.com.tw\/?p=12782","title":{"rendered":"D2HGDH\u91cd\u7d44\u6d3b\u6027\u86cb\u767d |Active D-2-Hydroxyglutarate Dehydrogenase \u8ca8\u865fP1001"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><span style=\"color: #ff6600; font-size: 14pt;\"><strong>\u85e5\u7269\u4ee3\u8b1d<\/strong><strong>\u7cfb\u5217\u5546\u54c1<\/strong><\/span><\/p>\n<p>\u6d3b\u9ad4\u5167\u7684\u85e5\u7269\u6216\u7570\u751f\u7269\uff08\u4efb\u4f55\u5916\u4f86\u5316\u5b78\u7269\u8cea\uff09\u5305\u62ec\u5206\u5b50\u7684\u5438\u6536\uff0c\u5206\u4f48\uff0c\u4ee3\u8b1d\u548c\u6392\u6cc4\uff08ADME\uff09\u6240\u6709\u53cd\u61c9\/\u751f\u7406\u6a5f\u5236\u3002\u5206\u5b50\u4e4bMetabolism and Excretion , ADME\u5f71\u97ff\u66b4\u9732\u65bc\u7d44\u7e54\u4e4b\u6fc3\u5ea6\u548c\u52d5\u529b\u5b78\uff0c\u6c7a\u5b9a\u7d66\u4e88\u5316\u5408\u7269\u7684\u4f5c\u7528\u3002 Xenobiotics\u53ef\u4ee5\u901a\u904e\u5404\u7a2e\u751f\u7269\u5316\u5b78\u4fee\u98fe\u5982\u6c27\u5316\u9084\u539f\uff0c\u6c34\u89e3\uff0c\u6c34\u5408\uff0c\u7db4\u5408\uff0c\u7e2e\u5408\u6216\u7570\u69cb\u5316\u800c\u4ee3\u8b1d\uff0c\u76ee\u6a19\u662f\u4f7f\u5206\u5b50\u66f4\u89aa\u6c34\uff0c\u56e0\u6b64\u66f4\u5bb9\u6613\u6392\u6cc4\u3002\u5305\u62ec\u7d30\u80de\u8272\u7d20P450\u9176\uff0c\u651d\u53d6\u548c\u6d41\u51fa\u8f49\u904b\u86cb\u767d\uff08P-\u7cd6\u86cb\u767d\uff0cMDR\u8f49\u904b\u86cb\u767d\uff09\u3002BIOVISION\u63d0\u4f9b\u4e86\u4e00\u7cfb\u5217\u5de5\u5177\uff08\u751f\u7269\u5316\u5b78\uff0c\u86cb\u767d\u8cea\uff0c\u6297\u9ad4\uff0c\u6e2c\u5b9a\u8a66\u5291\u76d2\uff09\uff0c\u7528\u65bc\u7814\u7a76\u9069\u7528\u65bc\u85e5\u7269\u8a2d\u8a08\uff0c\u85e5\u7269\u4ee3\u8b1d\/\u8f49\u904b\uff0c\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u85e5\u7269\u4ee3\u8b1d\u9176\u548c\u8f49\u904b\u86cb\u767d\u8868\u9054\u7684\u8868\u9054\/\u8abf\u63a7ADME\u7684\u5404\u500b\u65b9\u9762\uff0c\u9776\u86cb\u767d\u7684\u7d50\u69cb &#8211; \u529f\u80fd\u95dc\u4fc2\u7b49\u5546\u54c1<\/p>\n<p><span style=\"color: #00ccff;\"><a style=\"color: #00ccff;\" href=\"http:\/\/biopioneer.com.tw\/?p=12782\" target=\"_blank\">D2HGDH\u91cd\u7d44\u6d3b\u6027\u86cb\u767d | Biovision\u8ca8\u865fP1001<\/a><\/span><\/p>\n<p>Active D-2-Hydroxyglutarate Dehydrogenase (D2HGDH), Recombinant<\/p>\n<p>\u50ac\u5316D-2-\u7fa5\u57fa\u620a\u4e8c\u9178\u6c27\u5316\u70ba\u03b1-\u916e\u620a\u4e8c\u9178\u7684\u6d3b\u6027\u86cb\u767d<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"cboxPhoto\" src=\"http:\/\/www.biovision.com\/media\/catalog\/product\/cache\/1\/image\/650x\/040ec09b1e35df139433887a97daa66f\/p\/1\/p1001.jpg\" alt=\"\" width=\"456\" height=\"438\" \/><\/p>\n<p>\u7522\u54c1\u4ecb\u7d39: D-2-\u7fa5\u57fa\u620a\u4e8c\u9178\uff08D2HG\uff09\u6c34\u5e73\u5728\u4ee3\u8b1d\u75be\u75c5\u548c\u5404\u7a2e\u764c\u75c7\u5982\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u4e2d\u660e\u986f\u5347\u9ad8\u3002 \u7814\u7a76\u8868\u660e\uff0cD2HG\u7684\u6aa2\u6e2c\u4f5c\u70ba\u8207IDH\uff08\u7570\u6ab8\u6aac\u9178\u812b\u6c2b\u9176\uff09\u7a81\u8b8a\u76f8\u95dc\u7684\u751f\u7269\u6a19\u8a8c\u7269\u6aa2\u6e2c\u3002 D2HGDH\u662f\u4e00\u7a2e\u7279\u7570\u7684NAD\u4f9d\u8cf4\u6027\u9176\uff0c\u5b83\u8207D2HG\u5177\u9ad4\u53cd\u61c9\u4e26\u5c07D2HG\u8f49\u5316\u70ba\u03b1-\u916e\u620a\u4e8c\u9178\u3002 D2HGDH\u662f\u5728\u751f\u7269\u6a19\u8a8c\u7269\u6e2c\u5b9a\u671f\u9593\u5340\u5206\u5169\u7a2e\u4ee3\u8b1d\u7269D2HG\u548cL-2-\u7fa5\u57fa\u620a\u4e8c\u9178\uff08L2HG\uff09\u7684\u95dc\u9375\u9176\u3002<\/p>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td>Alternate Name<\/td>\n<td>D-2-hydroxyglutarate dehydrogenase, D2HGDH, D2HGD<\/td>\n<\/tr>\n<tr>\n<td>Gene Symbol<\/td>\n<td>D2HGDH<\/td>\n<\/tr>\n<tr>\n<td>Source<\/td>\n<td>E. coli<\/td>\n<\/tr>\n<tr>\n<td>Appearance<\/td>\n<td>Dry powder<\/td>\n<\/tr>\n<tr>\n<td>Physical Form Description<\/td>\n<td>Lyophilized powder<\/td>\n<\/tr>\n<tr>\n<td>Molecular Weight<\/td>\n<td>39 kDa<\/td>\n<\/tr>\n<tr>\n<td>Purity by SDS-PAGE<\/td>\n<td>\u226599%<\/td>\n<\/tr>\n<tr>\n<td>Reconstitution Instructions<\/td>\n<td>Reconstitute in water to a concentration of 0.1-5 mg\/ml. The solution can be diluted into other aqueous buffers and stored at \u201320\u00b0C for future use.<\/td>\n<\/tr>\n<tr>\n<td>Amino Acid Sequence<\/td>\n<td>Full-length his-tagged D2HGDH<\/td>\n<\/tr>\n<tr>\n<td>Handling<\/td>\n<td>Centrifuge the vial prior to opening.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"color: #ff0000;\">\u76f8\u95dc\u5546\u54c1<\/span> <span style=\"color: #0000ff;\"><u>\uff08MDR1 \/ P-gp\uff09\u914d\u9ad4\u7be9\u9078<\/u> | <strong><a style=\"color: #0000ff;\" href=\"http:\/\/biopioneer.com.tw\/?p=12755\" target=\"_blank\">\u9ec3\u9eb4\u9709\u6bd2\u7d20\u5206\u6790<\/a><\/strong>\u00a0| <a style=\"color: #0000ff;\" href=\"http:\/\/biopioneer.com.tw\/?p=12786\" target=\"_blank\">P-glycoprotein\u591a\u682a\u6297\u9ad4<\/a>\u00a0|<a style=\"color: #0000ff;\" href=\"http:\/\/biopioneer.com.tw\/?p=12762\" target=\"_blank\">\u78fa\u91af\u80fa\u6b98\u7559ELISA\u8a66\u5291<\/a>\u00a0| <a style=\"color: #0000ff;\" href=\"http:\/\/biopioneer.com.tw\/?p=12765\">\u6c1f\u55b9\u8afe\u916e\u985e\u85e5\u7269ELISA<\/a>\u00a0|<a style=\"color: #0000ff;\" href=\"http:\/\/biopioneer.com.tw\/?p=12776\" target=\"_blank\">MK-571 sodium<strong>\uff5c<\/strong><\/a> <a style=\"color: #0000ff;\" href=\"http:\/\/biopioneer.com.tw\/?p=12782\" target=\"_blank\">D2HGDH\u91cd\u7d44\u6d3b\u6027\u86cb\u767d<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u85e5\u7269\u4ee3\u8b1d\u7cfb\u5217\u5546\u54c1 \u6d3b\u9ad4\u5167\u7684\u85e5\u7269\u6216\u7570\u751f\u7269\uff08\u4efb\u4f55\u5916\u4f86\u5316\u5b78\u7269\u8cea\uff09\u5305\u62ec\u5206\u5b50\u7684\u5438\u6536\uff0c\u5206\u4f48\uff0c\u4ee3\u8b1d\u548c\u6392\u6cc4\uff08AD [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":8690,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[486],"tags":[3360],"_links":{"self":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/12782"}],"collection":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12782"}],"version-history":[{"count":3,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/12782\/revisions"}],"predecessor-version":[{"id":12792,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/12782\/revisions\/12792"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=\/wp\/v2\/media\/8690"}],"wp:attachment":[{"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12782"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/biopioneer.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}